WO1995002586A1 - Derive de 5-acetylthiazoline oxime - Google Patents

Derive de 5-acetylthiazoline oxime Download PDF

Info

Publication number
WO1995002586A1
WO1995002586A1 PCT/JP1994/001107 JP9401107W WO9502586A1 WO 1995002586 A1 WO1995002586 A1 WO 1995002586A1 JP 9401107 W JP9401107 W JP 9401107W WO 9502586 A1 WO9502586 A1 WO 9502586A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
carbon atoms
compound
formula
substituted
Prior art date
Application number
PCT/JP1994/001107
Other languages
English (en)
Japanese (ja)
Inventor
Masakazu Sato
Akira Manaka
Keiko Takahashi
Yutaka Kawashima
Katsuo Hatayama
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Priority to AU70842/94A priority Critical patent/AU7084294A/en
Publication of WO1995002586A1 publication Critical patent/WO1995002586A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention a pour but de fournir un composé excellent par l'antagonisme contre le récepteur de fibrinogènes et le facteur d'adhésion des cellules. Ce composé est constitué par un dérivé de 5-acéthylthiazoline oxime représenté par la formule générale (I) et l'un de ses sels, formule où R1 représente cyano, thiocarbamoyle, alkylthio-imidoyle ou un groupe représenté par la formule (II), où R?11 et R12¿ représentent, indépendamment l'un de l'autre, hydrogène, alkyle, cycloalkyle, phényle, phényle substitué, benzyle ou benzyle substitué, à condition que R?11 et R12¿ puissent être combinés l'un avec l'autre pour représenter un groupe hétérocyclique avec l'atome d'azote auquel ils sont fixés; R2 représente alkyle, alcényle ou aralkyle; et R3 représente hydrogène, alkyle ou 4-méthoxybenzyle.
PCT/JP1994/001107 1993-07-14 1994-07-07 Derive de 5-acetylthiazoline oxime WO1995002586A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70842/94A AU7084294A (en) 1993-07-14 1994-07-07 5-acetylthiazoline oxime derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP17385193 1993-07-14
JP5/173851 1993-07-14
JP5/278242 1993-11-08
JP27824293 1993-11-08

Publications (1)

Publication Number Publication Date
WO1995002586A1 true WO1995002586A1 (fr) 1995-01-26

Family

ID=26495666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1994/001107 WO1995002586A1 (fr) 1993-07-14 1994-07-07 Derive de 5-acetylthiazoline oxime

Country Status (2)

Country Link
AU (1) AU7084294A (fr)
WO (1) WO1995002586A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62226971A (ja) * 1986-03-13 1987-10-05 ドクトル　カ−ル　ト−メ−　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツンク 新規な置換チアゾ−ルおよびオキサゾ−ル化合物
JPH0217177A (ja) * 1988-05-24 1990-01-22 Pfizer Inc ベンズアミド系プロテアーゼ阻止剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62226971A (ja) * 1986-03-13 1987-10-05 ドクトル　カ−ル　ト−メ−　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツンク 新規な置換チアゾ−ルおよびオキサゾ−ル化合物
JPH0217177A (ja) * 1988-05-24 1990-01-22 Pfizer Inc ベンズアミド系プロテアーゼ阻止剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 75, 1970, Abstract No. 35865. *
J. PRAKT. CHEM., Vol. 313, No. 2, 1971, SUCIU D., "Preparation of Some Mannich Bases From 2-Amino- and -2-Allylmino-4-methyl-5-acetyl Thiazole", pages 193-204. *

Also Published As

Publication number Publication date
AU7084294A (en) 1995-02-13

Similar Documents

Publication Publication Date Title
RU2140918C1 (ru) Три-замещенные имидазолы, обладающие терапевтическими свойствами, способ получения, фармацевтическая композиция, способ лечения
JPH072851A (ja) ５員複素環化合物、それらの調製方法及びこれらの化合物を含む医薬組成物
US20080312220A1 (en) Oxadiazole Derivatives with Crth2 Receptor Activity
JPH08505862A (ja) アミノ酸誘導体、これらの化合物を含む医薬組成物及びそれらの調製方法
JP2002510328A (ja) ビトロネクチン受容体アンタゴニスト
WO2002088122A1 (fr) Composes heterocycliques
JPH0428698B2 (fr)
KR20070084506A (ko) 트롬보포이에틴 활성 조절 화합물 및 방법
WO2007062678A1 (fr) Derives d'acide phenoxyacetique comme ligands du recepteur crth2
JP2008503447A (ja) Ｃｒｔｈ２リガンドとしての置換チアゾール酢酸
CS207790B2 (en) Method of making the derivatives of the thiadiazole
SE465928B (sv) 1,2,4-triazolonfoereningar med antidepressiv aktivitet, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
EP0649843B1 (fr) Derive de thiazoline
JP2000063363A (ja) 新規なトリアゾール誘導体
JP4189867B2 (ja) 良性前立腺肥大症の治療で有用なアリール置換ピペラジン類
HUT75096A (en) Substituted 4-phenyl-thiazol derviatives, process for producing them and pharmaceutical compositions containing them
US5478945A (en) Thiazoline derivatives
WO1995002586A1 (fr) Derive de 5-acetylthiazoline oxime
US4914092A (en) Benzothiazepin-4-one derivatives, their preparation and their application in therapy
WO1997010214A1 (fr) Nouveaux derives d'acide phenylacetique et compositions medicinales les contenant
JP2001525398A (ja) 選択的β３アドレナリン作動性アゴニスト
JP3235319B2 (ja) チアゾリン誘導体
JP2962176B2 (ja) ２−［４−（置換アミジノ）ベンゾイルイミノ］チアゾリン誘導体
JP3750144B2 (ja) ３−アリールチアゾリン誘導体
JP3169413B2 (ja) イミダゾール誘導体

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA JP KR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA