AR073061A1 - Compuestos organicos para la cicatrizacion de heridas - Google Patents

Compuestos organicos para la cicatrizacion de heridas

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Publication number
AR073061A1
AR073061A1 ARP090103148A ARP090103148A AR073061A1 AR 073061 A1 AR073061 A1 AR 073061A1 AR P090103148 A ARP090103148 A AR P090103148A AR P090103148 A ARP090103148 A AR P090103148A AR 073061 A1 AR073061 A1 AR 073061A1
Authority
AR
Argentina
Prior art keywords
methyl
amino
pyrrolidin
pyrimidin
acetyl
Prior art date
Application number
ARP090103148A
Other languages
English (en)
Inventor
Thomas Klein
Michael Mark
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2008/060740 external-priority patent/WO2009024542A2/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR073061A1 publication Critical patent/AR073061A1/es

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: Un inhibidor de DPP-4 tanto, en una primera realizacion (realizacion A), de formula (1) o de formula (2) o de formula (3) o de formula (4) en las que R1 se refiere a ([1,5]naftiridin-2-il)metilo, (quinazolin-2-il)metilo, (quinoxalin-6-il)metilo, (4-metil-quinazolin-2-il)metilo, 2-ciano-bencilo, (3-ciano-quinolin-2-il)metilo, (3-ciano-piridin-2-il)metilo, (4-metil-pirimidin-2-il)metilo o (4,6-dimetil-pirimidin-2-il)metilo y R2 se refiere a 3-(R)-amino-piperidin-1-ilo, (2-amino-2-metil-propil)-metilamino o (2-(S)-amino-propil)-metilamino, o su sal farmacéuticamente aceptable; o como en una segunda realizacion (realizacion B), seleccionado entre el grupo que consiste en sitagliptina, vildagliptina, saxagliptina, alogliptina, (2S)-1-{[2-(5-metil-2-feniloxazol-4-il)etilamino]acetil}pirrolidin-2-carbonitrilo, (2S)-1-{[1,1-dimetil-3-(4-piridin-3-ilimidazol-1-il)propilamino]acetil}pirrolidin-2-carbonitrilo, (S)-1-((2S,3S,11bS)-2-amino-9,10-dimetoxi-1,3,4,6,7,11b-hexahidro-2H-pirido[2,1-a]isoquinolin-3-il)-4-fluorometilpirrolidin-2-ona, (3,3-difluoropirrolidin-1-il)-((2S,4S)-4-(4-(pirimidin-2-il)piperazin-1-il)pirrolidin-2-il)metanona, (1-((3S,4S)-4-amino-1-(4-(3,3-difluoropirrolidin-1-il)-1,3,5-triazin-2-il)pirrolidin-3-il)-5,5-difluoropiperidin-2-ona, (2S,4S)-1-{2-[(3S,1R)-3-(1H-1,2,4-triazol-1-ilmetil)ciclopentilamino]-acetil}-4-fluoropirrolidin-2-carbonitrilo, (R)-2-[6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro-2H-pirimidin-1-ilmetil]-4-fluoro-benzonitrilo, bis-dimetilamida del ácido 5-{(S)-2-[2-((S)-2-ciano-pirrolidin-1-il)-2-oxo-etilamino]-propil)-5-(1H-tetrazol-5-il)-10,11-dihidro-5H-dibenzo[a,d]ciclohepten-2,8-dicarboxílico, 3-{(2S,4S)-4-[4-(3-metil-1-fenil-1H-pirazol-5-il)piperazin-1-il]pirrolidin-2-ilcarbonil}tiazolidina, ácido [(2R)-1-{[(3R)-pirrolidin-3-ilamino]acetil}pirrolidin-2-il]boronico, (2S,4S)-1-[2-[(4-etoxicarbonilbiciclo[2.2.2]oct-1-il)amino]acetil]-4-fluoropirrolidina-2-carbonitrilo, 2-({6-[(3R)-3-amino-3-metilpiperidin-1-il]-1,3-dimetil-2,4-dioxo-1,2,3,4-tetrahidro-5H-pirrolo[3,2-d]pirimidin-5-il}metil)-4-fluorobenzonitrilo, y 6-[(3R)-3-amino-piperidin-1-il]-5-(2-cloro-5-fluoro-bencil)-1,3-dimetil-1,5-dihidro-pirrolo[3,2-d]pirimidin-2,4-diona, o su sal farmacéuticamente aceptable, caracterizado porque se utiliza en la cicatrizacion de heridas.
ARP090103148A 2008-08-15 2009-08-14 Compuestos organicos para la cicatrizacion de heridas AR073061A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2008/060740 WO2009024542A2 (en) 2007-08-17 2008-08-15 Purin derivatives for use in the treatment of fab-related diseases
EP09150252 2009-01-08
EP09160682 2009-05-19

Publications (1)

Publication Number Publication Date
AR073061A1 true AR073061A1 (es) 2010-10-13

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ARP090103148A AR073061A1 (es) 2008-08-15 2009-08-14 Compuestos organicos para la cicatrizacion de heridas

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US (2) US20110190322A1 (es)
EP (2) EP2326326B1 (es)
JP (2) JP5906086B2 (es)
KR (2) KR101791403B1 (es)
CN (2) CN103816158A (es)
AR (1) AR073061A1 (es)
AU (1) AU2009281122C1 (es)
BR (1) BRPI0917675A2 (es)
CA (1) CA2735562C (es)
CO (1) CO6351742A2 (es)
EA (1) EA031225B1 (es)
EC (1) ECSP11010831A (es)
ES (1) ES2764251T3 (es)
HK (1) HK1153926A1 (es)
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MA (1) MA32562B1 (es)
MX (2) MX370599B (es)
MY (1) MY164581A (es)
NZ (1) NZ604091A (es)
PE (1) PE20110297A1 (es)
PH (1) PH12018500768A1 (es)
TW (1) TWI450901B (es)
UA (1) UA119131C2 (es)
UY (1) UY32048A (es)
WO (1) WO2010018217A2 (es)

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