SA515361180B1 - تركيبات وطرق للعلاج المناعي - Google Patents

تركيبات وطرق للعلاج المناعي Download PDF

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SA515361180B1
SA515361180B1 SA515361180A SA515361180A SA515361180B1 SA 515361180 B1 SA515361180 B1 SA 515361180B1 SA 515361180 A SA515361180 A SA 515361180A SA 515361180 A SA515361180 A SA 515361180A SA 515361180 B1 SA515361180 B1 SA 515361180B1
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cells
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car
icar
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SA515361180A
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دي. فيدروف فيكتور
ساديلين مايكل
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ميموريال سلوان-كيترينج كانسر سينتر
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Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
EP4098275A1 (en) * 2013-03-15 2022-12-07 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
WO2014165707A2 (en) * 2013-04-03 2014-10-09 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
RU2717984C2 (ru) 2013-11-21 2020-03-27 ЮСиЭл БИЗНЕС ЛТД Клетка
SG11201609118RA (en) 2014-05-15 2016-11-29 Univ Singapore Modified natural killer cells and uses thereof
AU2015344769B2 (en) * 2014-11-12 2020-07-09 Allogene Therapeutics, Inc. Inhibitory chimeric antigen receptors
US11266739B2 (en) 2014-12-03 2022-03-08 Juno Therapeutics, Inc. Methods and compositions for adoptive cell therapy
KR102376242B1 (ko) 2014-12-24 2022-03-21 오토러스 리미티드 세포
JP6800859B2 (ja) 2015-01-26 2020-12-16 フェイト セラピューティクス,インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
CA2977106A1 (en) * 2015-02-27 2016-09-01 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof
WO2016179319A1 (en) * 2015-05-04 2016-11-10 Cellerant Therapeutics, Inc. Chimeric antigen receptors with ctla4 signal transduction domains
PT3298033T (pt) 2015-05-18 2020-09-22 Tcr2 Therapeutics Inc Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão
GB201509413D0 (en) * 2015-06-01 2015-07-15 Ucl Business Plc Fusion protein
HK1258041A1 (zh) 2015-09-04 2019-11-01 纪念斯隆-凯特林癌症中心 免疫细胞组合物和使用方法
US20180291080A1 (en) * 2015-09-28 2018-10-11 Trustees Of Dartmouth College Chimeric antigen receptor, regulatory cells and methods of use
EP4249074A3 (en) 2015-11-04 2024-01-10 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
CN115927199A (zh) 2015-11-04 2023-04-07 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
WO2017087723A1 (en) * 2015-11-19 2017-05-26 The Regents Of The University Of California Conditionally repressible immune cell receptors and methods of use thereof
AU2016366226B2 (en) 2015-12-09 2023-06-01 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of using same
JP7438662B2 (ja) 2016-01-25 2024-02-27 ジェネンテック, インコーポレイテッド T細胞依存性二重特異的抗体をアッセイするための方法
CN105567640A (zh) * 2016-01-27 2016-05-11 苏州佰通生物科技有限公司 一种嵌合抗原受体脂肪干细胞及其制备方法
US11768203B2 (en) * 2016-03-31 2023-09-26 University Of Southern California Highly sensitive and specific luciferase based reporter assay for antigen detection
WO2018018958A1 (en) 2016-04-22 2018-02-01 Carsgen Therapeutics Co., Ltd. Compositions and methods of cellular immunotherapy
KR20190028662A (ko) * 2016-05-25 2019-03-19 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 면역요법의 방법
CN105950561A (zh) * 2016-05-26 2016-09-21 江苏杰晟生物科技有限公司 一种靶向乳腺癌干细胞的双特异性嵌合抗原受体基因修饰的t淋巴细胞的制备方法及其产品
JP2019517518A (ja) * 2016-06-03 2019-06-24 メモリアル スローン ケタリング キャンサー センター 早期治療選択肢としての養子細胞療法
AU2017306432A1 (en) 2016-08-02 2019-03-21 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
GB201614162D0 (en) * 2016-08-18 2016-10-05 Polytherics Ltd Antibodies, uses thereof and conjugates thereof
AU2017319151B2 (en) 2016-08-30 2024-01-11 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use for treating viral and other infections
BR112019006006A2 (pt) * 2016-09-28 2019-06-25 Gavish Galilee Bio Appl Ltd molécula de ácido nucleico, vetor, métodos para preparação de um receptor de antígeno quimérico inibidor, para preparar uma célula imune efetora segura, para selecionar um biomarcador personalizado e para tratar o câncer em um paciente com um tumor, célula imune efetora segura, e, combinação de duas ou mais moléculas de ácido nucleico.
CA3036745A1 (en) 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
CN107988164B (zh) 2016-10-26 2020-07-07 阿思科力(苏州)生物科技有限公司 一种pd-1 car nk-92细胞及其制备方法与应用
EP3315511A1 (en) * 2016-10-29 2018-05-02 Miltenyi Biotec GmbH Adapter chimeric antigen receptor expressing cells for targeting of multiple antigens
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
CN108204958A (zh) * 2016-12-19 2018-06-26 伊缪泰普有限公司 结合测定
WO2018115146A1 (en) * 2016-12-21 2018-06-28 Danmarks Tekniske Universitet Antigen presenting scaffolds for immune-cell manipulation
EP3567049A4 (en) 2016-12-28 2020-08-26 Green Cross Lab Cell Corporation CHEMERICAL ANTIGENIC RECEPTOR AND NATURAL KILLER CELLS EXPRESSING THE SAME
AU2018231190B2 (en) * 2017-03-08 2023-05-25 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
RU2019128544A (ru) 2017-03-27 2021-04-28 Нэшнл Юниверсити Оф Сингапур Линии стимулирующих клеток для ex vivo размножения и активации клеток-натуральных киллеров
CN110636851B (zh) 2017-03-27 2023-11-03 新加坡国立大学 截短的nkg2d嵌合受体及其在自然杀伤细胞免疫疗法中的用途
CN109097401B (zh) * 2017-03-31 2021-09-07 国健呈诺生物科技(北京)有限公司 一种重组载体CAR-CD244-antiPSMA的制备方法
CA3060443A1 (en) * 2017-04-19 2018-10-25 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
GB201707779D0 (en) * 2017-05-15 2017-06-28 Autolus Ltd Cell
AU2018275891B2 (en) * 2017-06-02 2025-02-27 Juno Therapeutics, Inc. Articles of manufacture and methods related to toxicity associated with cell therapy
CA3077174A1 (en) * 2017-09-28 2019-04-04 Immpact-Bio Ltd. A universal platform for preparing an inhibitory chimeric antigen receptor (icar)
CN109593721B (zh) * 2017-09-30 2022-11-01 亘喜生物科技(上海)有限公司 具有自杀基因开关的靶向人间皮素的工程化免疫细胞
GB201717524D0 (en) 2017-10-25 2017-12-06 Autolus Ltd Vectors
US11649294B2 (en) 2017-11-14 2023-05-16 GC Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
CN111655732B (zh) 2017-11-14 2023-09-12 Gc细胞治疗 抗her2抗体或其抗原结合片段及包含其的嵌合抗原受体
PL3720883T3 (pl) 2017-12-05 2023-09-11 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Komórki t zawierające chimeryczne receptory antygenowe anty-cd38 i anty-cd138 oraz ich zastosowania
EP3720882A4 (en) 2017-12-05 2021-10-27 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center T LYMPHOCYTES INCLUDING TWO DIFFERENT ANTIGENIC CHEMERICAL RECEPTORS AND THEIR USES
GB201721802D0 (en) * 2017-12-22 2018-02-07 Almac Discovery Ltd Ror1-specific antigen binding molecules
MX2020006834A (es) 2017-12-29 2020-09-03 Memorial Sloan Kettering Cancer Center Receptores mejorados de antigeno quimerico y usos de los mismos.
WO2019134036A1 (en) 2018-01-03 2019-07-11 Qu Biologics Inc. Innate targeting of adoptive cellular therapies
CA3089170A1 (en) 2018-02-09 2019-08-15 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN109321530B (zh) * 2018-02-12 2021-03-12 华东师范大学 一种安全型嵌合抗原受体t细胞及其用途
EP3755349A4 (en) 2018-02-21 2021-11-17 Board of Regents, The University of Texas System PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
WO2019199793A1 (en) * 2018-04-09 2019-10-17 Mayo Foundation For Medical Education And Research Methods and materials for treating graft-versus-host disease
CN110526976A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 一种靶向psma的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
CN110526984A (zh) * 2018-05-25 2019-12-03 深圳宾德生物技术有限公司 一种靶向psma的嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
CN112292147A (zh) * 2018-06-19 2021-01-29 南京传奇生物科技有限公司 工程化的细胞及其用途
TW202016144A (zh) * 2018-06-21 2020-05-01 日商第一三共股份有限公司 包括cd3抗原結合片段之組成物及其用途
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
WO2020065406A2 (en) 2018-09-28 2020-04-02 Immpact-Bio Ltd. Methods for identifying activating antigen receptor (acar)/inhibitory chimeric antigen receptor (icar) pairs for use in cancer therapies
EP3856769A4 (en) * 2018-09-28 2022-08-17 Memorial Sloan Kettering Cancer Center IMMUNOREACTIVE CELLS EXPRESSING DOMINANT NEGATIVE FAS AND USES THEREOF
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
WO2020092736A1 (en) 2018-10-31 2020-05-07 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
EP3873500A4 (en) 2018-10-31 2023-01-11 Mayo Foundation for Medical Education and Research METHODS AND MATERIALS FOR THE TREATMENT OF CANCER
CN109517799B (zh) * 2018-11-30 2022-07-26 北京美康基免生物科技有限公司 一种基于cd19和cd22的双重嵌合抗原受体基因修饰的免疫细胞及其应用
WO2020152197A1 (en) 2019-01-23 2020-07-30 Miltenyi Biotec B.V. & Co. KG A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject
EP3927735A4 (en) * 2019-02-18 2023-09-06 Memorial Sloan Kettering Cancer Center COMBINATIONS OF MULTIPLE CHIMERIC ANTIGEN RECEPTORS FOR IMMUNOTHERAPY
SG11202109057XA (en) 2019-03-05 2021-09-29 Nkarta Inc Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
KR20220016083A (ko) 2019-04-30 2022-02-08 센티 바이오사이언시스, 인코포레이티드 키메라 수용체 및 이의 사용 방법
CN110592014A (zh) * 2019-08-14 2019-12-20 广东美赛尔细胞生物科技有限公司 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法
EP4017510A4 (en) * 2019-08-20 2023-11-22 Senti Biosciences, Inc. CHIMERIC INHIBITOR RECEPTOR
US20220378822A1 (en) * 2019-08-28 2022-12-01 Senti Bioscience, Inc. Combinatorial cancer immunotherapy
WO2021044213A2 (en) * 2019-09-05 2021-03-11 Migal-galilee Research Institute Ltd. Blocking chimeric antigen receptors for prevention of undesired activation of effector and regulatory immune cells
WO2021076939A1 (en) * 2019-10-18 2021-04-22 Board Of Regents, The University Of Texas System Hla-restricted vcx/y peptides and t cell receptors and use thereof
BR112022011399A2 (pt) 2019-12-11 2022-08-30 A2 Biotherapeutics Inc Receptor de antígeno quimérico baseado em lilrb1
US20230100000A1 (en) 2020-02-04 2023-03-30 Miltenyi Biotec B.V. & Co. KG Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens
WO2021168317A1 (en) * 2020-02-20 2021-08-26 Senti Biosciences, Inc. Inhibitory chimeric receptor architectures
CN111249314B (zh) * 2020-03-03 2022-03-29 深圳未知君生物科技有限公司 人体共生菌群在提高肿瘤免疫治疗应答中的作用
EP4153218A1 (en) * 2020-05-20 2023-03-29 Miltenyi Biotec B.V. & Co. KG Compositions and methods for treating cancer expressing cd90 and cd326
US12286465B2 (en) 2020-05-28 2025-04-29 Miltenyi Biotec B.V. & Co. KG Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains
WO2022007784A1 (en) * 2020-07-06 2022-01-13 Nanjing Legend Biotech Co., Ltd. Methods of reducing graft rejection of allogeneic cell therapy
EP4182339A1 (en) 2020-07-16 2023-05-24 Umoja Biopharma, Inc. Gated adapter targeting receptor
US20230257441A1 (en) * 2020-08-13 2023-08-17 A2 Biotherapeutics, Inc. Compositions and methods for treating cancers
US20230357427A1 (en) * 2020-08-19 2023-11-09 Shanghai Immunohead Biotechnology Co., Ltd Humanized antibody, chimeric antigen receptor, nucleic acid, vector, cell and use
MX2023002041A (es) 2020-08-20 2023-04-27 A2 Biotherapeutics Inc Composiciones y métodos para tratar cánceres positivos para mesotelina.
CN116724052A (zh) 2020-08-20 2023-09-08 A2生物治疗股份有限公司 用于治疗ceacam阳性癌症的组合物和方法
HUE067417T2 (hu) 2020-08-20 2024-10-28 A2 Biotherapeutics Inc Készítmények és módszerek EGFR-pozitív rákok kezelésére
US11976297B2 (en) 2020-09-21 2024-05-07 A2 Biotherapeutics, Inc. Engineered immune cells with receptor cross-talk
WO2022096664A1 (en) 2020-11-09 2022-05-12 Miltenyi Biotec B.V. & Co. KG Methods and compositions for eliminating engineered immune cells
CN114569708B (zh) * 2020-12-02 2023-07-04 四川大学华西医院 Nkg2d car-免疫细胞在抗衰老中应用
JP2023553419A (ja) 2020-12-03 2023-12-21 センチュリー セラピューティクス,インコーポレイテッド 遺伝子操作細胞およびその使用
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
EP4255454A4 (en) * 2020-12-07 2025-01-08 The Johns Hopkins University NATURAL KILLER CELL ENGINEERING METHODS TO ENHANCE TUMOR TARGETING
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN114853900A (zh) * 2021-02-03 2022-08-05 南京北恒生物科技有限公司 新型嵌合抗原受体及其用途
EP4294828A4 (en) 2021-02-16 2025-02-26 A2 Biotherapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATING HER2-POSITIVE CANCERS
US20240336698A1 (en) * 2021-03-22 2024-10-10 Memorial Sloan Kettering Cancer Center CD38 Chimeric Co-Stimulating Receptor and Uses Thereof
US20250235477A1 (en) 2021-10-06 2025-07-24 Miltenyi Biotec B.V. & Co. KG Method for targeted gene insertion into immune cells
JP2025501522A (ja) 2021-12-17 2025-01-22 シャンハイ・ヘンリウス・バイオテック・インコーポレイテッド 抗ox40抗体及び使用方法
JP2024547020A (ja) 2021-12-17 2024-12-26 シャンハイ・ヘンリウス・バイオテック・インコーポレイテッド 抗ox40抗体、多重特異性抗体及びその使用方法
CN118974096A (zh) 2022-03-25 2024-11-15 上海复宏汉霖生物技术股份有限公司 抗msln抗体及使用方法
EP4602171A1 (en) 2022-10-15 2025-08-20 Miltenyi Biotec B.V. & Co. KG Transduction of gammadelta t cells with pseudotyped retroviral vectors
CN116785458A (zh) * 2023-02-14 2023-09-22 青岛大学 半滑舌鳎抗病蛋白shp-1基因的应用
CN116376844B (zh) * 2023-05-31 2023-08-11 四川大学华西医院 包含shp2 sh2结构域的靶向her2阳性肿瘤的car-t及制备方法和应用
CN119119191B (zh) * 2024-09-13 2025-04-01 渤海大学 一种海参肠多肽及其在制备胃部疾病药物中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1975A (en) 1841-02-12 Manner of constructing corn-shellers
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
US8496927B2 (en) 2006-09-25 2013-07-30 National University Corporation Nagoya University CD20 negatively converted B-cell malignant lymphoma cell line and utilization thereof
EP2126054B1 (en) * 2007-01-31 2016-07-06 Yeda Research And Development Company Limited Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
SI2856876T1 (en) * 2007-03-30 2018-04-30 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
EP3915588A1 (en) * 2011-07-29 2021-12-01 The Trustees of the University of Pennsylvania Switch costimulatory receptors
US10117896B2 (en) * 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
AU2013204922B2 (en) * 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
AU2014214850C1 (en) 2013-02-06 2018-12-06 Celgene Corporation Modified T lymphocytes having improved specificity
IL298125A (en) * 2013-02-26 2023-01-01 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
US9745368B2 (en) * 2013-03-15 2017-08-29 The Trustees Of The University Of Pennsylvania Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
EP4098275A1 (en) * 2013-03-15 2022-12-07 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy

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