AR041291A1 - Imidazopiridinas como inhibidores de quinasa dependientes de ciclina - Google Patents
Imidazopiridinas como inhibidores de quinasa dependientes de ciclinaInfo
- Publication number
- AR041291A1 AR041291A1 ARP030103373A ARP030103373A AR041291A1 AR 041291 A1 AR041291 A1 AR 041291A1 AR P030103373 A ARP030103373 A AR P030103373A AR P030103373 A ARP030103373 A AR P030103373A AR 041291 A1 AR041291 A1 AR 041291A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- cycloalkyl
- nr5r6
- heteroaryl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 23
- 125000003118 aryl group Chemical group 0.000 abstract 23
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 23
- 125000000623 heterocyclic group Chemical group 0.000 abstract 16
- 125000001072 heteroaryl group Chemical group 0.000 abstract 15
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 12
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 12
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 11
- 229910052736 halogen Inorganic materials 0.000 abstract 10
- 150000002367 halogens Chemical class 0.000 abstract 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 10
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 7
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 7
- 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 229910006069 SO3H Inorganic materials 0.000 abstract 2
- -1 -C (O) R7 Chemical group 0.000 abstract 1
- VNHBYKHXBCYPBJ-UHFFFAOYSA-N 5-ethynylimidazo[1,2-a]pyridine Chemical class C#CC1=CC=CC2=NC=CN12 VNHBYKHXBCYPBJ-UHFFFAOYSA-N 0.000 abstract 1
- 108091007914 CDKs Proteins 0.000 abstract 1
- 102000016736 Cyclin Human genes 0.000 abstract 1
- 108050006400 Cyclin Proteins 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 230000006872 improvement Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41206302P | 2002-09-19 | 2002-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041291A1 true AR041291A1 (es) | 2005-05-11 |
Family
ID=32030794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103373A AR041291A1 (es) | 2002-09-19 | 2003-09-17 | Imidazopiridinas como inhibidores de quinasa dependientes de ciclina |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6992080B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1539756B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4845379B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20050052500A (cg-RX-API-DMAC7.html) |
| CN (1) | CN100549011C (cg-RX-API-DMAC7.html) |
| AR (1) | AR041291A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE378336T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003295332B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2499639C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60317529T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2293068T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL167433A (cg-RX-API-DMAC7.html) |
| MX (1) | MXPA05003058A (cg-RX-API-DMAC7.html) |
| MY (1) | MY133311A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ538566A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI351405B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004026867A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200502278B (cg-RX-API-DMAC7.html) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20040037818A1 (en) * | 1998-07-30 | 2004-02-26 | Brand Stephen J. | Treatment for diabetes |
| GB9819530D0 (en) | 1998-09-09 | 1998-10-28 | Smithkline Beecham Plc | Novel compositions and use |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| ES2204295B1 (es) * | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| KR101173510B1 (ko) | 2002-08-23 | 2012-08-21 | 슬로안-케테링인스티튜트퍼캔서리서치 | 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 |
| EP1651612B9 (en) | 2003-07-22 | 2012-09-05 | Astex Therapeutics Limited | 3,4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| GB0418328D0 (en) * | 2004-08-17 | 2004-09-22 | Imp College Innovations Ltd | Cancer methods and medicaments |
| ES2552338T3 (es) * | 2005-01-21 | 2015-11-27 | Astex Therapeutics Limited | Compuestos farmacéuticos |
| MX2007008810A (es) * | 2005-01-21 | 2007-11-21 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| RU2007131101A (ru) * | 2005-01-21 | 2009-02-27 | Астекс Терапьютикс Лимитед (Gb) | Комбинации пиразольных ингибиторов киназы и других средств против злокачественных новообразований |
| JP2008536817A (ja) * | 2005-03-24 | 2008-09-11 | グラクソ グループ リミテッド | 胃腸疾患の処置用医薬として有用なイミダゾ（１，２−ａ）ピリジン誘導体 |
| US7700773B2 (en) | 2005-09-09 | 2010-04-20 | Schering Corporation | 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors |
| US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| KR20080103996A (ko) | 2006-02-16 | 2008-11-28 | 쉐링 코포레이션 | Ｅｒｋ 억제제로서 피롤리딘 유도체 |
| EP2026805A1 (en) * | 2006-05-08 | 2009-02-25 | Astex Therapeutics Limited | Pharmaceutical combinations of diazole derivatives for cancer treatment |
| FR2906250B1 (fr) | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| EP2099798A1 (en) * | 2006-12-01 | 2009-09-16 | Galapagos N.V. | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases |
| CA2672213C (en) | 2006-12-22 | 2016-02-16 | Astex Therapeutics Limited | Bicyclic amine derivatives as protein tyrosine kinase inhibitors |
| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| CN101952283B (zh) * | 2007-12-14 | 2013-04-17 | 霍夫曼-拉罗奇有限公司 | 咪唑并[1，2-a]吡啶和咪唑并[1，2-b]哒嗪衍生物 |
| US8426441B2 (en) | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
| WO2009085983A1 (en) * | 2007-12-19 | 2009-07-09 | Genentech, Inc. | 5-anilinoimidazopyridines and methods of use |
| JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ，インコーポレーテッド | ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法 |
| US8716483B2 (en) | 2008-02-21 | 2014-05-06 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| US8338604B2 (en) | 2008-06-20 | 2012-12-25 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| ES2552681T3 (es) | 2008-07-15 | 2015-12-01 | F. Hoffmann-La Roche Ag | Nuevas fenil-imidazopiridinas y piridazinas |
| TW201018682A (en) * | 2008-09-25 | 2010-05-16 | Kyorin Seiyaku Kk | Heterocyclic biaryl derivative, and pde inhibitor comprising same as active ingredient |
| ES2590804T3 (es) | 2008-12-08 | 2016-11-23 | Gilead Connecticut, Inc. | Inhibidores de Imidazopyrazine Syk |
| SG10201707798SA (en) | 2008-12-08 | 2017-10-30 | Gilead Connecticut Inc | Imidazopyrazine syk inhibitors |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| PH12012500778A1 (en) | 2009-10-30 | 2012-11-26 | Janssen Pharmaceutica Nv | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| AU2011226689B2 (en) * | 2010-03-11 | 2016-09-01 | Kronos Bio, Inc. | Imidazopyridines Syk inhibitors |
| CA2832310A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and intermediates thereof |
| ES2575092T3 (es) | 2011-06-27 | 2016-06-24 | Janssen Pharmaceutica, N.V. | Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxalina |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| ES2855575T3 (es) | 2012-06-26 | 2021-09-23 | Janssen Pharmaceutica Nv | Combinaciones que comprenden compuestos de 4-metil-[1,2,4]triazolo[4,3-a]quinoxalina como inhibidores de PDE2 e inhibidores de PDE10 para su uso en el tratamiento de trastornos neurológicos o metabólicos |
| ES2607184T3 (es) | 2012-07-09 | 2017-03-29 | Janssen Pharmaceutica, N.V. | Inhibidores de la enzima fosfodiesterasa 10 |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| KR20170116203A (ko) | 2013-07-30 | 2017-10-18 | 질레드 코네티컷 인코포레이티드 | Ｓｙｋ 억제제의 제제 |
| NZ715776A (en) | 2013-07-30 | 2017-04-28 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
| DK3076976T3 (da) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Fremgangsmåder til behandling af cancer |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| EA201790086A1 (ru) | 2014-07-14 | 2017-07-31 | Джилид Сайэнс, Инк. | Комбинации для лечения раковых заболеваний |
| WO2017087409A1 (en) | 2015-11-18 | 2017-05-26 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
| US10196396B2 (en) | 2016-01-14 | 2019-02-05 | Handok Inc. | Compounds antagonizing A3 adenosine receptor, method for preparing them, and medical-use thereof |
| EP3575298B1 (en) | 2017-01-24 | 2022-03-02 | Sumitomo Chemical Company, Limited | Fused heterocyclic compound and composition containing same |
| TW201841916A (zh) * | 2017-04-12 | 2018-12-01 | 美商麥珍塔治療學股份有限公司 | 芳香烴受體拮抗劑及其用途 |
| AU2018256459B2 (en) | 2017-04-21 | 2023-12-07 | Ikena Oncology, Inc. | Indole AHR inhibitors and uses thereof |
| WO2019040298A1 (en) | 2017-08-25 | 2019-02-28 | Gilead Sciences, Inc. | SYK INHIBITORY POLYMORPHS |
| US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
| EP4065582B1 (en) | 2019-11-26 | 2025-02-19 | Ikena Oncology, Inc. | Polymorphic carbazole derivatives and uses thereof |
| CN120019056A (zh) * | 2022-09-28 | 2025-05-16 | 原真股份有限公司 | 新型cdk9抑制剂 |
| WO2025058459A1 (ko) * | 2023-09-15 | 2025-03-20 | (주)휴온스 | 신규한 이미다조피리딘계 화합물 및 이를 유효성분으로 포함하는 위장관 염증질환 또는 위산-관련 질환의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
| DE69433353T2 (de) * | 1993-09-10 | 2004-09-09 | Eisai Co., Ltd. | Bicyclische, heterocyclische sulfonamide und sulfonsäureester |
| JPH11505524A (ja) | 1995-05-01 | 1999-05-21 | 藤沢薬品工業株式会社 | イミダゾ１，２−ａピリジンおよびイミダゾ１，２−ａピリデジン誘導体、および骨吸収阻害剤としてのその用途 |
| SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
| SE9801526D0 (sv) | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| JP4007743B2 (ja) * | 1999-02-26 | 2007-11-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害剤 |
| WO2001056607A1 (en) | 2000-02-03 | 2001-08-09 | Eisai Co., Ltd. | Integrin expression inhibitors |
| SE0003186D0 (sv) | 2000-09-07 | 2000-09-07 | Astrazeneca Ab | New process |
| WO2002069968A1 (en) * | 2001-03-08 | 2002-09-12 | Astrazeneca Ab | New use |
-
2003
- 2003-09-17 AU AU2003295332A patent/AU2003295332B2/en not_active Ceased
- 2003-09-17 NZ NZ538566A patent/NZ538566A/en not_active IP Right Cessation
- 2003-09-17 MY MYPI20033536A patent/MY133311A/en unknown
- 2003-09-17 ES ES03786514T patent/ES2293068T3/es not_active Expired - Lifetime
- 2003-09-17 TW TW092125636A patent/TWI351405B/zh not_active IP Right Cessation
- 2003-09-17 CA CA2499639A patent/CA2499639C/en not_active Expired - Fee Related
- 2003-09-17 EP EP03786514A patent/EP1539756B1/en not_active Expired - Lifetime
- 2003-09-17 DE DE60317529T patent/DE60317529T2/de not_active Expired - Lifetime
- 2003-09-17 JP JP2004538237A patent/JP4845379B2/ja not_active Expired - Fee Related
- 2003-09-17 KR KR1020057004361A patent/KR20050052500A/ko not_active Abandoned
- 2003-09-17 US US10/664,338 patent/US6992080B2/en not_active Expired - Lifetime
- 2003-09-17 AT AT03786514T patent/ATE378336T1/de not_active IP Right Cessation
- 2003-09-17 MX MXPA05003058A patent/MXPA05003058A/es active IP Right Grant
- 2003-09-17 CN CNB038250470A patent/CN100549011C/zh not_active Expired - Fee Related
- 2003-09-17 AR ARP030103373A patent/AR041291A1/es not_active Application Discontinuation
- 2003-09-17 WO PCT/US2003/029498 patent/WO2004026867A2/en not_active Ceased
-
2005
- 2005-03-15 IL IL167433A patent/IL167433A/en not_active IP Right Cessation
- 2005-03-17 ZA ZA200502278A patent/ZA200502278B/en unknown
- 2005-09-29 US US11/238,597 patent/US7452902B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004026867A2 (en) | 2004-04-01 |
| ES2293068T3 (es) | 2008-03-16 |
| US20060030555A1 (en) | 2006-02-09 |
| HK1071757A1 (en) | 2005-07-29 |
| MXPA05003058A (es) | 2005-05-27 |
| CA2499639A1 (en) | 2004-04-01 |
| AU2003295332A1 (en) | 2004-04-08 |
| EP1539756B1 (en) | 2007-11-14 |
| MY133311A (en) | 2007-11-30 |
| US6992080B2 (en) | 2006-01-31 |
| US20040097517A1 (en) | 2004-05-20 |
| JP2006507254A (ja) | 2006-03-02 |
| JP4845379B2 (ja) | 2011-12-28 |
| AU2003295332B2 (en) | 2007-01-18 |
| CN1703414A (zh) | 2005-11-30 |
| EP1539756A2 (en) | 2005-06-15 |
| DE60317529D1 (de) | 2007-12-27 |
| CN100549011C (zh) | 2009-10-14 |
| IL167433A (en) | 2011-03-31 |
| ATE378336T1 (de) | 2007-11-15 |
| WO2004026867A3 (en) | 2004-08-05 |
| CA2499639C (en) | 2011-11-08 |
| NZ538566A (en) | 2008-02-29 |
| DE60317529T2 (de) | 2008-09-25 |
| TWI351405B (en) | 2011-11-01 |
| KR20050052500A (ko) | 2005-06-02 |
| ZA200502278B (en) | 2006-05-31 |
| US7452902B2 (en) | 2008-11-18 |
| TW200407322A (en) | 2004-05-16 |
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