JP4330996B2 - 肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 - Google Patents

肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 Download PDF

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JP4330996B2
JP4330996B2 JP2003548823A JP2003548823A JP4330996B2 JP 4330996 B2 JP4330996 B2 JP 4330996B2 JP 2003548823 A JP2003548823 A JP 2003548823A JP 2003548823 A JP2003548823 A JP 2003548823A JP 4330996 B2 JP4330996 B2 JP 4330996B2
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JP2005511656A5 (enExample
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ジョン ダブリュー. クラダー,
アナンダン パラニ,
ルオ シュー,
ブリアー, マーク ディー. マク
ジン スー,
ハイクン タン,
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Merck Sharp and Dohme LLC
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Schering Corp
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US7304065B2 (en) 2003-10-01 2007-12-04 The Procter & Gamble Company Melanin concentrating hormone antagonists
WO2005034947A1 (en) * 2003-10-02 2005-04-21 Schering Corporation Aminobenzimidazoles as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
DE102004003811A1 (de) * 2004-01-25 2005-08-11 Aventis Pharma Deutschland Gmbh Substituierte N-Cyclohexylimidazolinone, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel
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EP1773822B1 (en) * 2004-07-16 2009-06-17 Shering Corporation Heterocyclyls as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
CA2583454A1 (en) * 2004-10-12 2006-04-27 Pharmacopeia Drug Discovery, Inc. Bicyclic compounds as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders
BRPI0518241A (pt) * 2004-11-01 2008-04-22 Amylin Pharmaceuticals Inc métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
AU2005305036B2 (en) * 2004-11-01 2011-03-10 Amylin Pharmaceuticals, Llc Treatment of obesity and related disorders
US20090264650A1 (en) * 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
US7799943B2 (en) * 2005-06-24 2010-09-21 Rohm And Haas Company Method for promoting Michael addition reactions
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US20080045725A1 (en) 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US8030495B2 (en) * 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2036578A1 (en) * 2007-09-13 2009-03-18 Bayer Schering Pharma Aktiengesellschaft Diagnostic agents for positron emission imaging using F-18 radio labeled amino-alcohols
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
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