KR890017237A - 벤즈아마이드 프로테아제 억제제 - Google Patents

벤즈아마이드 프로테아제 억제제 Download PDF

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KR890017237A
KR890017237A KR1019890006888A KR890006888A KR890017237A KR 890017237 A KR890017237 A KR 890017237A KR 1019890006888 A KR1019890006888 A KR 1019890006888A KR 890006888 A KR890006888 A KR 890006888A KR 890017237 A KR890017237 A KR 890017237A
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compound
hydrogen
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quinol
thiadiazol
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프란츠 조세프 플리리 안톤
카우렌 슈너 로드니
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윌리암 데이비스 헌
화이자 인코포레이티드
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Abstract

내용 없음

Description

벤즈아마이드 프로테아제 억제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기 일반식의 화합물 또는 이의 약제학적 허용가능한 염.
    상기식에서, HET는 피리미드-2-일, 디메틸피리미드-4-일, 티아졸-2-일, 4-페닐티아졸-2-일, 4-페닐-5-카베톡시-티아졸-2-일, 4-비페닐릴티아졸-2-일, 피라진-2-일, 6-클로로피라진-2-일, 퀴놀-8-일, 6-메톡시퀴놀-8-일, 퀴놀-3-일, 1,3,4-티아디아졸-2-일, 3-페닐-1,2,4-티아디아졸-5-일, 5-트리플루오로메틸-1,3,4-티아디아졸-2-일, 5-메틸이소옥사졸-3-일, 5-클로로피리드-2-일, 4,5-디시아노이미다졸-2-일, 5-클로로벤즈옥사졸-2-일, 인다졸-5-일-2-카베톡시인돌-5-일 또는 하기 일반식의 벤즈이미다졸-2-일이며 R1은 수소 또는 (C1-C3)알킬이다.
    (상기식에서, X는 수소 또는 메틸이고, Y는 수소, 메틸, 벤조일, 니트로, 클로로, 플루오로, 브로모 또는 메톡시이고; R²는 수소, (C₁-C₃)알킬, 펜에틸, 펜아실, N-(C₁-C₃)알킬카바밀메틸, N,N-디(C₁-C₃)알킬-카바밀메틸, N-(C₁-C₃)알킬카바밀, (C₁-C₃)알콕시카보닐메틸 또는 N-(p-클로로벤질)카바밀메틸이며; n은 0 내지 2의 정수이다.)
  2. 제 1 항에 있어서, R¹이 수소이고 n이 0인 화합물.
  3. 제 2 항에 있어서, HET가 피라진-2-일인 화합물.
  4. 제 2 항에 있어서, HET가 피리미드-2-일인 화합물.
  5. 제 2 항에 있어서, HET가 1,3,4-티아디아졸-2-일인 화합물.
  6. 제 2 항에 있어서, HET가 퀴놀-8-일인 화합물.
  7. 제 2 항에 있어서, HET가 티아졸-2-일인 화합물.
  8. 제 2 항에 있어서, HET가 인다졸-5-일인 화합물.
  9. 제 2 항에 있어서, HET가 하기 일반식의 벤즈-이미다졸-2-일(X가 수소이다)인 화합물.
  10. 제 9 항에 있어서, Y 및R ²가 각각 수소인 화합물.
  11. 제 9 항에 있어서, Y 및 5-니트로이고 R²가 수소인 화합물.
  12. 제 9 항에 있어서, Y 및 5-클로로이고 R²가 수소인 화합물.
  13. 제 9 항에 있어서, Y가 수소이고 R²가 N,N-디에틸카바밀메틸인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890006888A 1988-05-24 1989-05-23 벤즈아마이드 프로테아제 억제제 KR910004207B1 (ko)

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DE68901746T2 (de) 1992-12-17
NO173867B (no) 1993-11-08
ZA893865B (en) 1991-01-30
FI892497A (fi) 1989-11-25
IL90336A (en) 1993-01-31
IE61151B1 (en) 1994-10-05
KR910004207B1 (ko) 1991-06-24
ES2032229T3 (es) 1993-01-16
AU602294B2 (en) 1990-10-04
NO892058D0 (no) 1989-05-23
DK249089D0 (da) 1989-05-23
DE68901746D1 (de) 1992-07-16
JPH0217177A (ja) 1990-01-22
DK249089A (da) 1989-11-27
NZ229235A (en) 1990-06-26
FI91254C (fi) 1994-06-10
PT90623A (pt) 1989-11-30
EP0343894A1 (en) 1989-11-29
FI91254B (fi) 1994-02-28
HUT49860A (en) 1989-11-28
HU201314B (en) 1990-10-28
GR3005072T3 (ko) 1993-05-24
US4874864A (en) 1989-10-17
MY104021A (en) 1993-10-30
EP0343894B1 (en) 1992-06-10
ATE77083T1 (de) 1992-06-15
AU3509789A (en) 1989-11-30
NO173867C (no) 1994-02-16
FI892497A0 (fi) 1989-05-23
JPH0667905B2 (ja) 1994-08-31
IE891668L (en) 1989-11-24
PT90623B (pt) 1994-10-31
NO892058L (no) 1989-11-27

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