EA200401137A1 - Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора - Google Patents

Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора

Info

Publication number
EA200401137A1
EA200401137A1 EA200401137A EA200401137A EA200401137A1 EA 200401137 A1 EA200401137 A1 EA 200401137A1 EA 200401137 A EA200401137 A EA 200401137A EA 200401137 A EA200401137 A EA 200401137A EA 200401137 A1 EA200401137 A1 EA 200401137A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pde3
antagonist
histamine receptor
pharmaceutical composition
composition containing
Prior art date
Application number
EA200401137A
Other languages
English (en)
Other versions
EA007903B1 (ru
Inventor
Рольф Бойме
Даниела Бундшух
Кристиан Ваймар
Штефан-Лутц Воллин
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of EA200401137A1 publication Critical patent/EA200401137A1/ru
Publication of EA007903B1 publication Critical patent/EA007903B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

В заявке описано комбинированное применение ингибиторов PDE4 или PDE3/4 и антагонистов гистаминового рецептора для лечения респираторных заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401137A 2002-03-06 2003-02-25 Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора EA007903B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004987 2002-03-06
PCT/EP2003/001876 WO2003074055A1 (en) 2002-03-06 2003-02-25 Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist

Publications (2)

Publication Number Publication Date
EA200401137A1 true EA200401137A1 (ru) 2005-04-28
EA007903B1 EA007903B1 (ru) 2007-02-27

Family

ID=27771841

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200601592A EA010886B1 (ru) 2002-03-06 2003-02-25 Фармацевтическая композиция, способ ее получения и ее применение для лечения респираторных заболеваний, фармацевтический продукт и его применение, набор
EA200401137A EA007903B1 (ru) 2002-03-06 2003-02-25 Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200601592A EA010886B1 (ru) 2002-03-06 2003-02-25 Фармацевтическая композиция, способ ее получения и ее применение для лечения респираторных заболеваний, фармацевтический продукт и его применение, набор

Country Status (32)

Country Link
US (1) US20050112069A1 (ru)
EP (2) EP1849468B1 (ru)
JP (1) JP5150034B2 (ru)
KR (1) KR20040095255A (ru)
CN (1) CN101257904A (ru)
AR (1) AR038858A1 (ru)
AT (1) ATE369134T1 (ru)
AU (1) AU2003212268B2 (ru)
BR (1) BR0308220A (ru)
CA (1) CA2478612C (ru)
CO (1) CO5611148A2 (ru)
CY (2) CY1106927T1 (ru)
DE (1) DE60315426T2 (ru)
DK (2) DK1482938T3 (ru)
EA (2) EA010886B1 (ru)
ES (2) ES2400670T3 (ru)
HK (1) HK1071308A1 (ru)
HR (1) HRP20040909B1 (ru)
IL (1) IL163336A (ru)
IS (2) IS2536B (ru)
MX (1) MXPA04008460A (ru)
NO (1) NO335254B1 (ru)
NZ (1) NZ535611A (ru)
PL (1) PL211574B1 (ru)
PT (2) PT1849468E (ru)
RS (1) RS51018B (ru)
SG (1) SG160197A1 (ru)
SI (2) SI1482938T1 (ru)
TW (1) TWI347845B (ru)
UA (1) UA80117C2 (ru)
WO (1) WO2003074055A1 (ru)
ZA (1) ZA200407104B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ568694A (en) * 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
EP2091538B1 (en) * 2006-12-20 2010-03-03 Glaxo Group Limited 4-benzyl-1(2h)-phthalazinones as h1 receptor antagonists
TW200902025A (en) * 2007-04-11 2009-01-16 Alcon Res Ltd Use of an inhibitor of TNF α plus an antihistamine to treat allergic rhinitis and allergic conjunctivitis
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
US8877816B2 (en) 2007-11-21 2014-11-04 Decode Genetics Ehf 4-(or 5-) substituted catechol derivatives
KR20090061972A (ko) * 2007-12-12 2009-06-17 한미약품 주식회사 베포타스틴 ｐ-톨루엔술폰산염의 결정형, 이의 제조방법 및이를 포함하는 약학 조성물
RS55624B1 (sr) 2011-02-07 2017-06-30 Scipharm Sàrl Nova kompozicija za lečenje cistične fibroze
KR102226833B1 (ko) * 2013-06-28 2021-03-12 한미약품 주식회사 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
JP2017525721A (ja) * 2014-08-26 2017-09-07 ファンダシオン パラ ラ インベスティガシオン メディカ アプリカダＦｕｎｄａｃｉｏｎ Ｐａｒａ Ｌａ Ｉｎｖｅｓｔｉｇａｓｉｏｎ Ｍｅｄｉｃａ Ａｐｌｉｃａｄａ 認知欠損または認知障害に伴って進行する神経障害のおよび神経変性疾患の処置および予防のための製品
AU2015330490B2 (en) 2014-10-09 2018-08-09 Guangdong Raynovent Biotech Co., Ltd. Hydroxyl purine compounds and applications thereof
CN109956947A (zh) * 2017-12-25 2019-07-02 江苏恒瑞医药股份有限公司 一种cns抑制剂的新晶型、制备方法及用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
CZ290266B6 (cs) * 1993-07-02 2002-06-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5990147A (en) * 1997-11-07 1999-11-23 Schering Corporation H3 receptor ligands of the phenyl-alkyl-imidazoles type
BR9804993A (pt) * 1998-11-10 2000-06-06 Panacea Biotec Ltd Composição antialérgica e antiinflamatória
US6174878B1 (en) * 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
IL148807A0 (en) * 1999-10-25 2002-09-12 Byk Gulden Lomberg Chem Fab Tetrahydrothiopyran derivatives and pharmaceutical compositions containing the same
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
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Also Published As

Publication number Publication date
MXPA04008460A (es) 2004-12-06
AR038858A1 (es) 2005-01-26
CY1106927T1 (el) 2012-09-26
KR20040095255A (ko) 2004-11-12
ATE369134T1 (de) 2007-08-15
PL211574B1 (pl) 2012-05-31
SI1482938T1 (sl) 2007-12-31
HRP20040909A2 (en) 2005-08-31
UA80117C2 (ru) 2007-08-27
NO335254B1 (no) 2014-10-27
ES2400670T3 (es) 2013-04-11
NO20044230L (no) 2004-12-06
EA007903B1 (ru) 2007-02-27
SI1849468T1 (sl) 2013-03-29
AU2003212268B2 (en) 2008-09-11
DE60315426T2 (de) 2008-07-03
CA2478612A1 (en) 2003-09-12
DK1849468T3 (da) 2013-02-04
TW200306855A (en) 2003-12-01
RS78004A (en) 2006-12-15
EA010886B1 (ru) 2008-12-30
EP1849468A2 (en) 2007-10-31
JP2005524666A (ja) 2005-08-18
PL371056A1 (en) 2005-06-13
ZA200407104B (en) 2006-12-27
US20050112069A1 (en) 2005-05-26
IS2536B (is) 2009-08-15
DK1482938T3 (da) 2007-12-03
EP1482938A1 (en) 2004-12-08
HRP20040909B1 (en) 2012-11-30
RS51018B (sr) 2010-10-31
SG160197A1 (en) 2010-04-29
BR0308220A (pt) 2005-01-04
HK1071308A1 (en) 2005-07-15
EP1482938B1 (en) 2007-08-08
ES2291618T3 (es) 2008-03-01
NZ535611A (en) 2006-03-31
EA200601592A1 (ru) 2006-12-29
DE60315426D1 (de) 2007-09-20
AU2003212268A1 (en) 2003-09-16
JP5150034B2 (ja) 2013-02-20
WO2003074055A1 (en) 2003-09-12
IL163336A (en) 2009-02-11
EP1849468A3 (en) 2007-11-07
CA2478612C (en) 2013-12-10
CO5611148A2 (es) 2006-02-28
TWI347845B (en) 2011-09-01
CN101257904A (zh) 2008-09-03
PT1482938E (pt) 2007-11-15
PT1849468E (pt) 2013-02-27
IS8760A (is) 2008-09-04
EP1849468B1 (en) 2012-12-05
CY1113894T1 (el) 2016-07-27
IS7438A (is) 2004-09-03

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Legal Events

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PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU