ZA202306503B - Compositions and methods for immunotherapy - Google Patents
Compositions and methods for immunotherapyInfo
- Publication number
- ZA202306503B ZA202306503B ZA2023/06503A ZA202306503A ZA202306503B ZA 202306503 B ZA202306503 B ZA 202306503B ZA 2023/06503 A ZA2023/06503 A ZA 2023/06503A ZA 202306503 A ZA202306503 A ZA 202306503A ZA 202306503 B ZA202306503 B ZA 202306503B
- Authority
- ZA
- South Africa
- Prior art keywords
- cells
- methods
- antigen
- immunotherapy
- compositions
- Prior art date
Links
Classifications
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Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2948544A4 (en) | 2013-01-28 | 2016-08-03 | St Jude Childrens Res Hospital | CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES |
| IL311390A (en) | 2013-03-15 | 2024-05-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
| WO2014165707A2 (en) * | 2013-04-03 | 2014-10-09 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted t-cells derived from pluripotent stem cells |
| MX373687B (es) | 2013-11-21 | 2020-07-07 | Ucl Business Ltd | Célula natural (nk) |
| DK3143134T3 (da) | 2014-05-15 | 2021-01-04 | Nat Univ Singapore | Modificerede, naturlige dræberceller og anvendelser deraf |
| WO2016075612A1 (en) | 2014-11-12 | 2016-05-19 | Rinat Neuroscience Corp. | Inhibitory chimeric antigen receptors |
| ES2819553T3 (es) | 2014-12-03 | 2021-04-16 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| PL3560953T3 (pl) | 2014-12-24 | 2024-05-13 | Autolus Limited | Komórka |
| WO2016123100A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| JP7237449B2 (ja) * | 2015-02-27 | 2023-03-13 | アイセル・ジーン・セラピューティクス・エルエルシー | 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法 |
| WO2016179319A1 (en) * | 2015-05-04 | 2016-11-10 | Cellerant Therapeutics, Inc. | Chimeric antigen receptors with ctla4 signal transduction domains |
| PL3298033T5 (pl) | 2015-05-18 | 2023-10-30 | TCR2 Therapeutics Inc. | Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych |
| GB201509413D0 (en) * | 2015-06-01 | 2015-07-15 | Ucl Business Plc | Fusion protein |
| CA2997551A1 (en) | 2015-09-04 | 2017-03-09 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
| US20180291080A1 (en) * | 2015-09-28 | 2018-10-11 | Trustees Of Dartmouth College | Chimeric antigen receptor, regulatory cells and methods of use |
| SG11201803145RA (en) | 2015-11-04 | 2018-05-30 | Fate Therapeutics Inc | Methods and compositions for inducing hematopoietic cell differentiation |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| US20210206826A1 (en) * | 2015-11-19 | 2021-07-08 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| JP7123794B2 (ja) | 2015-12-09 | 2022-08-23 | メモリアル スローン ケタリング キャンサー センター | 免疫細胞組成物及びそれを使用する方法 |
| CN109073635A (zh) | 2016-01-25 | 2018-12-21 | 豪夫迈·罗氏有限公司 | 用于测定t细胞依赖性双特异性抗体的方法 |
| CN105567640A (zh) * | 2016-01-27 | 2016-05-11 | 苏州佰通生物科技有限公司 | 一种嵌合抗原受体脂肪干细胞及其制备方法 |
| US11768203B2 (en) * | 2016-03-31 | 2023-09-26 | University Of Southern California | Highly sensitive and specific luciferase based reporter assay for antigen detection |
| CN121102467A (zh) | 2016-04-22 | 2025-12-12 | 克莱格医学有限公司 | 用于细胞免疫疗法的组合物和方法 |
| WO2017203356A1 (en) * | 2016-05-25 | 2017-11-30 | The Council Of The Queensland Institute Of Medical Research | Methods of immunotherapy |
| CN105950561A (zh) * | 2016-05-26 | 2016-09-21 | 江苏杰晟生物科技有限公司 | 一种靶向乳腺癌干细胞的双特异性嵌合抗原受体基因修饰的t淋巴细胞的制备方法及其产品 |
| EP4011381A1 (en) * | 2016-06-03 | 2022-06-15 | Memorial Sloan-Kettering Cancer Center | Adoptive cell therapies as early treatment options |
| CA3032498A1 (en) | 2016-08-02 | 2018-02-08 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| GB201614162D0 (en) * | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| CN109863242A (zh) | 2016-08-30 | 2019-06-07 | 纪念斯隆-凯特林癌症中心 | 用于治疗病毒感染和其它感染的免疫细胞组合物和使用方法 |
| BR112019006006A2 (pt) * | 2016-09-28 | 2019-06-25 | Gavish-Galilee Bio Applications Ltd. | molécula de ácido nucleico, vetor, métodos para preparação de um receptor de antígeno quimérico inibidor, para preparar uma célula imune efetora segura, para selecionar um biomarcador personalizado e para tratar o câncer em um paciente com um tumor, célula imune efetora segura, e, combinação de duas ou mais moléculas de ácido nucleico. |
| WO2018067993A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CN107988164B (zh) | 2016-10-26 | 2020-07-07 | 阿思科力(苏州)生物科技有限公司 | 一种pd-1 car nk-92细胞及其制备方法与应用 |
| EP3315511A1 (en) * | 2016-10-29 | 2018-05-02 | Miltenyi Biotec GmbH | Adapter chimeric antigen receptor expressing cells for targeting of multiple antigens |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法 |
| CN108204958A (zh) * | 2016-12-19 | 2018-06-26 | 伊缪泰普有限公司 | 结合测定 |
| CN110381989A (zh) * | 2016-12-21 | 2019-10-25 | 丹麦技术大学 | 用于免疫细胞操作的抗原呈递支架 |
| EP3567049A4 (en) * | 2016-12-28 | 2020-08-26 | Green Cross Lab Cell Corporation | CHEMERICAL ANTIGENIC RECEPTOR AND NATURAL KILLER CELLS EXPRESSING THE SAME |
| EP3592368A1 (en) * | 2017-03-08 | 2020-01-15 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| CA3056591A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| CN107034237B (zh) * | 2017-03-31 | 2018-10-16 | 北京呈诺医学科技有限公司 | 一种car-nk细胞及其制备方法与应用 |
| EP3612210A4 (en) * | 2017-04-19 | 2021-01-27 | Board Of Regents, The University Of Texas System | MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS |
| GB201707779D0 (en) * | 2017-05-15 | 2017-06-28 | Autolus Ltd | Cell |
| MA48781A (fr) * | 2017-06-02 | 2020-04-08 | Juno Therapeutics Inc | Articles de fabrication et procédés liés à la toxicité associée à la thérapie cellulaire |
| WO2019068007A1 (en) | 2017-09-28 | 2019-04-04 | Immpact-Bio Ltd. | UNIVERSAL PLATFORM FOR PREPARING AN INHIBITORY CHIMERIC ANTIGEN RECEPTOR (ICAR) |
| CN109593721B (zh) * | 2017-09-30 | 2022-11-01 | 亘喜生物科技(上海)有限公司 | 具有自杀基因开关的靶向人间皮素的工程化免疫细胞 |
| GB201717524D0 (en) | 2017-10-25 | 2017-12-06 | Autolus Ltd | Vectors |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| KR102774451B1 (ko) | 2017-11-14 | 2025-02-28 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| EP3720882A4 (en) | 2017-12-05 | 2021-10-27 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | T-CELLS WITH TWO DIFFERENT CHIMERIC ANTIGEN RECEPTORS AND THEIR USE |
| EP3720883B1 (en) | 2017-12-05 | 2023-04-19 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | T-cells comprising anti-cd38 and anti-cd138 chimeric antigen receptors and uses thereof |
| GB201721802D0 (en) * | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| JP7416695B2 (ja) | 2017-12-29 | 2024-01-17 | メモリアル スローン-ケタリング キャンサー センター | 増強されたキメラ抗原受容体およびその使用 |
| EP3735265A4 (en) | 2018-01-03 | 2021-11-10 | Qu Biologics Inc. | INNATE TARGETING OF ADOPTIVE CELL THERAPIES |
| EP3749685A4 (en) | 2018-02-09 | 2021-12-22 | National University of Singapore | ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY |
| CN109321530B (zh) * | 2018-02-12 | 2021-03-12 | 华东师范大学 | 一种安全型嵌合抗原受体t细胞及其用途 |
| US12473336B2 (en) | 2018-02-21 | 2025-11-18 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses thereof |
| JP7334985B2 (ja) | 2018-04-02 | 2023-08-29 | ナショナル ユニヴァーシティー オブ シンガポール | 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和 |
| CN111954527A (zh) * | 2018-04-09 | 2020-11-17 | 梅约医学教育与研究基金会 | 治疗移植物抗宿主病的方法和材料 |
| CN110526984A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向psma的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN110526976A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向psma的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| SG11202008731XA (en) * | 2018-06-19 | 2020-10-29 | Nanjing Legend Biotech Co Ltd | Engineered cells and uses thereof |
| TW202016144A (zh) * | 2018-06-21 | 2020-05-01 | 日商第一三共股份有限公司 | 包括cd3抗原結合片段之組成物及其用途 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| CN113166226B (zh) * | 2018-09-28 | 2025-06-27 | 纪念斯隆-凯特琳癌症中心 | 表达显性负性fas的免疫应答细胞及其用途 |
| BR112021006100A2 (pt) * | 2018-09-28 | 2021-07-20 | Immpact-Bio Ltd. | métodos para identificação de pares de receptor de antígeno ativador (acar)/receptor de antígeno quimérico inibitório (icar) para uso em terapias de câncer |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3873540A4 (en) | 2018-10-31 | 2022-07-27 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR THE TREATMENT OF CANCER |
| WO2020092839A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2020097395A1 (en) | 2018-11-08 | 2020-05-14 | The Regents Of The University Of California | Systems and methods for targeting cancer cells |
| CA3120563A1 (en) | 2018-11-26 | 2020-06-04 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| CN109517799B (zh) * | 2018-11-30 | 2022-07-26 | 北京美康基免生物科技有限公司 | 一种基于cd19和cd22的双重嵌合抗原受体基因修饰的免疫细胞及其应用 |
| ES3051182T3 (en) | 2019-01-23 | 2025-12-26 | Miltenyi Biotec Bv & Co Kg | A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject |
| AU2020226401A1 (en) * | 2019-02-18 | 2021-10-14 | Memorial Sloan-Kettering Cancer Center | Combinations of multiple chimeric antigen receptors for immunotherapy |
| EP3773918A4 (en) | 2019-03-05 | 2022-01-05 | Nkarta, Inc. | CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY |
| TW202110873A (zh) | 2019-04-30 | 2021-03-16 | 美商聖堤生物科技股份有限公司 | 嵌合受體及其使用方法 |
| CN110592014A (zh) * | 2019-08-14 | 2019-12-20 | 广东美赛尔细胞生物科技有限公司 | 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法 |
| JP2022546315A (ja) * | 2019-08-20 | 2022-11-04 | センティ バイオサイエンシズ インコーポレイテッド | キメラ抑制性受容体 |
| WO2021041920A1 (en) * | 2019-08-28 | 2021-03-04 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EP4025594A2 (en) * | 2019-09-05 | 2022-07-13 | Migal Galilee Research Institute Ltd. | Blocking chimeric antigen receptors for prevention of undesired activation of effector and regulatory immune cells |
| US20220372092A1 (en) * | 2019-10-18 | 2022-11-24 | Board Of Regents, The University Of Texas System | Hla-restricted vcx/y peptides and t cell receptors and use thereof |
| CN115052887B (zh) | 2019-12-11 | 2026-03-31 | A2生物治疗公司 | 基于lilrb1的嵌合抗原受体 |
| WO2021156277A1 (en) | 2020-02-04 | 2021-08-12 | Miltenyi Biotec B.V. & Co. KG | Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens |
| EP4107175A4 (en) * | 2020-02-20 | 2024-03-20 | Senti Biosciences, Inc. | ARCHITECTURES OF INHIBITORY CHIMERIC RECEPTORS |
| CN111249314B (zh) * | 2020-03-03 | 2022-03-29 | 深圳未知君生物科技有限公司 | 人体共生菌群在提高肿瘤免疫治疗应答中的作用 |
| WO2021234006A1 (en) * | 2020-05-20 | 2021-11-25 | Miltenyi Biotec B.V. & Co. KG | Compositions and methods for treating cancer expressing cd90 and cd326 |
| US12286465B2 (en) | 2020-05-28 | 2025-04-29 | Miltenyi Biotec B.V. & Co. KG | Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains |
| WO2022007784A1 (en) * | 2020-07-06 | 2022-01-13 | Nanjing Legend Biotech Co., Ltd. | Methods of reducing graft rejection of allogeneic cell therapy |
| WO2022015955A1 (en) | 2020-07-16 | 2022-01-20 | Umoja Biopharma, Inc. | Gated adapter targeting receptor |
| WO2022036065A2 (en) * | 2020-08-13 | 2022-02-17 | A2 Biotherapeutics, Inc. | Compositions and methods for treating cancers |
| JP7570653B2 (ja) * | 2020-08-19 | 2024-10-22 | ▲蘇▼州易慕峰生物科技有限公司 | ヒト化抗体、キメラ抗原受容体、核酸、ベクター、細胞及び応用 |
| WO2022040444A1 (en) | 2020-08-20 | 2022-02-24 | A2 Biotherapeutics, Inc. | Compositions and methods for treating egfr positive cancers |
| IL300500A (en) | 2020-08-20 | 2023-04-01 | A2 Biotherapeutics Inc | Preparations and methods for the treatment of mesothelin positive cancer |
| CA3188867A1 (en) | 2020-08-20 | 2022-02-24 | Xueyin Wang | Compositions and methods for treating ceacam positive cancers |
| US20220090013A1 (en) * | 2020-09-21 | 2022-03-24 | A2 Biotherapeutics, Inc. | Engineering immune cells based on antigen levels |
| WO2022096664A1 (en) | 2020-11-09 | 2022-05-12 | Miltenyi Biotec B.V. & Co. KG | Methods and compositions for eliminating engineered immune cells |
| CN114569708B (zh) * | 2020-12-02 | 2023-07-04 | 四川大学华西医院 | Nkg2d car-免疫细胞在抗衰老中应用 |
| WO2022116877A1 (en) | 2020-12-02 | 2022-06-09 | Shanghai Henlius Biotech, Inc. | ANTI-GARP/TGFβ ANTIBODIES AND METHODS OF USE |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| EP4255454A4 (en) * | 2020-12-07 | 2025-01-08 | The Johns Hopkins University | NATURAL KILLER CELL ENGINEERING METHODS TO ENHANCE TUMOR TARGETING |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| CN114853900A (zh) * | 2021-02-03 | 2022-08-05 | 南京北恒生物科技有限公司 | 新型嵌合抗原受体及其用途 |
| WO2022177979A1 (en) | 2021-02-16 | 2022-08-25 | A2 Biotherapeutics, Inc. | Compositions and methods for treating her2 positive cancers |
| CA3213040A1 (en) * | 2021-03-22 | 2022-09-29 | Michel Sadelain | Cd38 chimeric co-stimulating receptor and uses thereof |
| WO2023057285A1 (en) | 2021-10-06 | 2023-04-13 | Miltenyi Biotec B.V. & Co. KG | Method for targeted gene insertion into immune cells |
| KR20240116755A (ko) | 2021-12-17 | 2024-07-30 | 상하이 헨리우스 바이오테크, 인크. | 항-ox40 항체, 다중 특이적 항체 및 이의 사용 방법 |
| KR20240122784A (ko) | 2021-12-17 | 2024-08-13 | 상하이 헨리우스 바이오테크, 인크. | 항-ox40 항체 및 사용 방법 |
| CA3245762A1 (en) | 2022-03-25 | 2023-09-28 | Shanghai Henlius Biologics Co., Ltd. | ANTI-MSLN ANTIBODIES AND METHODS OF USE |
| WO2024078995A1 (en) | 2022-10-15 | 2024-04-18 | Miltenyi Biotec B.V. & Co. KG | Transduction of gammadelta t cells with pseudotyped retroviral vectors |
| CN116785458A (zh) * | 2023-02-14 | 2023-09-22 | 青岛大学 | 半滑舌鳎抗病蛋白shp-1基因的应用 |
| CN116376844B (zh) * | 2023-05-31 | 2023-08-11 | 四川大学华西医院 | 包含shp2 sh2结构域的靶向her2阳性肿瘤的car-t及制备方法和应用 |
| CN119119191B (zh) * | 2024-09-13 | 2025-04-01 | 渤海大学 | 一种海参肠多肽及其在制备胃部疾病药物中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1975A (en) | 1841-02-12 | Manner of constructing corn-shellers | ||
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US8496927B2 (en) | 2006-09-25 | 2013-07-30 | National University Corporation Nagoya University | CD20 negatively converted B-cell malignant lymphoma cell line and utilization thereof |
| EP2126054B1 (en) * | 2007-01-31 | 2016-07-06 | Yeda Research And Development Company Limited | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
| SI2856876T1 (en) * | 2007-03-30 | 2018-04-30 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| MX2014001222A (es) * | 2011-07-29 | 2014-09-15 | Univ Pennsylvania | Receptores coestimuladores de cambio. |
| WO2014055657A1 (en) * | 2012-10-05 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| AU2013204922B2 (en) * | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| CN113005091A (zh) | 2013-02-06 | 2021-06-22 | 细胞基因公司 | 具有改进特异性的修饰的t淋巴细胞 |
| CN113684185A (zh) * | 2013-02-26 | 2021-11-23 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| WO2014145252A2 (en) * | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| IL311390A (en) * | 2013-03-15 | 2024-05-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
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