AR032892A1 - Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen - Google Patents

Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen

Info

Publication number
AR032892A1
AR032892A1 ARP010104023A ARP010104023A AR032892A1 AR 032892 A1 AR032892 A1 AR 032892A1 AR P010104023 A ARP010104023 A AR P010104023A AR P010104023 A ARP010104023 A AR P010104023A AR 032892 A1 AR032892 A1 AR 032892A1
Authority
AR
Argentina
Prior art keywords
group
general formula
linear
alkyl
branched
Prior art date
Application number
ARP010104023A
Other languages
English (en)
Spanish (es)
Inventor
Jean Louis Assens
Claude Bernhart
Frederique Cabanel-Haudricourt
Patrick Gautier
Dino Nisato
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR032892A1 publication Critical patent/AR032892A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
ARP010104023A 2000-08-23 2001-08-23 Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen AR032892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0010834A FR2813306B1 (fr) 2000-08-23 2000-08-23 Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant

Publications (1)

Publication Number Publication Date
AR032892A1 true AR032892A1 (es) 2003-12-03

Family

ID=8853674

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010104023A AR032892A1 (es) 2000-08-23 2001-08-23 Derivados de benzofurano o de benzotiofeno, su utilizacion, su procedimiento de preparacion y medicamentos y composiciones farmaceuticas o veterinarias que los contienen

Country Status (36)

Country Link
US (1) US6949583B2 (US06949583-20050927-C00117.png)
EP (1) EP1315709B1 (US06949583-20050927-C00117.png)
JP (2) JP5081363B2 (US06949583-20050927-C00117.png)
KR (1) KR100911280B1 (US06949583-20050927-C00117.png)
CN (1) CN1246315C (US06949583-20050927-C00117.png)
AR (1) AR032892A1 (US06949583-20050927-C00117.png)
AT (1) ATE469138T1 (US06949583-20050927-C00117.png)
AU (2) AU2001284149B2 (US06949583-20050927-C00117.png)
BG (1) BG66240B1 (US06949583-20050927-C00117.png)
BR (1) BR0113425B1 (US06949583-20050927-C00117.png)
CA (1) CA2415847C (US06949583-20050927-C00117.png)
CY (1) CY1110738T1 (US06949583-20050927-C00117.png)
CZ (1) CZ304003B6 (US06949583-20050927-C00117.png)
DE (1) DE60142240D1 (US06949583-20050927-C00117.png)
DK (1) DK1315709T3 (US06949583-20050927-C00117.png)
EA (1) EA006237B1 (US06949583-20050927-C00117.png)
ES (1) ES2346291T3 (US06949583-20050927-C00117.png)
FR (1) FR2813306B1 (US06949583-20050927-C00117.png)
HK (1) HK1053113A1 (US06949583-20050927-C00117.png)
HU (1) HU229456B1 (US06949583-20050927-C00117.png)
IL (2) IL153632A0 (US06949583-20050927-C00117.png)
IS (1) IS2821B (US06949583-20050927-C00117.png)
MA (1) MA26943A1 (US06949583-20050927-C00117.png)
ME (2) MEP23008A (US06949583-20050927-C00117.png)
MX (1) MXPA03001463A (US06949583-20050927-C00117.png)
NO (1) NO328138B1 (US06949583-20050927-C00117.png)
NZ (1) NZ523446A (US06949583-20050927-C00117.png)
OA (1) OA12359A (US06949583-20050927-C00117.png)
PL (1) PL219848B1 (US06949583-20050927-C00117.png)
PT (1) PT1315709E (US06949583-20050927-C00117.png)
RS (1) RS51603B (US06949583-20050927-C00117.png)
SI (1) SI1315709T1 (US06949583-20050927-C00117.png)
SK (1) SK288126B6 (US06949583-20050927-C00117.png)
TW (1) TWI290920B (US06949583-20050927-C00117.png)
WO (1) WO2002016339A1 (US06949583-20050927-C00117.png)
ZA (1) ZA200300744B (US06949583-20050927-C00117.png)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7401072B2 (en) * 2003-06-10 2008-07-15 Google Inc. Named URL entry
RU2409352C2 (ru) * 2005-05-05 2011-01-20 САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи Стабильные составы наночастиц
FR2893616B1 (fr) * 2005-11-23 2008-01-04 Sanofi Aventis Sa Nouveaux derives d'indolizine, leur procede de preparation et les compositions therapeutiques les comprenant
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
EP2308488A1 (en) 2009-10-09 2011-04-13 Sanofi-Aventis Use of celivarone for the preparation of a medicament for use in the prevention of implantable cardioverter defibrillator interventions or death
US20110207811A1 (en) * 2010-02-19 2011-08-25 Sanofi-Aventis Use of celivarone for reducing occurrences of cardiovascular hospitalization
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
FR2967067A1 (fr) 2010-11-10 2012-05-11 Sanofi Aventis Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
CN102757444B (zh) * 2011-04-29 2016-02-10 南京信诺泰医药有限公司 具有一氧化氮供体性质的苯并呋喃类化合物
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
WO2013121235A2 (en) 2012-02-13 2013-08-22 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
WO2013124745A1 (en) 2012-02-22 2013-08-29 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
CN105315245B (zh) * 2014-06-16 2018-10-12 华润赛科药业有限责任公司 苯并呋喃类衍生物、其制备方法和应用

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US3248401A (en) * 1966-04-26 Diethylaminoe hoxybenzoyl benzofurans
GB1345872A (en) * 1970-09-03 1974-02-06 Wyeth John & Brother Ltd Amino-and acylamino-pyridine and hydropyridine derivatives
US4806663A (en) * 1987-04-06 1989-02-21 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4851554A (en) 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US4831054A (en) * 1988-04-18 1989-05-16 Taro Pharmaceuticals, Ltd. 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia
AT391316B (de) * 1988-09-15 1990-09-25 Ebewe Arzneimittel Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US5364880A (en) * 1993-06-16 1994-11-15 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5482950A (en) * 1993-10-15 1996-01-09 Eli Lilly And Company Methods for lowering serum cholesterol
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
CA2217373A1 (en) * 1996-10-10 1998-04-10 Michael John Martin Benzo¬b|thiophene compounds, intermediates, formulations, and methods

Also Published As

Publication number Publication date
NO20030800L (no) 2003-04-23
TWI290920B (en) 2007-12-11
NO20030800D0 (no) 2003-02-20
BR0113425A (pt) 2003-07-15
KR100911280B1 (ko) 2009-08-11
EA200300062A1 (ru) 2003-08-28
AU8414901A (en) 2002-03-04
IS6677A (is) 2003-01-13
IL153632A (en) 2007-07-24
JP5081363B2 (ja) 2012-11-28
IS2821B (is) 2013-02-15
JP2012097100A (ja) 2012-05-24
CZ304003B6 (cs) 2013-08-14
PL219848B1 (pl) 2015-07-31
NZ523446A (en) 2004-12-24
YU12903A (sh) 2006-05-25
US6949583B2 (en) 2005-09-27
JP2004506727A (ja) 2004-03-04
BG107527A (bg) 2003-10-31
PL362119A1 (en) 2004-10-18
CN1246315C (zh) 2006-03-22
FR2813306B1 (fr) 2005-10-21
US20030225100A1 (en) 2003-12-04
DK1315709T3 (da) 2010-09-20
EP1315709A1 (fr) 2003-06-04
WO2002016339A1 (fr) 2002-02-28
DE60142240D1 (de) 2010-07-08
SI1315709T1 (sl) 2010-09-30
ES2346291T3 (es) 2010-10-14
ATE469138T1 (de) 2010-06-15
MEP23008A (en) 2010-06-10
HK1053113A1 (en) 2003-10-10
BR0113425B1 (pt) 2014-02-25
CY1110738T1 (el) 2015-06-10
MXPA03001463A (es) 2004-05-04
SK288126B6 (sk) 2013-10-02
ZA200300744B (en) 2004-02-05
CZ2003521A3 (cs) 2003-05-14
HU229456B1 (en) 2013-12-30
HUP0302968A2 (hu) 2003-12-29
ME00106B (me) 2010-10-10
OA12359A (fr) 2006-05-16
EA006237B1 (ru) 2005-10-27
RS51603B (sr) 2011-08-31
EP1315709B1 (fr) 2010-05-26
CA2415847A1 (fr) 2002-02-28
HUP0302968A3 (en) 2005-02-28
JP5603849B2 (ja) 2014-10-08
NO328138B1 (no) 2009-12-14
BG66240B1 (bg) 2012-08-31
CA2415847C (fr) 2011-09-27
PT1315709E (pt) 2010-07-29
AU2001284149B2 (en) 2006-09-21
CN1471521A (zh) 2004-01-28
IL153632A0 (en) 2003-07-06
SK2162003A3 (en) 2003-08-05
FR2813306A1 (fr) 2002-03-01
KR20030023767A (ko) 2003-03-19
MA26943A1 (fr) 2004-12-20

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