BR0007595A - 4-(heterociclisulfonamido)-5-metóxi-6-(2-metoxifenó xi)-2-fenil-ou piridilpirimidinas como antagonistas de receptor de endotelina - Google Patents

4-(heterociclisulfonamido)-5-metóxi-6-(2-metoxifenó xi)-2-fenil-ou piridilpirimidinas como antagonistas de receptor de endotelina

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Publication number
BR0007595A
BR0007595A BR0007595-7A BR0007595A BR0007595A BR 0007595 A BR0007595 A BR 0007595A BR 0007595 A BR0007595 A BR 0007595A BR 0007595 A BR0007595 A BR 0007595A
Authority
BR
Brazil
Prior art keywords
phenyl
receptor antagonists
heterocyclisulfonamido
pyridylpyrimidines
methoxyphenoxide
Prior art date
Application number
BR0007595-7A
Other languages
English (en)
Inventor
Volker Breu
Philippe Coassolo
Rolf Hubert
Werner Neidhart
Henri Ramuz
Sebastien Roux
Hans Peter Wessel
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0007595A publication Critical patent/BR0007595A/pt

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"4-(HETEROCICLISULFONAMIDO)-5-METóXI-6-(2-METOXIFENó XI)-2-FENIL-OU PIRIDILPIRIMIDINAS COMO ANTAGONISTAS DE RECEPTOR DE ENDOTELINA". Os compostos de fórmula (1), na qual R^1^, R^2^ e X têm o significado como mencionado na descrição, como inibidores de receptores de endotelina e podem portanto ser empregados para o tratamento de distúrbios que são associados com o tónus vascular anormal e disfunção endotelial.
BR0007595-7A 1999-01-18 2000-01-10 4-(heterociclisulfonamido)-5-metóxi-6-(2-metoxifenó xi)-2-fenil-ou piridilpirimidinas como antagonistas de receptor de endotelina BR0007595A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100784 1999-01-18
PCT/EP2000/000103 WO2000042035A1 (en) 1999-01-18 2000-01-10 4-(heterocyclylsulfonamido) -5-methoxy-6- (2-methoxyphenoxy) -2-phenyl- or pyridylpyrimidines as endothelin receptor antagonists

Publications (1)

Publication Number Publication Date
BR0007595A true BR0007595A (pt) 2001-10-16

Family

ID=8237359

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007595-7A BR0007595A (pt) 1999-01-18 2000-01-10 4-(heterociclisulfonamido)-5-metóxi-6-(2-metoxifenó xi)-2-fenil-ou piridilpirimidinas como antagonistas de receptor de endotelina

Country Status (31)

Country Link
US (1) US6242601B1 (pt)
EP (1) EP1149091B1 (pt)
JP (1) JP3983477B2 (pt)
KR (1) KR100478797B1 (pt)
CN (1) CN1340049A (pt)
AR (1) AR029879A1 (pt)
AT (1) ATE389648T1 (pt)
AU (1) AU763112B2 (pt)
BR (1) BR0007595A (pt)
CA (1) CA2359363C (pt)
CO (1) CO5150187A1 (pt)
CZ (1) CZ20012546A3 (pt)
DE (1) DE60038365D1 (pt)
ES (1) ES2301476T3 (pt)
GC (1) GC0000248A (pt)
HR (1) HRP20010515A2 (pt)
HU (1) HUP0200021A3 (pt)
IL (2) IL144055A0 (pt)
MA (1) MA27124A1 (pt)
MY (1) MY121136A (pt)
NO (1) NO322800B1 (pt)
NZ (1) NZ512662A (pt)
PE (1) PE20001421A1 (pt)
PL (1) PL350093A1 (pt)
RU (1) RU2224757C2 (pt)
TR (1) TR200102071T2 (pt)
TW (1) TWI284642B (pt)
UY (1) UY25904A1 (pt)
WO (1) WO2000042035A1 (pt)
YU (1) YU50001A (pt)
ZA (1) ZA200105279B (pt)

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US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
EP1140840B1 (en) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
ME00275B (me) * 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
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MY140724A (en) 2000-07-21 2010-01-15 Actelion Pharmaceuticals Ltd Novel arylethene-sulfonamides
DE60118782T2 (de) * 2000-12-18 2007-01-25 Actelion Pharmaceuticals Ltd. Neue sulfamiden und deren verwendung als endothelin-antagonisten
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
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WO2003068229A1 (en) * 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
AU2003210969A1 (en) * 2002-02-11 2003-09-04 Bayer Corporation Aryl ureas with raf kinase and angiogenesis inhibiting activity
AU2003209116A1 (en) 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
WO2003068746A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Aryl ureas as kinase inhibitors
ATE423103T1 (de) * 2002-12-02 2009-03-15 Actelion Pharmaceuticals Ltd Pyrimidin-sulfonamide und ihre verwendung als endothelin-rezeptor-antagonisten
US7557129B2 (en) * 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
US7269460B2 (en) * 2003-02-28 2007-09-11 Medtronic, Inc. Method and apparatus for evaluating and optimizing ventricular synchronization
PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
JP4777887B2 (ja) 2003-07-23 2011-09-21 バイエル、ファーマシューテイカルズ、コーポレイション 病気および状態の処置および防止のためのフロロ置換オメガカルボキシアリールジフェニル尿素
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
US20100022568A1 (en) * 2006-04-13 2010-01-28 Actelion Pharmaceeuticals Ltd. Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
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AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.
HUE054520T2 (hu) * 2014-11-21 2021-09-28 Daikin Ind Ltd Fluorozott telítetlen ciklusos karbonát, és eljárás ennek elõállítására
CN109260164A (zh) * 2018-10-07 2019-01-25 威海贯标信息科技有限公司 一种阿伏生坦片剂组合物
CN112778215B (zh) * 2021-01-29 2023-06-20 中国医科大学 2-甲氧基苯氧基嘧啶类抗肿瘤化合物及其制备方法和应用
CN112898208B (zh) * 2021-01-29 2023-06-20 中国医科大学 苯基嘧啶胺类抗肿瘤化合物及其制备方法和应用
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Also Published As

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JP3983477B2 (ja) 2007-09-26
UY25904A1 (es) 2001-07-31
NO20013454L (no) 2001-07-12
CZ20012546A3 (cs) 2001-12-12
YU50001A (sh) 2004-03-12
US6242601B1 (en) 2001-06-05
EP1149091B1 (en) 2008-03-19
HRP20010515A2 (en) 2003-06-30
AR029879A1 (es) 2003-07-23
ZA200105279B (en) 2002-10-07
PL350093A1 (en) 2002-11-04
TR200102071T2 (tr) 2002-03-21
DE60038365D1 (en) 2008-04-30
KR20010094746A (ko) 2001-11-01
HUP0200021A3 (en) 2003-01-28
EP1149091A1 (en) 2001-10-31
TWI284642B (en) 2007-08-01
ATE389648T1 (de) 2008-04-15
MY121136A (en) 2005-12-30
ES2301476T3 (es) 2008-07-01
AU2663000A (en) 2000-08-01
CO5150187A1 (es) 2002-04-29
KR100478797B1 (ko) 2005-03-24
CA2359363A1 (en) 2000-07-20
NO20013454D0 (no) 2001-07-12
NO322800B1 (no) 2006-12-11
MA27124A1 (fr) 2005-01-03
GC0000248A (en) 2006-11-01
WO2000042035A1 (en) 2000-07-20
CA2359363C (en) 2006-03-14
JP2002534518A (ja) 2002-10-15
RU2224757C2 (ru) 2004-02-27
CN1340049A (zh) 2002-03-13
IL144055A (en) 2007-07-24
AU763112B2 (en) 2003-07-10
PE20001421A1 (es) 2000-12-18
HUP0200021A2 (hu) 2002-05-29
NZ512662A (en) 2003-11-28
IL144055A0 (en) 2002-04-21

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