DE69722580D1 - Neue stabile flüssige paracetamolmittel und verfahren zu deren herstellung - Google Patents

Neue stabile flüssige paracetamolmittel und verfahren zu deren herstellung

Info

Publication number
DE69722580D1
DE69722580D1 DE69722580T DE69722580T DE69722580D1 DE 69722580 D1 DE69722580 D1 DE 69722580D1 DE 69722580 T DE69722580 T DE 69722580T DE 69722580 T DE69722580 T DE 69722580T DE 69722580 D1 DE69722580 D1 DE 69722580D1
Authority
DE
Germany
Prior art keywords
agents
production
stable liquid
new stable
liquid paracetamol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722580T
Other languages
English (en)
Other versions
DE69722580T2 (de
Inventor
Francois Dietlin
Daniele Fredj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCR PHARMATOP VERSAILLES
Original Assignee
SCR PHARMATOP VERSAILLES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9494820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69722580(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SCR PHARMATOP VERSAILLES filed Critical SCR PHARMATOP VERSAILLES
Publication of DE69722580D1 publication Critical patent/DE69722580D1/de
Application granted granted Critical
Publication of DE69722580T2 publication Critical patent/DE69722580T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69722580T 1996-08-05 1997-08-05 Neue stabile flüssige paracetamolmittel und verfahren zu deren herstellung Expired - Lifetime DE69722580T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9609858 1996-08-05
FR9609858A FR2751875B1 (fr) 1996-08-05 1996-08-05 Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
PCT/FR1997/001452 WO1998005314A1 (fr) 1996-08-05 1997-08-05 Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation

Publications (2)

Publication Number Publication Date
DE69722580D1 true DE69722580D1 (de) 2003-07-10
DE69722580T2 DE69722580T2 (de) 2004-04-29

Family

ID=9494820

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722580T Expired - Lifetime DE69722580T2 (de) 1996-08-05 1997-08-05 Neue stabile flüssige paracetamolmittel und verfahren zu deren herstellung

Country Status (23)

Country Link
US (1) US6028222A (de)
EP (1) EP0858329B1 (de)
JP (2) JP5060681B2 (de)
KR (1) KR100521235B1 (de)
CN (1) CN1133426C (de)
AP (1) AP957A (de)
AT (1) ATE241972T1 (de)
AU (1) AU742576B2 (de)
BR (1) BR9702362A (de)
CA (1) CA2233924C (de)
CZ (1) CZ298427B6 (de)
DE (1) DE69722580T2 (de)
DK (1) DK0858329T3 (de)
ES (1) ES2201316T3 (de)
FR (1) FR2751875B1 (de)
HU (1) HU226117B1 (de)
MX (1) MX9802734A (de)
NZ (1) NZ330136A (de)
OA (1) OA10678A (de)
PL (1) PL193104B1 (de)
PT (1) PT858329E (de)
RU (1) RU2192249C2 (de)
WO (1) WO1998005314A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160020A (en) * 1996-12-20 2000-12-12 Mcneill-Ppc, Inc. Alkali metal and alkaline-earth metal salts of acetaminophen
US8524277B2 (en) 1998-03-06 2013-09-03 Alza Corporation Extended release dosage form
US6245357B1 (en) * 1998-03-06 2001-06-12 Alza Corporation Extended release dosage form
FR2779061B1 (fr) * 1998-04-14 2004-08-20 Pharmatop Nouveau procede de stabilisation de composes phenoliques et les compositions pharmaceutiques en resultant
IT1301976B1 (it) * 1998-07-31 2000-07-20 Angelini Ricerche Spa Composizione farmaceutica iniettabile a base di paracetamolo
AU759894B2 (en) * 1999-05-28 2003-05-01 Novartis Ag Package for a pharmaceutical product and method of sterilising the package
DE19932157A1 (de) * 1999-07-13 2001-01-18 Pharmasol Gmbh Verfahren zur schonenden Herstellung von hochfeinen Mikropartikeln und Nanopartikeln
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
IT1313579B1 (it) * 1999-07-30 2002-09-09 Acraf Composizione farmaceutica liquida a base di paracetamolo.
GB0006897D0 (en) * 2000-03-23 2000-05-10 Smithkline Beecham Plc Medicaments
AU2006203741B2 (en) * 2000-06-06 2009-11-05 Scr Pharmatop Method for obtaining aqueous formulations with active principles susceptible to oxidation and the aqueous solutions thus obtained
FR2809619B1 (fr) * 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
DE10112325A1 (de) * 2001-03-13 2002-10-02 Fresenius Kabi De Gmbh Lagerstabile Fertiginfusionslösungen des Paracetamols
ITMI20012135A1 (it) * 2001-10-16 2003-04-16 Bioren S A Soluzioni iniettabili pronte all'uso di paracetamolo
HUP0402549A3 (en) * 2001-12-18 2006-01-30 Tseti Ioulia Parenteral composition of paracetamol
FR2851164B1 (fr) * 2003-02-14 2005-04-22 Xuan Tho Nguyen Formulation liquide injectable de paracetamol
BG65674B1 (bg) * 2003-07-10 2009-06-30 Нихфи Ад Течна форма на комбинирано лекарствено средство за лечение на простудни и грипни заболявания
DK1767219T3 (da) * 2004-03-10 2010-05-10 Shimoda Biotech Pty Ltd Stabile injicerbare diclofenac-sammensætninger
US20060205752A1 (en) * 2005-03-14 2006-09-14 Keith Whitehead Stabilized hydrocodone pharmaceutical compositions with ethylenediaminetetraacetic acid
DE102005037653A1 (de) * 2005-08-05 2007-02-15 Theraselect Gmbh Stabile, flüssige Formulierung von Paracetamol
US20070098790A1 (en) * 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
FR2894154B1 (fr) * 2005-12-06 2008-03-14 Pharmatop Scr Nouveau procede de stabilisation de substances minerales ou organiques sensibles a l'oxydation.
AU2007230716B2 (en) * 2006-03-28 2012-05-03 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US10022339B2 (en) 2006-04-21 2018-07-17 The Procter & Gamble Company Compositions and methods useful for treatment of respiratory illness
US20070249727A1 (en) 2006-04-21 2007-10-25 The Proctor & Gamble Company Compositions and kits useful for treatment of respiratory illness
CA2628806C (en) * 2006-07-18 2012-08-21 Genfarma Laboratorio S.L. Injectable liquid paracetamol formulation
EP1992334A1 (de) * 2007-05-08 2008-11-19 Docpharma NV/SA Lagerfähige Formulierung eines oxidationsempfindlichen phenolhaltigen Arzneimittels, insbesondere Paracetamol, mit einer wässrigen, durch ein temperaturgeregeltes Herstellungsverfahren desoxidierten Arzneimittellösung
EP2170313A2 (de) * 2007-06-18 2010-04-07 Combino Pharm, S.L. Wässrige formulierungen aus acetaminophen zur injektion
WO2009081283A2 (en) * 2007-06-18 2009-07-02 Combino Pharm, S.L. Aqueous formulations of acetaminophen for injection
WO2009064928A1 (en) * 2007-11-13 2009-05-22 Cadence Pharmaceuticals Reduced dose intravenous acetaminophen
WO2009098716A2 (en) * 2008-01-17 2009-08-13 Aptuit Laurus Private Limited Stable pharmaceutical aqueous compositions
FR2926992B1 (fr) * 2008-02-06 2011-01-14 Moly Pharma Formulation d'une solution de paracetamol injectable,procede de preparation et de conditionnement d'une telle solution et dispositif de conditionnement d'une telle solution
WO2009157010A1 (en) * 2008-06-25 2009-12-30 Akums Drugs And Pharmaceuticals Limited An intravenous drug delivery system
WO2009157009A1 (en) * 2008-06-25 2009-12-30 Akums Drugs And Pharmaceuticals Limited An intravenous drug delivery system
EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
JP2012533559A (ja) * 2009-07-15 2012-12-27 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アセトアミノフェンの治療効果を改善するためのｎ−アセチルシステイン組成物および方法
SI2277546T1 (sl) * 2009-07-23 2015-09-30 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Stabilen pripravljen za uporabo injekcijski sestavek paracetamola
EP2464332B1 (de) 2009-08-13 2016-03-02 Neogen N.V. Lagerstabile formulierung von paracetamol in einer wässrigen lösung
US8404748B2 (en) * 2009-08-13 2013-03-26 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
FR2950533B1 (fr) * 2009-09-28 2012-01-13 Maco Pharma Sa Formulation liquide, stable, prete a l'emploi de ketoprofene
EP2308463A1 (de) * 2009-10-12 2011-04-13 EMP Pharma GmbH Wässrige Acetaminophenzusammensetzungen und Herstellungsverfahren
WO2011071400A1 (en) 2009-12-10 2011-06-16 Tecnimede - Sociedade Técnico-Medicinal, S.A. Method and composition for preparing stable liquid formulations of paracetamol
RU2446799C2 (ru) * 2010-01-22 2012-04-10 Анатолий Брониславович Гаврилов Антиоксидантная композиция
US20110207824A1 (en) * 2010-02-25 2011-08-25 Moly Pharma Formulation of an injectable paracetamol solution, method for preparing and packaging such a solution and device for packaging such a solution
ES2389760T3 (es) * 2010-04-14 2012-10-31 B. Braun Melsungen Ag Composición de acetaminofeno
GR1007315B (el) * 2010-04-19 2011-06-14 Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε Με Δ.Τ. Uni-Pharma Abee, Υγρομορφη παρεντερικης χορηγησης συνθεση που περιλαμβανει τραμαδολη hci και παρακεταμολη
PL2389923T3 (pl) 2010-05-19 2013-06-28 Uni Pharma Kleon Tsetis Pharmaceutical Laboratories S A Trwały, gotowy do użycia iniekcyjny preparat paracetamolu
EP2389931A1 (de) 2010-05-21 2011-11-30 Raw Materials Internatinal LLC Wässrige pharmazeutische Zusammensetzungen mit Liponsäure als Antioxidationsmittel
BR112012031928B1 (pt) * 2010-06-30 2021-08-31 Troikaa Pharmaceuticals Ltd Composições farmacêuticas as quais incluem paracetamol e processo para preparação do mesmo
WO2012077696A1 (ja) 2010-12-09 2012-06-14 丸石製薬株式会社 アセトアミノフェンの安定化剤
AU2011200289B2 (en) * 2011-01-24 2016-10-13 Ioulia Tseti Stable ready to use injectable paracetamol formulation
CN102600068A (zh) * 2011-01-24 2012-07-25 联康药业克雷恩特塞提斯制药实验室有限责任公司 稳定即用的可注射扑热息痛制剂
AU2011359032A1 (en) 2011-02-10 2013-08-29 Neogen N.V. Storage-stable formulation of paracetamol in aqueous solution
ES2414557B1 (es) 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
ITMI20121154A1 (it) 2012-06-29 2013-12-30 Sint Sa Soluzione iniettabile di acetaminofene per la somministrazione spinale
US8568747B1 (en) 2012-10-05 2013-10-29 Silvergate Pharmaceuticals, Inc. Enalapril compositions
ZA201300398B (en) 2012-11-27 2013-09-25 Genfarma Laboratories S L Injectable liquid formulation of the combination of tramadol and paracetamol
MX2016008459A (es) 2013-12-24 2016-10-14 Univ Virginia Commonwealth Usos de sulfatos de colesterol oxigenados (soc).
BR102014005885B1 (pt) 2014-03-13 2021-04-13 Biotec Biológica Indústria Farmacêutica Ltda E.P.P Formulação farmacêutica líquida injetável estável de paracetamol em bolsa plástica pronta para uso
EP3171868B1 (de) 2014-07-25 2020-09-30 Terumo Kabushiki Kaisha Komprimiertes acetaminopheninjektionslösungspräparat
PE20171305A1 (es) 2014-12-20 2017-09-05 Troikaa Pharmaceuticals Ltd Formulaciones inyectables de paracetamol
US9463183B1 (en) 2015-10-30 2016-10-11 Silvergate Pharmaceuticals, Inc. Lisinopril formulations
HUE053952T4 (hu) * 2016-02-05 2021-09-28 Innopharma Inc Eljárás oxidációra érzékeny készítményhez stabil, alkalmazásra kész infúziós tasak elõállítására
US9669008B1 (en) 2016-03-18 2017-06-06 Silvergate Pharmaceuticals, Inc. Enalapril formulations
KR20190057349A (ko) * 2016-09-23 2019-05-28 그뤼넨탈 게엠베하 타펜타돌의 비경구 투여용 안정한 제제
WO2018139842A1 (ko) * 2017-01-24 2018-08-02 주식회사 우성제약 아세트아미노펜을 함유하는 주사제 조성물
WO2018140894A1 (en) 2017-01-30 2018-08-02 Nevakar, Inc Norepinephrine compositions and methods therefor
WO2018192664A1 (en) 2017-04-20 2018-10-25 Hyloris Developments Sa METHOD FOR PREPARING A COMPOSITION WITH A LOW DISSOLVED OXYGEN CONTENT, COMPRISING ACETAMINOPHEN, AND OPTIONALLY ONE OR MORE NSAIDs, AND A COMPOSITION OBTAINED THEREOF
RU2737852C2 (ru) * 2017-12-28 2020-12-03 Беккер Герман Петрович Способ получения лекарственного средства на основе олигопептида аллоферона-1, имеющего противовирусную и иммуномодулирующую направленность, и лекарственное средство увеличенного срока хранения, полученное с его помощью
CN115385818B (zh) * 2022-09-01 2023-09-29 江苏海洋大学 一种扑热息痛杂质及制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314989A (en) * 1980-05-07 1982-02-09 Rosen Gerald M Methionine sulfoxide amflioration of acetaminophen toxicity
RO82841A2 (ro) * 1981-08-04 1983-11-01 Intreprinderea De Medicamente "Biofarm",Ro Suspensie cu paracetamol
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
FR2646773B1 (fr) * 1989-05-12 1994-05-13 Chauvin Sa Laboratoire Composition pharmaceutique a base de paracetamol
JPH0714872B2 (ja) * 1990-02-06 1995-02-22 昭和薬品化工株式会社 シロップ剤組成物
JPH0672897A (ja) * 1991-03-27 1994-03-15 Cullim & Assoc Inc 月経前の及び月経の不快な諸症状を軽減するための組成物
US5252313A (en) * 1991-12-20 1993-10-12 Colgate-Palmolive Company Visually clear gel dentifrice
US5272137A (en) * 1992-02-14 1993-12-21 Mcneil-Pfc, Inc. Aqueous pharmaceutical suspension for pharmaceutical actives
US5474757A (en) * 1992-10-16 1995-12-12 Rutgers University Prevention of acetaminophen overdose toxicity with organosulfur compounds
EP0620001A1 (de) * 1993-04-16 1994-10-19 McNEIL-PPC, INC. Wässrige pharmazeutische Suspension und Verfahren zu ihrer Herstellung
DE4327462A1 (de) * 1993-08-16 1995-02-23 Carl Heinrich Dr Weischer Neue N-Acetyl-p-Aminophenol-Derivate zur Bekämpfung von Schmerzzuständen
JPH07206689A (ja) * 1994-01-21 1995-08-08 Barnett Lab Ltd 治療組成物および宿酔の治療のためのこの組成物の使用法
WO1995019759A1 (en) * 1994-01-24 1995-07-27 The Procter & Gamble Company Process for solubilizing difficultly soluble pharmaceutical actives
US5510389A (en) * 1994-03-02 1996-04-23 The Procter & Gamble Company Concentrated acetaminophen solution compositions
JPH09286724A (ja) * 1996-04-19 1997-11-04 Takeda Chem Ind Ltd 経口用安定液剤

Also Published As

Publication number Publication date
HUP9901893A2 (hu) 1999-09-28
WO1998005314A1 (fr) 1998-02-12
RU2192249C2 (ru) 2002-11-10
PL326069A1 (en) 1998-08-17
JP5060681B2 (ja) 2012-10-31
FR2751875A1 (fr) 1998-02-06
US6028222A (en) 2000-02-22
KR100521235B1 (ko) 2006-01-27
DE69722580T2 (de) 2004-04-29
JPH11514013A (ja) 1999-11-30
HU226117B1 (en) 2008-04-28
NZ330136A (en) 2000-03-27
CZ104898A3 (cs) 1998-09-16
CN1133426C (zh) 2004-01-07
AP9801223A0 (en) 1998-06-30
CN1204960A (zh) 1999-01-13
KR19990063978A (ko) 1999-07-26
JP2010163462A (ja) 2010-07-29
FR2751875B1 (fr) 1998-12-24
PT858329E (pt) 2003-09-30
EP0858329A1 (de) 1998-08-19
PL193104B1 (pl) 2007-01-31
ES2201316T3 (es) 2004-03-16
CA2233924A1 (fr) 1998-02-12
CZ298427B6 (cs) 2007-10-03
JP5122604B2 (ja) 2013-01-16
HUP9901893A3 (en) 2000-06-28
CA2233924C (fr) 2012-08-21
ATE241972T1 (de) 2003-06-15
MX9802734A (es) 1998-11-30
EP0858329B1 (de) 2003-06-04
AU3945197A (en) 1998-02-25
AP957A (en) 2001-04-12
BR9702362A (pt) 1999-12-28
AU742576B2 (en) 2002-01-10
OA10678A (fr) 2002-11-20
DK0858329T3 (da) 2003-09-29

Similar Documents

Publication Publication Date Title
ATE241972T1 (de) Neue stabile flüssige paracetamolmittel und verfahren zu deren herstellung
DE69736009D1 (de) Poröse strukturen und verfahren zu deren herstellung
DE69504892D1 (de) Mischelement und Verfahren zu dessen Herstellung
DE69720523D1 (de) Polyolefin-polyethylenoxid-mischungen und verfahren zu deren herstellung
DE59807086D1 (de) Cholesterische effektschichten und verfahren zu deren herstellung
DE59603890D1 (de) Bürste und verfahren zu deren herstellung
DE69635345D1 (de) Kautschukzusammensetzung und verfahren zu deren herstellung
DE69634152D1 (de) Mit flammspritzen beschichtete elektrodenkomponente und verfahren zu deren herstellung
DE59809806D1 (de) Chemische mikroreaktoren und verfahren zu deren herstellung
DE69810948T2 (de) Fulleren enthaltende struktur und verfahren zu deren herstellung
DE69530312D1 (de) Stabiles lycopin konzentrat und verfahren zu seiner herstellung
DE69518313T2 (de) Flüssigkristallcomposit und verfahren zu dessen herstellung
DE69506841T2 (de) Flüssigkeitsbehälter und verfahren zu seiner herstellung
DE69713845T2 (de) Druckvorrichtung und verfahren zu deren herstellung
DE59913422D1 (de) Femfet-vorrichtung und verfahren zu deren herstellung
DE59805833D1 (de) Beschichtungsmittel und verfahren zu dessen herstellung
DE69408160T3 (de) Wasch- und reinigungsmittel und verfahren zu dessen herstellung
DE59502654D1 (de) Mikroelektronisches bauelement und verfahren zu dessen herstellung
DE69814203D1 (de) Flüssigkristallverbindungen und Verfahren zur Herstellung
DE69620593D1 (de) Hexacyclische camptothecinanaloga und verfahren zu deren herstellung
DE69704240D1 (de) Flüssigentwicklerzusammensetzung und Verfahren zu deren Herstellung
DE69801727T2 (de) Flüssigkristallvorrichtung und Verfahren zu deren Herstellung
DE69804618T2 (de) Flussige wasch- und reinigungszusammensetzungen und verfahren zu deren herstellung
DE69808221T2 (de) Flüssigkeitsabgabevorrichtung und Verfahren
DE69704822D1 (de) Flüssigentwicklerzusammensetzung und Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition