AR037621A1 - Antagonistas de la hormona concentradora de melanina (mch), composiciones farmaceuticas, un proceso para elaborar una composicion farmaceutica y el uso de dichos compuestos, solos o en combinacion para la fabricacion de un medicamento para el tratamiento de la obesidad - Google Patents

Antagonistas de la hormona concentradora de melanina (mch), composiciones farmaceuticas, un proceso para elaborar una composicion farmaceutica y el uso de dichos compuestos, solos o en combinacion para la fabricacion de un medicamento para el tratamiento de la obesidad

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Publication number
AR037621A1
AR037621A1 ARP020104668A ARP020104668A AR037621A1 AR 037621 A1 AR037621 A1 AR 037621A1 AR P020104668 A ARP020104668 A AR P020104668A AR P020104668 A ARP020104668 A AR P020104668A AR 037621 A1 AR037621 A1 AR 037621A1
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AR
Argentina
Prior art keywords
alkyl
aryl
group
groups
heteroaryl
Prior art date
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ARP020104668A
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English (en)
Spanish (es)
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Schering Corp
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Publication of AR037621A1 publication Critical patent/AR037621A1/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms

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ARP020104668A 2001-12-04 2002-12-03 Antagonistas de la hormona concentradora de melanina (mch), composiciones farmaceuticas, un proceso para elaborar una composicion farmaceutica y el uso de dichos compuestos, solos o en combinacion para la fabricacion de un medicamento para el tratamiento de la obesidad AR037621A1 (es)

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DE102004003811A1 (de) * 2004-01-25 2005-08-11 Aventis Pharma Deutschland Gmbh Substituierte N-Cyclohexylimidazolinone, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
ES2327763T3 (es) * 2004-07-16 2009-11-03 Schering Corporation Heterociclilos utilizados como antagonistas del receptor de la hormona concentrada de melanina para el tratamiento de la obesidad y trastornos relacionados.
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US7550467B2 (en) * 2004-10-12 2009-06-23 Schering Corporation Bicyclic compounds as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
DK1814590T4 (da) * 2004-11-01 2014-02-24 Amylin Pharmaceuticals Llc Behandling af obesitet og beslægtede sygdomme.
AU2005305036B2 (en) * 2004-11-01 2011-03-10 Amylin Pharmaceuticals, Llc Treatment of obesity and related disorders
EP1864971A4 (en) * 2005-03-31 2010-02-10 Takeda Pharmaceutical PROPHYLACTIC / THERAPEUTIC AGENT AGAINST DIABETES
US7799943B2 (en) * 2005-06-24 2010-09-21 Rohm And Haas Company Method for promoting Michael addition reactions
ZA200801825B (en) 2005-07-27 2009-12-30 Dov Pharmaceutical Inc Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: Preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US8030495B2 (en) * 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2036578A1 (en) * 2007-09-13 2009-03-18 Bayer Schering Pharma Aktiengesellschaft Diagnostic agents for positron emission imaging using F-18 radio labeled amino-alcohols
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
CN102875385A (zh) * 2012-10-18 2013-01-16 浙江大学 N,n-二异丙基乙胺的合成方法
WO2018026890A1 (en) 2016-08-03 2018-02-08 Cymabay Therapeutics Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
CN114269719A (zh) * 2019-06-28 2022-04-01 Rti国际 作为cb1变构调节剂的脲衍生物

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TW209868B (enExample) 1991-04-04 1993-07-21 Yoshitomi Pharmaceutical
US5908830A (en) * 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
US6043246A (en) * 1996-12-03 2000-03-28 Banyu Pharmaceutical Co., Ltd. Urea derivatives
ATE232200T1 (de) 1998-06-08 2003-02-15 Schering Corp Neuropeptid y5-rezeptorantagonisten
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WO2003047568A1 (en) 2003-06-12
EP1453501A1 (en) 2004-09-08
CA2468967A1 (en) 2003-06-12
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KR20050044664A (ko) 2005-05-12
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US7348328B2 (en) 2008-03-25
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US20040122017A1 (en) 2004-06-24
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