AR016702A1 - Heteroaril aminoguanidinas y alcoxiguanidinas que actuan como inhibidores de las proteasas, composicion farmaceutica que las contiene, metodos in vitro deuso de las mismas, dispositivo que las emplea, y proceso para prepararlas. - Google Patents
Heteroaril aminoguanidinas y alcoxiguanidinas que actuan como inhibidores de las proteasas, composicion farmaceutica que las contiene, metodos in vitro deuso de las mismas, dispositivo que las emplea, y proceso para prepararlas.Info
- Publication number
- AR016702A1 AR016702A1 ARP980106006A ARP980106006A AR016702A1 AR 016702 A1 AR016702 A1 AR 016702A1 AR P980106006 A ARP980106006 A AR P980106006A AR P980106006 A ARP980106006 A AR P980106006A AR 016702 A1 AR016702 A1 AR 016702A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- thienyl
- indolyl
- optionally substituted
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Abstract
Heteroaril aminoguanidinas y alcoxiguanidinas que tienen la formula VII, o un solvato, hidrato o sal farmacéuticamente aceptable del mismo, en el cual. R1es alquilo, cicloalquilo, cicloalquilalquilo, alquenilo, alquinilo, arilo, aralquilo, oheteroci clo seleccionado a partir del grupo formado por piperidinilo,piperazinilo, 2-oxopiperazinilo, 2-oxopiperidinilo, 2-oxopirrolidinilo, 2-oxoazepinilo, azepinilo, pirrolilo, 4-piperidonilo, pirrolidinilo, pirazolilo,pirazolidinilo,imidazolilo, imidazol inilo, imidazolidinilo, piridilo, pirazinilo, pirimidinilo, piridazinilo, oxazolilo, oxazolidinilo, isoxazolilo,isoxazolidinilo, morfolinilo, tiazolilo, tiazolidinilo, isotiazolilo, quinuclidinilo, isotiazolidinilo, indolilo,quinolinilo, isoquinolin ilo, bencimidazolilo,tiadiazolilo, benzopiranilo, benzotiazolilo, benzoxazolilo, furilo, tetrahidrofurilo, tetrahidropiranilo, tienilo, benzotienilo, tiamorfolinilo, tiamorfolinilsulfoxido, tiamorfolinil sulfona,oxadiazolilo, benzotiadiazolilo, y te trahidroquinolinilo, o heterocicloalquilo seleccionado a partir del grupo formado porpiridilmetilo, tienilmetilo, pirazolilmetilo, imidazolilmetilo, quinolinilmetilo, isoquinolinilmetilo, ytetrahidroquinolinilmetilo, cualquiera de los cualespuede es tar opcionalmente sustituido; Z es -SO2-, -OCO-, -CO-, -NR2CO-o un enlace covalente, donde R2 es hidrogeno, alquilo, aralquilo, arilo, hidroxi-alquiloC2-10, amino-alquilo C2-10,monoalquilamino-alquilo C2-10, dialquilamino-alquilo C2-10 o carboxialqu ilo;formulas (A)(B)(C);Het se selecciona a partir del grupoformado por R3, R4 y R5 son independientemente H, alquilo, cicloalquilo, alquenilo, alquinilo, arilo opcionalmentesustituido, aralquilo opcionalmentesustituido, heteroarilo opcionalmente su stituido seleccionado a partir del grupo formado por tienilo, benzo[b]tienilo, nafto[2,3-b]tienilo, tiantrenilo,furilopiranilo,isobenzofuranilo,benzoxazolilo,cromenilo,xantenilo, fenoxatiinilo, 2H-pirrolilo,pirrolilo,imidazolilo,pirazolilo, piridilo ,pirazinilo, pirimidilo,piridazinilo, indolizinilo, isoindolilo, 3H-indolilo, indolilo, inidazolilo, purinilo, 4H-quinolizinilo, isoquinolilo, quinolilo, ftalazinilo,
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6647597P | 1997-11-26 | 1997-11-26 | |
US6732497P | 1997-12-05 | 1997-12-05 | |
US7910798P | 1998-03-23 | 1998-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016702A1 true AR016702A1 (es) | 2001-07-25 |
Family
ID=27370979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980106006A AR016702A1 (es) | 1997-11-26 | 1998-11-26 | Heteroaril aminoguanidinas y alcoxiguanidinas que actuan como inhibidores de las proteasas, composicion farmaceutica que las contiene, metodos in vitro deuso de las mismas, dispositivo que las emplea, y proceso para prepararlas. |
Country Status (14)
Country | Link |
---|---|
US (8) | US6037356A (es) |
EP (1) | EP1036063B1 (es) |
JP (1) | JP2001524467A (es) |
AR (1) | AR016702A1 (es) |
AT (1) | ATE344246T1 (es) |
AU (1) | AU751412B2 (es) |
BR (1) | BR9815325A (es) |
CA (1) | CA2311969A1 (es) |
DE (1) | DE69836346T2 (es) |
EA (1) | EA004180B1 (es) |
ES (1) | ES2274587T3 (es) |
PL (1) | PL340560A1 (es) |
TW (1) | TWI222441B (es) |
WO (1) | WO1999026926A1 (es) |
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1998
- 1998-11-25 JP JP2000522084A patent/JP2001524467A/ja active Pending
- 1998-11-25 ES ES98962838T patent/ES2274587T3/es not_active Expired - Lifetime
- 1998-11-25 EP EP98962838A patent/EP1036063B1/en not_active Expired - Lifetime
- 1998-11-25 AU AU17991/99A patent/AU751412B2/en not_active Ceased
- 1998-11-25 AT AT98962838T patent/ATE344246T1/de not_active IP Right Cessation
- 1998-11-25 TW TW087119488A patent/TWI222441B/zh not_active IP Right Cessation
- 1998-11-25 DE DE69836346T patent/DE69836346T2/de not_active Expired - Fee Related
- 1998-11-25 CA CA002311969A patent/CA2311969A1/en not_active Abandoned
- 1998-11-25 BR BR9815325-0A patent/BR9815325A/pt not_active Application Discontinuation
- 1998-11-25 US US09/199,167 patent/US6037356A/en not_active Expired - Lifetime
- 1998-11-25 PL PL98340560A patent/PL340560A1/xx not_active Application Discontinuation
- 1998-11-25 WO PCT/US1998/025185 patent/WO1999026926A1/en active IP Right Grant
- 1998-11-25 EA EA200000578A patent/EA004180B1/ru not_active IP Right Cessation
- 1998-11-26 AR ARP980106006A patent/AR016702A1/es unknown
-
2000
- 2000-01-14 US US09/482,540 patent/US6245763B1/en not_active Expired - Lifetime
-
2001
- 2001-04-06 US US09/827,292 patent/US6350764B2/en not_active Expired - Lifetime
- 2001-12-12 US US10/012,445 patent/US6472399B2/en not_active Expired - Lifetime
-
2002
- 2002-09-12 US US10/241,513 patent/US6566379B1/en not_active Expired - Lifetime
-
2003
- 2003-03-27 US US10/400,073 patent/US6706021B2/en not_active Expired - Lifetime
- 2003-11-17 US US10/714,988 patent/US7029654B2/en not_active Expired - Lifetime
-
2005
- 2005-10-19 US US11/254,086 patent/US7402586B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999026926A1 (en) | 1999-06-03 |
DE69836346T2 (de) | 2007-05-24 |
US20040106633A1 (en) | 2004-06-03 |
US7029654B2 (en) | 2006-04-18 |
AU751412B2 (en) | 2002-08-15 |
EP1036063A1 (en) | 2000-09-20 |
US6706021B2 (en) | 2004-03-16 |
US20030087921A1 (en) | 2003-05-08 |
US6245763B1 (en) | 2001-06-12 |
EA004180B1 (ru) | 2004-02-26 |
ES2274587T3 (es) | 2007-05-16 |
BR9815325A (pt) | 2001-12-26 |
DE69836346D1 (de) | 2006-12-14 |
CA2311969A1 (en) | 1999-06-03 |
TWI222441B (en) | 2004-10-21 |
US7402586B2 (en) | 2008-07-22 |
PL340560A1 (en) | 2001-02-12 |
US6472399B2 (en) | 2002-10-29 |
ATE344246T1 (de) | 2006-11-15 |
JP2001524467A (ja) | 2001-12-04 |
US20030225115A1 (en) | 2003-12-04 |
US20020007070A1 (en) | 2002-01-17 |
US6037356A (en) | 2000-03-14 |
US20060211719A1 (en) | 2006-09-21 |
US20020086872A1 (en) | 2002-07-04 |
EA200000578A1 (ru) | 2001-02-26 |
AU1799199A (en) | 1999-06-15 |
EP1036063B1 (en) | 2006-11-02 |
US6350764B2 (en) | 2002-02-26 |
US6566379B1 (en) | 2003-05-20 |
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