ZA9711576B - Method of crystallizing a tetrahydropyridine derivative and crystalline forms thereby obtained. - Google Patents

Method of crystallizing a tetrahydropyridine derivative and crystalline forms thereby obtained.

Info

Publication number
ZA9711576B
ZA9711576B ZA9711576A ZA9711576A ZA9711576B ZA 9711576 B ZA9711576 B ZA 9711576B ZA 9711576 A ZA9711576 A ZA 9711576A ZA 9711576 A ZA9711576 A ZA 9711576A ZA 9711576 B ZA9711576 B ZA 9711576B
Authority
ZA
South Africa
Prior art keywords
crystallizing
crystalline forms
tetrahydropyridine derivative
tetrahydropyridine
derivative
Prior art date
Application number
ZA9711576A
Other languages
English (en)
Inventor
Antoine Caron
Bruno Franc
Olivier Monnier
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ZA9711576B publication Critical patent/ZA9711576B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9711576A 1996-12-23 1997-12-23 Method of crystallizing a tetrahydropyridine derivative and crystalline forms thereby obtained. ZA9711576B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615904A FR2757543B1 (fr) 1996-12-23 1996-12-23 Procede pour la cristallisation d'un derive de tetrahydropyridine et formes cristallines ainsi obtenues

Publications (1)

Publication Number Publication Date
ZA9711576B true ZA9711576B (en) 1998-06-25

Family

ID=9499043

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9711576A ZA9711576B (en) 1996-12-23 1997-12-23 Method of crystallizing a tetrahydropyridine derivative and crystalline forms thereby obtained.

Country Status (38)

Country Link
EP (1) EP0950050B1 (enrdf_load_html_response)
JP (2) JP4499188B2 (enrdf_load_html_response)
KR (1) KR100586670B1 (enrdf_load_html_response)
CN (1) CN1129580C (enrdf_load_html_response)
AR (1) AR009672A1 (enrdf_load_html_response)
AT (1) ATE307802T1 (enrdf_load_html_response)
AU (1) AU736697B2 (enrdf_load_html_response)
BR (1) BR9714081A (enrdf_load_html_response)
CA (1) CA2275596C (enrdf_load_html_response)
CO (1) CO5070688A1 (enrdf_load_html_response)
CZ (1) CZ296689B6 (enrdf_load_html_response)
DE (1) DE69734460T2 (enrdf_load_html_response)
DK (1) DK0950050T3 (enrdf_load_html_response)
DZ (1) DZ2383A1 (enrdf_load_html_response)
EE (1) EE04188B1 (enrdf_load_html_response)
EG (1) EG21567A (enrdf_load_html_response)
ES (1) ES2251038T3 (enrdf_load_html_response)
FR (1) FR2757543B1 (enrdf_load_html_response)
HR (1) HRP970699B1 (enrdf_load_html_response)
HU (1) HU227425B1 (enrdf_load_html_response)
IL (1) IL129938A (enrdf_load_html_response)
IN (1) IN186976B (enrdf_load_html_response)
IS (1) IS2357B (enrdf_load_html_response)
MY (1) MY118015A (enrdf_load_html_response)
NO (1) NO312364B1 (enrdf_load_html_response)
NZ (1) NZ336130A (enrdf_load_html_response)
PL (1) PL190494B1 (enrdf_load_html_response)
RS (1) RS49882B (enrdf_load_html_response)
RU (1) RU2192416C2 (enrdf_load_html_response)
SA (1) SA98180971B1 (enrdf_load_html_response)
SI (1) SI0950050T1 (enrdf_load_html_response)
SK (1) SK285088B6 (enrdf_load_html_response)
TR (1) TR199901363T2 (enrdf_load_html_response)
TW (1) TW518322B (enrdf_load_html_response)
UA (1) UA60324C2 (enrdf_load_html_response)
UY (1) UY24825A1 (enrdf_load_html_response)
WO (1) WO1998028271A1 (enrdf_load_html_response)
ZA (1) ZA9711576B (enrdf_load_html_response)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2757543B1 (fr) * 1996-12-23 1999-04-02 Sanofi Sa Procede pour la cristallisation d'un derive de tetrahydropyridine et formes cristallines ainsi obtenues
FR2782082B3 (fr) * 1998-08-05 2000-09-22 Sanofi Sa Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
US10307506B2 (en) 2010-03-12 2019-06-04 Nippon Shokubai Co., Ltd. Process for producing water-absorbing resin
JP5870183B2 (ja) * 2011-04-15 2016-02-24 エムキュア ファーマシューティカルズ リミテッド リルピビリン中間体の合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2531707A1 (fr) * 1982-08-16 1984-02-17 Midy Spa Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
FR2757543B1 (fr) * 1996-12-23 1999-04-02 Sanofi Sa Procede pour la cristallisation d'un derive de tetrahydropyridine et formes cristallines ainsi obtenues

Also Published As

Publication number Publication date
NZ336130A (en) 2001-01-26
RU2192416C2 (ru) 2002-11-10
UA60324C2 (uk) 2003-10-15
EE9900264A (et) 2000-02-15
YU28999A (sh) 2003-01-31
DE69734460T2 (de) 2006-07-06
EP0950050A1 (fr) 1999-10-20
EP0950050B1 (fr) 2005-10-26
IS2357B (is) 2008-04-15
AR009672A1 (es) 2000-04-26
TW518322B (en) 2003-01-21
JP2009197022A (ja) 2009-09-03
ES2251038T3 (es) 2006-04-16
SI0950050T1 (sl) 2006-04-30
HRP970699A2 (en) 1998-10-31
HK1024002A1 (en) 2000-09-29
PL334256A1 (en) 2000-02-14
WO1998028271A1 (fr) 1998-07-02
MY118015A (en) 2004-08-30
NO312364B1 (no) 2002-04-29
PL190494B1 (pl) 2005-12-30
EG21567A (en) 2001-12-31
FR2757543B1 (fr) 1999-04-02
HUP0001387A3 (en) 2002-03-28
CO5070688A1 (es) 2001-08-28
DE69734460D1 (de) 2005-12-01
NO993076L (no) 1999-06-22
TR199901363T2 (xx) 1999-08-23
IL129938A (en) 2004-06-20
BR9714081A (pt) 2000-05-09
AU736697B2 (en) 2001-08-02
UY24825A1 (es) 1998-04-21
HRP970699B1 (en) 2007-03-31
HUP0001387A2 (hu) 2000-09-28
FR2757543A1 (fr) 1998-06-26
JP4499188B2 (ja) 2010-07-07
SK285088B6 (sk) 2006-06-01
EE04188B1 (et) 2003-12-15
IN186976B (enrdf_load_html_response) 2001-12-22
JP2001507012A (ja) 2001-05-29
DZ2383A1 (fr) 2002-12-28
CA2275596C (en) 2005-10-11
CZ296689B6 (cs) 2006-05-17
HU227425B1 (en) 2011-05-30
CN1129580C (zh) 2003-12-03
CA2275596A1 (en) 1998-07-02
KR100586670B1 (ko) 2006-06-07
KR20000069504A (ko) 2000-11-25
NO993076D0 (no) 1999-06-22
SA98180971B1 (ar) 2006-09-13
IL129938A0 (en) 2000-02-29
SK82899A3 (en) 1999-12-10
ATE307802T1 (de) 2005-11-15
AU5668498A (en) 1998-07-17
IS5076A (is) 1999-06-10
RS49882B (sr) 2008-08-07
CZ229299A3 (cs) 1999-09-15
DK0950050T3 (da) 2006-01-23
CN1241180A (zh) 2000-01-12

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