AP957A - Novel stable liquid paracetamol compositions, and method for preparing same. - Google Patents
Novel stable liquid paracetamol compositions, and method for preparing same. Download PDFInfo
- Publication number
- AP957A AP957A APAP/P/1998/001223A AP9801223A AP957A AP 957 A AP957 A AP 957A AP 9801223 A AP9801223 A AP 9801223A AP 957 A AP957 A AP 957A
- Authority
- AP
- ARIPO
- Prior art keywords
- paracetamol
- stable
- liquid formulations
- formulations according
- solution
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims abstract description 131
- 229960005489 paracetamol Drugs 0.000 title claims abstract description 129
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 239000007788 liquid Substances 0.000 title description 5
- 238000000034 method Methods 0.000 title description 5
- 150000003254 radicals Chemical class 0.000 claims abstract description 10
- 239000003125 aqueous solvent Substances 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 4
- 239000011261 inert gas Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 239000012669 liquid formulation Substances 0.000 claims description 27
- -1 alkali metal ascorbates Chemical class 0.000 claims description 23
- 239000002516 radical scavenger Substances 0.000 claims description 23
- 229940123457 Free radical scavenger Drugs 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 17
- 230000005587 bubbling Effects 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 16
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 16
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 14
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 11
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 11
- 235000003969 glutathione Nutrition 0.000 claims description 11
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- 238000002360 preparation method Methods 0.000 claims description 11
- 150000003573 thiols Chemical group 0.000 claims description 11
- 230000000202 analgesic effect Effects 0.000 claims description 10
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 8
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- 229930195725 Mannitol Natural products 0.000 claims description 8
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
- 239000005557 antagonist Substances 0.000 claims description 6
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 229960005181 morphine Drugs 0.000 claims description 6
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 5
- 239000008139 complexing agent Substances 0.000 claims description 5
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- 229960004126 codeine Drugs 0.000 claims description 4
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- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
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- ZNEWHQLOPFWXOF-UHFFFAOYSA-N coenzyme M Chemical compound OS(=O)(=O)CCS ZNEWHQLOPFWXOF-UHFFFAOYSA-N 0.000 claims description 3
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- 229960004635 mesna Drugs 0.000 claims description 3
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 3
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- 239000012736 aqueous medium Substances 0.000 claims description 2
- 239000003246 corticosteroid Substances 0.000 claims description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 2
- 229960000367 inositol Drugs 0.000 claims description 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical group OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 2
- 229960000991 ketoprofen Drugs 0.000 claims description 2
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960003424 phenylacetic acid Drugs 0.000 claims description 2
- 239000003279 phenylacetic acid Substances 0.000 claims description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 claims description 2
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- PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical compound CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-MVHIGOERSA-N D-ascorbic acid Chemical compound OC[C@@H](O)[C@@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-MVHIGOERSA-N 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 229940125683 antiemetic agent Drugs 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 239000000872 buffer Substances 0.000 abstract description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract description 6
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- 208000002193 Pain Diseases 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 239000000730 antalgic agent Substances 0.000 abstract 1
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 48
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9609858A FR2751875B1 (fr) | 1996-08-05 | 1996-08-05 | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9801223A0 AP9801223A0 (en) | 1998-06-30 |
| AP957A true AP957A (en) | 2001-04-12 |
Family
ID=9494820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1998/001223A AP957A (en) | 1996-08-05 | 1997-08-05 | Novel stable liquid paracetamol compositions, and method for preparing same. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6028222A (de) |
| EP (1) | EP0858329B1 (de) |
| JP (2) | JP5060681B2 (de) |
| KR (1) | KR100521235B1 (de) |
| CN (1) | CN1133426C (de) |
| AP (1) | AP957A (de) |
| AT (1) | ATE241972T1 (de) |
| AU (1) | AU742576B2 (de) |
| BR (1) | BR9702362A (de) |
| CA (1) | CA2233924C (de) |
| CZ (1) | CZ298427B6 (de) |
| DE (1) | DE69722580T2 (de) |
| DK (1) | DK0858329T3 (de) |
| ES (1) | ES2201316T3 (de) |
| FR (1) | FR2751875B1 (de) |
| HU (1) | HU226117B1 (de) |
| MX (1) | MX9802734A (de) |
| NZ (1) | NZ330136A (de) |
| OA (1) | OA10678A (de) |
| PL (1) | PL193104B1 (de) |
| PT (1) | PT858329E (de) |
| RU (1) | RU2192249C2 (de) |
| WO (1) | WO1998005314A1 (de) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6160020A (en) * | 1996-12-20 | 2000-12-12 | Mcneill-Ppc, Inc. | Alkali metal and alkaline-earth metal salts of acetaminophen |
| US8524277B2 (en) | 1998-03-06 | 2013-09-03 | Alza Corporation | Extended release dosage form |
| US6245357B1 (en) * | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
| FR2779061B1 (fr) * | 1998-04-14 | 2004-08-20 | Pharmatop | Nouveau procede de stabilisation de composes phenoliques et les compositions pharmaceutiques en resultant |
| IT1301976B1 (it) | 1998-07-31 | 2000-07-20 | Angelini Ricerche Spa | Composizione farmaceutica iniettabile a base di paracetamolo |
| PT1352837E (pt) * | 1999-05-28 | 2006-06-30 | Novartis Ag | Processo para fabricacao de uma embalagem compressivel esterilizada para um produto farmaceutico |
| DE19932157A1 (de) * | 1999-07-13 | 2001-01-18 | Pharmasol Gmbh | Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln |
| US6334859B1 (en) | 1999-07-26 | 2002-01-01 | Zuli Holdings Ltd. | Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments |
| IT1313579B1 (it) * | 1999-07-30 | 2002-09-09 | Acraf | Composizione farmaceutica liquida a base di paracetamolo. |
| GB0006897D0 (en) * | 2000-03-23 | 2000-05-10 | Smithkline Beecham Plc | Medicaments |
| FR2809619B1 (fr) * | 2000-06-06 | 2004-09-24 | Pharmatop | Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention |
| AU2006203741B2 (en) * | 2000-06-06 | 2009-11-05 | Scr Pharmatop | Method for obtaining aqueous formulations with active principles susceptible to oxidation and the aqueous solutions thus obtained |
| DE10112325A1 (de) * | 2001-03-13 | 2002-10-02 | Fresenius Kabi De Gmbh | Lagerstabile Fertiginfusionslösungen des Paracetamols |
| ITMI20012135A1 (it) * | 2001-10-16 | 2003-04-16 | Bioren S A | Soluzioni iniettabili pronte all'uso di paracetamolo |
| EE200400094A (et) * | 2001-12-18 | 2004-08-16 | Uni-Pharma Kleon Tsetis Pharmaceutical Laboratoires S.A. | Paratsetamooli parenteraalne kompositsioon |
| FR2851164B1 (fr) | 2003-02-14 | 2005-04-22 | Xuan Tho Nguyen | Formulation liquide injectable de paracetamol |
| BG65674B1 (bg) * | 2003-07-10 | 2009-06-30 | Нихфи Ад | Течна форма на комбинирано лекарствено средство за лечение на простудни и грипни заболявания |
| DK1574221T3 (da) * | 2004-03-10 | 2007-07-16 | Shimoda Biotech Pty Ltd | Stabile, injicérbare diclofenacsammensætninger |
| RU2286770C2 (ru) * | 2004-11-22 | 2006-11-10 | Закрытое акционерное общество "Научно-производственное объединение "Антивирал" (ЗАО "НПО "Антивирал") | Антигриппозное средство |
| US20060205752A1 (en) * | 2005-03-14 | 2006-09-14 | Keith Whitehead | Stabilized hydrocodone pharmaceutical compositions with ethylenediaminetetraacetic acid |
| DE102005037653A1 (de) * | 2005-08-05 | 2007-02-15 | Theraselect Gmbh | Stabile, flüssige Formulierung von Paracetamol |
| US20070098790A1 (en) * | 2005-10-31 | 2007-05-03 | David Jiang | Nutritional supplement for the enhancement of the health of the liver |
| FR2894154B1 (fr) * | 2005-12-06 | 2008-03-14 | Pharmatop Scr | Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation. |
| US8580954B2 (en) * | 2006-03-28 | 2013-11-12 | Hospira, Inc. | Formulations of low dose diclofenac and beta-cyclodextrin |
| US10022339B2 (en) | 2006-04-21 | 2018-07-17 | The Procter & Gamble Company | Compositions and methods useful for treatment of respiratory illness |
| US20070249727A1 (en) | 2006-04-21 | 2007-10-25 | The Proctor & Gamble Company | Compositions and kits useful for treatment of respiratory illness |
| JP4929352B2 (ja) | 2006-07-18 | 2012-05-09 | スペイン ファルマ ソシエダ アノニマ | 注入可能なパラセタモール液剤 |
| EP1992334A1 (de) * | 2007-05-08 | 2008-11-19 | Docpharma NV/SA | Lagerfähige Formulierung eines oxidationsempfindlichen phenolhaltigen Arzneimittels, insbesondere Paracetamol, mit einer wässrigen, durch ein temperaturgeregeltes Herstellungsverfahren desoxidierten Arzneimittellösung |
| AR067047A1 (es) * | 2007-06-18 | 2009-09-30 | Combino Pharm Sl | Formulaciones acuosas de acetaminofen para inyeccion. |
| WO2009047634A2 (en) * | 2007-06-18 | 2009-04-16 | Combino Pharm, S.L. | Aqueous formulations of acetaminophen for injection |
| CA2705733C (en) * | 2007-11-13 | 2015-02-03 | Cadence Pharmaceuticals | Reduced dose intravenous acetaminophen |
| EP2307056B1 (de) * | 2008-01-17 | 2021-12-15 | Pharmis Biofarmacêutica, LDA | Stabilisierte wässrige formulierung mit paracetamol |
| FR2926992B1 (fr) * | 2008-02-06 | 2011-01-14 | Moly Pharma | Formulation d'une solution de paracetamol injectable,procede de preparation et de conditionnement d'une telle solution et dispositif de conditionnement d'une telle solution |
| WO2009157010A1 (en) * | 2008-06-25 | 2009-12-30 | Akums Drugs And Pharmaceuticals Limited | An intravenous drug delivery system |
| WO2009157009A1 (en) * | 2008-06-25 | 2009-12-30 | Akums Drugs And Pharmaceuticals Limited | An intravenous drug delivery system |
| EP2243477A1 (de) | 2009-04-22 | 2010-10-27 | Fresenius Kabi Deutschland GmbH | Paracetamol zur parenteralen Verabreichung |
| EP2453743B1 (de) * | 2009-07-15 | 2017-04-12 | The Board of Trustees of The Leland Stanford Junior University | N-acetyl-cysteinzusammensetzungen und ihre verwendung zur verbesserung der therapeutischen wirkung von acetaminophen |
| PT2277546E (pt) | 2009-07-23 | 2015-09-25 | Uni Pharma Kleon Tsetis Pharmaceutical Lab S A | Formulação de paracetamol injectável estável pronta a utilizar |
| US8404748B2 (en) * | 2009-08-13 | 2013-03-26 | Neogen N.V. | Storage-stable formulation of paracetamol in aqueous solution |
| EP2464332B2 (de) | 2009-08-13 | 2025-10-15 | Neogen N.V. | Verfahren zur herstellung einer lagerstabilen formulierung von paracetamol in wässriger lösung |
| FR2950533B1 (fr) * | 2009-09-28 | 2012-01-13 | Maco Pharma Sa | Formulation liquide, stable, prete a l'emploi de ketoprofene |
| EP2308463A1 (de) * | 2009-10-12 | 2011-04-13 | EMP Pharma GmbH | Wässrige Acetaminophenzusammensetzungen und Herstellungsverfahren |
| US20120245230A1 (en) | 2009-12-10 | 2012-09-27 | Tecnimede-Sociedade Tecnico- Medicinal, S.A. | Method and composition for preparing stable liquid formulations of paracetamol |
| RU2446799C2 (ru) * | 2010-01-22 | 2012-04-10 | Анатолий Брониславович Гаврилов | Антиоксидантная композиция |
| US20110207824A1 (en) * | 2010-02-25 | 2011-08-25 | Moly Pharma | Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution |
| PT2377516E (pt) | 2010-04-14 | 2012-07-02 | Braun Melsungen Ag | Composição acetaminofeno |
| GR1007315B (el) * | 2010-04-19 | 2011-06-14 | Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, | Υγρομορφη παρεντερικης χορηγησης συνθεση που περιλαμβανει τραμαδολη hci και παρακεταμολη |
| PL2389923T3 (pl) | 2010-05-19 | 2013-06-28 | Uni Pharma Kleon Tsetis Pharmaceutical Laboratories S A | Trwały, gotowy do użycia iniekcyjny preparat paracetamolu |
| EP2389931A1 (de) | 2010-05-21 | 2011-11-30 | Raw Materials Internatinal LLC | Wässrige pharmazeutische Zusammensetzungen mit Liponsäure als Antioxidationsmittel |
| US9616128B2 (en) * | 2010-06-30 | 2017-04-11 | Troikaa Pharmaceuticals Ltd | Pharmaceutical compositions comprising paracetamol and process for preparing the same |
| EP2649993B1 (de) * | 2010-12-09 | 2017-04-05 | Maruishi Pharmaceutical Co., Ltd. | Stabilisator für acetaminophen |
| CN102600068A (zh) * | 2011-01-24 | 2012-07-25 | 联康药业克雷恩特塞提斯制药实验室有限责任公司 | 稳定即用的可注射扑热息痛制剂 |
| AU2011200289B2 (en) * | 2011-01-24 | 2016-10-13 | Ioulia Tseti | Stable ready to use injectable paracetamol formulation |
| US9089477B2 (en) | 2011-02-10 | 2015-07-28 | Neogen N.V. | Storage-stable formulation of paracetamol in aqueous solution |
| ES2414557B1 (es) | 2012-01-16 | 2014-06-10 | Novocat Farma, S.A. | Composición acuosa de paracetamol para inyección |
| ITMI20121154A1 (it) | 2012-06-29 | 2013-12-30 | Sint Sa | Soluzione iniettabile di acetaminofene per la somministrazione spinale |
| US8568747B1 (en) | 2012-10-05 | 2013-10-29 | Silvergate Pharmaceuticals, Inc. | Enalapril compositions |
| ZA201300398B (en) | 2012-11-27 | 2013-09-25 | Genfarma Laboratories S L | Injectable liquid formulation of the combination of tramadol and paracetamol |
| PL3639828T3 (pl) | 2013-12-24 | 2022-05-02 | Virginia Commonwealth University | Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby |
| BR102014005885B1 (pt) | 2014-03-13 | 2021-04-13 | Biotec Biológica Indústria Farmacêutica Ltda E.P.P | Formulação farmacêutica líquida injetável estável de paracetamol em bolsa plástica pronta para uso |
| EP3171868B1 (de) | 2014-07-25 | 2020-09-30 | Terumo Kabushiki Kaisha | Komprimiertes acetaminopheninjektionslösungspräparat |
| TN2017000232A1 (en) * | 2014-12-20 | 2018-10-19 | Troikaa Pharmaceuticals Ltd | Injectable formulations of paracetamol |
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| US9669008B1 (en) | 2016-03-18 | 2017-06-06 | Silvergate Pharmaceuticals, Inc. | Enalapril formulations |
| KR20240005122A (ko) | 2016-09-16 | 2024-01-11 | 사이덱스 파마슈티칼스, 인크. | 아세트아미노펜 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 |
| CN109996533A (zh) * | 2016-09-23 | 2019-07-09 | 格吕伦塔尔有限公司 | 用于肠胃外施用他喷他多的稳定制剂 |
| US11040007B2 (en) * | 2017-01-24 | 2021-06-22 | Woosung Pharmaceutical Co., Ltd. | Injection composition containing acetaminophen |
| US20250177328A1 (en) | 2017-01-30 | 2025-06-05 | Nevakar Injectables Inc. | Norepinephrine compositions and methods therefor |
| CA3051467C (en) | 2017-01-30 | 2022-11-29 | Nevakar, Inc | Norepinephrine compositions and methods therefor |
| WO2018192664A1 (en) * | 2017-04-20 | 2018-10-25 | Hyloris Developments Sa | METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF |
| RU2737852C2 (ru) * | 2017-12-28 | 2020-12-03 | Беккер Герман Петрович | Способ получения лекарственного средства на основе олигопептида аллоферона-1, имеющего противовирусную и иммуномодулирующую направленность, и лекарственное средство увеличенного срока хранения, полученное с его помощью |
| CN115385818B (zh) * | 2022-09-01 | 2023-09-29 | 江苏海洋大学 | 一种扑热息痛杂质及制备方法 |
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| US4314989A (en) * | 1980-05-07 | 1982-02-09 | Rosen Gerald M | Methionine sulfoxide amflioration of acetaminophen toxicity |
| US5474757A (en) * | 1992-10-16 | 1995-12-12 | Rutgers University | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
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| RO82841A2 (ro) * | 1981-08-04 | 1983-11-01 | Intreprinderea De Medicamente "Biofarm",Ro | Suspensie cu paracetamol |
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1996
- 1996-08-05 FR FR9609858A patent/FR2751875B1/fr not_active Expired - Fee Related
-
1997
- 1997-08-05 ES ES97936739T patent/ES2201316T3/es not_active Expired - Lifetime
- 1997-08-05 JP JP50768698A patent/JP5060681B2/ja not_active Expired - Lifetime
- 1997-08-05 EP EP97936739A patent/EP0858329B1/de not_active Expired - Lifetime
- 1997-08-05 DK DK97936739T patent/DK0858329T3/da active
- 1997-08-05 BR BR9702362-0A patent/BR9702362A/pt not_active IP Right Cessation
- 1997-08-05 PT PT97936739T patent/PT858329E/pt unknown
- 1997-08-05 KR KR1019980702453A patent/KR100521235B1/ko not_active Expired - Lifetime
- 1997-08-05 AT AT97936739T patent/ATE241972T1/de active
- 1997-08-05 RU RU98108032/14A patent/RU2192249C2/ru active
- 1997-08-05 AP APAP/P/1998/001223A patent/AP957A/en active
- 1997-08-05 PL PL326069A patent/PL193104B1/pl unknown
- 1997-08-05 WO PCT/FR1997/001452 patent/WO1998005314A1/fr not_active Ceased
- 1997-08-05 DE DE69722580T patent/DE69722580T2/de not_active Expired - Lifetime
- 1997-08-05 AU AU39451/97A patent/AU742576B2/en not_active Expired
- 1997-08-05 CN CNB971913714A patent/CN1133426C/zh not_active Expired - Lifetime
- 1997-08-05 US US09/051,246 patent/US6028222A/en not_active Expired - Lifetime
- 1997-08-05 NZ NZ330136A patent/NZ330136A/xx not_active IP Right Cessation
- 1997-08-05 CZ CZ0104898A patent/CZ298427B6/cs not_active IP Right Cessation
- 1997-08-05 CA CA2233924A patent/CA2233924C/fr not_active Expired - Lifetime
- 1997-08-05 HU HU9901893A patent/HU226117B1/hu unknown
-
1998
- 1998-04-03 OA OA9800039A patent/OA10678A/fr unknown
- 1998-04-03 MX MX9802734A patent/MX9802734A/es unknown
-
2010
- 2010-04-28 JP JP2010104213A patent/JP5122604B2/ja not_active Expired - Lifetime
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| US4314989A (en) * | 1980-05-07 | 1982-02-09 | Rosen Gerald M | Methionine sulfoxide amflioration of acetaminophen toxicity |
| US5474757A (en) * | 1992-10-16 | 1995-12-12 | Rutgers University | Prevention of acetaminophen overdose toxicity with organosulfur compounds |
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