ZA201303253B - Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-yl-thio)acetic acid and uses thereof - Google Patents

Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-yl-thio)acetic acid and uses thereof

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Publication number
ZA201303253B
ZA201303253B ZA2013/03253A ZA201303253A ZA201303253B ZA 201303253 B ZA201303253 B ZA 201303253B ZA 2013/03253 A ZA2013/03253 A ZA 2013/03253A ZA 201303253 A ZA201303253 A ZA 201303253A ZA 201303253 B ZA201303253 B ZA 201303253B
Authority
ZA
South Africa
Prior art keywords
cyclopropylnaphthalen
triazol
thio
bromo
acetic acid
Prior art date
Application number
ZA2013/03253A
Other languages
English (en)
Inventor
Laszlo R Treiber
Irina Zamansky
Jean-Luc Girardet
Gabriel Galvin
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46381300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201303253(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of ZA201303253B publication Critical patent/ZA201303253B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA2013/03253A 2010-12-30 2013-05-06 Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-yl-thio)acetic acid and uses thereof ZA201303253B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061428660P 2010-12-30 2010-12-30
PCT/US2011/067657 WO2012092395A2 (en) 2010-12-30 2011-12-28 Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-ylthio) acetic acid and uses thereof

Publications (1)

Publication Number Publication Date
ZA201303253B true ZA201303253B (en) 2016-01-27

Family

ID=46381300

Family Applications (1)

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ZA2013/03253A ZA201303253B (en) 2010-12-30 2013-05-06 Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4h-1,2,4-triazol-3-yl-thio)acetic acid and uses thereof

Country Status (29)

Country Link
US (6) US8546436B2 (enExample)
EP (1) EP2658846B1 (enExample)
JP (2) JP5781627B2 (enExample)
KR (1) KR101541629B1 (enExample)
CN (1) CN103298796B (enExample)
AR (1) AR084639A1 (enExample)
AU (1) AU2011352129B2 (enExample)
BR (1) BR112013016982A2 (enExample)
CA (1) CA2817249C (enExample)
CY (1) CY1118621T1 (enExample)
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EA (1) EA022301B1 (enExample)
ES (1) ES2614914T3 (enExample)
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HU (1) HUE031766T2 (enExample)
IL (1) IL226367A (enExample)
LT (1) LT2658846T (enExample)
MX (1) MX2013007505A (enExample)
MY (1) MY172534A (enExample)
NZ (1) NZ610104A (enExample)
PL (1) PL2658846T3 (enExample)
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RS (1) RS55667B1 (enExample)
SG (1) SG190902A1 (enExample)
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TW (1) TWI452037B (enExample)
UA (1) UA109172C2 (enExample)
WO (1) WO2012092395A2 (enExample)
ZA (1) ZA201303253B (enExample)

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CN107298660A (zh) * 2016-04-15 2017-10-27 浙江京新药业股份有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型iii
CN107298657A (zh) * 2016-04-15 2017-10-27 浙江京新药业股份有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型ii
CN107298658A (zh) * 2016-04-15 2017-10-27 浙江京新药业股份有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸轴手性对映体的晶型v
CN107337649B (zh) * 2016-04-29 2020-10-16 四川科伦药物研究院有限公司 一种乙酸钠水合物无定型及其制备方法和用途
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CN106905250A (zh) * 2017-03-07 2017-06-30 江苏艾立康药业股份有限公司 一种雷西纳德的新晶型
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CA2817249C (en) 2015-02-10
IL226367A (en) 2015-04-30
US20180235939A1 (en) 2018-08-23
WO2012092395A3 (en) 2012-09-13
SI2658846T1 (sl) 2017-03-31
EA022301B1 (ru) 2015-12-30
CY1118621T1 (el) 2017-07-12
PL2658846T3 (pl) 2017-05-31
CN103298796A (zh) 2013-09-11
US20150105410A1 (en) 2015-04-16
PT2658846T (pt) 2017-02-07
CN103298796B (zh) 2016-06-15
TWI452037B (zh) 2014-09-11
SG190902A1 (en) 2013-07-31
AU2011352129B2 (en) 2015-01-22
WO2012092395A2 (en) 2012-07-05
BR112013016982A2 (pt) 2016-10-25
UA109172C2 (xx) 2015-07-27
AR084639A1 (es) 2013-05-29
LT2658846T (lt) 2017-02-27
MX2013007505A (es) 2013-08-01
DK2658846T3 (en) 2017-02-13
KR20130105902A (ko) 2013-09-26
EP2658846A4 (en) 2014-07-02
AU2011352129A1 (en) 2013-05-02
RS55667B1 (sr) 2017-06-30
ES2614914T3 (es) 2017-06-02
TW201302718A (zh) 2013-01-16
US20190111028A1 (en) 2019-04-18
NZ610104A (en) 2014-09-26
MY172534A (en) 2019-11-29
US20130331403A1 (en) 2013-12-12
CA2817249A1 (en) 2012-07-05
IL226367A0 (en) 2013-07-31
JP2014501282A (ja) 2014-01-20
US20120172405A1 (en) 2012-07-05
HUE031766T2 (en) 2017-07-28
EA201370150A1 (ru) 2013-11-29
JP5781627B2 (ja) 2015-09-24
KR101541629B1 (ko) 2015-08-03
US8546436B2 (en) 2013-10-01
JP2015172053A (ja) 2015-10-01
HRP20170187T1 (hr) 2017-03-24
EP2658846A2 (en) 2013-11-06
EP2658846B1 (en) 2016-12-14
US9956205B2 (en) 2018-05-01
US20160250193A1 (en) 2016-09-01

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