WO2001074817A1 - Hydrazide derivatives - Google Patents

Hydrazide derivatives Download PDF

Info

Publication number
WO2001074817A1
WO2001074817A1 PCT/JP2001/002674 JP0102674W WO0174817A1 WO 2001074817 A1 WO2001074817 A1 WO 2001074817A1 JP 0102674 W JP0102674 W JP 0102674W WO 0174817 A1 WO0174817 A1 WO 0174817A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrocarbyl
different
same
hydrazide derivatives
ring
Prior art date
Application number
PCT/JP2001/002674
Other languages
French (fr)
Japanese (ja)
Inventor
Akira Suga
Masanori Miura
Naoki Imanishi
Hideki Kubota
Hiroshi Moritani
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Priority to AU2001244635A priority Critical patent/AU2001244635A1/en
Publication of WO2001074817A1 publication Critical patent/WO2001074817A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Abstract

Novel hydrazide derivatives represented by the following general formula (I). Because of having an excellent activity of inhibiting apo B-associated lipoprotein secretion, these hydrazide derivatives are useful as drugs for hyperlipemia, preferably cholesterol- or triglyceride-lowering agents wherein the ring A is an optionally substituted benzene or pyridine ring; Z1 represents lower alkylene; R1 to R3 may be the same or different and each represents H, hydrocarbyl, a heterocycle, etc.; R4 to R6 may be the same or different and each represents H, halogeno, hydrocarbyl, etc.; and R7 to R9 may be the same or different and each represents H, hydrocarbyl, etc.
PCT/JP2001/002674 2000-03-30 2001-03-29 Hydrazide derivatives WO2001074817A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001244635A AU2001244635A1 (en) 2000-03-30 2001-03-29 Hydrazide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-093056 2000-03-30
JP2000093056 2000-03-30

Publications (1)

Publication Number Publication Date
WO2001074817A1 true WO2001074817A1 (en) 2001-10-11

Family

ID=18608293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/002674 WO2001074817A1 (en) 2000-03-30 2001-03-29 Hydrazide derivatives

Country Status (2)

Country Link
AU (1) AU2001244635A1 (en)
WO (1) WO2001074817A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051382A1 (en) * 2003-11-28 2005-06-09 Astellas Pharma Inc. Agent enhancing lipid-loewring effect

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799828A2 (en) * 1996-04-04 1997-10-08 Bayer Ag Pyrimido [1,2-a] indoles
US5684014A (en) * 1994-10-04 1997-11-04 Bayer Aktiengesellschaft Cycloalkano-indole and -azaindole derivatives
US5952498A (en) * 1996-04-04 1999-09-14 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido 1,2a! indolcarboxcyclic acids and their activated derivatives
EP0950661A1 (en) * 1998-04-17 1999-10-20 Eli Lilly And Company Substituted tricyclics useful in sPLA2 induced diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684014A (en) * 1994-10-04 1997-11-04 Bayer Aktiengesellschaft Cycloalkano-indole and -azaindole derivatives
EP0799828A2 (en) * 1996-04-04 1997-10-08 Bayer Ag Pyrimido [1,2-a] indoles
US5952498A (en) * 1996-04-04 1999-09-14 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido 1,2a! indolcarboxcyclic acids and their activated derivatives
EP0950661A1 (en) * 1998-04-17 1999-10-20 Eli Lilly And Company Substituted tricyclics useful in sPLA2 induced diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051382A1 (en) * 2003-11-28 2005-06-09 Astellas Pharma Inc. Agent enhancing lipid-loewring effect

Also Published As

Publication number Publication date
AU2001244635A1 (en) 2001-10-15

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