AR040868A1 - Proceso para la fabricacion de sal de calcio del acido (e)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino] piridin-5-il] (3r,5s)-3,5-dihidroxihept-6-enoico y producto que se obtiene a partir del mismo - Google Patents

Proceso para la fabricacion de sal de calcio del acido (e)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino] piridin-5-il] (3r,5s)-3,5-dihidroxihept-6-enoico y producto que se obtiene a partir del mismo

Info

Publication number
AR040868A1
AR040868A1 AR20030102929A ARP030102929A AR040868A1 AR 040868 A1 AR040868 A1 AR 040868A1 AR 20030102929 A AR20030102929 A AR 20030102929A AR P030102929 A ARP030102929 A AR P030102929A AR 040868 A1 AR040868 A1 AR 040868A1
Authority
AR
Argentina
Prior art keywords
fluorophenyl
amino
methyl
manufacture
product obtained
Prior art date
Application number
AR20030102929A
Other languages
English (en)
Inventor
John Horbury
Nigel Philip Taylor
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9942204&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR040868(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of AR040868A1 publication Critical patent/AR040868A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un proceso mejorado para la fabricación de sal de calcio del ácido (E)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil(metilsulfonil)amino]pirimidin-5-il](3R,5S)-3,5-dihidroxihept-6-enoico, de la siguiente fórmula (1). En este proceso se mezcla una solución de cloruro de calcio con una solución de una sal soluble en agua del ácido (1); en el proceso los parámetros de selección para dar un producto que demuestra mayor eficiencia de filtración. Este compuesto es útil para la producción de una composición farmacéutica que se utiliza en el tratamiento de, entre otras afecciones, la hipercolesterolemia, la hiperlipoproteinemia y la ateroesclerosis. También se describe el producto que se obtiene a partir de dicho proceso.
AR20030102929A 2002-08-13 2003-08-13 Proceso para la fabricacion de sal de calcio del acido (e)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino] piridin-5-il] (3r,5s)-3,5-dihidroxihept-6-enoico y producto que se obtiene a partir del mismo AR040868A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0218781.3A GB0218781D0 (en) 2002-08-13 2002-08-13 Chemical process

Publications (1)

Publication Number Publication Date
AR040868A1 true AR040868A1 (es) 2005-04-20

Family

ID=9942204

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102929A AR040868A1 (es) 2002-08-13 2003-08-13 Proceso para la fabricacion de sal de calcio del acido (e)-7-[4-(4-fluorofenil)-6-isopropil-2-[metil (metilsulfonil) amino] piridin-5-il] (3r,5s)-3,5-dihidroxihept-6-enoico y producto que se obtiene a partir del mismo

Country Status (30)

Country Link
US (2) US7511140B2 (es)
EP (1) EP1539711B1 (es)
JP (1) JP4588446B2 (es)
KR (1) KR101325827B1 (es)
CN (1) CN100361979C (es)
AR (1) AR040868A1 (es)
AT (1) ATE501125T1 (es)
AU (1) AU2003251369B2 (es)
BR (1) BR0313394A (es)
CA (1) CA2495296C (es)
CY (1) CY1112412T1 (es)
DE (1) DE60336326D1 (es)
DK (1) DK1539711T3 (es)
ES (1) ES2361009T3 (es)
GB (1) GB0218781D0 (es)
HK (1) HK1082735A1 (es)
IL (1) IL166626A (es)
IS (1) IS7728A (es)
MX (1) MXPA05001582A (es)
MY (1) MY135301A (es)
NO (1) NO329439B1 (es)
NZ (1) NZ538070A (es)
PL (1) PL375296A1 (es)
PT (1) PT1539711E (es)
RU (1) RU2326871C2 (es)
SI (1) SI1539711T1 (es)
TW (1) TWI316058B (es)
UA (1) UA83805C2 (es)
WO (1) WO2004014872A1 (es)
ZA (1) ZA200500745B (es)

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