CA2275596A1 - Method for the crystallisation of a tetrahydropyridin derivative and resulting crystalline forms - Google Patents
Method for the crystallisation of a tetrahydropyridin derivative and resulting crystalline forms Download PDFInfo
- Publication number
- CA2275596A1 CA2275596A1 CA002275596A CA2275596A CA2275596A1 CA 2275596 A1 CA2275596 A1 CA 2275596A1 CA 002275596 A CA002275596 A CA 002275596A CA 2275596 A CA2275596 A CA 2275596A CA 2275596 A1 CA2275596 A1 CA 2275596A1
- Authority
- CA
- Canada
- Prior art keywords
- crystalline forms
- crystallisation
- resulting crystalline
- derivative
- tetrahydropyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical class C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002425 crystallisation Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a method of crystallizing a tetrahydropyridine derivative, to the novel crystalline forms thereby obtained and to the pharmaceutical compositions containing said tetrahydropyridine derivative in a given crystalline form as the active principle.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR96/15904 | 1996-12-23 | ||
| FR9615904A FR2757543B1 (en) | 1996-12-23 | 1996-12-23 | PROCESS FOR THE CRYSTALLIZATION OF A TETRAHYDROPYRIDINE DERIVATIVE AND CRYSTALLINE FORMS THUS OBTAINED |
| PCT/FR1997/002393 WO1998028271A1 (en) | 1996-12-23 | 1997-12-23 | Method for the crystallisation of a tetrahydopyridin derivative and resulting crystalline forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2275596A1 true CA2275596A1 (en) | 1998-07-02 |
| CA2275596C CA2275596C (en) | 2005-10-11 |
Family
ID=9499043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002275596A Expired - Fee Related CA2275596C (en) | 1996-12-23 | 1997-12-23 | Method for the crystallisation of a tetrahydropyridin derivative and resulting crystalline forms |
Country Status (39)
| Country | Link |
|---|---|
| EP (1) | EP0950050B1 (en) |
| JP (2) | JP4499188B2 (en) |
| KR (1) | KR100586670B1 (en) |
| CN (1) | CN1129580C (en) |
| AR (1) | AR009672A1 (en) |
| AT (1) | ATE307802T1 (en) |
| AU (1) | AU736697B2 (en) |
| BR (1) | BR9714081A (en) |
| CA (1) | CA2275596C (en) |
| CO (1) | CO5070688A1 (en) |
| CZ (1) | CZ296689B6 (en) |
| DE (1) | DE69734460T2 (en) |
| DK (1) | DK0950050T3 (en) |
| DZ (1) | DZ2383A1 (en) |
| EE (1) | EE04188B1 (en) |
| EG (1) | EG21567A (en) |
| ES (1) | ES2251038T3 (en) |
| FR (1) | FR2757543B1 (en) |
| HK (1) | HK1024002A1 (en) |
| HR (1) | HRP970699B1 (en) |
| HU (1) | HU227425B1 (en) |
| IL (1) | IL129938A (en) |
| IN (1) | IN186976B (en) |
| IS (1) | IS2357B (en) |
| MY (1) | MY118015A (en) |
| NO (1) | NO312364B1 (en) |
| NZ (1) | NZ336130A (en) |
| PL (1) | PL190494B1 (en) |
| RS (1) | RS49882B (en) |
| RU (1) | RU2192416C2 (en) |
| SA (1) | SA98180971B1 (en) |
| SI (1) | SI0950050T1 (en) |
| SK (1) | SK285088B6 (en) |
| TR (1) | TR199901363T2 (en) |
| TW (1) | TW518322B (en) |
| UA (1) | UA60324C2 (en) |
| UY (1) | UY24825A1 (en) |
| WO (1) | WO1998028271A1 (en) |
| ZA (1) | ZA9711576B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2757543B1 (en) * | 1996-12-23 | 1999-04-02 | Sanofi Sa | PROCESS FOR THE CRYSTALLIZATION OF A TETRAHYDROPYRIDINE DERIVATIVE AND CRYSTALLINE FORMS THUS OBTAINED |
| FR2782082B3 (en) * | 1998-08-05 | 2000-09-22 | Sanofi Sa | CRYSTALLINE FORMS OF (R) - (+) - N - [[3- [1-BENZOYL-3- (3,4- DICHLOROPHENYL) PIPERIDIN-3-YL] PROP-1-YL] -4-PHENYLPIPERIDIN-4 - YL] -N-METHYLACETAMIDE (OSANETANT) AND PROCESS FOR THE PREPARATION OF SAID COMPOUND |
| JP5504334B2 (en) | 2010-03-12 | 2014-05-28 | 株式会社日本触媒 | Method for producing water absorbent resin |
| AP2013006779A0 (en) * | 2011-04-15 | 2013-03-31 | Emcure Pharmaceuticals Ltd | An improved rilpivirine process |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2531707A1 (en) * | 1982-08-16 | 1984-02-17 | Midy Spa | SUBSTITUTED TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES WITH ANOREXIGENIC ACTIVITY, A PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS |
| FR2757543B1 (en) * | 1996-12-23 | 1999-04-02 | Sanofi Sa | PROCESS FOR THE CRYSTALLIZATION OF A TETRAHYDROPYRIDINE DERIVATIVE AND CRYSTALLINE FORMS THUS OBTAINED |
-
1996
- 1996-12-23 FR FR9615904A patent/FR2757543B1/en not_active Expired - Fee Related
-
1997
- 1997-12-19 AR ARP970106029A patent/AR009672A1/en not_active Application Discontinuation
- 1997-12-22 DZ DZ970233A patent/DZ2383A1/en active
- 1997-12-22 HR HR970699A patent/HRP970699B1/en not_active IP Right Cessation
- 1997-12-22 MY MYPI97006233A patent/MY118015A/en unknown
- 1997-12-23 CO CO97074792A patent/CO5070688A1/en unknown
- 1997-12-23 RU RU99116597/04A patent/RU2192416C2/en not_active IP Right Cessation
- 1997-12-23 BR BR9714081-3A patent/BR9714081A/en not_active Application Discontinuation
- 1997-12-23 NZ NZ336130A patent/NZ336130A/en not_active IP Right Cessation
- 1997-12-23 IN IN3761DE1997 patent/IN186976B/en unknown
- 1997-12-23 CZ CZ0229299A patent/CZ296689B6/en not_active IP Right Cessation
- 1997-12-23 CN CN97180863A patent/CN1129580C/en not_active Expired - Fee Related
- 1997-12-23 RS YUP-289/99A patent/RS49882B/en unknown
- 1997-12-23 TR TR1999/01363T patent/TR199901363T2/en unknown
- 1997-12-23 HU HU0001387A patent/HU227425B1/en not_active IP Right Cessation
- 1997-12-23 EE EEP199900264A patent/EE04188B1/en not_active IP Right Cessation
- 1997-12-23 AT AT97952986T patent/ATE307802T1/en active
- 1997-12-23 UA UA99063521A patent/UA60324C2/en unknown
- 1997-12-23 SI SI9730720T patent/SI0950050T1/en unknown
- 1997-12-23 IL IL12993897A patent/IL129938A/en not_active IP Right Cessation
- 1997-12-23 UY UY24825A patent/UY24825A1/en not_active IP Right Cessation
- 1997-12-23 PL PL97334256A patent/PL190494B1/en not_active IP Right Cessation
- 1997-12-23 CA CA002275596A patent/CA2275596C/en not_active Expired - Fee Related
- 1997-12-23 WO PCT/FR1997/002393 patent/WO1998028271A1/en active IP Right Grant
- 1997-12-23 DE DE69734460T patent/DE69734460T2/en not_active Expired - Lifetime
- 1997-12-23 JP JP52848198A patent/JP4499188B2/en not_active Expired - Fee Related
- 1997-12-23 ZA ZA9711576A patent/ZA9711576B/en unknown
- 1997-12-23 DK DK97952986T patent/DK0950050T3/en active
- 1997-12-23 EP EP97952986A patent/EP0950050B1/en not_active Expired - Lifetime
- 1997-12-23 KR KR1019997005373A patent/KR100586670B1/en not_active IP Right Cessation
- 1997-12-23 SK SK828-99A patent/SK285088B6/en not_active IP Right Cessation
- 1997-12-23 ES ES97952986T patent/ES2251038T3/en not_active Expired - Lifetime
- 1997-12-23 AU AU56684/98A patent/AU736697B2/en not_active Ceased
- 1997-12-23 EG EG138397A patent/EG21567A/en active
-
1998
- 1998-01-21 TW TW086119629A patent/TW518322B/en not_active IP Right Cessation
- 1998-03-11 SA SA98180971A patent/SA98180971B1/en unknown
-
1999
- 1999-06-10 IS IS5076A patent/IS2357B/en unknown
- 1999-06-22 NO NO19993076A patent/NO312364B1/en not_active IP Right Cessation
-
2000
- 2000-06-01 HK HK00103287A patent/HK1024002A1/en not_active IP Right Cessation
-
2009
- 2009-05-07 JP JP2009112971A patent/JP2009197022A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20121224 |