AR012250A1 - Derivados de 2-(iminometil)amino-fenilo, procedimientos para su preparacion, intermediarios utilizados en dichos procedimientos, medicamento y composicion farmaceutica que contienen a dichos derivados y uso de estos derivados para manufacturar un medicamento - Google Patents
Derivados de 2-(iminometil)amino-fenilo, procedimientos para su preparacion, intermediarios utilizados en dichos procedimientos, medicamento y composicion farmaceutica que contienen a dichos derivados y uso de estos derivados para manufacturar un medicamentoInfo
- Publication number
- AR012250A1 AR012250A1 ARP980102907A ARP980102907A AR012250A1 AR 012250 A1 AR012250 A1 AR 012250A1 AR P980102907 A ARP980102907 A AR P980102907A AR P980102907 A ARP980102907 A AR P980102907A AR 012250 A1 AR012250 A1 AR 012250A1
- Authority
- AR
- Argentina
- Prior art keywords
- thiazoline
- derivatives
- radical
- branched
- linear
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D521/00—Heterocyclic compounds containing unspecified hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de 2-(iminometil)amino-fenilo de la formula general (I): en la cual A es un átomo de hidrogeno o preferiblmente un aromático que tiene lasestructuras de formula (II), en donde R1 y R2 representan, independientemente, hidrogeno, halogeno ,CH, un radical alquilo C1-C6 lineal o ramificado, unradical alcoxi C1-C6 lineal o ramificado, R3 representa hidrogeno, un radical alquilo C1-C6 lineal o ramificado o un radical -COR4, representando R4 unradical alqulo C1-C6 de formula (III), o Brepresenta n radical alqulo C1-C6 lineal o ramificado, fenilo, piridinilo o un heterociclo con 5 miembros conteniendo 1 a 4 heteroátomos elegidos de O, S, N y más particularmente: tiofeno, furano, pirrol o tiazol, cuyos átomos de carbono está nopcionalmentesubstituídos por uno o más grupos elegidos de un radical alquilo C1-C6 lineal o ramificado; un radical alcoxi C1-C6 o halogeno; X representa -CO-N(R3)-X-, -NH-CO-X, -CH=, -CO- o un enlace representando X el resto -CH2)n-, siendo n unentero de 0 a 6, Y representa -Y-, -CO-NH-Y-, -Y-NH-CO, -CO-Y-, -N(R3)-Y,-Y-N(R3)-, -Y-CH2-N(R3)-CO-, -O-Y-,Y-O-, -Y-S-, -Y-O-Y, -Y-N(R3)-Y- o un enlace, Yrepresenta -(CH2)n siendo n un entero de 0 a 6; Het representa unheterociclo que contiene de1 a 5 heteroátomos elegidos de O, N, S, los cuales pueden estar sustituidos por uno o más sustituyentes X-OR3, X-NR3, X-S-R3,tal como por ejemplo: exetano, pirrol, pirrolidina, furano, tetrahidrofurano, tiofeno, tetrahidrotiofeno, sulfolano, imidazol, imidazolina, dihidroimidazol-2-ona, dihidroimidazol-2-tiona, oxazol, isoxazol, oxazolina, isoxazolina, oxaxolidina, oxazoolidinona, tiazol, tiazolina, tiazolidina, tiazolidinona,hidantoina, 1,2,4-tiazol, 1,3,4-oxadiazol, 1,1-dioxido-1,2,5-tiadiazolidina, 1,2,4-triazol-3-ona, tetrazol, tetrahidropirina, con la excepcion de los ..2
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9707701A FR2764889B1 (fr) | 1997-06-20 | 1997-06-20 | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR012250A1 true AR012250A1 (es) | 2000-09-27 |
Family
ID=9508226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980102907A AR012250A1 (es) | 1997-06-20 | 1998-06-18 | Derivados de 2-(iminometil)amino-fenilo, procedimientos para su preparacion, intermediarios utilizados en dichos procedimientos, medicamento y composicion farmaceutica que contienen a dichos derivados y uso de estos derivados para manufacturar un medicamento |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0991654B1 (es) |
| JP (1) | JP2002507965A (es) |
| KR (2) | KR100545946B1 (es) |
| CN (1) | CN1195762C (es) |
| AR (1) | AR012250A1 (es) |
| AT (1) | ATE297935T1 (es) |
| AU (1) | AU737964B2 (es) |
| BR (1) | BR9810197B1 (es) |
| CA (1) | CA2294809C (es) |
| CZ (1) | CZ299237B6 (es) |
| DE (1) | DE69830584T2 (es) |
| DK (1) | DK0991654T3 (es) |
| ES (1) | ES2244068T3 (es) |
| FR (1) | FR2764889B1 (es) |
| HK (1) | HK1030218A1 (es) |
| HU (1) | HUP0002425A3 (es) |
| IL (1) | IL133223A (es) |
| MY (1) | MY123193A (es) |
| NO (1) | NO315321B1 (es) |
| NZ (1) | NZ501656A (es) |
| PL (1) | PL191987B1 (es) |
| PT (1) | PT991654E (es) |
| RU (1) | RU2202543C2 (es) |
| SK (1) | SK286911B6 (es) |
| TR (1) | TR199903175T2 (es) |
| TW (1) | TW422842B (es) |
| UA (1) | UA70921C2 (es) |
| WO (1) | WO1998058934A1 (es) |
| ZA (1) | ZA985392B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9801990D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
| AR019190A1 (es) * | 1998-07-08 | 2001-12-26 | Sod Conseils Rech Applic | Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos |
| WO2000008018A1 (fr) * | 1998-08-07 | 2000-02-17 | Takeda Chemical Industries, Ltd. | Derives de benzothiepine, leur procede de preparation et leurs utilisations |
| FR2783519B1 (fr) * | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| FR2798127A1 (fr) * | 1999-09-03 | 2001-03-09 | Expansia Sa | Nouveau procede de preparation d'amidines derivees de l'acide 6-hydroxy-2,5,7,8-tetramethylchrommane-2-carboxy- lique |
| FR2799461B1 (fr) * | 1999-10-11 | 2002-01-04 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
| RU2380362C2 (ru) * | 1999-10-11 | 2010-01-27 | Сосьете Де Консей Де Решерш З | Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств |
| TWI292316B (en) * | 1999-10-11 | 2008-01-11 | Sod Conseils Rech Applic | Pharmaceutical composition of thiazole derivatives intended to inhibit mao and/or lipidic peroxidation and/or to act as modulators of sodium channels and the use thereof |
| FR2812546B1 (fr) * | 2000-08-01 | 2008-11-21 | Sod Conseils Rech Applic | Derives d'heterocycles a 5 chainons, leur preparation et leur application a titre de medicaments |
| FR2801053B1 (fr) * | 1999-11-16 | 2004-06-25 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments |
| SE9904677D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
| SE9904676D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
| GB0019006D0 (en) * | 2000-08-04 | 2000-09-20 | Astrazeneca Ab | Novel compounds |
| WO2002020511A1 (en) * | 2000-09-05 | 2002-03-14 | Astrazeneca Ab | Amidine derivatives which are inhibitors of nitric oxide synthase |
| TWI248438B (en) * | 2001-04-10 | 2006-02-01 | Sod Conseils Rech Applic | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
| AU2002314944B2 (en) | 2001-06-08 | 2008-03-06 | Cytokine Pharmasciences, Inc. | Isoxazoline compounds having MIF antagonist activity |
| HU228783B1 (en) * | 2001-07-26 | 2013-05-28 | Greenearth Cleaning | Dry cleaning apparatus and method capable of utilizing a siloxane solvent |
| FR2842808B1 (fr) * | 2002-07-25 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux derives d'arylimidazoles, leur preparation et leurs applications therapeutiques |
| DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7141561B2 (en) | 2002-07-25 | 2006-11-28 | Sanofi-Aventis Deutschland Gmbh | Substituted diaryl heterocycles, process for their preparation and their use as medicaments |
| CN101098697B (zh) * | 2004-03-26 | 2010-11-10 | 塞托凯恩药物科学公司 | 与抑制巨噬细胞游走抑制因子有关的化合物、组合物、其制备方法和使用方法 |
| WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| BRPI0608402B8 (pt) | 2005-03-11 | 2021-05-25 | Armaron Bio Pty Ltd | compostos de flavonóide e composições compreendendo os mesmos |
| AU2010289281A1 (en) | 2009-09-04 | 2012-04-12 | Vanderbilt University | mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2011058766A1 (en) * | 2009-11-16 | 2011-05-19 | Raqualia Pharma Inc. | Aryl carboxamide derivatives as ttx-s blockers |
| JP6292721B2 (ja) * | 2012-07-12 | 2018-03-14 | コンドリオン アイピー ビー．ブイ．Ｋｈｏｎｄｒｉｏｎ Ｉｐ Ｂ．Ｖ． | ミトコンドリア病を治療するためのクロマニル誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9127376D0 (en) * | 1991-12-24 | 1992-02-19 | Wellcome Found | Amidino derivatives |
| IL110643A (en) * | 1993-08-12 | 1998-07-15 | Astra Ab | History of amidine, their preparation and the pharmaceutical preparations containing them |
| ATE182889T1 (de) * | 1994-05-07 | 1999-08-15 | Astra Ab | Bicyclische amidinderivate als no-synthetase inhibitoren |
-
1997
- 1997-06-20 FR FR9707701A patent/FR2764889B1/fr not_active Expired - Fee Related
-
1998
- 1998-06-10 TW TW087109245A patent/TW422842B/zh not_active IP Right Cessation
- 1998-06-15 KR KR1019997012010A patent/KR100545946B1/ko not_active IP Right Cessation
- 1998-06-15 SK SK1796-99A patent/SK286911B6/sk not_active IP Right Cessation
- 1998-06-15 KR KR1020057016237A patent/KR100618478B1/ko not_active IP Right Cessation
- 1998-06-15 IL IL13322398A patent/IL133223A/en not_active IP Right Cessation
- 1998-06-15 PL PL337499A patent/PL191987B1/pl not_active IP Right Cessation
- 1998-06-15 EP EP98932205A patent/EP0991654B1/fr not_active Expired - Lifetime
- 1998-06-15 ES ES98932205T patent/ES2244068T3/es not_active Expired - Lifetime
- 1998-06-15 TR TR1999/03175T patent/TR199903175T2/xx unknown
- 1998-06-15 CZ CZ0459799A patent/CZ299237B6/cs not_active IP Right Cessation
- 1998-06-15 DE DE69830584T patent/DE69830584T2/de not_active Expired - Lifetime
- 1998-06-15 PT PT98932205T patent/PT991654E/pt unknown
- 1998-06-15 AU AU82189/98A patent/AU737964B2/en not_active Ceased
- 1998-06-15 AT AT98932205T patent/ATE297935T1/de active
- 1998-06-15 NZ NZ501656A patent/NZ501656A/en not_active IP Right Cessation
- 1998-06-15 DK DK98932205T patent/DK0991654T3/da active
- 1998-06-15 WO PCT/FR1998/001250 patent/WO1998058934A1/fr active IP Right Grant
- 1998-06-15 RU RU2000101328/04A patent/RU2202543C2/ru not_active IP Right Cessation
- 1998-06-15 UA UA99126913A patent/UA70921C2/uk unknown
- 1998-06-15 JP JP50387199A patent/JP2002507965A/ja active Pending
- 1998-06-15 CA CA002294809A patent/CA2294809C/fr not_active Expired - Fee Related
- 1998-06-15 CN CNB988073927A patent/CN1195762C/zh not_active Expired - Fee Related
- 1998-06-15 BR BRPI9810197-8A patent/BR9810197B1/pt not_active IP Right Cessation
- 1998-06-15 HU HU0002425A patent/HUP0002425A3/hu unknown
- 1998-06-18 AR ARP980102907A patent/AR012250A1/es active IP Right Grant
- 1998-06-19 MY MYPI98002787A patent/MY123193A/en unknown
- 1998-06-19 ZA ZA985392A patent/ZA985392B/xx unknown
-
1999
- 1999-12-15 NO NO19996208A patent/NO315321B1/no not_active IP Right Cessation
-
2001
- 2001-02-21 HK HK01101230A patent/HK1030218A1/xx not_active IP Right Cessation
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