YU50001A - 4-(heterociklilsulfonamido)-5-metoksi-6-(2-metoksi-fenoksi) -2-fenil-ili piridil-pirimidini kao antagonisti endotelinskih receptora - Google Patents

4-(heterociklilsulfonamido)-5-metoksi-6-(2-metoksi-fenoksi) -2-fenil-ili piridil-pirimidini kao antagonisti endotelinskih receptora

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Publication number
YU50001A
YU50001A YU50001A YUP50001A YU50001A YU 50001 A YU50001 A YU 50001A YU 50001 A YU50001 A YU 50001A YU P50001 A YUP50001 A YU P50001A YU 50001 A YU50001 A YU 50001A
Authority
YU
Yugoslavia
Prior art keywords
heterocyclylsulfonamido
pyridylpyrimidines
methoxyphenoxy
methoxy
phenyl
Prior art date
Application number
YU50001A
Other languages
English (en)
Inventor
Volker Breu
Philippe Coassolo
Rolf Huber
Werner Neidhart
Henri Ramuz
Sebastien Roux
Hans Peter Wessel
Original Assignee
F.Hofman-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hofman-La Roche Ag. filed Critical F.Hofman-La Roche Ag.
Publication of YU50001A publication Critical patent/YU50001A/sh

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Jedinjenja formule (I), u kojoj R1, R2 i X imaju značenja data u opisu, su inhibitori endotelinskih receptora i otuda se mogu primeniti za lečenje poremećaja koji su u vezi sa abnormalnim vaskularnim tonusom i endotelnom disfunkcijom.
YU50001A 1999-01-18 2000-01-10 4-(heterociklilsulfonamido)-5-metoksi-6-(2-metoksi-fenoksi) -2-fenil-ili piridil-pirimidini kao antagonisti endotelinskih receptora YU50001A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99100784 1999-01-18

Publications (1)

Publication Number Publication Date
YU50001A true YU50001A (sh) 2004-03-12

Family

ID=8237359

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50001A YU50001A (sh) 1999-01-18 2000-01-10 4-(heterociklilsulfonamido)-5-metoksi-6-(2-metoksi-fenoksi) -2-fenil-ili piridil-pirimidini kao antagonisti endotelinskih receptora

Country Status (31)

Country Link
US (1) US6242601B1 (sh)
EP (1) EP1149091B1 (sh)
JP (1) JP3983477B2 (sh)
KR (1) KR100478797B1 (sh)
CN (1) CN1340049A (sh)
AR (1) AR029879A1 (sh)
AT (1) ATE389648T1 (sh)
AU (1) AU763112B2 (sh)
BR (1) BR0007595A (sh)
CA (1) CA2359363C (sh)
CO (1) CO5150187A1 (sh)
CZ (1) CZ20012546A3 (sh)
DE (1) DE60038365D1 (sh)
ES (1) ES2301476T3 (sh)
GC (1) GC0000248A (sh)
HR (1) HRP20010515A2 (sh)
HU (1) HUP0200021A3 (sh)
IL (2) IL144055A0 (sh)
MA (1) MA27124A1 (sh)
MY (1) MY121136A (sh)
NO (1) NO322800B1 (sh)
NZ (1) NZ512662A (sh)
PE (1) PE20001421A1 (sh)
PL (1) PL350093A1 (sh)
RU (1) RU2224757C2 (sh)
TR (1) TR200102071T2 (sh)
TW (1) TWI284642B (sh)
UY (1) UY25904A1 (sh)
WO (1) WO2000042035A1 (sh)
YU (1) YU50001A (sh)
ZA (1) ZA200105279B (sh)

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US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
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EP1158985B1 (en) 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
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US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2400070T3 (es) * 2001-12-03 2013-04-05 Bayer Healthcare Llc Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
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PT1478358E (pt) 2002-02-11 2013-09-11 Bayer Healthcare Llc Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal
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AU2007237874A1 (en) * 2006-04-13 2007-10-25 Actelion Pharmaceuticals Ltd Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
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AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
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JP6458808B2 (ja) * 2014-11-21 2019-01-30 ダイキン工業株式会社 新規なフッ素化不飽和環状カーボネート及びその製造方法
CN109260164A (zh) * 2018-10-07 2019-01-25 威海贯标信息科技有限公司 一种阿伏生坦片剂组合物
CN112898208B (zh) * 2021-01-29 2023-06-20 中国医科大学 苯基嘧啶胺类抗肿瘤化合物及其制备方法和应用
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CN1340049A (zh) 2002-03-13
JP2002534518A (ja) 2002-10-15
MA27124A1 (fr) 2005-01-03
EP1149091A1 (en) 2001-10-31
EP1149091B1 (en) 2008-03-19
RU2224757C2 (ru) 2004-02-27
HRP20010515A2 (en) 2003-06-30
CA2359363A1 (en) 2000-07-20
AR029879A1 (es) 2003-07-23
CO5150187A1 (es) 2002-04-29
AU763112B2 (en) 2003-07-10
PE20001421A1 (es) 2000-12-18
NZ512662A (en) 2003-11-28
PL350093A1 (en) 2002-11-04
IL144055A0 (en) 2002-04-21
KR20010094746A (ko) 2001-11-01
NO322800B1 (no) 2006-12-11
KR100478797B1 (ko) 2005-03-24
US6242601B1 (en) 2001-06-05
MY121136A (en) 2005-12-30
ES2301476T3 (es) 2008-07-01
UY25904A1 (es) 2001-07-31
JP3983477B2 (ja) 2007-09-26
GC0000248A (en) 2006-11-01
ATE389648T1 (de) 2008-04-15
IL144055A (en) 2007-07-24
DE60038365D1 (en) 2008-04-30
ZA200105279B (en) 2002-10-07
WO2000042035A1 (en) 2000-07-20
TWI284642B (en) 2007-08-01
NO20013454D0 (no) 2001-07-12
CA2359363C (en) 2006-03-14
HUP0200021A3 (en) 2003-01-28
NO20013454L (no) 2001-07-12
TR200102071T2 (tr) 2002-03-21
CZ20012546A3 (cs) 2001-12-12
AU2663000A (en) 2000-08-01
HUP0200021A2 (hu) 2002-05-29
BR0007595A (pt) 2001-10-16

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