ZA918489B - Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated - Google Patents
Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulatedInfo
- Publication number
- ZA918489B ZA918489B ZA918489A ZA918489A ZA918489B ZA 918489 B ZA918489 B ZA 918489B ZA 918489 A ZA918489 A ZA 918489A ZA 918489 A ZA918489 A ZA 918489A ZA 918489 B ZA918489 B ZA 918489B
- Authority
- ZA
- South Africa
- Prior art keywords
- pct
- encapsulated
- enhanced
- foreign substances
- making liposomes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90810969 | 1990-12-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA918489B true ZA918489B (en) | 1992-07-29 |
Family
ID=8205973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA918489A ZA918489B (en) | 1990-12-11 | 1991-10-24 | Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated |
Country Status (20)
Country | Link |
---|---|
US (1) | US5393530A (ja) |
EP (1) | EP0514523B1 (ja) |
JP (1) | JP3241720B2 (ja) |
KR (1) | KR0137783B1 (ja) |
AT (1) | ATE131724T1 (ja) |
AU (1) | AU635456B2 (ja) |
CA (1) | CA2072559C (ja) |
DE (1) | DE69115682T2 (ja) |
DK (1) | DK0514523T3 (ja) |
ES (1) | ES2081605T3 (ja) |
GR (1) | GR3018506T3 (ja) |
HU (1) | HUT62458A (ja) |
IE (1) | IE72163B1 (ja) |
IL (1) | IL99835A (ja) |
IN (1) | IN172269B (ja) |
IS (1) | IS1685B (ja) |
MX (1) | MX9102516A (ja) |
NZ (1) | NZ240817A (ja) |
WO (1) | WO1992010166A1 (ja) |
ZA (1) | ZA918489B (ja) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
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US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
WO1994008626A1 (de) * | 1992-10-16 | 1994-04-28 | Andreas Sachse | Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme |
US5869305A (en) * | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
US6217849B1 (en) | 1993-09-29 | 2001-04-17 | Bracco Research S.A. | Liposome suspensions as blood pool imaging contrast agents |
DE69527194T2 (de) * | 1994-03-28 | 2003-02-06 | Daiichi Pharmaceutical Co., Ltd. | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
ES2165971T3 (es) * | 1995-02-24 | 2002-04-01 | Bracco Research Sa | Suspensiones de liposomas como agentes de contraste para la imagineria de la sangre. |
US5738868A (en) * | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
US6447800B2 (en) | 1996-01-18 | 2002-09-10 | The University Of British Columbia | Method of loading preformed liposomes using ethanol |
US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
US20010051131A1 (en) * | 1996-06-19 | 2001-12-13 | Evan C. Unger | Methods for delivering bioactive agents |
DE19639811A1 (de) * | 1996-09-27 | 1998-04-02 | Artur Herzog Dr Mesmer | Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln |
GB9624918D0 (en) * | 1996-11-29 | 1997-01-15 | Nycomed Imaging As | Particulate components |
AU7104598A (en) | 1997-04-09 | 1998-10-30 | Philipp Lang | New technique to monitor drug delivery noninvasively (in vivo) |
DE19731591C2 (de) * | 1997-07-17 | 1999-09-16 | Schering Ag | Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie |
US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
ES2373861T3 (es) | 1997-09-18 | 2012-02-09 | Pacira Pharmaceuticals, Inc. | Composiciones anestésicas liposomiales de liberación sostenida. |
EP1030652B1 (en) | 1997-11-14 | 2012-04-25 | Pacira Pharmaceuticals, Inc. | Production of multivesicular liposomes |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
DE19813773A1 (de) * | 1998-03-27 | 1999-09-30 | Clemens Unger | Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen |
ES2325141T3 (es) | 1998-07-17 | 2009-08-26 | Pacira Pharmaceuticals, Inc. | Composiciones biodegradables para la liberacion controlada de sustancias encapsuladas. |
US6511676B1 (en) | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
EP2286843A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
DE10121903A1 (de) * | 2001-04-27 | 2002-10-31 | Nimbus Biotechnologie Gmbh | System für die Membranpermeationsmessung |
IL158819A0 (en) * | 2001-05-31 | 2004-05-12 | Skyepharma Inc | Encapsulation of nanosuspensions in liposomes and microspheres |
US7615233B2 (en) * | 2001-07-10 | 2009-11-10 | Canon Kabushiki Kaisha | Particulate construct comprising polyhydroxyalkanoate and method for producing it |
JP3990880B2 (ja) * | 2001-07-10 | 2007-10-17 | キヤノン株式会社 | ポリヒドロキシアルカノエート被覆リポソームの製造方法 |
JP4555569B2 (ja) * | 2001-11-13 | 2010-10-06 | セレーター ファーマシューティカルズ, インコーポレイテッド | 増強された血中安定性を有する脂質キャリア組成物 |
ES2290333T3 (es) * | 2001-11-13 | 2008-02-16 | Celator Pharmaceuticals, Inc. | Composiciones de vehiculos lipidicos y metodos para la retencion mejorada de farmacos. |
US20030129224A1 (en) * | 2001-11-13 | 2003-07-10 | Paul Tardi | Lipid carrier compositions and methods for improved drug retention |
US20050129750A1 (en) * | 2003-12-15 | 2005-06-16 | Yu-Fang Hu | Process for producing liposome suspension and product containing liposome suspension produced thereby |
EP1547580A1 (en) * | 2003-12-23 | 2005-06-29 | MediGene Oncology GmbH | Loading of a camptothecin drug into colloidal nanoparticles |
EP1547582A1 (en) * | 2003-12-23 | 2005-06-29 | MediGene Oncology GmbH | Method of producing lipid complexed camptothecin-carboxylate |
US7749485B2 (en) | 2004-06-03 | 2010-07-06 | Bracco Research S.A. | Liposomal assembly for therapeutic and/or diagnostic use |
JP2008515929A (ja) * | 2004-10-08 | 2008-05-15 | アルザ コーポレイション | 脂質連結部分を予備形成した脂質集合体にマイクロ波を使用して挿入する方法 |
CA2595731A1 (en) * | 2005-01-26 | 2006-08-03 | Celator Pharmaceuticals, Inc. | Lipid carrier compositions with reduced polydispersity |
US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
ES2275443B1 (es) * | 2005-11-30 | 2008-06-01 | Italfarmaco, S.A. | Procedimiento de preparacion de liposomas. |
JP5080779B2 (ja) * | 2006-10-25 | 2012-11-21 | テルモ株式会社 | リポソーム製剤の製造方法 |
US20110059549A1 (en) * | 2007-05-09 | 2011-03-10 | Coleman Matthew A | Methods and systems for producing nanolipoprotein particles |
EP2224963A1 (en) * | 2007-11-19 | 2010-09-08 | CeramOptec GmbH | Pegylated compounds for age-related macular degeneration |
US9688718B2 (en) | 2008-01-11 | 2017-06-27 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles comprising hydrogenases and related products, methods and systems |
US8883729B2 (en) * | 2008-05-22 | 2014-11-11 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles and related compositions, methods and systems |
US9303273B2 (en) | 2008-05-09 | 2016-04-05 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems |
US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
CA2748995C (en) | 2008-10-07 | 2018-01-16 | Bracco Suisse Sa | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
EP2184054A1 (en) * | 2008-11-08 | 2010-05-12 | Lipoxen Technologies Limited | Small Interfering RNA Delivery |
US10151037B2 (en) | 2009-01-12 | 2018-12-11 | Lawrence Livermore National Security, Llc | Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
WO2011038068A1 (en) | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes |
BR112013017939B1 (pt) | 2011-01-13 | 2022-11-16 | Variation Biotechnologies Inc | Composição imunogênica liofilizada termoestável, uso e método para preparação da mesma |
US9644038B2 (en) | 2011-12-21 | 2017-05-09 | The Regents Of The University Of California | Apolipoprotein nanodiscs with telodendrimer |
AU2013208693B2 (en) | 2012-01-12 | 2017-12-07 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
EP4008354A1 (en) * | 2012-01-27 | 2022-06-08 | Variation Biotechnologies Inc. | Methods and compositions for therapeutic agents |
MX364310B (es) * | 2013-11-05 | 2019-04-22 | Gustavo A Garcia Sanchez | Método para preparar una formulación inmunosupresora. |
RS61273B1 (sr) | 2014-04-30 | 2021-01-29 | Fujifilm Corp | Lipozomska kompozicija i postupak za njeno dobijanje |
WO2015166987A1 (ja) * | 2014-04-30 | 2015-11-05 | 富士フイルム株式会社 | リポソーム組成物及びその製造方法 |
EP3240579B1 (en) | 2014-12-31 | 2022-07-27 | Lantheus Medical Imaging, Inc. | Lipid-encapsulated gas microsphere compositions and related methods |
JP6715265B2 (ja) | 2015-05-04 | 2020-07-01 | フェルザンティス アーゲーVersantis Ag | 膜内外pH勾配ベシクルを調製する方法 |
WO2017044899A1 (en) | 2015-09-11 | 2017-03-16 | Lawrence Livermore National Security, Llc | Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation |
JP6564873B2 (ja) * | 2015-11-02 | 2019-08-21 | 富士フイルム株式会社 | リポソーム組成物およびその製造方法 |
TWI832081B (zh) | 2016-05-04 | 2024-02-11 | 美商藍瑟斯醫學影像公司 | 用於形成充氣微球體及成像個體之方法、震盪裝置及電腦可讀軟體 |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
US12083223B2 (en) | 2017-05-02 | 2024-09-10 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles and related compositions methods and systems for loading RNA |
WO2018204421A2 (en) | 2017-05-02 | 2018-11-08 | Lawrence Livermore National Security, Llc | Momp telonanoparticles, and related compositions, methods and systems |
KR20220027941A (ko) * | 2019-06-28 | 2022-03-08 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 리포솜 아나마이신의 재구성 방법 |
US11980636B2 (en) | 2020-11-18 | 2024-05-14 | Jazz Pharmaceuticals Ireland Limited | Treatment of hematological disorders |
US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5186117A (en) * | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
CA1270198A (en) * | 1984-08-08 | 1990-06-12 | Marcel B. Bally | Encapsulation of antineoplastic agents in liposomes |
JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
JPS63211222A (ja) * | 1987-02-27 | 1988-09-02 | Terumo Corp | リポソ−ムの製法 |
US4963297A (en) * | 1987-12-22 | 1990-10-16 | The Liposome Company, Inc. | Spontaneous vesticulation of multilamellar liposomes |
CH672733A5 (ja) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
US4870160A (en) * | 1987-08-19 | 1989-09-26 | Regents Of The University Of Minnesota | Polypeptides with laminin activity |
IE63518B1 (en) * | 1987-11-18 | 1995-05-03 | Vestar Inc | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
CA1330199C (en) * | 1987-12-22 | 1994-06-14 | Thomas D. Madden | Spontaneous vesiculation of multilamellar liposomes |
JPH03504382A (ja) * | 1988-05-20 | 1991-09-26 | ザ リポソーム カンパニー,インコーポレイテッド | 高比率活性剤:脂質複合体 |
IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
-
1991
- 1991-10-22 IS IS3773A patent/IS1685B/is unknown
- 1991-10-23 IL IL9983591A patent/IL99835A/en not_active IP Right Cessation
- 1991-10-24 ZA ZA918489A patent/ZA918489B/xx unknown
- 1991-10-24 IN IN809MA1991 patent/IN172269B/en unknown
- 1991-11-29 NZ NZ240817A patent/NZ240817A/xx unknown
- 1991-12-09 JP JP50206292A patent/JP3241720B2/ja not_active Expired - Fee Related
- 1991-12-09 HU HU922595A patent/HUT62458A/hu unknown
- 1991-12-09 WO PCT/EP1991/002377 patent/WO1992010166A1/en active IP Right Grant
- 1991-12-09 AU AU90629/91A patent/AU635456B2/en not_active Ceased
- 1991-12-09 DK DK92901231.8T patent/DK0514523T3/da active
- 1991-12-09 AT AT92901231T patent/ATE131724T1/de not_active IP Right Cessation
- 1991-12-09 EP EP92901231A patent/EP0514523B1/en not_active Expired - Lifetime
- 1991-12-09 ES ES92901231T patent/ES2081605T3/es not_active Expired - Lifetime
- 1991-12-09 DE DE69115682T patent/DE69115682T2/de not_active Expired - Lifetime
- 1991-12-09 KR KR1019920701929A patent/KR0137783B1/ko not_active IP Right Cessation
- 1991-12-09 CA CA002072559A patent/CA2072559C/en not_active Expired - Lifetime
- 1991-12-10 IE IE428991A patent/IE72163B1/en not_active IP Right Cessation
- 1991-12-11 MX MX9102516A patent/MX9102516A/es not_active IP Right Cessation
-
1992
- 1992-12-09 US US07/861,889 patent/US5393530A/en not_active Expired - Lifetime
-
1995
- 1995-12-21 GR GR950403587T patent/GR3018506T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0514523A1 (en) | 1992-11-25 |
KR920703014A (ko) | 1992-12-17 |
IL99835A0 (en) | 1992-08-18 |
ATE131724T1 (de) | 1996-01-15 |
ES2081605T3 (es) | 1996-03-16 |
IN172269B (ja) | 1993-05-29 |
IE72163B1 (en) | 1997-03-26 |
IE914289A1 (en) | 1992-06-17 |
JP3241720B2 (ja) | 2001-12-25 |
AU635456B2 (en) | 1993-03-18 |
IS3773A7 (is) | 1992-06-12 |
AU9062991A (en) | 1992-07-08 |
KR0137783B1 (ko) | 1998-05-15 |
IL99835A (en) | 1995-11-27 |
HUT62458A (en) | 1993-05-28 |
US5393530A (en) | 1995-02-28 |
MX9102516A (es) | 1992-06-01 |
CA2072559C (en) | 1997-03-18 |
DE69115682T2 (de) | 1996-05-15 |
GR3018506T3 (en) | 1996-03-31 |
DK0514523T3 (da) | 1996-01-29 |
IS1685B (is) | 1998-02-24 |
JPH05504150A (ja) | 1993-07-01 |
EP0514523B1 (en) | 1995-12-20 |
CA2072559A1 (en) | 1992-06-12 |
NZ240817A (en) | 1993-01-27 |
WO1992010166A1 (en) | 1992-06-25 |
DE69115682D1 (de) | 1996-02-01 |
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