CN102548984B - Pi3激酶和/或mtor的抑制剂 - Google Patents

Pi3激酶和/或mtor的抑制剂 Download PDF

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Publication number
CN102548984B
CN102548984B CN201080030184.6A CN201080030184A CN102548984B CN 102548984 B CN102548984 B CN 102548984B CN 201080030184 A CN201080030184 A CN 201080030184A CN 102548984 B CN102548984 B CN 102548984B
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China
Prior art keywords
methyl
amine
triazin
amino
pyridyl
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Expired - Fee Related
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CN201080030184.6A
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English (en)
Chinese (zh)
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CN102548984A (zh
Inventor
K·安德鲁斯
Y·Y·伯
S·布克
V·J·西
N·德安格罗
B·J·赫贝里奇
F-T·洪
C·L·M·杰克逊
B·A·兰曼
H·廖
L·刘
N·尼施穆拉
M·H·诺尔曼
L·H·佩图斯
A·B·里德
A·L·史密斯
S·泰德斯
N·A·塔马约
B·吴
R·乌尔茨
K·杨
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201080030184.6A 2009-04-28 2010-04-27 Pi3激酶和/或mtor的抑制剂 Expired - Fee Related CN102548984B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17352009P 2009-04-28 2009-04-28
US61/173520 2009-04-28
US61/173,520 2009-04-28
US25853209P 2009-11-05 2009-11-05
US61/258532 2009-11-05
US61/258,532 2009-11-05
PCT/US2010/032593 WO2010126895A1 (en) 2009-04-28 2010-04-27 Inhibitors of pi3 kinase and / or mtor

Publications (2)

Publication Number Publication Date
CN102548984A CN102548984A (zh) 2012-07-04
CN102548984B true CN102548984B (zh) 2015-11-25

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US (2) US8362241B2 (enExample)
EP (1) EP2424859B1 (enExample)
JP (1) JP5697662B2 (enExample)
KR (1) KR20120007540A (enExample)
CN (1) CN102548984B (enExample)
AR (1) AR076486A1 (enExample)
AU (1) AU2010241723B2 (enExample)
BR (1) BRPI1015262A2 (enExample)
CA (1) CA2758986C (enExample)
CL (1) CL2011002691A1 (enExample)
CO (1) CO6440596A2 (enExample)
CR (1) CR20110634A (enExample)
EA (1) EA019700B1 (enExample)
IL (1) IL215731A0 (enExample)
MA (1) MA34207B1 (enExample)
MX (1) MX2011011335A (enExample)
NZ (1) NZ595572A (enExample)
PE (1) PE20121159A1 (enExample)
SG (1) SG175364A1 (enExample)
TW (1) TW201103902A (enExample)
UY (1) UY32582A (enExample)
WO (1) WO2010126895A1 (enExample)
ZA (1) ZA201108101B (enExample)

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US8772480B2 (en) 2014-07-08
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