ZA992773B - Substituted tricyclics. - Google Patents

Substituted tricyclics.

Info

Publication number
ZA992773B
ZA992773B ZA9902773A ZA992773A ZA992773B ZA 992773 B ZA992773 B ZA 992773B ZA 9902773 A ZA9902773 A ZA 9902773A ZA 992773 A ZA992773 A ZA 992773A ZA 992773 B ZA992773 B ZA 992773B
Authority
ZA
South Africa
Prior art keywords
substituted tricyclics
tricyclics
substituted
Prior art date
Application number
ZA9902773A
Other languages
English (en)
Inventor
Nicholas James Bach
Jolie Anne Bastian
Douglas Wade Beight
Michael Dean Kennick
Michael John Martinelli
Edward David Mihelich
Junior John Michael Morin
Daniel Jon Sall
Jason Scott Sawyer
Edward C R Smith
Tulio Suarez
Qiuping Wang
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA992773B publication Critical patent/ZA992773B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA9902773A 1998-04-17 1999-04-16 Substituted tricyclics. ZA992773B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6216598A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
ZA992773B true ZA992773B (en) 2002-07-16

Family

ID=22040624

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9902773A ZA992773B (en) 1998-04-17 1999-04-16 Substituted tricyclics.

Country Status (27)

Country Link
EP (2) EP1156050B1 (enExample)
JP (1) JP4435325B2 (enExample)
KR (1) KR19990083234A (enExample)
CN (1) CN1235968A (enExample)
AR (1) AR018185A1 (enExample)
AT (2) ATE254128T1 (enExample)
AU (1) AU757454B2 (enExample)
BR (1) BR9901275A (enExample)
CA (1) CA2269256A1 (enExample)
CO (1) CO5080728A1 (enExample)
CZ (1) CZ137199A3 (enExample)
DE (2) DE69912670T2 (enExample)
EA (1) EA003129B1 (enExample)
ES (2) ES2210979T3 (enExample)
HU (1) HUP9901219A1 (enExample)
ID (1) ID23219A (enExample)
IL (1) IL129484A0 (enExample)
NO (1) NO991823L (enExample)
NZ (1) NZ335252A (enExample)
PE (1) PE20000472A1 (enExample)
PL (1) PL332564A1 (enExample)
SG (1) SG106035A1 (enExample)
SV (1) SV1999000052A (enExample)
TR (1) TR199900842A2 (enExample)
TW (1) TW555760B (enExample)
YU (1) YU19099A (enExample)
ZA (1) ZA992773B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2301586A1 (en) * 1997-08-28 1999-03-04 William Louis Macias Method for treatment of non-rheumatoid arthritis
AU2001244635A1 (en) * 2000-03-30 2001-10-15 Yamanouchi Pharmaceutical Co..Ltd. Hydrazide derivatives
EP1303262A2 (en) * 2000-07-14 2003-04-23 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
AU2002239264A1 (en) * 2000-12-18 2002-07-01 Eli Lilly And Company Tetracyclic derivatives as spla2 inhibitors
US6933313B2 (en) 2001-03-28 2005-08-23 Eli Lilly And Company Substituted carbazoles as inhibitors of sPLA2
JP2005527466A (ja) * 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプトＢインドール誘導体
JP2005527464A (ja) * 2001-08-09 2005-09-15 イーライ・リリー・アンド・カンパニー ｓＰＬＡ２インヒビターとしてのシクロヘプタＢインドール誘導体
US6992100B2 (en) 2001-12-06 2006-01-31 Eli Lilly And Company sPLA2 inhibitors
MX2007005199A (es) 2004-11-01 2007-05-11 Wyeth Corp Indolizinas sustituidas y derivados como agentes del sistema nervioso central.
BRPI0907122B8 (pt) 2008-01-11 2021-05-25 Albany Molecular Res Inc compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
JP5964945B2 (ja) * 2011-04-14 2016-08-03 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ７−（ヘテロアリ−ル−アミノ）−６，７，８，９−テトラヒドロピリド［１，２−ａ］インド−ル酢酸誘導体及びプロスタグランジンＤ２受容体調節剤としてのそれらの使用
SG11201405328SA (en) 2012-03-16 2014-11-27 Vitae Pharmaceuticals Inc Liver x receptor modulators
SMT201700009T1 (it) 2012-03-16 2017-03-08 Vitae Pharmaceuticals Inc Modulatori del recettore x del fegato

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
BR9508298A (pt) * 1994-07-21 1998-11-03 Shionogi & Co Inibidores de indolizina de spla2
US6160175A (en) * 1995-12-13 2000-12-12 Eli Lilly And Company Naphthyl acetamides as sPLA2 inhibitors
KR20000049210A (ko) * 1996-10-30 2000-07-25 피터 지. 스트링거 치환된 트리시클릭류
CA2304482A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
CA2310250A1 (en) * 1997-11-14 1999-05-27 August Masaru Watanabe Treatment for alzheimer's disease

Also Published As

Publication number Publication date
TW555760B (en) 2003-10-01
HUP9901219A1 (hu) 2000-08-28
NO991823L (no) 1999-10-18
JPH11322745A (ja) 1999-11-24
AR018185A1 (es) 2001-10-31
KR19990083234A (ko) 1999-11-25
DE69914951D1 (de) 2004-03-25
CN1235968A (zh) 1999-11-24
DE69914951T2 (de) 2004-12-23
ATE259818T1 (de) 2004-03-15
ES2210979T3 (es) 2004-07-01
AU2381899A (en) 1999-10-28
EP1156050B1 (en) 2004-02-18
ID23219A (id) 2000-03-30
EP0950661B1 (en) 2003-11-12
ES2213668T3 (es) 2004-09-01
JP4435325B2 (ja) 2010-03-17
CO5080728A1 (es) 2001-09-25
EA003129B1 (ru) 2003-02-27
YU19099A (sh) 2001-09-28
NZ335252A (en) 2000-11-24
PE20000472A1 (es) 2000-06-02
CA2269256A1 (en) 1999-10-17
HU9901219D0 (en) 1999-06-28
TR199900842A2 (xx) 2000-09-21
ATE254128T1 (de) 2003-11-15
EA199900304A2 (ru) 1999-10-28
EA199900304A3 (ru) 2000-04-24
SG106035A1 (en) 2004-09-30
EP1156050A2 (en) 2001-11-21
DE69912670T2 (de) 2004-08-12
AU757454B2 (en) 2003-02-20
IL129484A0 (en) 2000-02-29
SV1999000052A (es) 2000-03-14
CZ137199A3 (cs) 1999-11-17
DE69912670D1 (de) 2003-12-18
EP0950661A1 (en) 1999-10-20
EP1156050A3 (en) 2001-11-28
BR9901275A (pt) 2000-05-02
PL332564A1 (en) 1999-10-25
NO991823D0 (no) 1999-04-16

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