AR038432A2 - Derivados 1,2-dihidro de parahercuamida y marcfortina - Google Patents

Derivados 1,2-dihidro de parahercuamida y marcfortina

Info

Publication number
AR038432A2
AR038432A2 ARP030100486A ARP030100486A AR038432A2 AR 038432 A2 AR038432 A2 AR 038432A2 AR P030100486 A ARP030100486 A AR P030100486A AR P030100486 A ARP030100486 A AR P030100486A AR 038432 A2 AR038432 A2 AR 038432A2
Authority
AR
Argentina
Prior art keywords
parahercuamida
marcfortina
dihidro
derivatives
alkyl
Prior art date
Application number
ARP030100486A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21695455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR038432(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR038432A2 publication Critical patent/AR038432A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Epoxy Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Un compuesto de 1,2-dihidro de la fórmula (1) en donde n es 1 ó 2; en donde R14 es -H y alquilo C1-4; en donde R15 es -H y alquilo C1-4; en donde R16 es -OH, sus N-óxidos y sus sales farmacéuticamente aceptables.
ARP030100486A 1995-07-21 2003-02-13 Derivados 1,2-dihidro de parahercuamida y marcfortina AR038432A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US132495P 1995-07-21 1995-07-21

Publications (1)

Publication Number Publication Date
AR038432A2 true AR038432A2 (es) 2005-01-12

Family

ID=21695455

Family Applications (10)

Application Number Title Priority Date Filing Date
ARP960103674A AR003466A1 (es) 1995-07-21 1996-07-19 Compuestos 14-hidroxi-2-desoxoparahercuamida b
ARP030100486A AR038432A2 (es) 1995-07-21 2003-02-13 Derivados 1,2-dihidro de parahercuamida y marcfortina
ARP030100485A AR038431A2 (es) 1995-07-21 2003-02-13 Derivados 2-desoxo-15-alquilo de marcfortina
ARP030100481A AR038427A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
ARP030100488A AR038434A2 (es) 1995-07-21 2003-02-13 Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
ARP030100487A AR038433A2 (es) 1995-07-21 2003-02-13 Derivados 2-alquil-2-desoxo de parahercuamida y marcfortina
ARP030100483A AR038429A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-16-hidroxilo de marcfortina
ARP030100484A AR038430A2 (es) 1995-07-21 2003-02-13 Derivados de parahercuamida b
ARP030100482A AR038428A2 (es) 1995-07-21 2003-02-13 Compuestos fluorados de marcfortina
ARP060100487A AR052907A1 (es) 1995-07-21 2006-02-10 Compuesto 14,15-deshidro-16-oxoparahercuamida y compuestos 2- desoxo de parahercuamida y marcfortina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP960103674A AR003466A1 (es) 1995-07-21 1996-07-19 Compuestos 14-hidroxi-2-desoxoparahercuamida b

Family Applications After (8)

Application Number Title Priority Date Filing Date
ARP030100485A AR038431A2 (es) 1995-07-21 2003-02-13 Derivados 2-desoxo-15-alquilo de marcfortina
ARP030100481A AR038427A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-14-hidroxilo de marcfortina y parahercuamida
ARP030100488A AR038434A2 (es) 1995-07-21 2003-02-13 Compuesto 14,15-dihidro-16-oxoparahercuamida y compuestos 2-desoxo de parahercuamida y marcfortina
ARP030100487A AR038433A2 (es) 1995-07-21 2003-02-13 Derivados 2-alquil-2-desoxo de parahercuamida y marcfortina
ARP030100483A AR038429A2 (es) 1995-07-21 2003-02-13 Compuestos 15-alquil-16-hidroxilo de marcfortina
ARP030100484A AR038430A2 (es) 1995-07-21 2003-02-13 Derivados de parahercuamida b
ARP030100482A AR038428A2 (es) 1995-07-21 2003-02-13 Compuestos fluorados de marcfortina
ARP060100487A AR052907A1 (es) 1995-07-21 2006-02-10 Compuesto 14,15-deshidro-16-oxoparahercuamida y compuestos 2- desoxo de parahercuamida y marcfortina

Country Status (31)

Country Link
US (2) US5703078A (es)
EP (3) EP1400523A3 (es)
JP (2) JP4122447B2 (es)
KR (1) KR100428335B1 (es)
CN (2) CN1277830C (es)
AR (10) AR003466A1 (es)
AT (1) ATE311390T1 (es)
AU (1) AU699644B2 (es)
BR (7) BR9609812B8 (es)
CA (1) CA2225813C (es)
CO (1) CO4750664A1 (es)
CZ (1) CZ296008B6 (es)
DE (1) DE69635524T2 (es)
DK (2) DK0871631T3 (es)
ES (2) ES2249783T3 (es)
FI (2) FI115912B (es)
HK (2) HK1017883A1 (es)
HU (1) HU226296B1 (es)
ID (1) ID30373A (es)
MX (1) MX9800625A (es)
MY (1) MY113806A (es)
NO (1) NO324287B1 (es)
NZ (1) NZ311952A (es)
PL (1) PL185007B1 (es)
PT (1) PT1489082E (es)
RU (1) RU2162090C2 (es)
SI (1) SI0871631T1 (es)
SK (2) SK285248B6 (es)
TW (1) TW334436B (es)
WO (1) WO1997003988A1 (es)
ZA (1) ZA965908B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA976761B (en) * 1996-09-09 1999-01-29 Upjohn Co 25 Methylene and 24,25-epoxy marcfortines and paraherquamides
WO1998021211A1 (en) * 1996-11-15 1998-05-22 Pharmacia & Upjohn Company 1- and 2-substituted marcfortines and paraherquamides as antiparasitic agents
PE20011289A1 (es) * 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
ME03409B (me) 2008-11-14 2020-01-20 Merial Inc ENANTIOMERNO OBOGAĆENA PARAZITICIDALNA JEDINJENJA ARILOAZOL-2-il CIJANOETILAMINO
EP2364147A2 (en) 2008-11-19 2011-09-14 Merial Limited Compositions comprising 1-arylpyrazole alone or in combination with formamidine for the treatment of parasitic infection
ES2537424T3 (es) 2008-12-04 2015-06-08 Merial Limited Derivados de dímeros de avermectina y de milbemicina
EP2314292A1 (en) 2009-10-20 2011-04-27 Novartis AG Endoparasiticidal compositions
CA2782902C (en) 2009-12-04 2017-10-17 Merial Limited Pesticidal bis-organosulfur compounds
EP2512467A1 (en) 2009-12-17 2012-10-24 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
WO2011075591A1 (en) 2009-12-17 2011-06-23 Merial Limited Anti parasitic dihydroazole compounds and compositions comprising same
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
CA2818563C (en) 2010-11-16 2019-11-12 Merial Limited Monensin derivatives for the treatment and prevention of protozoal infections.
WO2013003168A1 (en) 2011-06-27 2013-01-03 Merial Limited Novel insect-repellent coumarin derivatives, syntheses, and methods of use
US8946270B2 (en) 2011-06-27 2015-02-03 Merial Limited Amido-pyridyl ether compounds and compositions and their use against parasites
HUE052594T2 (hu) 2011-09-12 2021-05-28 Boehringer Ingelheim Animal Health Usa Inc Izoxazolint tartalmazó parazita-ellenes készítmények, ezek elõállítása és alkalmazása
US20130079394A1 (en) 2011-09-23 2013-03-28 Cnrs (Centre National Recherche Scientifique) Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
MX368738B (es) 2011-11-17 2019-10-14 Boehringer Ingelheim Animal Health Usa Inc Composiciones que comprenden un aril pirazol y un imidazol sustituido, metodos y usos de las mismas.
PT2785719T (pt) 2011-12-02 2018-02-08 Merial Inc Formulações injetáveis de moxidectina de ação prolongada e novas formas cristalinas de moxidectina
PL232463B1 (pl) 2012-02-06 2019-06-28 Merial Inc Miękka, nadająca się do żucia kompozycja weterynaryjna do leczenia i/lub zapobiegania infekcji lub inwazji pasożytniczej u zwierzęcia oraz jej zastosowanie
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
UA115981C2 (uk) 2012-04-20 2018-01-25 Меріал, Інк. Паразитицидні композиції, що містять похідні бензимідазолу, способи їх одержання та застосування
JP5737255B2 (ja) * 2012-09-27 2015-06-17 ダイキン工業株式会社 チオノカルボン酸エステルの製造方法
NZ723198A (en) 2012-11-20 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic compounds and compositions and methods of using thereof
EP3063144B1 (en) 2013-11-01 2021-09-08 Boehringer Ingelheim Animal Health USA Inc. Antiparasitic and pesticidal isoxazoline compounds
NZ726251A (en) 2014-04-17 2017-11-24 Merial Inc Use of malononitrile compounds for protecting animals from parasites
AU2015264336B2 (en) 2014-05-19 2018-08-30 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic compounds
ES2895826T3 (es) 2014-06-19 2022-02-22 Boehringer Ingelheim Animal Health Usa Inc Composiciones parasiticidas que comprenden derivados de indol, procedimientos y usos de las mismas
WO2016069983A1 (en) 2014-10-31 2016-05-06 Merial, Inc. Parasiticidal composition comprising fipronil
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
PT3298027T (pt) 2015-05-20 2022-01-26 Boehringer Ingelheim Animal Health Usa Inc Compostos depsipéptidos antelmínticos
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
EP3525590A1 (en) 2016-10-14 2019-08-21 Boehringer Ingelheim Animal Health USA Inc. Pesticidal and parasiticidal vinyl isoxazoline compounds
BR112019009977A2 (pt) 2016-11-16 2019-08-27 Boehringer Ingelheim Animal Health Usa Inc compostos depsipeptídicos anti-helmínticos
WO2019036407A1 (en) 2017-08-14 2019-02-21 Merial, Inc. PYRAZOLE-ISOXAZOLINE COMPOUNDS WITH PESTICIDE AND PARASITICIDE ACTIVITY
US11583545B2 (en) 2018-02-08 2023-02-21 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
US20220048903A1 (en) 2018-07-09 2022-02-17 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic Heterocyclic Compounds
WO2020112374A1 (en) 2018-11-20 2020-06-04 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
BR112021016196A2 (pt) 2019-03-01 2021-10-05 Boehringer Ingelheim Animal Health USA Inc. Composições injetáveis de clorsulon, métodos e usos das mesmas
CA3133100A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
JP2023528822A (ja) 2020-05-29 2023-07-06 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性複素環式化合物
CN111748503B (zh) * 2020-08-04 2021-12-14 华中农业大学 一种深海独岛枝芽胞杆菌培养基和剂型
AU2021410052A1 (en) 2020-12-21 2023-08-03 Boehringer Ingelheim Vetmedica Gmbh Parasiticidal collar comprising isoxazoline compounds
US20230312207A1 (en) 2022-02-17 2023-10-05 Boehringer Ingelheim Vetmedica Gmbh Method and system for providing a fluid product mailer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075307A (en) * 1987-07-28 1991-12-24 Merck & Co., Inc. Paraherquamide and dihydroparaherquamide as antihelminthic agents
US4873247A (en) * 1987-11-27 1989-10-10 Goegelman Robert T Derivatives of paraherquamide isolated from a fermentation broth active as antiparasitic agents
US4978656A (en) * 1988-08-12 1990-12-18 Merck & Co., Inc. Synthetic derivatives of paraherquamide
US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
US4923867A (en) * 1988-08-24 1990-05-08 Merck & Co., Inc. Synthetic marcfortine derivatives useful as antiparasitic agents
NZ233043A (en) * 1989-03-30 1992-09-25 Merck & Co Inc Anthelmintic heterocyclic compounds prepared by action of cunninghamella blakesleeana on (dihydro)paraherquamide
IE904606A1 (en) * 1989-12-21 1991-07-03 Beecham Group Plc Novel products
GB9014194D0 (en) * 1990-06-26 1990-08-15 Pfizer Ltd Antiparasitic agents
WO1992022555A1 (en) * 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
TW410227B (en) * 1993-06-16 2000-11-01 Upjohn Co 14-substituted marcfortines and derivatives useful as antiparasitic agents

Also Published As

Publication number Publication date
JP4122447B2 (ja) 2008-07-23
CN1125824C (zh) 2003-10-29
FI115912B (fi) 2005-08-15
EP1489082B1 (en) 2013-11-20
HK1017883A1 (en) 1999-12-03
AR003466A1 (es) 1998-08-05
BR9612975B8 (pt) 2014-10-29
AU6337396A (en) 1997-02-18
NO980255D0 (no) 1998-01-20
AU699644B2 (en) 1998-12-10
DE69635524T2 (de) 2006-07-06
CN1277830C (zh) 2006-10-04
SK284833B6 (sk) 2005-12-01
BR9609812A (pt) 1999-03-02
PL185007B1 (pl) 2003-01-31
BR9612972B8 (pt) 2014-10-29
NZ311952A (en) 1999-03-29
US5750695A (en) 1998-05-12
RU2162090C2 (ru) 2001-01-20
MX9800625A (es) 1998-04-30
US5703078A (en) 1997-12-30
WO1997003988A1 (en) 1997-02-06
CO4750664A1 (es) 1999-03-31
ES2439569T3 (es) 2014-01-23
FI118471B (fi) 2007-11-30
JPH11509550A (ja) 1999-08-24
AR038427A2 (es) 2005-01-12
EP0871631B1 (en) 2005-11-30
DE69635524D1 (de) 2006-01-05
FI980112A (fi) 1998-01-20
EP1489082A1 (en) 2004-12-22
BR9612973B8 (pt) 2014-10-29
SI0871631T1 (sl) 2006-04-30
HUP9802221A2 (hu) 1999-02-01
CZ11098A3 (cs) 1998-06-17
BR9612963B8 (pt) 2014-10-29
HUP9802221A3 (en) 2000-05-29
CA2225813A1 (en) 1997-02-06
EP1400523A3 (en) 2004-04-07
FI20050238A (fi) 2005-03-04
PT1489082E (pt) 2013-12-23
AR038428A2 (es) 2005-01-12
JP2008007516A (ja) 2008-01-17
AR038430A2 (es) 2005-01-12
PL324574A1 (en) 1998-06-08
AR038429A2 (es) 2005-01-12
BR9612974B8 (pt) 2014-10-29
CZ296008B6 (cs) 2005-12-14
BR9609812B8 (pt) 2014-10-29
ZA965908B (en) 1997-01-12
KR100428335B1 (ko) 2004-06-16
HU226296B1 (hu) 2008-08-28
EP0871631A1 (en) 1998-10-21
SK5498A3 (en) 1998-08-05
DK0871631T3 (da) 2006-03-13
CN1495183A (zh) 2004-05-12
MY113806A (en) 2002-05-31
ATE311390T1 (de) 2005-12-15
AR038434A2 (es) 2005-01-12
AR038431A2 (es) 2005-01-12
CA2225813C (en) 2008-02-26
TW334436B (en) 1998-06-21
AR052907A1 (es) 2007-04-11
NO324287B1 (no) 2007-09-17
FI980112A0 (fi) 1998-01-20
BR9612944B8 (pt) 2014-10-29
DK1489082T3 (da) 2013-12-09
NO980255L (no) 1998-03-20
AR038433A2 (es) 2005-01-12
SK285248B6 (sk) 2006-09-07
HK1061242A1 (en) 2004-09-10
ES2249783T3 (es) 2006-04-01
EP1400523A2 (en) 2004-03-24
ID30373A (id) 1997-01-23
CN1191537A (zh) 1998-08-26

Similar Documents

Publication Publication Date Title
AR038432A2 (es) Derivados 1,2-dihidro de parahercuamida y marcfortina
ES2133430T3 (es) Derivados de n-heteroaril-n-fenilurea, su preparacion y utilizacion.
DE69032981D1 (de) N-Heteroarylamidederivate als Inhibitoren von Acyl-Coenzym A: Cholesterol-Acyl-Transferase
DE69425162D1 (de) 4,5-diaryloxazol-derivate
TR199701654T1 (xx) 4-Fenilaminotiyazol t�revleri.
UY24625A1 (es) Derivados de la 4-hidroxi-piperidina
DK0444659T3 (da) Farmaceutisk opløsning indeholdende derivater af FK 506
ATE214698T1 (de) Neue carbamazepin hapten analoge
FI931855A (fi) Farmaceutisk sammansaettning som innehaoller kinolin- och kinazolinderivat samt nya foereningar daerfoer
MX9300222A (es) Nuevos derivados de arilcicloalquilo, su preparacion y su utilizacion.
AU3182793A (en) Imidazole derivatives having anti-hiv activity
EP1000923A4 (en) CYCLOPENTEN DERIVATIVES
ES2093091T3 (es) Derivado de glutation.
NO944309D0 (no) Fremgangsmåte for fremstilling av ribonukleotidreduktase-inhibitorer
FI964278A0 (fi) Menetelmä 5,6-dihydroksi-2-amino-1,2,3,4-tetrahydronaftaleenin johdannaisten valmistamiseksi
TW324719B (en) Succinamide compound, production thereof and use thereof
KR960702307A (ko) 항불안약 (anxiolytic agent)
TR199800039T1 (xx) Pirimidin n�kleozit t�revleri.

Legal Events

Date Code Title Description
FG Grant, registration