AR046081A1 - Inhibidores heterociclicos de mek y uso de los mismos - Google Patents
Inhibidores heterociclicos de mek y uso de los mismosInfo
- Publication number
- AR046081A1 AR046081A1 ARP040103151A ARP040103151A AR046081A1 AR 046081 A1 AR046081 A1 AR 046081A1 AR P040103151 A ARP040103151 A AR P040103151A AR P040103151 A ARP040103151 A AR P040103151A AR 046081 A1 AR046081 A1 AR 046081A1
- Authority
- AR
- Argentina
- Prior art keywords
- heteroaryl
- aryl
- heterocyclyl
- arylalkyl
- alkyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 39
- 125000001072 heteroaryl group Chemical group 0.000 abstract 30
- 125000003118 aryl group Chemical group 0.000 abstract 28
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 26
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 20
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 18
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 15
- 125000000217 alkyl group Chemical group 0.000 abstract 13
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 12
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 12
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 12
- 125000005843 halogen group Chemical group 0.000 abstract 12
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 12
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 12
- 125000003342 alkenyl group Chemical group 0.000 abstract 10
- 125000000304 alkynyl group Chemical group 0.000 abstract 10
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 8
- 125000002837 carbocyclic group Chemical group 0.000 abstract 8
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 6
- 125000004429 atom Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000004043 oxo group Chemical group O=* 0.000 abstract 5
- 229920006395 saturated elastomer Polymers 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/654,580 US7144907B2 (en) | 2003-09-03 | 2003-09-03 | Heterocyclic inhibitors of MEK and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046081A1 true AR046081A1 (es) | 2005-11-23 |
Family
ID=34218110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040103151A AR046081A1 (es) | 2003-09-03 | 2004-09-02 | Inhibidores heterociclicos de mek y uso de los mismos |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7144907B2 (OSRAM) |
| EP (1) | EP1673339B1 (OSRAM) |
| JP (1) | JP4131741B2 (OSRAM) |
| KR (1) | KR20060070558A (OSRAM) |
| CN (1) | CN1874769A (OSRAM) |
| AR (1) | AR046081A1 (OSRAM) |
| AU (1) | AU2004270699B2 (OSRAM) |
| BR (1) | BRPI0414111A (OSRAM) |
| CA (1) | CA2537321A1 (OSRAM) |
| IL (4) | IL173936A (OSRAM) |
| IS (1) | IS8392A (OSRAM) |
| MX (1) | MXPA06002466A (OSRAM) |
| NO (1) | NO20061506L (OSRAM) |
| PT (1) | PT1673339E (OSRAM) |
| RU (1) | RU2006109599A (OSRAM) |
| TW (1) | TW200526607A (OSRAM) |
| WO (1) | WO2005023759A2 (OSRAM) |
| ZA (1) | ZA200602581B (OSRAM) |
Families Citing this family (73)
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| CN103204827B (zh) * | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途 |
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| KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
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-
2003
- 2003-09-03 US US10/654,580 patent/US7144907B2/en not_active Expired - Fee Related
-
2004
- 2004-08-30 US US10/929,295 patent/US7230099B2/en not_active Expired - Fee Related
- 2004-09-01 BR BRPI0414111-3A patent/BRPI0414111A/pt not_active IP Right Cessation
- 2004-09-01 MX MXPA06002466A patent/MXPA06002466A/es not_active Application Discontinuation
- 2004-09-01 WO PCT/US2004/028649 patent/WO2005023759A2/en not_active Ceased
- 2004-09-01 ZA ZA200602581A patent/ZA200602581B/en unknown
- 2004-09-01 JP JP2006525449A patent/JP4131741B2/ja not_active Expired - Fee Related
- 2004-09-01 EP EP04783028.6A patent/EP1673339B1/en not_active Expired - Lifetime
- 2004-09-01 CA CA002537321A patent/CA2537321A1/en not_active Abandoned
- 2004-09-01 KR KR1020067004505A patent/KR20060070558A/ko not_active Withdrawn
- 2004-09-01 AU AU2004270699A patent/AU2004270699B2/en not_active Ceased
- 2004-09-01 RU RU2006109599/04A patent/RU2006109599A/ru not_active Application Discontinuation
- 2004-09-01 PT PT47830286T patent/PT1673339E/pt unknown
- 2004-09-01 CN CNA2004800326551A patent/CN1874769A/zh active Pending
- 2004-09-02 AR ARP040103151A patent/AR046081A1/es not_active Application Discontinuation
- 2004-09-02 TW TW093126520A patent/TW200526607A/zh unknown
-
2006
- 2006-02-26 IL IL173936A patent/IL173936A/en not_active IP Right Cessation
- 2006-03-31 IS IS8392A patent/IS8392A/is unknown
- 2006-04-03 NO NO20061506A patent/NO20061506L/no not_active Application Discontinuation
- 2006-04-24 US US11/410,344 patent/US20060189668A1/en not_active Abandoned
- 2006-04-24 US US11/410,343 patent/US7271178B2/en not_active Expired - Fee Related
- 2006-04-24 US US11/410,336 patent/US7511058B2/en not_active Expired - Fee Related
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2012
- 2012-05-08 IL IL219669A patent/IL219669A0/en unknown
- 2012-05-08 IL IL219671A patent/IL219671A0/en unknown
- 2012-05-08 IL IL219670A patent/IL219670A/en not_active IP Right Cessation
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