AP785A - Novel taxoids, preparation thereof and pharmaceutical compositions containing same. - Google Patents

Novel taxoids, preparation thereof and pharmaceutical compositions containing same. Download PDF

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Publication number
AP785A
AP785A APAP/P/1997/001090A AP9701090A AP785A AP 785 A AP785 A AP 785A AP 9701090 A AP9701090 A AP 9701090A AP 785 A AP785 A AP 785A
Authority
AP
ARIPO
Prior art keywords
radical
carbon atoms
general formula
radicals
atoms
Prior art date
Application number
APAP/P/1997/001090A
Other languages
English (en)
Other versions
AP9701090A0 (en
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9503545A external-priority patent/FR2732340B1/fr
Priority claimed from FR9515381A external-priority patent/FR2742754B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP9701090A0 publication Critical patent/AP9701090A0/xx
Application granted granted Critical
Publication of AP785A publication Critical patent/AP785A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
APAP/P/1997/001090A 1995-03-27 1996-03-25 Novel taxoids, preparation thereof and pharmaceutical compositions containing same. AP785A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9503545A FR2732340B1 (fr) 1995-03-27 1995-03-27 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR9515381A FR2742754B1 (fr) 1995-12-22 1995-12-22 Procede de preparation de taxoides
PCT/FR1996/000441 WO1996030356A1 (fr) 1995-03-27 1996-03-25 Nouveaux taxoïdes, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
AP9701090A0 AP9701090A0 (en) 1997-10-31
AP785A true AP785A (en) 1999-11-26

Family

ID=26231838

Family Applications (2)

Application Number Title Priority Date Filing Date
APAP/P/1997/001090A AP785A (en) 1995-03-27 1996-03-25 Novel taxoids, preparation thereof and pharmaceutical compositions containing same.
APAP/P/1997/001093A AP753A (en) 1995-03-27 1996-03-25 Novel taxoids, preparation thereof and pharmaceutical compositions containing same.

Family Applications After (1)

Application Number Title Priority Date Filing Date
APAP/P/1997/001093A AP753A (en) 1995-03-27 1996-03-25 Novel taxoids, preparation thereof and pharmaceutical compositions containing same.

Country Status (41)

Country Link
US (3) US5889043A (fr)
EP (2) EP0817779B1 (fr)
JP (2) JP3790826B2 (fr)
KR (2) KR100297196B1 (fr)
CN (2) CN1152870C (fr)
AP (2) AP785A (fr)
AR (1) AR001440A1 (fr)
AT (2) ATE188471T1 (fr)
AU (2) AU703278B2 (fr)
BG (2) BG63121B1 (fr)
BR (2) BR9607930A (fr)
CA (2) CA2214319C (fr)
CO (1) CO4700576A1 (fr)
CZ (2) CZ287468B6 (fr)
DE (2) DE69606028T2 (fr)
DK (2) DK0817779T3 (fr)
DZ (1) DZ2009A1 (fr)
EA (2) EA000709B1 (fr)
EE (2) EE03608B1 (fr)
ES (2) ES2140075T3 (fr)
GE (2) GEP20002188B (fr)
GR (2) GR3031526T3 (fr)
HU (2) HU223732B1 (fr)
IL (1) IL117636A (fr)
IS (2) IS2058B (fr)
MA (1) MA23823A1 (fr)
MY (1) MY121225A (fr)
NO (2) NO316379B1 (fr)
NZ (2) NZ304900A (fr)
OA (2) OA10514A (fr)
PE (1) PE51097A1 (fr)
PL (2) PL188284B1 (fr)
PT (1) PT817779E (fr)
RO (2) RO115877B1 (fr)
SK (2) SK281928B6 (fr)
TN (1) TNSN96043A1 (fr)
TR (2) TR199701042T1 (fr)
TW (1) TW394765B (fr)
UY (2) UY24192A1 (fr)
WO (2) WO1996030356A1 (fr)
ZA (1) ZA962399B (fr)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
EP0982027A1 (fr) * 1998-08-17 2000-03-01 Aventis Pharma S.A. Dérivés taxoides pour traiter les proliférations cellulaires anormales du cerveau
EP0982028A1 (fr) * 1998-08-20 2000-03-01 Aventis Pharma S.A. Nouvelle utilisation de dérivés de taxoides
MXPA01001721A (es) * 1998-08-20 2005-06-03 Aventis Pharma Sa Nuevo uso de derivados de taxoide.
EP1020188A1 (fr) * 1999-01-13 2000-07-19 Aventis Pharma S.A. Nouvelle utilisation de dérivés taxoides
HUP0200750A3 (en) * 2000-02-02 2005-02-28 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
US8147816B2 (en) * 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
WO2002024178A2 (fr) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Procede de reduction de chimiotherapies combinees
MXPA03002494A (es) * 2000-09-22 2004-05-24 Bristol Myers Squibb Co Metodo para reducir toxicidad de quimio terapias combinadas.
US6593334B1 (en) 2002-05-02 2003-07-15 The University Of North Carolina At Chapel Hill Camptothecin-taxoid conjugates as antimitotic and antitumor agents
EP2277551B1 (fr) 2002-09-06 2013-05-08 Cerulean Pharma Inc. Polymeres a base de cyclodextrine pour l'administration de medicament lies par liaison covalente
US20040122081A1 (en) * 2002-11-08 2004-06-24 Gogate Uday Shankar Pharmaceutical compositions and methods of using taxane derivatives
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7064980B2 (en) * 2003-09-17 2006-06-20 Sandisk Corporation Non-volatile memory and method with bit line coupled compensation
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
GT200500025A (es) * 2004-02-13 2005-09-30 Taxanos sustituidos con esteres de ciclopentilo en c10
PE20050693A1 (es) * 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2006088767A2 (fr) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. Compositions de taxane a substitution cyclopropyl ester en c10
CA2599888C (fr) 2005-03-31 2010-06-15 Bioxel Pharma Inc. Preparation de taxanes a partir de la 9-dihydro-13-acetylbaccatine iii
WO2007051306A1 (fr) * 2005-11-04 2007-05-10 Bioxel Pharma Inc. Procedes de preparation de taxanes au moyen d'auxiliaires chiraux
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
WO2009006590A2 (fr) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Procédés de préparation de docétaxel et de polymorphes
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
EP2276755A4 (fr) * 2008-03-31 2011-05-04 Univ Florida State Res Found Taxanes substitués par un ester éthylique en c(10) et un ester cyclopropylique en c(10)
US8637466B2 (en) 2008-08-11 2014-01-28 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
FR2945211A1 (fr) 2009-05-06 2010-11-12 Sanofi Aventis Combinaison antitumorale comprenant la cabazitaxel et la capecitabine
EP2493466B1 (fr) 2009-10-29 2021-03-10 Sanofi Mature IP Nouvelle utilisation antitumorale du cabazitaxel
EP2503888A4 (fr) * 2009-11-23 2015-07-29 Cerulean Pharma Inc Polymères à base de cyclodextrine pour une administration thérapeutique
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
CN102060815B (zh) * 2010-12-24 2012-09-26 重庆泰濠制药有限公司 一种紫杉烷类化合物的制备方法
PT2678011T (pt) 2011-02-25 2019-09-26 Sanofi Mature Ip Combinação antitumoral que compreende cabazitaxel e cisplatina
EP2620148A1 (fr) 2012-01-27 2013-07-31 Aventis Pharma S.A. Combinaison antitumorale comprenant du cabazitaxel et de la cisplatine
EP2491925A1 (fr) 2011-02-25 2012-08-29 Aventis Pharma S.A. Combinaison antitumorale comprenant du cabazitaxel et de la cisplatine
CN103764637A (zh) 2011-04-12 2014-04-30 普拉斯化学品有限公司 卡巴他赛的固态形式及其制备方法
JP5605511B2 (ja) 2011-08-02 2014-10-15 アステラス製薬株式会社 薬剤の併用による癌治療方法
TWI526437B (zh) 2011-09-09 2016-03-21 台灣神隆股份有限公司 卡巴他賽之結晶型
ES2712804T3 (es) * 2011-09-26 2019-05-14 Fresenius Kabi Oncology Ltd Procedimientos para la preparación de carbazitaxel que implican la sililación en C(7)-OH y C(13)-OH o solo la sililación en C(7)-OH
CN102336726B (zh) * 2011-09-30 2014-11-26 重庆泰濠制药有限公司 一种卡巴他赛的制备方法
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN102408397B (zh) * 2011-10-19 2014-08-20 上海贝美医药科技有限公司 紫杉烷类衍生物及其制备方法
CN102516281B (zh) * 2011-10-20 2015-02-04 江苏红豆杉生物科技股份有限公司 一种10-脱乙酰基巴卡丁iii及其衍生物甲氧基化的方法
CN102424672A (zh) * 2011-10-20 2012-04-25 江苏红豆杉生物科技有限公司 脱保护基制备二甲氧基紫杉烷类化合物的方法
CN102603724B (zh) * 2011-10-20 2014-02-26 江苏红豆杉生物科技股份有限公司 二甲氧基紫杉烷类化合物纯化精制的方法
CN103906747A (zh) * 2011-10-31 2014-07-02 台湾神隆股份有限公司 卡巴他赛及其中间体的制备方法
CN102417491B (zh) * 2011-10-31 2013-11-06 江苏红豆杉生物科技有限公司 以10-去乙酰基-巴卡丁iii为原料制备卡巴他赛的方法
DE112012004569T5 (de) * 2011-11-01 2014-08-14 Fresenius Kabi Oncology Ltd. Amorphe Form von Cabazitaxel und Verfahren zum Herstellen davon
CN103159705B (zh) * 2011-12-12 2015-05-27 福建南方制药股份有限公司 卡巴他赛中间体的制备方法
CN102532064B (zh) * 2011-12-13 2015-06-17 重庆泰濠制药有限公司 二甲氧基多西他赛的合成方法
EP2791122B1 (fr) 2011-12-13 2019-01-23 Aventis Pharma S.A. Forme cristalline du cabazitaxel et son procédé de préparation
EP2880021A4 (fr) * 2012-07-31 2015-06-17 Yung Shin Pharm Ind Co Ltd Cabazitaxel amorphe
CN102775435B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种用于制备7,10-甲氧基多西他赛的中间体的合成方法
CN102775434B (zh) * 2012-08-21 2015-04-08 江苏红豆杉生物科技股份有限公司 一种7,10-二甲氧基紫杉烷化合物中间体的合成方法
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
CN103804323A (zh) * 2012-11-14 2014-05-21 上海希迈医药科技有限公司 一种卡巴他赛溶剂化物及其制备方法和应用
KR101407353B1 (ko) 2012-12-04 2014-06-17 주식회사 삼양바이오팜 10-디아세틸바카틴 iii으로부터 카바지탁셀을 고수율로 제조하는 새로운 방법 및 이를 위한 신규 중간체
EP2743264A1 (fr) 2012-12-13 2014-06-18 INDENA S.p.A. Nouvelle forme cristalline de cabazitaxel, procédé de préparation et ses compositions pharmaceutiques
EP2815749A1 (fr) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Forme solide de 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione ayant un réseau de diffraction de rayons X spécifique
EP2865674A1 (fr) 2013-10-23 2015-04-29 INDENA S.p.A. Formes dissoutes cristallines de Cabazitaxel
EP2865675A1 (fr) 2013-10-23 2015-04-29 INDENA S.p.A. Forme cristalline anhydre de Cabazitaxel, procédé de préparation et ses compositions pharmaceutiques
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物
CN104086514A (zh) * 2014-06-19 2014-10-08 上海应用技术学院 紫杉醇衍生物及其制备方法
ES2817331T3 (es) 2015-02-17 2021-04-07 Univ Erasmus Med Ct Rotterdam Uso del cabazitaxel en el tratamiento del cáncer de próstata
EP3093014A1 (fr) 2015-05-13 2016-11-16 Aventis Pharma S.A. Cabazitaxel et son utilisation pour le traitement du cancer
WO2020249507A1 (fr) 2019-06-11 2020-12-17 Indena S.P.A. Forme cristalline anhydre du cabazitaxel, procédé pour sa préparation et compositions pharmaceutiques la contenant
CA3148115A1 (fr) 2019-08-08 2021-02-11 Laekna Limited Methode de traitement du cancer
EP3808345A1 (fr) 2019-10-15 2021-04-21 Sanofi Mature IP Cabazitaxel chez des patients atteints d'un cprcm précédemment traités avec du docétaxel et qui ont résisté à un traitement antérieur impliquant un agent inhibiteur ciblé de la signalisation d'androgène
EP3797834A1 (fr) 2019-09-25 2021-03-31 Sanofi Mature IP Cabazitaxel chez des patients atteints d'un cprcm précédemment traités avec du docétaxel et qui ont résisté à un traitement antérieur impliquant un agent inhibiteur ciblé de la signalisation d'androgène
WO2026064520A1 (fr) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Conjugués médicamenteux à induction covalente ciblant kras et comprenant une charge utile inhibitrice de tubuline
WO2026064527A1 (fr) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Conjugués médicamenteux à induction covalente ciblant kras comprenant une charge utile d'inhibiteur de tubuline

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018164A1 (fr) * 1993-02-01 1994-08-18 The Research Foundation Of State University Of New York PROCEDE DE PREPARATION DE DERIVES DE TAXANE ET INTERMEDIAIRES DE β-LACTAME UTILISES A CET EFFET
EP0639577A1 (fr) * 1993-08-17 1995-02-22 Bristol-Myers Squibb Company Ethers phosphonooxyméthyliques ou méthylthiométhyliques de dérivés ou taxane comme agents antitumoraux

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5739362A (en) 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696459B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
CA2111527C (fr) 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethylethers de derives du taxane
TW467896B (en) 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
CA2179490A1 (fr) 1993-12-21 1995-06-29 Trimurtulu Golakoti Nouvelles cryptophycines
WO1996000724A1 (fr) 1994-06-28 1996-01-11 Pharmacia & Upjohn Company Analogues de 7-ether-taxol, utilisation antineoplasique et compositions pharmaceutiques les contenant
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
US5481018A (en) 1995-03-31 1996-01-02 The Dow Chemical Company Amino nitrile intermediate for the preparation of alanine diacetic acid
FR2745814B1 (fr) 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2771092B1 (fr) 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994018164A1 (fr) * 1993-02-01 1994-08-18 The Research Foundation Of State University Of New York PROCEDE DE PREPARATION DE DERIVES DE TAXANE ET INTERMEDIAIRES DE β-LACTAME UTILISES A CET EFFET
EP0639577A1 (fr) * 1993-08-17 1995-02-22 Bristol-Myers Squibb Company Ethers phosphonooxyméthyliques ou méthylthiométhyliques de dérivés ou taxane comme agents antitumoraux

Also Published As

Publication number Publication date
EA199700270A1 (ru) 1998-02-26
TW394765B (en) 2000-06-21
EA199700269A1 (ru) 1998-04-30
SK281927B6 (sk) 2001-09-11
IL117636A0 (en) 1996-07-23
NO973922L (no) 1997-08-26
US20020038038A1 (en) 2002-03-28
MA23823A1 (fr) 1996-10-01
US5889043A (en) 1999-03-30
IS2058B (is) 2005-10-14
IS4536A (is) 1997-07-31
PE51097A1 (es) 1997-12-22
TR199701042T1 (xx) 1998-01-21
CN1213042C (zh) 2005-08-03
PL188987B1 (pl) 2005-05-31
EA000567B1 (ru) 1999-12-29
UY24192A1 (es) 1996-06-14
GEP20002188B (en) 2000-07-25
CZ287326B6 (en) 2000-10-11
EE9700323A (et) 1998-06-15
RO115877B1 (ro) 2000-07-28
EP0817779B1 (fr) 2000-01-05
EE03608B1 (et) 2002-02-15
KR100485309B1 (ko) 2005-10-12
WO1996030355A1 (fr) 1996-10-03
AU5278196A (en) 1996-10-16
MX9706278A (es) 1997-10-31
DZ2009A1 (fr) 2002-10-23
PL188284B1 (pl) 2005-01-31
MY121225A (en) 2006-01-28
NZ304901A (en) 1998-12-23
UY24370A1 (es) 2001-10-25
GEP20002211B (en) 2000-08-25
DE69606028T2 (de) 2000-08-10
BG101917A (en) 1998-10-30
SK281928B6 (sk) 2001-09-11
EP0817780A1 (fr) 1998-01-14
ES2143187T3 (es) 2000-05-01
CA2214321A1 (fr) 1996-10-03
CA2214321C (fr) 2008-01-22
DK0817780T3 (da) 2000-03-27
AU5278096A (en) 1996-10-16
HU223666B1 (hu) 2004-11-29
GR3032316T3 (en) 2000-04-27
DE69604653D1 (de) 1999-11-18
WO1996030356A1 (fr) 1996-10-03
MX9706568A (es) 1997-11-29
ATE188471T1 (de) 2000-01-15
TNSN96043A1 (fr) 2005-03-15
ZA962399B (en) 1996-10-01
AP9701093A0 (en) 1997-10-31
IS2056B (is) 2005-10-14
AP753A (en) 1999-07-21
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JP3790826B2 (ja) 2006-06-28
US6387946B1 (en) 2002-05-14
PL322499A1 (en) 1998-02-02
US6331635B1 (en) 2001-12-18
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CZ303297A3 (cs) 1998-01-14
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JP2941951B2 (ja) 1999-08-30
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BR9607930A (pt) 1998-06-02
DK0817779T3 (da) 2000-06-19
EE03609B1 (et) 2002-02-15
CA2214319A1 (fr) 1996-10-03
CN1179776A (zh) 1998-04-22
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JPH11502531A (ja) 1999-03-02
IS4567A (is) 1997-09-23
BR9607929A (pt) 1998-06-02
EP0817779A1 (fr) 1998-01-14
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KR19980703357A (ko) 1998-10-15
CA2214319C (fr) 2004-02-17
SK130297A3 (en) 1998-03-04
NO316607B1 (no) 2004-03-08
CN1152870C (zh) 2004-06-09
NO973923L (no) 1997-08-26
NO973923D0 (no) 1997-08-26
AR001440A1 (es) 1997-10-22
OA10513A (fr) 2002-04-22
EP0817780B1 (fr) 1999-10-13
DE69604653T2 (de) 2000-05-31
NO316379B1 (no) 2004-01-19
OA10514A (fr) 2002-04-22
HUP9801204A3 (en) 2000-12-28
HU223732B1 (hu) 2004-12-28
EE9700315A (et) 1998-06-15
BG63121B1 (bg) 2001-04-30
AP9701090A0 (en) 1997-10-31
AU703278B2 (en) 1999-03-25
EA000709B1 (ru) 2000-02-28
PT817779E (pt) 2000-04-28
IL117636A (en) 2004-08-31
KR19980703287A (ko) 1998-10-15
HUP9801201A2 (hu) 2000-05-28
CZ287468B6 (en) 2000-12-13
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AU711227B2 (en) 1999-10-07
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SK130197A3 (en) 1998-04-08

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