AR016314A1 - Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienen - Google Patents
Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR016314A1 AR016314A1 ARP980103330A ARP980103330A AR016314A1 AR 016314 A1 AR016314 A1 AR 016314A1 AR P980103330 A ARP980103330 A AR P980103330A AR P980103330 A ARP980103330 A AR P980103330A AR 016314 A1 AR016314 A1 AR 016314A1
- Authority
- AR
- Argentina
- Prior art keywords
- carboxy
- alkyl
- hydroxy
- lower alkyl
- aminoalkoxy
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/24—Antidepressants
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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Abstract
Se refiere al uso de 2-arilalquenil-, 2-heteroarilalquenil-, 2-arilalquinil-2-heteroarilalquinil-2-arilazo, y 2-heteroarilazo-piridinas, o una salfarmacéuticamente aceptable de las mismas que son utiles en el tratamiento de desordenes asociados con irregularidades de la transmision de la senalglutamatérgica y de desordenes del sistema nervioso mediados total o parcialmente por mGluR5. Compuestos de la formula (I) en donde R1 denota hidrogeno,alquilo inferior, hidroxialquilo inferior, alquilo inferior-amino, piperidino, carboxi, carboxi esterificado, carboxi amidado, N-alquilo inferior-N-fenilcarbamoílo insustituido o sustituido por alquilo inferior, alcoxi inferior, halogeno, y/o trifluorometilo; alcoxi inferior, haloalquilo inferior, ohaloalcoxi inferior, R2 denota hidrogeno, alquilo inferior, carboxi, carboxi esterificado, carboxi amidado, hidroxialquilo inferior, hidroxi, alcoxi inferior,o alcanoiloxi inferior, 4-(4-fluoro-benzoil)-piperidin-1-il-carboxi, 4-butiloxi terciario-carbonil-piperazin-1-il-carboxi, 4-(4-azido 2-hidroxibenzoil)-piperazin-1-il-carboxi o 4-(4-azido-2-hidroxi-3-yodo-benzoil)-piperazin-1-il-carboxi, R3 representa hidrogeno, alquilo inferior, carboxi, alcoxi inferiorcarbonilo, alquilo inferior-carbamoílo, hidroxialquilo inferior, dialquilo inferior-aminometilo, morfolinocarbonilo, o 4-(4-fluoro-benzoil)-piperidin-1-il-carboxi, R4 representa hidrogeno, alquilo inferior, hidroxi, hidroxialquilo inferior, aminalquilo inferior, alquilo inferior-aminoalquilo inferior, dialquiloinferior-aminoalquilo inferior, alquileno inferior-aminoalquilo inferior insustituido o sustituido por hidroxi, alcoxi inferior, alcanoiloxi inferior,aminoalcoxi inferior, alquilo inferior-aminoalcoxi inferior, dialquilo inferior-aminoalcoxi inferio, ftalimidoalcoxi inferior, alquileno inferior-aminoalcoxiinferior insustituido o sustituido por hidroxi o por 2-oxo-imidazolidin-1-ilo: carboxi, carboxi esterificado o amidado, carboxialcoxi inferior o carboxialcoxiesterificado;X representa un grupo alquenileno o alquinileno inferior opcionalmente sustituido por halogeno enlazado por medio de átomos de carbono insaturado
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US89169197A | 1997-07-11 | 1997-07-11 | |
US89068997A | 1997-07-11 | 1997-07-11 |
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ARP980103330A AR016314A1 (es) | 1997-07-11 | 1998-07-08 | Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienen |
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EP (1) | EP0998459B1 (es) |
JP (1) | JP3481208B2 (es) |
KR (1) | KR20010021712A (es) |
CN (1) | CN1203060C (es) |
AR (1) | AR016314A1 (es) |
AT (1) | ATE393145T1 (es) |
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CA (1) | CA2295678C (es) |
DE (1) | DE69839398T2 (es) |
ES (1) | ES2308811T3 (es) |
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ID (1) | ID23889A (es) |
IL (1) | IL133904A0 (es) |
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IT1276153B1 (it) * | 1995-11-17 | 1997-10-27 | Roberto Pellicciari | Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato |
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1998
- 1998-07-06 TW TW087110887A patent/TW544448B/zh not_active IP Right Cessation
- 1998-07-08 AR ARP980103330A patent/AR016314A1/es unknown
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- 1998-07-09 SK SK23-2000A patent/SK232000A3/sk unknown
- 1998-07-09 CN CNB988070502A patent/CN1203060C/zh not_active Expired - Fee Related
- 1998-07-09 KR KR1020007000271A patent/KR20010021712A/ko not_active Application Discontinuation
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AU8974398A (en) | 1999-02-08 |
AU738973B2 (en) | 2001-10-04 |
TW544448B (en) | 2003-08-01 |
EP0998459A2 (en) | 2000-05-10 |
JP2001509504A (ja) | 2001-07-24 |
DE69839398T2 (de) | 2009-05-28 |
CN1203060C (zh) | 2005-05-25 |
ID23889A (id) | 2000-05-25 |
KR20010021712A (ko) | 2001-03-15 |
HUP0004225A2 (hu) | 2001-05-28 |
BR9811685A (pt) | 2000-09-19 |
IL133904A0 (en) | 2001-04-30 |
MY119800A (en) | 2005-07-29 |
TR200000059T2 (tr) | 2000-06-21 |
SK232000A3 (en) | 2000-06-12 |
EP0998459B1 (en) | 2008-04-23 |
WO1999002497A3 (en) | 1999-04-01 |
ES2308811T3 (es) | 2008-12-01 |
PE97799A1 (es) | 1999-11-08 |
CN1262676A (zh) | 2000-08-09 |
NO20000124D0 (no) | 2000-01-10 |
HUP0004225A3 (en) | 2001-06-28 |
CA2295678C (en) | 2010-04-13 |
DE69839398D1 (de) | 2008-06-05 |
RU2203889C2 (ru) | 2003-05-10 |
JP3481208B2 (ja) | 2003-12-22 |
ATE393145T1 (de) | 2008-05-15 |
WO1999002497A2 (en) | 1999-01-21 |
US6656957B1 (en) | 2003-12-02 |
PL343865A1 (en) | 2001-09-10 |
CA2295678A1 (en) | 1999-01-21 |
NO20000124L (no) | 2000-03-02 |
PT998459E (pt) | 2008-07-31 |
NZ502210A (en) | 2002-07-26 |
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