AR027636A1 - Inhibidor de la actividad de la alfa-amilasa - Google Patents
Inhibidor de la actividad de la alfa-amilasaInfo
- Publication number
- AR027636A1 AR027636A1 ARP010101126A ARP010101126A AR027636A1 AR 027636 A1 AR027636 A1 AR 027636A1 AR P010101126 A ARP010101126 A AR P010101126A AR P010101126 A ARP010101126 A AR P010101126A AR 027636 A1 AR027636 A1 AR 027636A1
- Authority
- AR
- Argentina
- Prior art keywords
- alpha
- amylase activity
- inhibitor
- fraction
- subjected
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 7
- 239000003112 inhibitor Substances 0.000 title abstract 6
- 239000004382 Amylase Substances 0.000 title 1
- 102000004139 alpha-Amylases Human genes 0.000 abstract 6
- 108090000637 alpha-Amylases Proteins 0.000 abstract 6
- 229940024171 alpha-amylase Drugs 0.000 abstract 6
- 241000508269 Psidium Species 0.000 abstract 3
- 235000013305 food Nutrition 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 235000013361 beverage Nutrition 0.000 abstract 2
- 238000010828 elution Methods 0.000 abstract 2
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 2
- 235000013824 polyphenols Nutrition 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000011231 conductive filler Substances 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 abstract 1
- 235000019799 monosodium phosphate Nutrition 0.000 abstract 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 abstract 1
- 229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 235000011008 sodium phosphates Nutrition 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medical Informatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Se refiere a un inhibidor de la actividad de la alfa-amilasa que contiene, como un componente efectivo, polifenoles obtenidos a través del siguienteproceso: hojas de guayaba y/o el fruto de la guayaba se someten a extraccion con uno o más solventes s eleccionados de entre agua y solventes hidrofílicos; elextracto resultante se somete a ultrafiltracion, para remover de tal modo sustancias que presentan un peso molecular inferior a 5,000; la fraccion restante sesomete a cromatografía hidrofobica em pleando un relleno de conduccion grupo butilo como una fase estacionaria, donde la fraccion se somete a elucion a unavelocidad de flujo de 1 mL/minuto con el uso de una solucion acuosa de dihidrogenfosfato de sodio (0,02 mol/L) y una solucion acuosa de fosfato de sodio (0,02mol/L) bajo un gradiente de concentracion entre las dos soluciones; y una fraccion de la sustancia elutada se recupera, dicha fraccion corresponde al tercerunico pico de una curva de elucion que se obtiene cuando la absorbenc ia de la sustancia se mide a 260 nm. La presente invencion se refiere también a uninhibidor de la actividad de la alfa-amilasa que contiene, como un componente efectivo, polifenoles que presentan propiedades fisioquímicas específicas, y aalimentos y bebidas que contienen el inhibidor de la actividad de la alfa-amilasa. El inhibidor de la actividad de la alfa-amilasa exhibe una actividadnotablemente excelente de la actividad inhibitoria de la alfa-amilasa comparada con el extracto de guayaba. Por consiguiente, los alimentos y bebidas quecontienen el inhibidor de la actividad de la alfa-amilasa son alimentos y bebidas dietéticos apropiados para aquellas personas con elevado nivel de azucar ensangre o hiperlipidemia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000066896 | 2000-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR027636A1 true AR027636A1 (es) | 2003-04-02 |
Family
ID=18586179
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010101126A AR027636A1 (es) | 2000-03-10 | 2001-03-09 | Inhibidor de la actividad de la alfa-amilasa |
ARP080104455A AR068851A2 (es) | 2000-03-10 | 2008-10-10 | Una composicion que comprende un inhibidor de la actividad de la alfa - amilasa , un alimento o bebida que la comprenden y un metodo para producir un alimento o bebida dieteticos que la comprenden |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104455A AR068851A2 (es) | 2000-03-10 | 2008-10-10 | Una composicion que comprende un inhibidor de la actividad de la alfa - amilasa , un alimento o bebida que la comprenden y un metodo para producir un alimento o bebida dieteticos que la comprenden |
Country Status (13)
Country | Link |
---|---|
US (1) | US7037536B2 (es) |
EP (1) | EP1262543B1 (es) |
JP (1) | JP5354833B2 (es) |
KR (1) | KR20020086503A (es) |
CN (1) | CN1264978C (es) |
AR (2) | AR027636A1 (es) |
AU (2) | AU2001241078B2 (es) |
BR (1) | BRPI0108957B1 (es) |
CA (1) | CA2402893C (es) |
ES (1) | ES2393667T3 (es) |
MX (1) | MXPA02008819A (es) |
TW (1) | TWI261497B (es) |
WO (1) | WO2001066714A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4776149B2 (ja) * | 2003-03-28 | 2011-09-21 | クラシエフーズ株式会社 | 糖質吸収抑制剤および食品 |
CA2568775C (en) | 2004-06-04 | 2012-09-11 | David Kannar | Natural sweetener |
JP2005350375A (ja) * | 2004-06-09 | 2005-12-22 | Kikkoman Corp | 血中尿酸値低下剤 |
JP2006056793A (ja) * | 2004-08-18 | 2006-03-02 | Bizen Chemical Co Ltd | ポリフェノール含有生成物の製造方法、ポリフェノール含有生成物、α−アミラーゼ阻害剤、抗酸化剤および食用組成物 |
JP2006056850A (ja) * | 2004-08-23 | 2006-03-02 | Suntory Ltd | リパーゼ阻害剤 |
JP2006104181A (ja) * | 2004-09-13 | 2006-04-20 | Takahiro Tsujita | ブナ科植物由来の糖質分解酵素阻害物質、及びその用途 |
JP4658560B2 (ja) * | 2004-10-06 | 2011-03-23 | 備前化成株式会社 | 更年期障害の改善・治療剤および前立腺ガンおよび乳ガンの予防・治療剤 |
CN1309826C (zh) * | 2004-10-27 | 2007-04-11 | 北京北大维信生物科技有限公司 | 纳豆激酶纯化工艺 |
BRPI0613305B1 (pt) | 2005-06-03 | 2020-09-29 | The Product Makers (Australia) Pty Ltd | Método não terapeutico para alterar a distribuição da massa do corpo de um indivíduo |
WO2007007732A1 (ja) * | 2005-07-12 | 2007-01-18 | Kabushiki Kaisha Yakult Honsha | アディポネクチン濃度上昇剤 |
US20090004270A1 (en) * | 2006-01-06 | 2009-01-01 | Amerilab Technologies, Inc. | Method of using guava extract |
US7611739B2 (en) * | 2006-01-06 | 2009-11-03 | Amerilab Technologies, Inc. | Method of using guava extract and composition including guava extract |
TWI386168B (zh) * | 2006-05-18 | 2013-02-21 | Yakult Honsha Kk | 番石榴葉萃取物粉末及其製造方法 |
JP2006298937A (ja) * | 2006-07-14 | 2006-11-02 | Kinji Ishida | 肥満防止改善組成物およびそれを用いた飲食品 |
BRPI0715018B1 (pt) * | 2006-09-19 | 2021-12-07 | The Product Makers (Australia) Pty Ltd | Processo de produção de um extrato derivado de cana de açúcar que possui características de redução de índice glicêmico |
GB0719545D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Novel use of cocoa extract |
GB0719542D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Use of cocoa extract |
GB0719544D0 (en) * | 2007-10-08 | 2007-11-14 | Barry Callebaut Ag | Cocoa extract and use thereof |
US20080293644A1 (en) * | 2007-04-27 | 2008-11-27 | Thomas Eidenberger | Guava extract |
CN102127508B (zh) * | 2010-12-25 | 2013-01-16 | 浙江工业大学 | α-淀粉酶抑制剂产生菌及其筛选方法 |
EP2672832B1 (en) | 2011-02-08 | 2020-03-25 | The Product Makers (Australia) Pty Ltd | Sugar extracts |
US20150050371A1 (en) | 2012-03-09 | 2015-02-19 | Biotropics Malaysia Berhad | Extract Formulations of Rhodamnia Cinerea And Uses Thereof |
EP2890467B1 (en) | 2012-08-28 | 2019-09-25 | The Product Makers (Australia) Pty Ltd | Extraction method |
US10350259B2 (en) | 2013-08-16 | 2019-07-16 | The Product Makers (Australia) Pty Ltd | Sugar cane derived extracts and methods of treatment |
CN107213203B (zh) * | 2017-06-14 | 2021-01-05 | 广东番石榴健康产业有限公司 | 一种从番石榴叶中提取总多酚的方法 |
CN107807102A (zh) * | 2017-11-02 | 2018-03-16 | 威海百合生物技术股份有限公司 | 一种α‑淀粉酶抑制剂活性的检测方法 |
CN111504997B (zh) * | 2020-05-15 | 2022-10-18 | 吉林鑫水科技开发有限公司 | 玉蜀黍须和秸秆成分提取及各成分体外降糖活性检验方法 |
CN111568969B (zh) * | 2020-06-08 | 2023-05-09 | 广西壮族自治区中国科学院广西植物研究所 | 以多聚体多酚为主的荔枝皮提取物在制备α-淀粉酶抑制剂中的应用 |
CN113884605B (zh) * | 2021-10-14 | 2023-06-16 | 安徽科技学院 | 一种土壤酚类物质用分级式高效分离纯化方法 |
CN114209057A (zh) * | 2021-11-30 | 2022-03-22 | 瀚科(浙江)生物科技有限责任公司 | 一种刺梨天然纳米颗粒及其提取方法和应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5429599B2 (es) * | 1974-12-28 | 1979-09-25 | ||
JPS6036746B2 (ja) * | 1983-09-06 | 1985-08-22 | 備前化成株式会社 | グアバ葉エキスからなる健康飲料 |
JP3018013B2 (ja) * | 1989-10-19 | 2000-03-13 | 三井農林株式会社 | α―アミラーゼ活性阻害剤 |
JP2670742B2 (ja) * | 1993-08-21 | 1997-10-29 | 備前化成株式会社 | α−アミラーゼ阻害物質 |
US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
IT1275905B1 (it) * | 1995-03-14 | 1997-10-24 | Indena Spa | Frazioni polifenoliche di te', loro uso e formulazioni che le contengono |
JPH092969A (ja) * | 1995-06-20 | 1997-01-07 | O S Kogyo Kk | アレルギー疾患治療剤 |
JP2974946B2 (ja) * | 1995-09-26 | 1999-11-10 | 株式会社ヤクルト本社 | グアバ茶飲料 |
DE69633502T2 (de) * | 1995-12-26 | 2006-02-23 | Suntory Ltd. | Procyanidin als den aktiven bestandteil enthaltende mittel gegen fettleibigkeit |
JP4109731B2 (ja) * | 1997-01-23 | 2008-07-02 | 備前化成株式会社 | 改良グアバ葉エキス抽出法 |
US5912363A (en) * | 1997-08-29 | 1999-06-15 | Interhealth Nutraceuticals | Method for extraction of proanthocyanidins from plant material |
-
2001
- 2001-03-09 EP EP01912225A patent/EP1262543B1/en not_active Expired - Lifetime
- 2001-03-09 ES ES01912225T patent/ES2393667T3/es not_active Expired - Lifetime
- 2001-03-09 WO PCT/JP2001/001857 patent/WO2001066714A1/ja active IP Right Grant
- 2001-03-09 AR ARP010101126A patent/AR027636A1/es not_active Application Discontinuation
- 2001-03-09 CN CNB018063284A patent/CN1264978C/zh not_active Expired - Fee Related
- 2001-03-09 MX MXPA02008819A patent/MXPA02008819A/es active IP Right Grant
- 2001-03-09 TW TW090105564A patent/TWI261497B/zh not_active IP Right Cessation
- 2001-03-09 AU AU2001241078A patent/AU2001241078B2/en not_active Ceased
- 2001-03-09 CA CA2402893A patent/CA2402893C/en not_active Expired - Lifetime
- 2001-03-09 JP JP2001565871A patent/JP5354833B2/ja not_active Expired - Fee Related
- 2001-03-09 US US10/220,280 patent/US7037536B2/en not_active Expired - Lifetime
- 2001-03-09 BR BRPI0108957A patent/BRPI0108957B1/pt not_active IP Right Cessation
- 2001-03-09 AU AU4107801A patent/AU4107801A/xx active Pending
- 2001-03-09 KR KR1020027010183A patent/KR20020086503A/ko not_active Application Discontinuation
-
2008
- 2008-10-10 AR ARP080104455A patent/AR068851A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR0108957A (pt) | 2002-12-24 |
MXPA02008819A (es) | 2003-02-12 |
CA2402893A1 (en) | 2002-09-10 |
EP1262543B1 (en) | 2012-10-24 |
US20030124208A1 (en) | 2003-07-03 |
AU2001241078B2 (en) | 2006-02-09 |
EP1262543A4 (en) | 2008-12-31 |
AR068851A2 (es) | 2009-12-09 |
KR20020086503A (ko) | 2002-11-18 |
ES2393667T3 (es) | 2012-12-27 |
CA2402893C (en) | 2011-01-18 |
AU4107801A (en) | 2001-09-17 |
CN1264978C (zh) | 2006-07-19 |
CN1416464A (zh) | 2003-05-07 |
US7037536B2 (en) | 2006-05-02 |
TWI261497B (en) | 2006-09-11 |
WO2001066714A1 (fr) | 2001-09-13 |
BRPI0108957B1 (pt) | 2016-05-17 |
JP5354833B2 (ja) | 2013-11-27 |
EP1262543A1 (en) | 2002-12-04 |
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