ZA757222B - New x-ray contrast media which are readily soluble in water,their use and processes for their preparation - Google Patents

New x-ray contrast media which are readily soluble in water,their use and processes for their preparation

Info

Publication number
ZA757222B
ZA757222B ZA757222A ZA757222A ZA757222B ZA 757222 B ZA757222 B ZA 757222B ZA 757222 A ZA757222 A ZA 757222A ZA 757222 A ZA757222 A ZA 757222A ZA 757222 B ZA757222 B ZA 757222B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
new
water
contrast media
Prior art date
Application number
ZA757222A
Other languages
English (en)
Inventor
Ernst Felder
Davide Pitre
Original Assignee
Savac Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savac Ag filed Critical Savac Ag
Publication of ZA757222B publication Critical patent/ZA757222B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA757222A 1974-12-13 1975-11-18 New x-ray contrast media which are readily soluble in water,their use and processes for their preparation ZA757222B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1658874A CH608189A5 (es) 1974-12-13 1974-12-13

Publications (1)

Publication Number Publication Date
ZA757222B true ZA757222B (en) 1976-11-24

Family

ID=4418593

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA757222A ZA757222B (en) 1974-12-13 1975-11-18 New x-ray contrast media which are readily soluble in water,their use and processes for their preparation

Country Status (29)

Country Link
US (1) US4001323A (es)
JP (1) JPS5182236A (es)
AR (1) AR211853A1 (es)
AT (2) AT340582B (es)
AU (1) AU475785B2 (es)
BE (1) BE836355A (es)
BG (1) BG26512A3 (es)
CA (1) CA1046082A (es)
CH (1) CH608189A5 (es)
CS (1) CS194234B2 (es)
DD (1) DD122475A5 (es)
DK (1) DK147336C (es)
ES (1) ES442651A1 (es)
FR (1) FR2293919A1 (es)
GB (1) GB1472050A (es)
HU (1) HU170216B (es)
IE (1) IE42620B1 (es)
IL (1) IL48484A (es)
IN (1) IN142089B (es)
MX (1) MX3174E (es)
NL (1) NL157295B (es)
NO (1) NO145096C (es)
PH (1) PH12321A (es)
PL (1) PL96082B1 (es)
RO (1) RO69615A (es)
SE (1) SE409993B (es)
SU (1) SU628813A3 (es)
YU (2) YU40448B (es)
ZA (1) ZA757222B (es)

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IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
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DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
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IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
JP4012567B2 (ja) * 1995-05-23 2007-11-21 ブラッコ イメージング エッセ ピ ア ジカルボン酸二塩化物の製造方法
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BR9606624A (pt) * 1995-09-08 1997-11-11 Bracco Int Bv Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água
JP4104656B2 (ja) * 1995-12-19 2008-06-18 ブラッコ・リサーチ・ソシエテ・アノニム トリヨードベンゼンポリマーからなる胃腸管の画像形成用組成物
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
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IT1289521B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la purificazione di un intermedio
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289520B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
KR100758741B1 (ko) * 1997-02-11 2007-09-14 브라코 인터내셔날 비이.브이. 선형 또는 분지형 (ｃ5-ｃ6) 알콜 또는 그의 혼합물로부터 (ｓ)-ｎ,ｎ'-비스[2-히드록시-1-(히드록시메틸)에틸]-5-[(2-히드록시-1-옥소프로필)아미노]-2,4,6-트리요오도-1,3-벤젠디카르복스아미드의 결정화 방법
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US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
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SE522098C2 (sv) * 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
SE0300620D0 (sv) * 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
SE0302983D0 (sv) * 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
ES2317344T3 (es) 2005-01-13 2009-04-16 Cinvention Ag Materiales compuestos que contienen nanoparticulas de carbono.
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HUE034436T2 (en) * 2008-11-18 2018-02-28 Bracco Imaging Spa A method for producing iodinated contrast media
JP2012514622A (ja) 2009-01-09 2012-06-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影製剤組成物
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
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RU2528402C2 (ru) 2009-07-07 2014-09-20 Бракко Имэджинг Спа Способ получения йодирующего агента
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
PT105770B (pt) * 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
KR102044772B1 (ko) 2012-12-11 2019-11-14 브라코 이미징 에스.피.에이. (s)-2-아세틸옥시프로피온산 클로라이드의 제조를 위한 연속식 공정
US10294107B2 (en) 2013-02-20 2019-05-21 Bone Support Ab Setting of hardenable bone substitute
CA3001399C (en) * 2013-11-05 2020-06-30 Bracco Imaging Spa Process for the preparation of iopamidol
LT3154928T (lt) 2014-06-10 2020-05-11 Bracco Imaging S.P.A. (s)-2-acetiloksipropioninės rūgšties ir jos darinių gavimo būdas
CN104230731B (zh) * 2014-09-24 2016-01-20 武汉理工大学 造影剂中间体三碘异酞酰氯的制备方法
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
WO2018104228A1 (en) 2016-12-05 2018-06-14 Bracco Imaging Spa Mechanochemical synthesis of radiographic agents intermediates
KR102562581B1 (ko) 2017-06-07 2023-08-02 브라코 이미징 에스.피.에이. 수성 용액으로부터 요오드의 회수 방법
CN116745260A (zh) 2021-03-22 2023-09-12 伯拉考成像股份公司 丝氨醇的工业合成
WO2023117667A1 (en) 2021-12-20 2023-06-29 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodoisophthalic bisamides

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FI53066C (es) * 1969-06-27 1978-02-10 Nyegaard & Co As
DE2124904C3 (de) * 1971-05-15 1980-09-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Hydroxy- und Alkoxyacetamido-trijodbenzoesäuren, deren Salze mit physiologisch verträglichen Basen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel
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CH576256A5 (es) * 1973-07-17 1976-06-15 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
ES442651A1 (es) 1977-04-16
PH12321A (en) 1979-01-16
PL96082B1 (pl) 1977-12-31
FR2293919B1 (es) 1980-06-20
DK567475A (da) 1976-06-14
IN142089B (es) 1977-05-28
ATA925075A (de) 1977-04-15
ATA925175A (de) 1977-08-15
BE836355A (fr) 1976-06-08
CH608189A5 (es) 1978-12-29
YU41540B (en) 1987-08-31
SE409993B (sv) 1979-09-17
NO145096C (no) 1982-01-13
YU196783A (en) 1984-12-31
SU628813A3 (ru) 1978-10-15
GB1472050A (en) 1977-04-27
DK147336B (da) 1984-06-25
BG26512A3 (es) 1979-04-12
RO69615A (ro) 1981-06-30
JPS5642581B2 (es) 1981-10-06
AR211853A1 (es) 1978-03-31
NL7512208A (nl) 1976-06-15
DE2547789B2 (de) 1977-02-24
MX3174E (es) 1980-06-09
AT342579B (de) 1978-04-10
YU315575A (en) 1982-02-28
IE42620L (en) 1976-06-13
IL48484A (en) 1978-08-31
AU475785B2 (en) 1976-09-02
DK147336C (da) 1985-01-21
CS194234B2 (en) 1979-11-30
NO754241L (es) 1976-06-15
DD122475A5 (es) 1976-10-12
IL48484A0 (en) 1976-01-30
CA1046082A (en) 1979-01-09
IE42620B1 (en) 1980-09-10
DE2547789A1 (de) 1976-06-24
FR2293919A1 (fr) 1976-07-09
YU40448B (en) 1986-02-28
US4001323A (en) 1977-01-04
NL157295B (nl) 1978-07-17
AT340582B (de) 1977-12-27
NO145096B (no) 1981-10-05
AU8751675A (en) 1976-09-02
JPS5182236A (en) 1976-07-19
HU170216B (es) 1977-04-28
SE7514076L (sv) 1976-06-14

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