JP4330996B2 - 肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 - Google Patents
肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 Download PDFInfo
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- JP4330996B2 JP4330996B2 JP2003548823A JP2003548823A JP4330996B2 JP 4330996 B2 JP4330996 B2 JP 4330996B2 JP 2003548823 A JP2003548823 A JP 2003548823A JP 2003548823 A JP2003548823 A JP 2003548823A JP 4330996 B2 JP4330996 B2 JP 4330996B2
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- ABKQUSBURBULSF-LOLKONATSA-N CCNC(N1CCN(CCN([C@H](CC2)C[C@@H](C3)[C@]23c2cc(C#N)ccc2)C(Nc(cc2Cl)ccc2F)=O)CC1)=O Chemical compound CCNC(N1CCN(CCN([C@H](CC2)C[C@@H](C3)[C@]23c2cc(C#N)ccc2)C(Nc(cc2Cl)ccc2F)=O)CC1)=O ABKQUSBURBULSF-LOLKONATSA-N 0.000 description 1
- DYRTUVBXZLYZQV-VBANMALSSA-N N#Cc1cccc([C@](C2)(CC3)[C@H]2C[C@@H]3N(CCN2CCNCC2)C(Nc(cc2Cl)ccc2F)=O)c1 Chemical compound N#Cc1cccc([C@](C2)(CC3)[C@H]2C[C@@H]3N(CCN2CCNCC2)C(Nc(cc2Cl)ccc2F)=O)c1 DYRTUVBXZLYZQV-VBANMALSSA-N 0.000 description 1
- XNOJRZNWAAJXGC-FGJSWWHZSA-N O=C(Nc(cc1)cc(F)c1F)N(CCCN1CCCC1)[C@@H](CC1)CC(C2)[C@@]12c1cc(-c2ncc[o]2)ccc1 Chemical compound O=C(Nc(cc1)cc(F)c1F)N(CCCN1CCCC1)[C@@H](CC1)CC(C2)[C@@]12c1cc(-c2ncc[o]2)ccc1 XNOJRZNWAAJXGC-FGJSWWHZSA-N 0.000 description 1
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
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- Hematology (AREA)
- Obesity (AREA)
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- Pain & Pain Management (AREA)
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- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33726201P | 2001-12-04 | 2001-12-04 | |
| US39985302P | 2002-07-31 | 2002-07-31 | |
| PCT/US2002/038408 WO2003047568A1 (en) | 2001-12-04 | 2002-12-03 | N-aryl-n'-arylcycloalkyl-urea derivatives as mch antagonists for the treatment of obesity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2009118103A Division JP2009235076A (ja) | 2001-12-04 | 2009-05-14 | 肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 |
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| JP2005511656A JP2005511656A (ja) | 2005-04-28 |
| JP2005511656A5 JP2005511656A5 (enExample) | 2006-03-09 |
| JP4330996B2 true JP4330996B2 (ja) | 2009-09-16 |
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| JP2009118103A Pending JP2009235076A (ja) | 2001-12-04 | 2009-05-14 | 肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2009118103A Pending JP2009235076A (ja) | 2001-12-04 | 2009-05-14 | 肥満の処置のためのmchアンタゴニストとしてのn−アリール−n’−アリールシクロアルキル−尿素−誘導体 |
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|---|---|
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| EP (1) | EP1453501B1 (enExample) |
| JP (2) | JP4330996B2 (enExample) |
| KR (1) | KR20050044664A (enExample) |
| CN (1) | CN1617718A (enExample) |
| AR (1) | AR037621A1 (enExample) |
| AT (1) | ATE404190T1 (enExample) |
| AU (1) | AU2002348269A1 (enExample) |
| CA (1) | CA2468967A1 (enExample) |
| DE (1) | DE60228317D1 (enExample) |
| ES (1) | ES2312637T3 (enExample) |
| HU (1) | HUP0500034A2 (enExample) |
| IL (1) | IL162311A0 (enExample) |
| MX (1) | MXPA04005503A (enExample) |
| PE (1) | PE20030680A1 (enExample) |
| TW (1) | TW200302719A (enExample) |
| WO (1) | WO2003047568A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7304065B2 (en) | 2003-10-01 | 2007-12-04 | The Procter & Gamble Company | Melanin concentrating hormone antagonists |
| WO2005034947A1 (en) * | 2003-10-02 | 2005-04-21 | Schering Corporation | Aminobenzimidazoles as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders |
| DE102004003811A1 (de) * | 2004-01-25 | 2005-08-11 | Aventis Pharma Deutschland Gmbh | Substituierte N-Cyclohexylimidazolinone, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| EP1773822B1 (en) * | 2004-07-16 | 2009-06-17 | Shering Corporation | Heterocyclyls as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders |
| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| CA2583454A1 (en) * | 2004-10-12 | 2006-04-27 | Pharmacopeia Drug Discovery, Inc. | Bicyclic compounds as selective melanin concentrating hormone receptor antagonists for the treatment of obesity and related disorders |
| BRPI0518241A (pt) * | 2004-11-01 | 2008-04-22 | Amylin Pharmaceuticals Inc | métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| AU2005305036B2 (en) * | 2004-11-01 | 2011-03-10 | Amylin Pharmaceuticals, Llc | Treatment of obesity and related disorders |
| US20090264650A1 (en) * | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| US7799943B2 (en) * | 2005-06-24 | 2010-09-21 | Rohm And Haas Company | Method for promoting Michael addition reactions |
| RU2008107336A (ru) | 2005-07-27 | 2009-09-10 | Дов Фармасьютикал, Инк. (Us) | Новые 1-арил-з-азабицикло{3.1.0.} гексаны: получение и применение для лечения психоневрологических расстройств |
| US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| US20080269348A1 (en) * | 2006-11-07 | 2008-10-30 | Phil Skolnick | Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use |
| US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US8030495B2 (en) * | 2007-05-23 | 2011-10-04 | Coleman Paul J | Cyclopropyl pyrrolidine orexin receptor antagonists |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| EP2036578A1 (en) * | 2007-09-13 | 2009-03-18 | Bayer Schering Pharma Aktiengesellschaft | Diagnostic agents for positron emission imaging using F-18 radio labeled amino-alcohols |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| CN102875385A (zh) * | 2012-10-18 | 2013-01-16 | 浙江大学 | N,n-二异丙基乙胺的合成方法 |
| WO2018026890A1 (en) | 2016-08-03 | 2018-02-08 | Cymabay Therapeutics | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| AU2020308862A1 (en) * | 2019-06-28 | 2022-01-20 | Research Triangle Institute | Urea derivatives as CB1 allosteric modulators |
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| TW209868B (enExample) | 1991-04-04 | 1993-07-21 | Yoshitomi Pharmaceutical | |
| US5908830A (en) * | 1996-10-31 | 1999-06-01 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes and obesity |
| CA2273102A1 (en) * | 1996-12-03 | 1998-06-11 | Banyu Pharmaceutical Co., Ltd. | Urea derivatives |
| CN1311773A (zh) * | 1998-06-08 | 2001-09-05 | 先灵公司 | 神经肽y5受体拮抗剂 |
| GB0010757D0 (en) * | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
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2002
- 2002-12-03 WO PCT/US2002/038408 patent/WO2003047568A1/en not_active Ceased
- 2002-12-03 DE DE60228317T patent/DE60228317D1/de not_active Expired - Lifetime
- 2002-12-03 AR ARP020104668A patent/AR037621A1/es unknown
- 2002-12-03 IL IL16231102A patent/IL162311A0/xx unknown
- 2002-12-03 AU AU2002348269A patent/AU2002348269A1/en not_active Abandoned
- 2002-12-03 US US10/308,782 patent/US7348328B2/en not_active Expired - Fee Related
- 2002-12-03 EP EP02782401A patent/EP1453501B1/en not_active Expired - Lifetime
- 2002-12-03 MX MXPA04005503A patent/MXPA04005503A/es not_active Application Discontinuation
- 2002-12-03 AT AT02782401T patent/ATE404190T1/de not_active IP Right Cessation
- 2002-12-03 CA CA002468967A patent/CA2468967A1/en not_active Abandoned
- 2002-12-03 HU HU0500034A patent/HUP0500034A2/hu unknown
- 2002-12-03 CN CNA028277554A patent/CN1617718A/zh active Pending
- 2002-12-03 PE PE2002001165A patent/PE20030680A1/es not_active Application Discontinuation
- 2002-12-03 KR KR1020047008490A patent/KR20050044664A/ko not_active Withdrawn
- 2002-12-03 ES ES02782401T patent/ES2312637T3/es not_active Expired - Lifetime
- 2002-12-03 TW TW091135038A patent/TW200302719A/zh unknown
- 2002-12-03 JP JP2003548823A patent/JP4330996B2/ja not_active Expired - Fee Related
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2009
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| Publication number | Publication date |
|---|---|
| ES2312637T3 (es) | 2009-03-01 |
| HUP0500034A2 (hu) | 2005-04-28 |
| US20040122017A1 (en) | 2004-06-24 |
| PE20030680A1 (es) | 2003-08-11 |
| EP1453501A1 (en) | 2004-09-08 |
| AR037621A1 (es) | 2004-11-17 |
| KR20050044664A (ko) | 2005-05-12 |
| US7348328B2 (en) | 2008-03-25 |
| CA2468967A1 (en) | 2003-06-12 |
| WO2003047568A1 (en) | 2003-06-12 |
| DE60228317D1 (de) | 2008-09-25 |
| JP2009235076A (ja) | 2009-10-15 |
| ATE404190T1 (de) | 2008-08-15 |
| MXPA04005503A (es) | 2004-12-06 |
| AU2002348269A1 (en) | 2003-06-17 |
| EP1453501B1 (en) | 2008-08-13 |
| JP2005511656A (ja) | 2005-04-28 |
| IL162311A0 (en) | 2005-11-20 |
| TW200302719A (en) | 2003-08-16 |
| CN1617718A (zh) | 2005-05-18 |
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