AR013838A1 - Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos - Google Patents

Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos

Info

Publication number
AR013838A1
AR013838A1 ARP970104362A ARP970104362A AR013838A1 AR 013838 A1 AR013838 A1 AR 013838A1 AR P970104362 A ARP970104362 A AR P970104362A AR P970104362 A ARP970104362 A AR P970104362A AR 013838 A1 AR013838 A1 AR 013838A1
Authority
AR
Argentina
Prior art keywords
olanzapine
dihydrates
methyl
substantially pure
piperazinyl
Prior art date
Application number
ARP970104362A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR013838(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR013838A1 publication Critical patent/AR013838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP970104362A 1996-09-23 1997-09-23 Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos AR013838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23

Publications (1)

Publication Number Publication Date
AR013838A1 true AR013838A1 (es) 2001-01-31

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104362A AR013838A1 (es) 1996-09-23 1997-09-23 Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos

Country Status (35)

Country Link
US (1) US6020487A (enExample)
EP (1) EP0831098B1 (enExample)
JP (2) JP2001500877A (enExample)
KR (1) KR100560015B1 (enExample)
CN (1) CN1122036C (enExample)
AR (1) AR013838A1 (enExample)
AT (1) ATE209208T1 (enExample)
AU (1) AU719441B2 (enExample)
BR (1) BR9712100A (enExample)
CA (1) CA2265712C (enExample)
CO (1) CO4910140A1 (enExample)
CZ (1) CZ299248B6 (enExample)
DE (1) DE69708428T2 (enExample)
DK (1) DK0831098T3 (enExample)
EA (1) EA001642B1 (enExample)
EG (1) EG23861A (enExample)
ES (1) ES2166051T3 (enExample)
HU (1) HU226484B1 (enExample)
ID (1) ID27275A (enExample)
IL (1) IL128962A (enExample)
IN (1) IN187156B (enExample)
MY (1) MY125565A (enExample)
NO (1) NO323980B1 (enExample)
NZ (1) NZ334448A (enExample)
PE (1) PE110398A1 (enExample)
PL (3) PL196068B1 (enExample)
PT (1) PT831098E (enExample)
RS (1) RS49598B (enExample)
SI (1) SI0831098T1 (enExample)
SV (1) SV1997000081A (enExample)
TR (1) TR199900640T2 (enExample)
TW (1) TW470746B (enExample)
UA (1) UA59371C2 (enExample)
WO (1) WO1998012199A1 (enExample)
ZA (1) ZA978515B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0114031A (pt) * 2000-08-31 2003-09-09 Reddy S Lab Ltd Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
AU2002340328A1 (en) * 2001-10-29 2003-05-12 Janet I. Cord Olanzapine dihydrate-ii a process for its preparation and use thereof
US6906062B2 (en) 2001-12-24 2005-06-14 Sun Pharmaceutical Industries Limited Crystalline form I of 2-methyl-4-(4-menthyl-1-piperazinyl) 10H thieno [2,3-b][1,5]benzodiazepine
WO2003091260A1 (en) * 2002-04-23 2003-11-06 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
SI1513846T1 (sl) 2002-05-31 2011-11-30 Sandoz Ag Postopek za pripravo olanzapina form I
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
JP2007511605A (ja) * 2003-11-18 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オランザピン含有経皮薬物送達組成物
ES2308304T3 (es) * 2003-12-22 2008-12-01 Teva Pharmaceutical Industries Ltd. Procedimientos de preparacion de la olanzapina.
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
EP1716154A1 (en) * 2004-02-19 2006-11-02 Neuland Laboratories Ltd Process for the preparation of olanzapine form 1 useful as antipsychotic drug
US20080009481A1 (en) * 2004-07-14 2008-01-10 Shasun Chemicals And Drugs Limited Process For Making Form I Of Olanzapine
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
ES2303462B1 (es) 2004-09-06 2009-06-05 Shasun Chemicals And Drugs Limited Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura.
EA200701065A1 (ru) * 2004-11-16 2007-12-28 Элан Фарма Интернэшнл Лтд. Инъецируемые составы, содержащие нанодисперсный оланзапин
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
NZ247703A (en) * 1992-05-29 1995-07-26 Lilly Industries Ltd Thienobenzdiazepine derivatives and medicaments thereof
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
WO1998011893A1 (en) * 1996-09-23 1998-03-26 Eli Lilly And Company Olanzapine dihydrate d

Also Published As

Publication number Publication date
EG23861A (en) 2007-11-18
EA001642B1 (ru) 2001-06-25
PL194565B1 (pl) 2007-06-29
UA59371C2 (uk) 2003-09-15
IN187156B (enExample) 2002-02-16
CN1122036C (zh) 2003-09-24
CA2265712C (en) 2006-10-31
HUP0000066A2 (hu) 2000-06-28
PE110398A1 (es) 1999-01-14
EP0831098A2 (en) 1998-03-25
PT831098E (pt) 2002-04-29
TR199900640T2 (xx) 1999-06-21
MY125565A (en) 2006-08-30
YU15599A (sh) 2001-12-26
DE69708428D1 (de) 2002-01-03
DE69708428T2 (de) 2002-07-04
KR100560015B1 (ko) 2006-03-15
HK1009807A1 (en) 1999-06-11
DK0831098T3 (da) 2002-05-21
ZA978515B (en) 1999-03-23
CO4910140A1 (es) 2000-04-24
BR9712100A (pt) 1999-08-31
JP2009242407A (ja) 2009-10-22
HUP0000066A3 (en) 2000-11-28
EP0831098B1 (en) 2001-11-21
CZ299248B6 (cs) 2008-05-28
PL196069B1 (pl) 2007-12-31
SI0831098T1 (en) 2002-04-30
KR20000048520A (ko) 2000-07-25
WO1998012199A1 (en) 1998-03-26
CA2265712A1 (en) 1998-03-26
ID27275A (id) 2001-03-22
IL128962A (en) 2003-01-12
ES2166051T3 (es) 2002-04-01
NO991382D0 (no) 1999-03-22
PL196068B1 (pl) 2007-12-31
TW470746B (en) 2002-01-01
US6020487A (en) 2000-02-01
IL128962A0 (en) 2000-02-17
PL332482A1 (en) 1999-09-13
AU719441B2 (en) 2000-05-11
EP0831098A3 (en) 1998-04-29
EA199900326A1 (ru) 1999-08-26
CZ99099A3 (cs) 1999-11-17
RS49598B (sr) 2007-06-04
NO323980B1 (no) 2007-07-30
CN1234802A (zh) 1999-11-10
SV1997000081A (es) 1999-01-14
NO991382L (no) 1999-03-22
HU226484B1 (en) 2009-03-02
AU4484197A (en) 1998-04-14
ATE209208T1 (de) 2001-12-15
JP2001500877A (ja) 2001-01-23
NZ334448A (en) 2000-08-25

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