ZA853635B - (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide - Google Patents

(s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Info

Publication number
ZA853635B
ZA853635B ZA853635A ZA853635A ZA853635B ZA 853635 B ZA853635 B ZA 853635B ZA 853635 A ZA853635 A ZA 853635A ZA 853635 A ZA853635 A ZA 853635A ZA 853635 B ZA853635 B ZA 853635B
Authority
ZA
South Africa
Prior art keywords
radical
oxo
alpha
ethyl
pyrrolidineacetamide
Prior art date
Application number
ZA853635A
Other languages
English (en)
Inventor
Jean Gobert
Jean-Pierre Geerts
Guy Bodson
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10560974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA853635(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of ZA853635B publication Critical patent/ZA853635B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Seasonings (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA853635A 1984-05-15 1985-05-14 (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide ZA853635B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848412357A GB8412357D0 (en) 1984-05-15 1984-05-15 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
ZA853635B true ZA853635B (en) 1985-12-24

Family

ID=10560974

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853635A ZA853635B (en) 1984-05-15 1985-05-14 (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Country Status (33)

Country Link
US (3) US4696943A (e)
EP (1) EP0162036B1 (e)
JP (1) JPH0629186B2 (e)
KR (1) KR920003819B1 (e)
CN (1) CN1015541B (e)
AT (1) ATE45567T1 (e)
AU (1) AU574465B2 (e)
BG (2) BG50156A3 (e)
CA (1) CA1235129A (e)
CY (2) CY1567A (e)
DE (3) DE10075021I1 (e)
DK (1) DK163501C (e)
ES (2) ES8608485A1 (e)
FI (1) FI80673C (e)
GB (1) GB8412357D0 (e)
GE (1) GEP20002001B (e)
GR (1) GR851155B (e)
HK (1) HK52391A (e)
IE (1) IE59950B1 (e)
IL (1) IL75179A (e)
LT (1) LT2584B (e)
LU (2) LU90615I2 (e)
LV (1) LV5233A3 (e)
MY (2) MY101726A (e)
NL (1) NL300028I2 (e)
NO (2) NO164534C (e)
PL (2) PL147386B1 (e)
PT (1) PT80460B (e)
SA (1) SA01210656A (e)
SG (1) SG80090G (e)
SU (3) SU1402260A3 (e)
UA (1) UA6158A1 (e)
ZA (1) ZA853635B (e)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827389D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
GB9319732D0 (en) * 1993-09-24 1993-11-10 Ucb Sa Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
US6124473A (en) * 1998-05-08 2000-09-26 Ucb, S.A. Process for preparing (s)- and (R)-α-ethyl-2-oxo-1-pyrrolidineacetamide
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
EA002380B1 (ru) * 1999-07-21 2002-04-25 Российский Государственный Педагогический Университет Им. А.И.Герцена Антиишемическое средство
EA002379B1 (ru) * 1999-07-21 2002-04-25 Российский Государственный Педагогический Университет Им. А.И.Герцена Средство, обладающее антиишемической, гипотензивной и антигипоксической активностью
JP4249415B2 (ja) * 1999-12-01 2009-04-02 ユセベ，ソシエテ アノニム Ｃｎｓ疾患の治療のためのピロリジンアセトアミド誘導体単体又は組み合わせ物
GB0004297D0 (en) * 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
WO2002042256A2 (en) * 2000-11-21 2002-05-30 Ucb, S.A. N-alkylated gaba compounds, processes for their preparation and their use as medicaments
JPWO2002053153A1 (ja) 2000-12-28 2004-04-30 第一製薬株式会社 神経因性疼痛治療及び予防薬
JP2004523557A (ja) * 2001-02-23 2004-08-05 ジョンズ・ホプキンス・ユニバーシティ チック、振せん、および関連疾患の治療
IL160045A0 (en) 2001-08-10 2004-06-20 Ucb Sa Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
CA2461961A1 (en) * 2001-10-08 2003-04-17 Ucb, S.A. Use of 2-oxo-1-pyrrolidine derivatives for the treatment of dyskinesia and movement disorders
AU2003242538A1 (en) * 2002-05-14 2003-11-11 Ucb, S.A. Use of 2-oxo-1-pyrrolidone derivatives for the preparation of a drug
US7132552B2 (en) * 2003-02-03 2006-11-07 Teva Pharmaceutical Industries, Ltd. Process for producing levetiracetam
ES2214147B1 (es) * 2003-02-28 2005-10-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
AU2003217438A1 (en) * 2003-03-18 2004-10-11 Hetero Drugs Limited Novel crystalline forms of levetiracetam
WO2005023763A1 (en) * 2003-09-05 2005-03-17 Ranbaxy Laboratories Limited Process for the preparation of pure levetiracetam
WO2005028435A1 (en) * 2003-09-24 2005-03-31 Ucb, S.A. Process for preparing 2-oxo-1-pyrrolidine derivatives
ES2323313T3 (es) 2003-12-02 2009-07-13 Ucb Pharma, S.A. Derivados de imidazol, procedimientos para prepararlos y sus usos.
US7531673B2 (en) 2004-02-18 2009-05-12 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
CA2488325C (en) * 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
CA2595988A1 (en) * 2005-01-27 2006-08-03 Alembic Limited Extended release formulation of levetiracetam
US20070298098A1 (en) * 2005-02-16 2007-12-27 Elan Pharma International Limited Controlled Release Compositions Comprising Levetiracetam
WO2006088864A1 (en) * 2005-02-16 2006-08-24 Elan Pharma International Limited Controlled release compositions comprising levetiracetam
WO2006090265A2 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Processes for the preparation of levetiracetam, its intermediate and the use of levetiracetam in pharmaceutical compositions
EP1863761A1 (en) * 2005-03-10 2007-12-12 Rubamin Limited Process for preparing levetiracetam
US8216611B2 (en) 2005-03-30 2012-07-10 Mylan Pharmaceuticals Ulc Combined-step process for pharmaceutical compositions
EP1879861A2 (en) * 2005-04-01 2008-01-23 Rubamin Laboratories Limited Process for preparing levetiracetam and racemization of (r)- and (s)-2-amino butynamide and the corresponding acid derivatives
EP2308870A3 (en) 2005-06-01 2011-10-19 UCB Pharma S.A. 2-oxo-1-pyrrolidine deriatives, processes for preparing them and their uses
BRPI0606121A2 (pt) * 2005-07-26 2009-10-06 Ucb Pharma Sa composição farmacêutica, processo de manufaturar a mesma, e, uso de uma composição farmacêutica
US8338621B2 (en) 2005-12-21 2012-12-25 Ucb S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
CN101360493A (zh) * 2006-01-24 2009-02-04 特瓦制药工业有限公司 左乙拉西坦制剂和制备方法
US20080014271A1 (en) * 2006-07-13 2008-01-17 Ucb, S.A. Novel pharmaceutical compositions comprising levetiracetam
WO2008012268A1 (en) * 2006-07-25 2008-01-31 Zach System S.P.A. Process for the preparation of levetiracetam
EP2051696A2 (en) * 2006-08-18 2009-04-29 Morton Grove Pharmaceuticals, Inc. Stable liquid levetiracetam compositions and methods
CN101130504B (zh) * 2006-08-25 2010-07-28 苏州雅本化学股份有限公司 经合成、拆分与消旋化制备手性药物左乙拉西坦中间体(s)-(+)-2-氨基丁酰胺盐酸盐的方法
EP1932922A1 (de) * 2006-12-13 2008-06-18 Desitin Arzneimittel GmbH Schnelltest zum Nachweis von DNA-Sequenzen
WO2008077035A2 (en) * 2006-12-18 2008-06-26 Dr. Reddy's Laboratories Ltd. Processes for the preparation of levetiracetam
CN101333180B (zh) * 2007-06-29 2011-05-18 浙江华海药业股份有限公司 一种制备左乙拉西坦中间体的方法
US20090082422A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched levetiracetam
WO2009050735A1 (en) * 2007-10-15 2009-04-23 Lupin Limited A novel polymorph of levetiracetam and a process for its preparation
US20090263481A1 (en) * 2008-04-17 2009-10-22 Atul Vishvanath Patil Levetiracetam formulations
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US20100190752A1 (en) * 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
CN102227217A (zh) * 2008-10-16 2011-10-26 约翰斯.霍普金斯大学 改善认知功能的方法和组合物
EP2179725A1 (en) 2008-10-23 2010-04-28 LEK Pharmaceuticals D.D. Pharmaceutical composition comprising levetiracetam
CA2741660A1 (en) * 2008-11-07 2010-05-14 Novabay Pharmaceuticals, Inc. Antimicrobial oxazolidinone, hydantoin and imidazolidinone compositions
US20100172979A1 (en) * 2008-12-24 2010-07-08 Zhongshui Yu Controlled-release formulations
US20100159009A1 (en) * 2008-12-24 2010-06-24 Zhongshui Yu Controlled-release formulations
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
CN101885696A (zh) * 2009-05-14 2010-11-17 上海华理生物医药有限公司 一种合成高纯度左乙拉西坦的方法
US20120171125A1 (en) 2009-08-07 2012-07-05 Ucb Pharma, S.A. Methods for Enhancing the Cognitive Function
EP2298290A1 (en) 2009-09-16 2011-03-23 LEK Pharmaceuticals d.d. Controlled release composition comprising levetiracetam
US7939676B2 (en) * 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
CN102574869A (zh) 2009-10-23 2012-07-11 Ucb医药有限公司 2-氧代-1-吡咯烷基咪唑并噻二唑衍生物
EA037187B1 (ru) 2010-02-09 2021-02-17 Дзе Джонс Хопкинс Юниверсити Способ и композиция для лечения когнитивного расстройства
EP2539444A4 (en) 2010-02-26 2013-09-18 Univ California COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE
WO2011136751A2 (en) 2010-04-26 2011-11-03 Mahmut Bilgic Water soluble pharmaceutical composition
US9333175B2 (en) 2010-06-16 2016-05-10 Mylan Inc. Controlled release levetiracetam formulations and methods for producing the same
EP2492354A1 (en) 2011-02-23 2012-08-29 Institut National De La Recherche Agronomique (INRA) Method for identifying compounds useful in the treatment of photosensitive reflex epilepsy
DK2699581T3 (en) 2011-04-18 2016-01-11 Ucb Biopharma Sprl 2-oxo-1-IMIDAZOLIDINYLIMIDAZOTHIADIAZOLDERIVATIVER
EP2524910A1 (en) 2011-05-17 2012-11-21 DSM IP Assets B.V. Process for the resolution of aminobutyramide
CN102382027B (zh) * 2011-09-20 2013-11-13 浙江江北药业有限公司 一种左乙拉西坦的制备方法
CN102617436B (zh) * 2012-03-20 2014-02-12 浙江洪波化工有限公司 2-(2-氧代吡咯烷基）丁酰胺的制备方法
CN102633675A (zh) * 2012-04-10 2012-08-15 南京大学 一种dl-2-氨基丁酰胺制备方法
CN102675181B (zh) * 2012-06-07 2013-11-20 北京师宏药物研制中心 一种左乙拉西坦的制备方法
CN102702063B (zh) * 2012-06-15 2013-09-04 孙威 一种左乙拉西坦制备方法
WO2014012563A1 (en) 2012-07-20 2014-01-23 Ucb Pharma, S.A. Compounds for enhancing the cognitive function
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103012190B (zh) * 2012-12-05 2015-03-18 江苏拜克新材料有限公司 一种s-2-氨基丁酰胺盐酸盐的合成方法
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
AU2014228990B2 (en) 2013-03-15 2017-02-02 Aprecia Pharmaceuticals LLC Rapid disperse dosage form containing levetiracetam
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
LT3096790T (lt) 2014-01-21 2019-10-10 Janssen Pharmaceutica, N.V. Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
WO2015110435A1 (en) 2014-01-21 2015-07-30 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
CN103922988A (zh) * 2014-04-29 2014-07-16 苏州天马精细化学品股份有限公司 一种左乙拉西坦粗品的纯化方法
CN103910649A (zh) * 2014-04-29 2014-07-09 苏州天马精细化学品股份有限公司 一种左乙拉西坦中间体（s）-n-[1-(氨基羰基)丙基]-4-氯代丁酰胺的合成方法
CN104860863B (zh) * 2015-04-10 2017-06-20 惠州信立泰药业有限公司 左乙拉西坦和含其的药物组合物
US10925834B2 (en) 2015-05-22 2021-02-23 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
EP3397253A1 (en) 2015-12-30 2018-11-07 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of seizure-related disorders
CN106432032B (zh) * 2016-09-14 2019-07-12 苏州天马药业有限公司 一种左乙拉西坦的制备方法
CN106591179B (zh) * 2016-12-05 2018-07-03 长兴制药股份有限公司 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用
BR112019011208A2 (pt) 2016-12-16 2019-10-15 Idorsia Pharmaceuticals Ltd combinação farmacêutica, composição farmacêutica, e, kit de partes.
CN108503610B (zh) 2017-02-24 2019-09-13 北京艾百诺医药股份有限公司 一种光学纯的(r)-4-正丙基-二氢呋喃-2(3h)-酮的制备方法
CN107337628B (zh) * 2017-08-10 2022-02-08 浙江华海药业股份有限公司 一种制备左乙拉西坦的方法
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物
CN110003074A (zh) 2019-04-23 2019-07-12 浙江华海药业股份有限公司 一种左乙拉西坦中间体的制备方法
TW202114655A (zh) 2019-08-14 2021-04-16 瑞士商辛鐵堤卡公司 左乙拉西坦(levetiracetam)之鞘內投藥
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
IL305471A (en) 2021-02-26 2023-10-01 Syndesi Therapeutics Sa Compounds for the treatment of cognitive disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB1583871A (en) * 1976-10-19 1981-02-04 Ucb Sa Anti-aggregants
FR2418790A1 (fr) * 1978-03-02 1979-09-28 Philagro Sa Nouveaux derives de pyrrolidinone-2 et compositions herbicides les contenant
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition

Also Published As

Publication number Publication date
DK163501C (da) 1992-07-27
HK52391A (en) 1991-07-19
CN1015541B (zh) 1992-02-19
DK212985A (da) 1985-11-16
SU1430392A1 (ru) 1988-10-15
CY2004007I1 (el) 2009-11-04
FI851875L (fi) 1985-11-16
ES543124A0 (es) 1986-06-16
NO2001008I2 (no) 2005-05-30
SU1402260A3 (ru) 1988-06-07
EP0162036B1 (fr) 1989-08-16
IL75179A (en) 1988-05-31
US4943639A (en) 1990-07-24
LV5233A3 (lv) 1993-10-10
FI80673B (fi) 1990-03-30
CA1235129A (en) 1988-04-12
JPH0629186B2 (ja) 1994-04-20
CY2004007I2 (el) 2009-11-04
SU1428195A3 (ru) 1988-09-30
BG50156A3 (en) 1992-05-15
US4837223A (en) 1989-06-06
DK212985D0 (da) 1985-05-14
JPS60252461A (ja) 1985-12-13
MY101726A (en) 1992-01-17
LU90682I2 (fr) 2001-01-30
UA6158A1 (uk) 1994-12-29
ES8608485A1 (es) 1986-06-16
NL300028I2 (nl) 2001-06-01
LT2584B (lt) 1994-03-25
ATE45567T1 (de) 1989-09-15
FI80673C (fi) 1990-07-10
EP0162036A1 (fr) 1985-11-21
KR920003819B1 (ko) 1992-05-15
IL75179A0 (en) 1985-09-29
PT80460A (fr) 1985-06-01
KR850008336A (ko) 1985-12-16
SA01210656A (ar) 2005-12-03
ES8704893B9 (es) 2012-02-07
GEP20002001B (en) 2000-03-10
CN85105301A (zh) 1987-01-14
MY101725A (en) 1992-01-17
DE10199005I1 (de) 2001-07-12
SG80090G (en) 1990-11-23
GB8412357D0 (en) 1984-06-20
DE10075021I1 (de) 2000-10-19
DE3572348D1 (de) 1989-09-21
NO164534B (no) 1990-07-09
NO851933L (no) 1985-11-18
PL144346B1 (en) 1988-05-31
PT80460B (pt) 1987-08-19
PL253374A1 (en) 1986-05-06
FI851875A0 (fi) 1985-05-13
DE10199005I2 (de) 2002-03-14
NO164534C (no) 1990-10-17
PL257385A1 (en) 1986-10-07
CY1567A (en) 1991-12-20
GR851155B (e) 1985-11-25
PL147386B1 (en) 1989-05-31
ES8704893A1 (es) 1987-04-16
US4696943A (en) 1987-09-29
LU90615I2 (fr) 2000-10-02
IE59950B1 (en) 1994-05-04
DK163501B (da) 1992-03-09
AU574465B2 (en) 1988-07-07
IE851193L (en) 1985-11-15
NL300028I1 (nl) 2001-02-01
BG47497A3 (en) 1990-07-16
AU4253085A (en) 1986-11-20

Similar Documents

Publication Publication Date Title
AU574465B2 (en) (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
AU574175B2 (en) (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide