YU40448B - Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water - Google Patents

Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water

Info

Publication number
YU40448B
YU40448B YU3155/75A YU315575A YU40448B YU 40448 B YU40448 B YU 40448B YU 3155/75 A YU3155/75 A YU 3155/75A YU 315575 A YU315575 A YU 315575A YU 40448 B YU40448 B YU 40448B
Authority
YU
Yugoslavia
Prior art keywords
triiodo
propionylamino
dihydroxy
amides
propyl
Prior art date
Application number
YU3155/75A
Other languages
English (en)
Other versions
YU315575A (en
Inventor
E Felder
D Pitre
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Priority to SI7513155A priority Critical patent/SI7513155A8/sl
Publication of YU315575A publication Critical patent/YU315575A/xx
Publication of YU40448B publication Critical patent/YU40448B/xx
Priority to HR931219A priority patent/HRP931219B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
YU3155/75A 1974-12-13 1975-12-12 Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water YU40448B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI7513155A SI7513155A8 (sl) 1974-12-13 1975-12-12 Postopek za pripravo bis-(dihidroksipropilamidov) 5-hidroksipropionilamino-2,4,6-trijod-izoftalove kisline, ki so lahko topni v vodi
HR931219A HRP931219B1 (en) 1975-12-12 1993-09-20 Process for the preparation of bis-(dihydroxypropylamides) 5-amino-2,4,6-triiodine of isophtalic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1658874A CH608189A5 (es) 1974-12-13 1974-12-13

Publications (2)

Publication Number Publication Date
YU315575A YU315575A (en) 1982-02-28
YU40448B true YU40448B (en) 1986-02-28

Family

ID=4418593

Family Applications (2)

Application Number Title Priority Date Filing Date
YU3155/75A YU40448B (en) 1974-12-13 1975-12-12 Process for preparing bis-(dihydroxy-propyl-amides) of 5-hydroxy-propionylamino-2,4,6-triiodo-isophthalic acid which are easily soluble in water
YU1967/83A YU41540B (en) 1974-12-13 1983-09-30 Process for preparing bis-(dihydroxy-propilamides) of 5-hydroxy-propionylamido-2,4,6-triido-isophthalic acid, which are readily soluble in water

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU1967/83A YU41540B (en) 1974-12-13 1983-09-30 Process for preparing bis-(dihydroxy-propilamides) of 5-hydroxy-propionylamido-2,4,6-triido-isophthalic acid, which are readily soluble in water

Country Status (29)

Country Link
US (1) US4001323A (es)
JP (1) JPS5182236A (es)
AR (1) AR211853A1 (es)
AT (2) AT340582B (es)
AU (1) AU475785B2 (es)
BE (1) BE836355A (es)
BG (1) BG26512A3 (es)
CA (1) CA1046082A (es)
CH (1) CH608189A5 (es)
CS (1) CS194234B2 (es)
DD (1) DD122475A5 (es)
DK (1) DK147336C (es)
ES (1) ES442651A1 (es)
FR (1) FR2293919A1 (es)
GB (1) GB1472050A (es)
HU (1) HU170216B (es)
IE (1) IE42620B1 (es)
IL (1) IL48484A (es)
IN (1) IN142089B (es)
MX (1) MX3174E (es)
NL (1) NL157295B (es)
NO (1) NO145096C (es)
PH (1) PH12321A (es)
PL (1) PL96082B1 (es)
RO (1) RO69615A (es)
SE (1) SE409993B (es)
SU (1) SU628813A3 (es)
YU (2) YU40448B (es)
ZA (1) ZA757222B (es)

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IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
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DE3038853A1 (de) 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
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DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
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US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
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US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
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DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
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IT1256248B (it) * 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
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US5424056A (en) * 1993-03-01 1995-06-13 Sterling Wintrhop Inc. X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays
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IT1271469B (it) * 1993-09-10 1997-05-28 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3 diossani
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
EP0773925B1 (en) * 1995-05-23 2000-02-09 Fructamine S.P.A. Process for the preparation of a dicarboxylic acid dichloride
WO1996037459A1 (en) * 1995-05-23 1996-11-28 Fructamine S.P.A. Process for the preparation of a dicarboxylic acid dichloride
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
JP4070235B2 (ja) * 1995-09-08 2008-04-02 ブラッコ・インテルナツィオナル・ベーヴェー （ｓ）−ｎ，ｎ’−ビス［２−ヒドロキシ−１−（ヒドロキシメチル）エチル］−５−［（２−ヒドロキシ−１−オキソプロピル）アミノ］−２，４，６−トリヨード−１，３−ベンゼンジカルボキサアミドの、水からの結晶化方法
JP4104656B2 (ja) * 1995-12-19 2008-06-18 ブラッコ・リサーチ・ソシエテ・アノニム トリヨードベンゼンポリマーからなる胃腸管の画像形成用組成物
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IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
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GB9624612D0 (en) * 1996-11-26 1997-01-15 Nycomed Imaging As Process
IT1286522B1 (it) * 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1289520B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289521B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la purificazione di un intermedio
ES2141691T3 (es) * 1997-02-11 2003-05-16 Bracco Int Bv Procedimiento para la cristalizacion de (s)-n,n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida en un alcohol (c5-c6) lineal o ramificado o sus mezclas.
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
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US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US6262303B1 (en) 1998-05-08 2001-07-17 Dibra S.P.A. Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide
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SE522098C2 (sv) * 2001-12-20 2004-01-13 Bone Support Ab Ett nytt benmineralsubstitut
SE0300620D0 (sv) * 2003-03-05 2003-03-05 Bone Support Ab A new bone substitute composition
SE0302983D0 (sv) * 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
SE527528C2 (sv) * 2004-06-22 2006-04-04 Bone Support Ab Anordning för framställning av härdbar massa samt användning av anordningen
KR20070101312A (ko) 2005-01-13 2007-10-16 신벤션 아게 탄소 나노입자를 함유하는 복합 물질
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KR101668042B1 (ko) * 2008-11-18 2016-10-20 브라코 이미징 에스.피.에이. 요오드화된 조영제의 제조방법
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KR101699065B1 (ko) 2009-07-07 2017-01-23 브라코 이미징 에스.피.에이. 요오드화제의 제조방법
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
PT105770B (pt) * 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
CN104955798A (zh) 2012-12-11 2015-09-30 伯拉考成像股份公司 制备(s)-2-乙酰氧基丙酰氯的连续方法
TR201807495T4 (tr) 2013-02-20 2018-06-21 Bone Support Ab Sertleştirilebilir kemik ikamesine yönelik geliştirilmiş katılaştırma.
RU2657238C2 (ru) * 2013-11-05 2018-06-09 Бракко Имэджинг Спа Способ получения йопамидола
PT3154928T (pt) 2014-06-10 2020-05-04 Bracco Imaging Spa Método para a preparação de ácido (s)-2-acetiloxipropiónico e seus derivados
CN104230731B (zh) * 2014-09-24 2016-01-20 武汉理工大学 造影剂中间体三碘异酞酰氯的制备方法
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN105461581A (zh) * 2015-11-17 2016-04-06 浙江海洲制药有限公司 碘帕醇杂质a和杂质b的合成方法
CN107778191A (zh) * 2016-08-26 2018-03-09 正大天晴药业集团股份有限公司 一种碘普罗胺及其中间体的制备方法
EP3548461B1 (en) * 2016-12-05 2021-02-03 Bracco Imaging SpA Mechanochemical synthesis of radiographic agents intermediates
JP7132252B2 (ja) 2017-06-07 2022-09-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 水溶液からのヨウ素の回収方法
EP4313934A1 (en) 2021-03-22 2024-02-07 Bracco Imaging SPA Industrial synthesis of serinol
WO2023117667A1 (en) 2021-12-20 2023-06-29 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodoisophthalic bisamides

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Also Published As

Publication number Publication date
IL48484A (en) 1978-08-31
ATA925075A (de) 1977-04-15
ES442651A1 (es) 1977-04-16
SE409993B (sv) 1979-09-17
AU8751675A (en) 1976-09-02
IN142089B (es) 1977-05-28
FR2293919A1 (fr) 1976-07-09
CS194234B2 (en) 1979-11-30
CA1046082A (en) 1979-01-09
PH12321A (en) 1979-01-16
DK147336C (da) 1985-01-21
FR2293919B1 (es) 1980-06-20
AU475785B2 (en) 1976-09-02
DE2547789A1 (de) 1976-06-24
US4001323A (en) 1977-01-04
ATA925175A (de) 1977-08-15
DE2547789B2 (de) 1977-02-24
NO145096B (no) 1981-10-05
PL96082B1 (pl) 1977-12-31
MX3174E (es) 1980-06-09
NL7512208A (nl) 1976-06-15
AT340582B (de) 1977-12-27
YU196783A (en) 1984-12-31
SU628813A3 (ru) 1978-10-15
GB1472050A (en) 1977-04-27
DK567475A (da) 1976-06-14
DD122475A5 (es) 1976-10-12
IE42620L (en) 1976-06-13
JPS5642581B2 (es) 1981-10-06
ZA757222B (en) 1976-11-24
BE836355A (fr) 1976-06-08
NL157295B (nl) 1978-07-17
AR211853A1 (es) 1978-03-31
YU41540B (en) 1987-08-31
AT342579B (de) 1978-04-10
RO69615A (ro) 1981-06-30
CH608189A5 (es) 1978-12-29
HU170216B (es) 1977-04-28
SE7514076L (sv) 1976-06-14
NO145096C (no) 1982-01-13
IL48484A0 (en) 1976-01-30
BG26512A3 (es) 1979-04-12
IE42620B1 (en) 1980-09-10
NO754241L (es) 1976-06-15
YU315575A (en) 1982-02-28
DK147336B (da) 1984-06-25
JPS5182236A (en) 1976-07-19

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