AR049536A1 - Compuestos heterociclicos condensados con actividad inhibitoria de la proteina tirosina cinasa; una composicion farmaceutica que los contiene como principio activo y su utilizacion en el tratamiento del cancer. - Google Patents

Compuestos heterociclicos condensados con actividad inhibitoria de la proteina tirosina cinasa; una composicion farmaceutica que los contiene como principio activo y su utilizacion en el tratamiento del cancer.

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Publication number
AR049536A1
AR049536A1 ARP050102668A ARP050102668A AR049536A1 AR 049536 A1 AR049536 A1 AR 049536A1 AR P050102668 A ARP050102668 A AR P050102668A AR P050102668 A ARP050102668 A AR P050102668A AR 049536 A1 AR049536 A1 AR 049536A1
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Argentina
Prior art keywords
substituted
alkyl
heteroaryl
aryl
heterocycloalkyl
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ARP050102668A
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English (en)
Inventor
Robert Borzilleri
Zhong Chen
Tram N Huynh
Wayne Vaccaro
Xiao-Tao Chen
Kyoung S Kim
Zhen-Wei Cai
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Bristol Myers Squibb Co
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Publication of AR049536A1 publication Critical patent/AR049536A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D495/04—Ortho-condensed systems

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Abstract

Los compuestos son utiles como inhibidores de la proteína cinasa y por lo tanto son utiles para el tratamiento del cáncer y de otras enfermedades mediada por la proteína cinasa. Reivindicacion 1: Un compuesto que tiene la formula (1) o (2) que incluye sales farmacéuticamente aceptables del mismo caracterizado porque: R1 es H, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilalquilo, arilalquilo substituido, arilo, arilo substituido, alquenilo, alquenilo substituido, alquinilo, alquinilo substituido, heteroarilo, heteroarilo substituido, heterociclo, heterociclo substituido, heteroarilalquilo, heteroarilalquilo substituido, heterocicloalquilo o heterocicloalquilo substituido; cada R2 es independientemente, H, halogeno, ciano, NO2, OR5, NR6R7, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilo, arilo substituido, heteroarilo, heteroarilo substituido, heterociclo, heterociclo substituido, arilalquilo, arilalquilo substituido, heterocicloalquilo, o heterocicloalquilo substituido; B es O, NR8, S, SO, SO2, CR9R10; V es NR11 o -(CR47R48)p-; W o X son independientemente C o N; Y es O, S, o NR12; Z es -CR13R14-, -(CR13R14)mNR15-; l es 0 hasta 4; m es 0 hasta 2; n es 0 hasta 4; p es 0 hasta 4, con la condicion de que si p es 0, R1 no es fenilo; A es un resto de formula (3) a (11); Q es CR19; D es CR20 o N; G es S, O, o NR21, con la condicion de que si A es un resto de formula (4) o de formula (5) y G es S, R4 no es un grupo fenilo substituido; R3, R5, R6, R7, R8, R11 y R15 son cada uno independientemente H, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilo, arilo substituido, heteroarilo, heteroarilo substituido, heterocicloalquilo, o heterocicloalquilo substituido; R4 es arilo, arilo substituido, heteroarilo, heteroarilo substituido, heterocicloalquilo, o heterocicloalquilo substituido; R9 y R10 son independientemente H, halogeno, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilo, arilo substituido, heteroarilo, heteroarilo substituido, heterocicloalquilo, o heterocicloalquilo substituido; R12 es H, alquilo, alquilo substituido, CN, NO2 o SO2NH2; R13, R14, R15, R47 y R48 son independientemente H, halogeno, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilo, arilo substituido, heteroarilo, heteroarilo substituido, heterociclo, heterociclo substituido o tomados juntos para formar un anillo heterocíclico o carbocíclico desde 3 hasta 8 átomos; R16, R17, R18, R20, R22, R23, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R75, R76, R78, y R79, son independientemente H, halogeno, NO2, ciano, OR26, NR27R28, CO2R29, C(O)NR30R31, SO2R32, SO2NR33R34, NR35SO2R36, NR37C(O)R38, NR39CO2R40, -CO(CH2)lR41; -CONH(CH2)lR42, alquilaminoalquilo, alquilaminoalquinilo, alquilo C1-6, alquilo C1-6 substituido, cicloalquilo C3-7, cicloalquilo C3-7 substituido, alquenilo, alquenilo substituido, alquinilo, alquinilo substituido, hidroxialquilo, arilo, arilo substituido, heteroarilo, heteroarilo substituido, arilalquilo, arilalquilo substituido, heterocicloalquilo, o heterocicloalquilo substituido; R19 es H o ciano; R21 y R24 son independientemente H, alquilo C1-6, o alquilo C1-6 substituido; R25, R74 y R77 son independientemente H, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilo, arilo substituido, arilalquilo, arilalquilo substituido, heteroarilo, heteroarilo substituido, heterocicloalquilo, o heterocicloalquilo substituido; R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, y R42 son independientemente H, alquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, arilo, arilo substituido, arilalquilo, arilalquilo substituido, heteroarilo, heteroarilo substituido, heterocicloalquilo, o heterocicloalquilo substituido.
ARP050102668A 2004-06-28 2005-06-28 Compuestos heterociclicos condensados con actividad inhibitoria de la proteina tirosina cinasa; una composicion farmaceutica que los contiene como principio activo y su utilizacion en el tratamiento del cancer. AR049536A1 (es)

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US58345904P 2004-06-28 2004-06-28
US61256304P 2004-09-23 2004-09-23

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ARP050102668A AR049536A1 (es) 2004-06-28 2005-06-28 Compuestos heterociclicos condensados con actividad inhibitoria de la proteina tirosina cinasa; una composicion farmaceutica que los contiene como principio activo y su utilizacion en el tratamiento del cancer.
ARP050102669A AR050254A1 (es) 2004-06-28 2005-06-28 Intermediarios y procesos para preparar dichos intermediarios utiles en la fabricacion de pirrolotriazinas

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ARP050102669A AR050254A1 (es) 2004-06-28 2005-06-28 Intermediarios y procesos para preparar dichos intermediarios utiles en la fabricacion de pirrolotriazinas

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US (2) US7173031B2 (es)
EP (3) EP1761268A4 (es)
JP (3) JP2008504368A (es)
KR (3) KR20070026621A (es)
AR (2) AR049536A1 (es)
AU (2) AU2005260056B2 (es)
BR (1) BRPI0512722A (es)
CA (1) CA2571680A1 (es)
IL (1) IL180325A0 (es)
MX (2) MXPA06015192A (es)
NO (3) NO20070453L (es)
PE (2) PE20060524A1 (es)
TW (2) TW200604184A (es)
WO (3) WO2006004636A2 (es)

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EP1771177A2 (en) 2007-04-11
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NO20070514L (no) 2007-03-12
IL180325A0 (en) 2007-07-04
JP2008504368A (ja) 2008-02-14
BRPI0512722A (pt) 2008-04-01
WO2006004884A3 (en) 2006-03-23
MXPA06015032A (es) 2007-02-08
WO2006004833A3 (en) 2006-07-13
AU2005259894B2 (en) 2009-03-19
KR20070026621A (ko) 2007-03-08
EP1761268A2 (en) 2007-03-14
EP1761268A4 (en) 2009-07-08
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AU2005259894A1 (en) 2006-01-12
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TW200604184A (en) 2006-02-01
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