AR070910A1 - Derivados de sulfonamida sustituida - Google Patents
Derivados de sulfonamida sustituidaInfo
- Publication number
- AR070910A1 AR070910A1 ARP090100936A ARP090100936A AR070910A1 AR 070910 A1 AR070910 A1 AR 070910A1 AR P090100936 A ARP090100936 A AR P090100936A AR P090100936 A ARP090100936 A AR P090100936A AR 070910 A1 AR070910 A1 AR 070910A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- heteroaryl
- cycloalkyl
- group
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
Abstract
La presente se relaciona con los derivados de sulfonamida sustituida, los procesos para la preparacion de estos, los medicamentos que contienen estos compuestos y el uso de los derivados de sulfonamida sustituida para la preparacion de medicamentos, para el dolor, migrana, diabetes, neuropatías, antialérgico. Reivindicacion 1: Un derivado de sulfonamida sustituida de la formula general 1 caracterizado porque m representa 0 o 1; n y p independiente uno del otro, cada uno representa 0, 1 o 2; u y v independiente uno del otro, cada uno representa 0, 1, 2, 3 o 4, con la condicion de que u + v = 1, 2, 3 o 4; Q representa un enlace simple, -CH2- o -O-; A representa un enlace simple y X representa N o A representa -N(R7)-(CH2)0-5- y X representa CH; R1 representa arilo, heteroarilo o un arilo o heteroarilo unido vía un grupo alquileno C1-3; R2 y R3 están definidos segun se describe en (i) o (ii); (i) R2 representa H, alquilo C1-6, cicloalquilo C3-8, arilo, heteroarilo: o denota un cicloalquilo C3-8, arilo o heteroarilo ligados vía un grupo alquileno C1-6, alquenileno C2-6 o alquinileno C2-6; R3 representa H, alquilo C1-6, arilo o heteroarilo, o denota un arilo o heteroarilo ligados vía un grupo alquileno C1-6, alquenileno C2-6 o alquinileno C2-6, o (ii) R2 y R3 junto con el grupo -N-(CH2)m-CH- que se une a ellos, forman un anillo heterocíclico, que se puede fusionar con un radical arilo o heteroarilo, en donde el anillo heterocíclico es saturado o al menos monoinsaturado, pero no aromático, tiene 4-, 5-, 6- o 7- miembros, puede contener, además del heteroátomo N al cual está ligado el radical R2, al menos un heteroátomo más o un grupo de heteroátomos, escogidos del grupo constituido por N, NR8, O, S, S=O o S(=O)2; en donde el radical R8 denota H, alquilo C1-6, -C(=O)-R9, cicloalquilo C3-8, arilo, heteroarilo o cicloalquilo C3-8, arilo o heteroarilo ligados vía un grupo alquileno C1-3, y R9 denota alquilo C1-6, cicloalquilo C3-8, arilo o heteroarilo ligados vía un grupo alquileno C1-3, o cicloalquilo C3-8, arilo o heteroarilo ligados via un grupo alquileno C1-3; R4 y R5 están definidos segun se describe en (iii) o (iv); (iii) R4 y R5 independiente uno del otro, cada uno denota H, alquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, heterocicloalquilo de 3- a 8- miembros, arilo o heteroarilo o cicloalquilo C3-8, heterocicloalquilo de 3- a 8- miembros, arilo o heteroarilo ligados vía un grupo alquileno C1-3; o (iv) R4 y R5 junto con el átomo de nitrogeno que se une a ellos, forman un anillo heterocíclico insustituido o mono o polisustituido, que se puede fusionar con un sistema de anillo saturado, al menos monoinsaturado o aromático, insustituido o mono o polisustituido, en donde el anillo heterocíclico es saturado o al menos monoinsaturado, pero no aromático, tiene 4-, 5-, 6- o 7- miembros, puede contener, además del heteroátomo N al cual están ligados los radicales R4 y R5, al menos un heteroátomo más o un grupo de heteroátomos, escogidos del grupo constituido por N, NR10, O, S, S=O y S(=O)2; R10 representa un radical tomado del grupo formado por H, alquilo C1-6, cicloalquilo C3-8, arilo, heteroarilo o un arilo, heteroarilo o cicloalquilo C3-8, ligados vía un grupo alquileno C1-3, y R11 representa un radical tomado del grupo formado por H, alquilo C1-6, cicloalquilo C3-8, arilo o heteroarilo o un arilo, heteroarilo o cicloalquilo C1-3, ligados vía un grupo alquileno C1-3; R6 representa un arilo, heteroarilo o un arilo o heteroarilo, ligados via un grupo alquileno C1-6; R7 representa H, alquilo C1-6, cicloalquilo C3-8 o un cicloalquilo C3-8, ligados vía un grupo alquileno C1-3; en donde los radicales mencionados anteriormente alquilo C1-6, alquenilo C2-6, alquileno C1-3, alquileno C1-6, alquenileno C2-6, alquinileno C2-6, cicloalquilo C3-8, heterocicloalquilo, arilo y heteroarilo, pueden en cada caso ser insustituidos o sustituidos una o varias veces por radicales idénticos o diferentes y los radicales mencionados anteriormente alquilo C1-6, alquenilo C2-6, alquileno C1-3, alquileno C1-6, alquenileno C2-6, pueden en cada caso ser ramificados o no ramificados: opcionalmente, en la forma de un enantiomero individual o de un diastereomero individual, en la forma del racemato, de los enantiomeros, de los diastereomeros, mezclas de los enantiomeros y/o de los diastereomeros, y en cada caso en la forma de sus bases y/o sales fisiologicamente compatibles.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08004922 | 2008-03-17 |
Publications (1)
Publication Number | Publication Date |
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AR070910A1 true AR070910A1 (es) | 2010-05-12 |
Family
ID=39743099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100936A AR070910A1 (es) | 2008-03-17 | 2009-03-16 | Derivados de sulfonamida sustituida |
Country Status (9)
Country | Link |
---|---|
US (1) | US20090253669A1 (es) |
EP (1) | EP2257527A1 (es) |
JP (1) | JP2011514368A (es) |
AR (1) | AR070910A1 (es) |
CA (1) | CA2718551A1 (es) |
CL (1) | CL2009000637A1 (es) |
PE (1) | PE20091579A1 (es) |
TW (1) | TW200940523A (es) |
WO (1) | WO2009115257A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2086935A1 (de) * | 2006-10-16 | 2009-08-12 | Grünenthal GmbH | Substituierte sulfonamid-derivate als bradykinin 1 rezeptor modulatoren |
US20110046106A1 (en) * | 2008-02-06 | 2011-02-24 | Boehringer Ingelheim International Gmbh | Aryl sulfonamides as effective analgesics |
RU2503674C2 (ru) * | 2008-04-08 | 2014-01-10 | Грюненталь Гмбх | Замещенные производные сульфонамида |
US20110152246A1 (en) * | 2009-12-18 | 2011-06-23 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
US8658827B2 (en) * | 2010-12-08 | 2014-02-25 | Gruenenthal Gmbh | Method for synthesizing substituted aminocyclohexanone compounds |
US9770026B2 (en) | 2012-10-25 | 2017-09-26 | Shenyang Sinochem Agrochemicals R&D Co., Ltd. | Substituted pyrimidine compound and uses thereof |
CN104710409B (zh) | 2013-12-13 | 2019-06-04 | 沈阳中化农药化工研发有限公司 | 吡唑基嘧啶胺类化合物及用途 |
EP3858810A1 (en) * | 2020-02-03 | 2021-08-04 | Esteve Pharmaceuticals, S.A. | Dialkylaminoarylcycloalkylamide derivatives having multimodal activity against pain |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026335B2 (en) * | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
EA008921B1 (ru) * | 2003-03-25 | 2007-08-31 | Лаборатуар Фурнье С.А. | Производные бензолсульфонамидов, способ их получения и их применение для лечения боли |
DE102004023508A1 (de) * | 2004-05-10 | 2005-12-08 | Grünenthal GmbH | Säurederivate substituierter Cyclohexyl-1,4-diamine |
US20060217362A1 (en) * | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
WO2007101007A2 (en) * | 2006-02-23 | 2007-09-07 | Neurogen Corporation | Aryl sulfonyl heterocycles |
-
2009
- 2009-02-27 TW TW098106277A patent/TW200940523A/zh unknown
- 2009-03-06 PE PE2009000337A patent/PE20091579A1/es not_active Application Discontinuation
- 2009-03-16 US US12/404,876 patent/US20090253669A1/en not_active Abandoned
- 2009-03-16 JP JP2011500091A patent/JP2011514368A/ja active Pending
- 2009-03-16 WO PCT/EP2009/001888 patent/WO2009115257A1/en active Application Filing
- 2009-03-16 EP EP09721918A patent/EP2257527A1/en not_active Withdrawn
- 2009-03-16 CA CA2718551A patent/CA2718551A1/en not_active Abandoned
- 2009-03-16 AR ARP090100936A patent/AR070910A1/es not_active Application Discontinuation
- 2009-03-17 CL CL2009000637A patent/CL2009000637A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2011514368A (ja) | 2011-05-06 |
CA2718551A1 (en) | 2009-09-24 |
EP2257527A1 (en) | 2010-12-08 |
CL2009000637A1 (es) | 2010-03-05 |
TW200940523A (en) | 2009-10-01 |
WO2009115257A1 (en) | 2009-09-24 |
US20090253669A1 (en) | 2009-10-08 |
PE20091579A1 (es) | 2009-10-23 |
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