AR074529A2 - Derivados de ciclohexano espirociclicos - Google Patents

Derivados de ciclohexano espirociclicos

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Publication number
AR074529A2
AR074529A2 ARP090103322A AR074529A2 AR 074529 A2 AR074529 A2 AR 074529A2 AR P090103322 A ARP090103322 A AR P090103322A AR 074529 A2 AR074529 A2 AR 074529A2
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Argentina
Prior art keywords
substituted
unsubstituted
unsaturated
saturated
alkyl
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Inventor
Brigitta Henkel
Bernd Sundermann
Claudia Hinze
Werner Englberger
Babette-Ivonne Kogel
Stefan Oberboersch
Hans Schick
Klaus Linz
Helmut Sonnenschein
Otto Aulenbacher
Elmar Friedrichs
Sally Rose
Mike Lipkin
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Gruenenthal Gmbh
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32185555&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR074529(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR074529A2 publication Critical patent/AR074529A2/es

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Abstract

Derivados de ciclohexano espirocíclicos que poseen la fórmula general (1) en la que: R1 y R2 son en forma independiente entre sí para H; alquilo C1-5 respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido, o CHO; o los restos R1 y R2 son juntos para CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 o (CH2)3-6, donde R11 significa H; alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, respectivamente saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo-, o heteroarilo, respectivamente sustituido en forma simple o múltiple o no sustituido; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente sustituido en forma simple o múltiple o no sustituido; R3 es para alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, respectivamente saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo, respectivamente no sustituido o sustituido en forma simple o múltiple; arilo, o cicloalquilo C3-8 unido por el grupo alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente no sustituido o sustituido en forma simple o múltiple; W es NR4 O ó S; y R4 es para H; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; arilo, o heteroarilo, respectivamente sustituido o no sustituido; arilo, heteroarilo o cicloalquilo unido por el grupo alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente sustituido en forma simple o múltiple o no sustituido; COR12; SO2R12, donde R12 significa H; alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, sustituido en forma simple o múltiple o no sustituido; cicloalquilo C3-8, respectivamente saturado o no saturado, sustituido en forma simple o múltiple o no sustituido; arilo-, o heteroarilo, respectivamente sustituido en forma simple o múltiple o no sustituido; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, respectivamente sustituido en forma simple o múltiple o no sustituido; OR13; NR14R15; R5 es para =O; H; COOR13, CONR13, OR13; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; R6 es para H; F, Cl, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15; alquilo C1-5, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o R5 y R6 significan juntos (CH2)n con n = 2, 3, 4, 5 ó 6, donde los átomos de hidrógeno individuales pueden estar reemplazados también por F, Cl, Br, I, NO2, CF3, OR13, CN o alquilo C1-5; R7, R8, R9 y R10 son en forma independiente entre sí para H, F, Cl, Br, I, NO2, CF3, OR13, SR13, SO2R13,SO2OR13, SO2NH2, CN, COOR13, NR14R15; alquilo C1-5, cicloalquilo C3-8, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; donde R13 significa H; alquilo C1-5 respectivamente saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; cicloalquilo C3-8, respectivamente saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; R14 y R15 significan en forma independiente entre sí H; alquilo C1-5, respectivamente saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o cicloalquilo C3-8, respectivamente saturado o no saturado, no sustituido o sustituido en forma simple o múltiple; arilo-, o heteroarilo, no sustituido o sustituido en forma simple o múltiple; o arilo, cicloalquilo C3-8 o heteroarilo unido por alquilo C1-3, saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; o R14 y R15 forman juntos CH2CH2OCH2CH2, CH2CH2NR16CH2CH2 o (CH2)3-6, donde R16 significa H; alquilo C1-5 saturado o no saturado, ramificado o no ramificado, no sustituido o sustituido en forma simple o múltiple; X representa NR17; R17 es para H, alquilo C1-5, saturado o no saturado, ramificado o no ramificado; COR12 o SO2R12; en la forma del racemato; de los enantiómeros, diastereómeros, mezclas de los enantiómeros o diastereómeros o de un enantiómero o diastereómero individual; de las bases y/o sales de ácidos o cationes fisiológicamente compatibles. Un procedimiento para su elaboración, medicamentos que contienen estos compuestos y el uso de los derivados de ciclohexano espirocíclicos para elaborar medicamentos.
ARP090103322 2002-11-11 2009-08-28 Derivados de ciclohexano espirociclicos AR074529A2 (es)

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