ES2308811T3 - Derivados de piridina. - Google Patents

Derivados de piridina. Download PDF

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Publication number
ES2308811T3
ES2308811T3 ES98941308T ES98941308T ES2308811T3 ES 2308811 T3 ES2308811 T3 ES 2308811T3 ES 98941308 T ES98941308 T ES 98941308T ES 98941308 T ES98941308 T ES 98941308T ES 2308811 T3 ES2308811 T3 ES 2308811T3
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Spain
Prior art keywords
alkoxy
alkyl
carboxyl
alkoxycarbonyl
hydrogen
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Expired - Lifetime
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ES98941308T
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English (en)
Inventor
Hans Allgeier
Yves Auberson
Michel Biollaz
Nicholas David Cosford
Fabrizio Gasparini
Roland Heckendorn
Edwin Carl Johnson
Rainer Kuhn
Mark Andrew Varney
Gonul Velicelebi
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Novartis AG
Merck and Co Inc
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Novartis AG
Merck and Co Inc
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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Abstract

El uso de un compuesto de fórmula I (Ver fórmula) en donde X representa un grupo alquenileno (C2 - 4) opcionalmente halo-sustituido o un grupo alquinileno enlazado a través de átomos de carbono vecinos insaturados, R1 es hidrógeno, alquilo (C1 - 4), alcoxi (C1 - 4), hidroxialquilo (C1 - 4), ciano, etinilo, carboxilo, alcoxicarbonilo (C1 - 4), di alquilamino (C1 - 4), alquilaminocarbonilo (C1 - 6), trifluorometil-fenilaminocarbonilo, R2 es hidrógeno, hidroxilo, alquilo (C1 - 4), hidroxialquilo (C1 - 4), alcoxi (C1 - 4), carboxilo, alcanoiloxi (C2 - 5), alcoxicarbonilo (C1 - 4), dialquilamino (C1 - 4) alcanoilo (C1 - 4), dialquilaminometilo (C1 - 4), 4-(4-fluoro-benzoil)-pi-peridin- 1-il-carboxilo, 4-t.-butiloxicarbonil-piperazin-1-il-carboxilo, 4-(4-azido-2-hidroxibenzoil)-piperazin-1-il-carboxilo o 4-(4-azido-2-hidroxilo-3-iodo-benzoil)-piperazin-1-il-carboxilo. R3 es hidrógeno, alquilo (C1 - 4), carboxilo, alcoxicarbonilo (C1 - 4), alquilcarbamoilo (C1 - 4), hidroxialquilo (C1 - 4), dialquilaminometilo (C1 - 4), morfolinocarbonilo o 4-(4-fluorobenzoil)-piperidin-1-il-carboxilo, R4 es hidrógeno, hidroxilo, alcoxi (C1 - 4), carboxilo, alcanoiloxi (C2 - 5), alcoxicarbonilo (C1 - 4), amino alcoxi (C1 - 4), dialquilamino (C1 - 4) alcoxi (C1 - 4), dialquilamino (C1 - 4) alquilo (C1 - 4), carboxilo alquilcarbonilo (C1 - 4), alcoxicarbonilo (C1 - 4) alcoxi (C1 - 4), hidroxilo alquilo (C1 - 4), dialquilamino (C1 - 4) alcoxi (C1 - 4), m-hidroxilo-p-azidofenil-carbonilamino alcoxi (C1 - 4), y R5 es un grupo de fórmula (Ver fórmula) en donde Ra y Rb son independientemente hidrógeno, hidroxilo, halógeno; nitro, ciano, carboxilo, alquilo (C1 - 4), alcoxi (C1 - 4), hidroxilo alquilo (C1 - 4), alcoxicarbonilo (C1 - 4), alcanoilo (C2 - 7), alcanoiloxi (C2 - 5), alcanoiloxi (C2 - 5) alquilo (C1 - 4), trifluorometilo, trifluorometoxi, trimetilsililetinilo, alquinilo (C2 - 5), amino, azido, amino alcoxi (C1 - 4), alcanoilamino (C2 - 5) alcoxi (C1 - 4), alquilamino (C1 - 4) alcoxi (C1 - 4), dialquilamino (C1 - 4) alcoxi (C1 - 4), alquilamino (C1 - 4), dialquilamino (C1 - 4), monohalobencilamino, tienilmetilamino, tienilcarbonilamino, trifluorometilfenilaminocarbonilo, tetrazolilo, alcanoilamino (C2 - 5), bencilcarbonilamino, alquilaminocarbonilamino (C1 - 4), alcoxicarbonil (C1 - 4)-aminocarbonilamino o alquilsulfonilo (C1 - 4), Rc es hidrógeno, flúor, cloro, bromo, hidroxilo, alquilo (C1 - 4), alcanoiloxi (C2 - 5), alcoxi (C1 - 4) o ciano, y Rd es hidrógeno, halógeno o alquilo (C1 - 4). en forma libre o en la forma de un N-óxido o una sal farmacéuticamente aceptable, para la fabricación de una composición farmacéutica para el tratamiento de trastornos asociados con irregularidades de la trasmisión de la señal glutamatérgica, y de trastornos del sistema nervioso mediados completamente o en parte por medio de mGluR5.
ES98941308T 1997-07-11 1998-07-09 Derivados de piridina. Expired - Lifetime ES2308811T3 (es)

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US89169197A 1997-07-11 1997-07-11
US89068997A 1997-07-11 1997-07-11
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