AR054385A1 - Inhibidores de la triazolopiridin -11- beta - hidroxiesteroide- deshidroogenasa tipo 1 - Google Patents

Inhibidores de la triazolopiridin -11- beta - hidroxiesteroide- deshidroogenasa tipo 1

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Publication number
AR054385A1
AR054385A1 ARP060102406A ARP060102406A AR054385A1 AR 054385 A1 AR054385 A1 AR 054385A1 AR P060102406 A ARP060102406 A AR P060102406A AR P060102406 A ARP060102406 A AR P060102406A AR 054385 A1 AR054385 A1 AR 054385A1
Authority
AR
Argentina
Prior art keywords
heteroaryl
aryl
heterocyclyl
alkyl
cycloalkyl
Prior art date
Application number
ARP060102406A
Other languages
English (en)
Inventor
James J Li
Haixia Wang
Lawrence G Hamann
Zheming Ruan
Christopher B Cooper
Jeffrey A Robi
Jun Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR054385A1 publication Critical patent/AR054385A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1), los enantiomeros, los diastereoisomeros, solvatos, sales o profármacos de los mismos caracterizado porque: W es arilo, cicloalquilo, heteroarilo o heterociclilo, todos los cuales pueden estar opcionalmente sustituidos con R1, R1a, R1b, R1c y R1d; R1, R1a, R1b, R1c y R1d son independientemente H, halogeno, -OH, -CN, -NO2, -CO2R2a, -CONR2R2a, -SO2NR2R2a, -SOR2a, -SO2R2a, -NR2SO2R6, -NR2CO2R6, alquilo, haloalquilo, cicloalquilo, alcoxi, ariloxi, alquenilo, haloalcoxi, alquiltio, ariltio, arilsulfonilo, alquilamino, aminoalquilo, arilamino, heteroarilamino, arilo, heteroarilo o heterociclilo, en donde el grupo arilo, heteroarilo o heterociclilo puede estar opcionalmente sustituido con R7, R7a, R7b y R7c; o alternativamente cualesquiera dos de R1, R1a, R1b, R1c y R1d pueden ser tomados conjuntamente para formar un arilo fusionado, heteroarilo, anillo de heterociclilo o anillo de espiro-heterociclilo; L es un enlace, O, S, SO, SO2, alquenilo, cicloalquilo,. NR5, CR2R2a, CR2R2aCR2bR2c, SO2NR2, OCR2R2a, OCR2R2aCR2bR2c, CR2R2aO, CR2bR2cCR2R2aO, N(R5)CR2R2a, CR2R2aN(R5), SCR2R2a, CR2R2aS, CR2R2aSO, CR2R2aSO2, SOCR2R2a, SO2CR2R2a, CR2R2aOCR2bR2c, CR2R2aSCR2bR2c, CR2R2aSO2CR2bR2c, SO2NR2CR2aR2b, COCR2R2a, CR2R2aCO, CONR5CR2aR2b, CR2R2aCR2bR2cS, CR2R2aCR2bR2cSO, CR2R2aCR2bR2cSO2, con la condicion de que L no sea un enlace cuando W es fenilo, R2, R2a, R2b y R2c son independientemente H, halogeno, alquilo o haloalquilo; o alternativamente cualesquiera dos de R2, R2a, R2b y R2c pueden ser tomados conjuntamente con el átomo al cual están enlazados para formar un cicloalquilo, cicloalquilo sustituido con halogeno o anillo de heterociclilo; R3, R3a y R3b son independientemente H, halogeno, -OH, -CN, -NO2, -CO2R2a, -CONR2R2a, -SO2NR2R2a, -SOR2a, -SO2R2a, -NR2SO2R6, -NR2CO2R6, alquilo, haloalquilo, cicloalquilo, alcoxi, ariloxi, alquenilo, haloalcoxi, alquiltio, ariltio, arilsulfonilo, alquilamino, aminoalquilo, arilamino, heteroarilamino, arilo, heteroarilo o heterociclilo, donde el arilo, heteroarilo o el heterociclilo puede estar opcionalmente sustituido con R7, R7a, R7b y R7c; R4 es biciclo[2,2,2]octilo o biciclo[2,2,1]heptilo, los cuales pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados de halogeno, -OH, -OR6, -SR6, -OCOR6, -CN, -NR5COR6, -NR5SO2R6, -COR6, -CO2R6, -CO2H, -OCONR2R2a, -CONR2R2a, -NR5CO2R6, -SO2R6, alquilo, alcoxi, arilo, amino, heterociclilo o heteroarilo, en donde los grupos alquilo, alcoxi, arilo, heteroarilo o heterociclilo pueden estar opcionalmente sustituidos con R7, R7a, R7b, y R7c; o R4 es cicloalquilo, diferente de biciclo[2,2,2]octilo o biciclo[2,2,1]heptilo, los cuales pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados de halogeno, -OH, -OR6, -SR6, -OCOR6, -CN, -NR5COR6, -NR5SO2R6, -COR6, -CO2R6, -CO2H, -OCONR2R2a, -CONR2R2a, - NR5CO2R6, -SO2R6, alquilo, alcoxi, arilo, amino, heterociclilo o heteroarilo, en donde los grupos alquilo, alcoxi, arilo, heteroarilo o heterociclilo pueden estar opcionalmente sustituidos con R7, R7a, R7b, y R7c; o R4 es heterociclilo, los cuales pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados de halogeno, -OH, -OR6, -SR6, -OCOR6, -CN, -NR5COR6, -NR5SO2R6, -COR6, -CO2R6, -CO2H, -OCONR2R2a, -CONR2R2a, -NR5CO2R6, -SO2R6, alquilo, alcoxi, arilo, amino, heterociclilo o heteroarilo, en donde los grupos alquilo, alcoxi, arilo, heteroarilo o heterociclilo pueden estar opcionalmente sustituidos con R7, R7a, R7b, y R7c; R5 en cada aparicion, es independientemente , alquilo, cicloalquilo, arilo, haloalquilo, COR2a, CO2R2a, SO2NR2R2a o SO2R2a; R6 n cada aparicion, e independientemente alquilo, cicloalquilo, arilo o heteroarilo, todos los cuales pueden estar opcionalmente sustituidos con R7, R7a, R7b y R7c; y R7, R7a, R7b, y R7c, en cada aparicion, son independientemente halo, alquilo, haloalquilo, alcoxi, arilo, ariloxi, arilarilo, arilalquilo, arilalquiloxi, alquenilo, cicloalquilo, cicloalquilalquilo, cicloalquilalquiloxi, amino, -OH, hidroxialquilo, acilo, heteroarilo, heteroariloxi, heteroarilalquilo, heteroarilalcoxi, ariloxialquilo, alquiltio, arilalquiltio, ariloxiarilo, alquilamido, alcanoilamino, arilcarbonilamino, -NO2, -CN o tiol.
ARP060102406A 2005-06-09 2006-06-08 Inhibidores de la triazolopiridin -11- beta - hidroxiesteroide- deshidroogenasa tipo 1 AR054385A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68899305P 2005-06-09 2005-06-09
US11/448,947 US7579360B2 (en) 2005-06-09 2006-06-07 Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors

Publications (1)

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AR054385A1 true AR054385A1 (es) 2007-06-20

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US (2) US7579360B2 (es)
EP (1) EP1888582B1 (es)
JP (1) JP4994368B2 (es)
KR (1) KR20080019276A (es)
CN (1) CN102558176A (es)
AR (1) AR054385A1 (es)
AT (1) ATE487717T1 (es)
AU (1) AU2006257924B2 (es)
BR (1) BRPI0611773A2 (es)
CA (1) CA2611529C (es)
CY (1) CY1111148T1 (es)
DE (1) DE602006018135D1 (es)
DK (1) DK1888582T3 (es)
EA (1) EA013017B1 (es)
GE (1) GEP20105073B (es)
HK (1) HK1112463A1 (es)
HR (1) HRP20110073T1 (es)
IL (1) IL187812A (es)
MX (1) MX2007015285A (es)
NO (1) NO20076055L (es)
NZ (1) NZ563457A (es)
PE (1) PE20070164A1 (es)
PL (1) PL1888582T3 (es)
PT (1) PT1888582E (es)
SI (1) SI1888582T1 (es)
TW (1) TW200716111A (es)
WO (1) WO2006135795A1 (es)

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