AR074275A1 - Derivados de oxoacetidina, procedimiento para su preparacion y su uso como moduladores de la melanocortina - Google Patents

Derivados de oxoacetidina, procedimiento para su preparacion y su uso como moduladores de la melanocortina

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Publication number
AR074275A1
AR074275A1 ARP090104265A ARP090104265A AR074275A1 AR 074275 A1 AR074275 A1 AR 074275A1 AR P090104265 A ARP090104265 A AR P090104265A AR P090104265 A ARP090104265 A AR P090104265A AR 074275 A1 AR074275 A1 AR 074275A1
Authority
AR
Argentina
Prior art keywords
substituted
preparation
general formula
alkoxy
oxoacetidine
Prior art date
Application number
ARP090104265A
Other languages
English (en)
Inventor
Nicolas Rodeville
Claire Bouix-Peter
Jean-Claude Pascal
Pascale Mauvais
Itaru Suzuki
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR074275A1 publication Critical patent/AR074275A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente se refiere a compuestos derivados de oxoazetidina correspondientes a la fórmula general (1), a las composiciones que los contienen, al procedimiento para su preparación y a su uso en composiciones farmacéuticas o cosméticas. Reivindicación 1: Compuesto de fórmula general (1) donde R1 representa un arilo, arilo sustituido o cicloalquilo; R2 representa un átomo de H, hidroxilo, alquilo inferior, alquilo inferior sustituido, alquilo superior, alquilo superior sustituido, cicloalquilo, cicloalquilalquilo, alcoxi inferior, alcoxi inferior sustituido, alcoxi superior, alcoxi superior sustituido, cicloalquilalcoxi, o un aciloxi; R3 representa aralquilo o aralquilo sustituido; R4 representa heteroaralquilo, heteroaralquilo sustituido, heteroalquilo o heteroalquilo sustituido; R5 representa H, hidroxilo, amino, una acilamina, o una sulfonamida; y también las sales y enantiómeros correspondientes de los compuestos de la fórmula general (1).
ARP090104265A 2008-11-04 2009-11-04 Derivados de oxoacetidina, procedimiento para su preparacion y su uso como moduladores de la melanocortina AR074275A1 (es)

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US11113008P 2008-11-04 2008-11-04
FR0857496A FR2937972B1 (fr) 2008-11-04 2008-11-04 Derives d'oxoazetidine, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique

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JP (1) JP5798486B2 (es)
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AR (1) AR074275A1 (es)
AU (1) AU2009312818B2 (es)
BR (1) BRPI0916069C1 (es)
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FR2984167B1 (fr) 2011-12-16 2014-01-17 Galderma Res & Dev Association d'un agoniste des recepteurs des prostaglandines et d'un agoniste du recepteur mc1r pour le traitement et/ou la prevention de desordres de la pigmentation
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FR2992317B1 (fr) 2012-06-22 2016-05-13 Diverchim Procede de preparation de peptides chiraux
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EP3573645B1 (en) * 2017-02-01 2024-03-13 Vallaurix Mc S.A.R.L. Alpha-msh analogues used in the treatment of xeroderma pigmentosum
CN110461328A (zh) 2017-03-28 2019-11-15 吉利德科学公司 治疗肝疾病的治疗组合
JP2022519906A (ja) 2019-02-19 2022-03-25 ギリアード サイエンシーズ， インコーポレイテッド Ｆｘｒアゴニストの固体形態
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WO2023173132A1 (en) 2022-03-11 2023-09-14 Regeneron Pharmaceuticals, Inc. Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof

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RU2011122637A (ru) 2012-12-20
BRPI0916069B8 (pt) 2019-12-17
EP2342194A1 (en) 2011-07-13
KR101689042B1 (ko) 2016-12-22
US20150045559A1 (en) 2015-02-12
AU2009312818A1 (en) 2010-05-14
JP2012507491A (ja) 2012-03-29
CN102203081A (zh) 2011-09-28
MX2011004068A (es) 2011-05-31
WO2010052253A1 (en) 2010-05-14
BRPI0916069C1 (pt) 2021-05-25
CA2738785A1 (en) 2010-05-14
EP2342194B1 (en) 2018-08-08
BRPI0916069A2 (pt) 2015-11-10
RU2671189C1 (ru) 2018-10-30
FR2937972A1 (fr) 2010-05-07
FR2937972B1 (fr) 2013-03-29
US9630949B2 (en) 2017-04-25
JP5798486B2 (ja) 2015-10-21
CA2738785C (en) 2017-05-16
US8871187B2 (en) 2014-10-28
RU2569886C2 (ru) 2015-12-10
BRPI0916069B1 (pt) 2019-11-05
CN104387372B (zh) 2018-06-26
AU2009312818B2 (en) 2014-11-06
US20110274638A1 (en) 2011-11-10
KR20110088555A (ko) 2011-08-03
CN104387372A (zh) 2015-03-04

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