HUP0200021A2 - 4-(Heterociklikus szulfonamido)-5-metoxi-6-(2-metoxi-fenoxi)-2-fenil- vagy -piridil-pirimidinek, mint endothelin receptor antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

4-(Heterociklikus szulfonamido)-5-metoxi-6-(2-metoxi-fenoxi)-2-fenil- vagy -piridil-pirimidinek, mint endothelin receptor antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0200021A2
HUP0200021A2 HU0200021A HUP0200021A HUP0200021A2 HU P0200021 A2 HUP0200021 A2 HU P0200021A2 HU 0200021 A HU0200021 A HU 0200021A HU P0200021 A HUP0200021 A HU P0200021A HU P0200021 A2 HUP0200021 A2 HU P0200021A2
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HU
Hungary
Prior art keywords
alkyl
hydrogen
heterocyclylsulfonamido
pyridylpyrimidines
methoxyphenoxy
Prior art date
Application number
HU0200021A
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English (en)
Inventor
Volker Breu
Philippe Coassolo
Rolf Huber
Werner Neidhart
Henri Ramuz
Sébastien Roux
Hans Peter Wessel
Original Assignee
F.Hoffmann-La Roche Ag.
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Application filed by F.Hoffmann-La Roche Ag. filed Critical F.Hoffmann-La Roche Ag.
Publication of HUP0200021A2 publication Critical patent/HUP0200021A2/hu
Publication of HUP0200021A3 publication Critical patent/HUP0200021A3/hu

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Az (I) általános képletű vegyületek[mely képletben R1 jelentésepiridil-, pirrolil-, imidazolil-, tiazolil-, tiazolinil- vagyoxazolil-csoport, amely csoportok adott esetben halogénatommal,alkil-, hidroxi-alkil- vagy alkenilcsoporttal helyettesítve lehetnek;R2 jelentése R21, -Y-R22 vagy heterociklikus csoport, amelyheterociklikus csoport adott esetben egy, két vagy három, azonos vagykülönböző hidroxil-, alkenil-, amino-, alkanoil-amino-, alkoxi-karbonil-amino-, alkil- és/vagy hidroxi- alkil-helyettesítőthordozhat; R21 jelentése ciano-, hidroxi- alkil-, karboxil-, -C(O)NRaRb, -(CH2)1-4-NHRc, -(CH2)1-4-NHC(O)NH(CH2)0-3CH3, amidino-,hidroxi-amidino-, alkoxi-karbonil- vagy hidroxi-alkoxi-karbonilcsoport; R22 jelentése hidrogénatom, alkanoil-, karboxialkil,alkoxi-karbonil-, alkoxi-karbonil- alkil-, karbamoil- alkil, di-alkil-karbamoil- alkil-, allil- alkil- vagy hidroxi- alkilcsoport; Rajelentése hidrogénatom vagy adott esetben hidroxil- vagyalkoxicsoporttal helyettesített alkilcsoport; Rb jelentésehidrogénatom vagy alkilcsoport; Rc jelentése hidrogénatom, acetil-vagy alkilszulfonilcsoport; X jelentése -CH- vagy -N- ; és Y jelentése-O- vagy -NH-] gyógyászatilag alkalmas sóik és észtereik rendellenesvaszkuláris tónussal és hibás endothel működéssel társultrendellenességek és betegségek kezelésére és/vagy megelőzésérealkalmazhatók. A találmány továbbá kiterjed a vegyletek előállításieljárására és hatóanyagként ezeket tartalmazó gyógyszerkészítményekreis. Ó
HU0200021A 1999-01-18 2000-01-10 4-(heterocyclylsulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2-phenyl- or pyridylpyrimidines as endothelin receptor antagonists, process for their preparation and pharmaceutical compositions containing them HUP0200021A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99100784 1999-01-18

Publications (2)

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HUP0200021A2 true HUP0200021A2 (hu) 2002-05-29
HUP0200021A3 HUP0200021A3 (en) 2003-01-28

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HU0200021A HUP0200021A3 (en) 1999-01-18 2000-01-10 4-(heterocyclylsulfonamido)-5-methoxy-6-(2-methoxyphenoxy)-2-phenyl- or pyridylpyrimidines as endothelin receptor antagonists, process for their preparation and pharmaceutical compositions containing them

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US (1) US6242601B1 (hu)
EP (1) EP1149091B1 (hu)
JP (1) JP3983477B2 (hu)
KR (1) KR100478797B1 (hu)
CN (1) CN1340049A (hu)
AR (1) AR029879A1 (hu)
AT (1) ATE389648T1 (hu)
AU (1) AU763112B2 (hu)
BR (1) BR0007595A (hu)
CA (1) CA2359363C (hu)
CO (1) CO5150187A1 (hu)
CZ (1) CZ20012546A3 (hu)
DE (1) DE60038365D1 (hu)
ES (1) ES2301476T3 (hu)
GC (1) GC0000248A (hu)
HR (1) HRP20010515A2 (hu)
HU (1) HUP0200021A3 (hu)
IL (2) IL144055A0 (hu)
MA (1) MA27124A1 (hu)
MY (1) MY121136A (hu)
NO (1) NO322800B1 (hu)
NZ (1) NZ512662A (hu)
PE (1) PE20001421A1 (hu)
PL (1) PL350093A1 (hu)
RU (1) RU2224757C2 (hu)
TR (1) TR200102071T2 (hu)
TW (1) TWI284642B (hu)
UY (1) UY25904A1 (hu)
WO (1) WO2000042035A1 (hu)
YU (1) YU50001A (hu)
ZA (1) ZA200105279B (hu)

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BR0007595A (pt) 2001-10-16
WO2000042035A1 (en) 2000-07-20
DE60038365D1 (en) 2008-04-30
IL144055A (en) 2007-07-24
NO322800B1 (no) 2006-12-11
PE20001421A1 (es) 2000-12-18
KR100478797B1 (ko) 2005-03-24
MA27124A1 (fr) 2005-01-03
AR029879A1 (es) 2003-07-23
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IL144055A0 (en) 2002-04-21
JP2002534518A (ja) 2002-10-15
CZ20012546A3 (cs) 2001-12-12
HUP0200021A3 (en) 2003-01-28
CN1340049A (zh) 2002-03-13
US6242601B1 (en) 2001-06-05
GC0000248A (en) 2006-11-01
PL350093A1 (en) 2002-11-04
NO20013454D0 (no) 2001-07-12
TWI284642B (en) 2007-08-01
KR20010094746A (ko) 2001-11-01
CA2359363A1 (en) 2000-07-20
MY121136A (en) 2005-12-30
UY25904A1 (es) 2001-07-31
ZA200105279B (en) 2002-10-07
NZ512662A (en) 2003-11-28
AU763112B2 (en) 2003-07-10
CO5150187A1 (es) 2002-04-29
ATE389648T1 (de) 2008-04-15
CA2359363C (en) 2006-03-14
TR200102071T2 (tr) 2002-03-21
AU2663000A (en) 2000-08-01
EP1149091A1 (en) 2001-10-31
YU50001A (sh) 2004-03-12
ES2301476T3 (es) 2008-07-01
RU2224757C2 (ru) 2004-02-27

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