ZA200803659B - Use of complement pathway inhibitors to treat ocular disease - Google Patents
Use of complement pathway inhibitors to treat ocular diseaseInfo
- Publication number
- ZA200803659B ZA200803659B ZA200803659A ZA200803659A ZA200803659B ZA 200803659 B ZA200803659 B ZA 200803659B ZA 200803659 A ZA200803659 A ZA 200803659A ZA 200803659 A ZA200803659 A ZA 200803659A ZA 200803659 B ZA200803659 B ZA 200803659B
- Authority
- ZA
- South Africa
- Prior art keywords
- complement pathway
- ocular disease
- pathway inhibitors
- treat ocular
- treat
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73376305P | 2005-11-04 | 2005-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200803659B true ZA200803659B (en) | 2009-07-29 |
Family
ID=38023865
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200803659A ZA200803659B (en) | 2005-11-04 | 2006-11-04 | Use of complement pathway inhibitors to treat ocular disease |
ZA2013/00649A ZA201300649B (en) | 2005-11-04 | 2013-01-24 | Use of complement pathway inhibitors to treat ocular diseases |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA2013/00649A ZA201300649B (en) | 2005-11-04 | 2013-01-24 | Use of complement pathway inhibitors to treat ocular diseases |
Country Status (29)
Country | Link |
---|---|
US (3) | US8753625B2 (de) |
EP (4) | EP2998318A1 (de) |
JP (7) | JP2009514888A (de) |
KR (6) | KR101511787B1 (de) |
CN (2) | CN101355956A (de) |
AU (1) | AU2006311803C1 (de) |
BR (1) | BRPI0619657A2 (de) |
CA (2) | CA2624393C (de) |
CR (1) | CR10041A (de) |
DK (1) | DK2500030T4 (de) |
EC (1) | ECSP088500A (de) |
ES (1) | ES2551202T5 (de) |
HK (2) | HK1175718A1 (de) |
HU (1) | HUE026423T2 (de) |
IL (3) | IL190547A (de) |
MA (1) | MA29976B1 (de) |
MX (3) | MX360959B (de) |
MY (1) | MY151064A (de) |
NO (1) | NO20082483L (de) |
NZ (2) | NZ567483A (de) |
PH (1) | PH12013501270A1 (de) |
PL (1) | PL2500030T5 (de) |
PT (1) | PT2500030E (de) |
RU (2) | RU2417099C2 (de) |
SG (1) | SG10201804008UA (de) |
SI (1) | SI2500030T2 (de) |
UA (1) | UA99591C2 (de) |
WO (1) | WO2007056227A2 (de) |
ZA (2) | ZA200803659B (de) |
Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2432112T3 (es) | 2004-02-10 | 2013-11-29 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición del factor B, de la vía alternativa del complemento y métodos relacionados |
WO2006096561A2 (en) | 2005-03-04 | 2006-09-14 | Duke University | Genetic variants increase the risk of age-related macular degeneration |
CA2610340C (en) | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
UA99591C2 (ru) | 2005-11-04 | 2012-09-10 | Дженентек, Инк. | Применение ингибиторов пути комплемента для лечения глазных болезней |
CA2656063C (en) | 2006-06-21 | 2016-10-18 | Musc Foundation For Research Development | Targeting complement factor h for treatment of diseases |
AU2007307375B2 (en) | 2006-10-10 | 2013-11-28 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
PL2097455T3 (pl) | 2006-11-02 | 2015-04-30 | Genentech Inc | Humanizowane przeciwciała przeciw czynnikowi D |
CN101668773B (zh) | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
KR20100015773A (ko) * | 2007-03-22 | 2010-02-12 | 노파르티스 아게 | C5 항원 및 그의 용도 |
AR066660A1 (es) * | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
US10131706B2 (en) | 2007-08-27 | 2018-11-20 | Novelmed Therapeutics, Inc. | Anti-factor Bb antibodies |
CN101970002B (zh) * | 2007-08-27 | 2016-05-18 | 诺福麦德治疗学股份有限公司 | 用因子Bb特异性抗体抑制补体活化的方法 |
GB0718737D0 (en) * | 2007-09-25 | 2007-11-07 | Glaxo Group Ltd | Antibodies |
MX2010005115A (es) * | 2007-11-08 | 2010-05-27 | Genentech Inc | Anticuerpos anti-factor b y sus usos. |
US20110182910A1 (en) * | 2008-03-06 | 2011-07-28 | Medof M Edward | Method of treating t cell mediated disorders |
CR20170001A (es) * | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
AU2013200637B2 (en) * | 2008-04-28 | 2015-07-16 | Genentech, Inc. | Humanized anti-Factor D antibodies and uses thereof |
SI2320925T1 (sl) * | 2008-07-10 | 2016-05-31 | Regenesance B.V. | Komplement antagonisti in njih uporaba |
MX2011001371A (es) | 2008-08-05 | 2011-06-16 | Novartis Ag | Composiciones y metodos para anticuerpos que se dirigen a la proteina de complementos c5. |
US8092013B2 (en) * | 2008-10-28 | 2012-01-10 | Johnson & Johnson Vision Care, Inc. | Apparatus and method for activation of components of an energized ophthalmic lens |
CN104887389B (zh) | 2009-01-29 | 2017-06-23 | 弗赛特影像4股份有限公司 | 后段给药 |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
EP2496259B1 (de) | 2009-11-05 | 2017-02-22 | Alexion Pharmaceuticals, Inc. | Behandlung von paroxysmaler nächtlicher hämoglobinurie |
US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
EP2533797A1 (de) | 2010-02-12 | 2012-12-19 | CeMM Forschungszentrum für Molekulare Medizin GmbH | Komplement-faktor h für krankheitsstadien bei oxidativem stress |
WO2011112993A2 (en) | 2010-03-11 | 2011-09-15 | University Of Louisville Research Foundation, Inc. | Methods of predicting and decreasing the risk of pregnancy loss |
WO2011137395A1 (en) | 2010-04-30 | 2011-11-03 | Rother Russell P | Anti-c5a antibodies and methods for using the antibodies |
US9650447B2 (en) | 2010-05-14 | 2017-05-16 | The Regents Of The University Of Colorado, A Body Corporate | Complement receptor 2 (CR2) targeting groups |
EA201291328A1 (ru) | 2010-06-22 | 2013-10-30 | Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт | АНТИТЕЛА К ФРАГМЕНТУ C3d КОМПОНЕНТА КОМПЛЕМЕНТА 3 |
WO2011163394A2 (en) | 2010-06-22 | 2011-12-29 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of neuropathic pain |
HUE057267T2 (hu) * | 2010-08-05 | 2022-05-28 | Forsight Vision4 Inc | Berendezés szem kezelésére |
US9370444B2 (en) | 2010-10-12 | 2016-06-21 | Emmett T. Cunningham, JR. | Subconjunctival conformer device and uses thereof |
US8915877B2 (en) | 2010-10-12 | 2014-12-23 | Emmett T. Cunningham, JR. | Glaucoma drainage device and uses thereof |
MX348025B (es) | 2010-11-01 | 2017-05-24 | Genentech Inc * | Prediccion del paso a degeneracion macular avanzada relacionada con la edad utilizando una puntuacion poligenica. |
WO2012068549A2 (en) | 2010-11-19 | 2012-05-24 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
WO2012075023A2 (en) * | 2010-11-29 | 2012-06-07 | Novelmed Therapeutics, Inc. | Neoantibodies for diagnosing tissue injury |
SG194780A1 (en) | 2011-05-05 | 2013-12-30 | Wellstat Immunotherapeutics Llc | Complement factor b analogs and their uses |
RU2653439C9 (ru) * | 2011-05-11 | 2018-10-16 | Апеллис Фармасьютикалс, Инк. | Клеточно-реактивные аналоги компстатина, аналоги компстатина длительного действия или аналоги компстатина нацеленного действия и их применение |
US10588879B2 (en) * | 2011-08-01 | 2020-03-17 | Aurin Biotech Inc. | Treatment of age-related macular degeneration |
SG10201703249PA (en) | 2011-12-21 | 2017-05-30 | Novartis Ag | Compositions and methods for antibodies targeting factor p |
PT2817329T (pt) * | 2012-02-20 | 2019-04-01 | Swedish Orphan Biovitrum Ab Publ | Polipeptioos que se ligam ao complemento humano c5 |
WO2013142362A1 (en) * | 2012-03-19 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Regulator of complement activation and uses thereof |
FR2988298A1 (fr) * | 2012-03-23 | 2013-09-27 | Lfb Biotechnologies | Facteur h pour son utilisation comme molecule antioxydante |
JP6244350B2 (ja) | 2012-04-03 | 2017-12-06 | ノーベルメッド セラピューティクス インコーポレイテッド. | ヒト化およびキメラ抗因子Bb抗体、ならびにその使用 |
US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
EP2855529A4 (de) | 2012-05-24 | 2015-12-09 | Alexion Pharma Inc | Humanisierte anti-faktor-b-antikörper |
EP2864322B1 (de) * | 2012-06-20 | 2016-04-27 | Novartis AG | Modulatoren des komplementweges und verwendungen davon |
KR102073312B1 (ko) | 2012-06-27 | 2020-02-05 | 엘지전자 주식회사 | 당뇨망막병증 진단용 마커 및 이의 용도 |
CN102743371A (zh) * | 2012-07-26 | 2012-10-24 | 山东省眼科研究所 | 一种治疗视网膜新生血管性疾病的药物 |
WO2014028865A1 (en) | 2012-08-17 | 2014-02-20 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
AU2013326932B2 (en) | 2012-10-04 | 2019-06-06 | Novelmed Therapeutics, Inc. | Alternative pathway specific antibodies for treating hemolytic diseases |
EP3660033B9 (de) | 2012-11-15 | 2022-06-22 | Apellis Pharmaceuticals, Inc. | Langwirkende compstatin-analoga sowie verwandte zusammensetzungen und verfahren |
BR112015018438A2 (pt) * | 2013-01-31 | 2017-07-18 | Seoul Nat Univ R&Db Foundation | anticorpo contra c5 e método para prevenir e tratar doenças relacionadas a complemento |
WO2014152959A1 (en) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
CN105229003B (zh) | 2013-03-14 | 2017-03-15 | 诺华股份有限公司 | 作为补体因子b抑制剂用于治疗眼科疾病的2‑(1h‑吲哚‑4‑基甲基)‑3h‑咪唑并[4,5‑b]吡啶‑6‑甲腈衍生物 |
WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
EP4302736A3 (de) | 2013-03-28 | 2024-04-03 | ForSight Vision4, Inc. | Ophthalmisches implantat zur abgabe von therapeutischen substanzen |
CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
SG11201510315TA (en) | 2013-07-12 | 2016-01-28 | Ophthotech Corp | Methods for treating or preventing ophthalmological conditions |
KR20180021234A (ko) * | 2013-08-12 | 2018-02-28 | 제넨테크, 인크. | 보체-연관 상태의 치료를 위한 조성물 및 방법 |
AU2014332021B2 (en) * | 2013-10-07 | 2020-05-07 | Massachusetts Eye And Ear Infirmary | Methods of preventing or reducing photoreceptor cell death |
US9676728B2 (en) | 2013-10-30 | 2017-06-13 | Novartis Ag | 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof |
CA2934462A1 (en) | 2013-12-24 | 2015-07-02 | Novelmed Therapeutics, Inc. | Compositions and methods of treating ocular diseases |
CA2939586A1 (en) * | 2014-02-27 | 2015-09-03 | Allergan, Inc. | Complement factor bb antibodies |
CA2944712A1 (en) | 2014-05-01 | 2015-11-05 | Genentech, Inc. | Anti-factor d antibody variants and uses thereof |
ES2750556T3 (es) | 2014-06-12 | 2020-03-26 | Ra Pharmaceuticals Inc | Modulación de actividad del complemento |
WO2016022750A1 (en) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
EP3183266B1 (de) * | 2014-08-20 | 2019-05-29 | Stichting Sanquin Bloedvoorziening | Faktor-h-spezifische antikörper und verwendungen davon |
CN107172879B (zh) | 2014-11-10 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 抗白细胞介素-33抗体及其用途 |
US9937222B2 (en) | 2015-01-28 | 2018-04-10 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
CN108291216B (zh) * | 2015-09-24 | 2022-09-16 | 宾夕法尼亚州大学信托人 | 用于治疗补体介导的疾病的组合物和方法 |
EP3359555B1 (de) | 2015-10-07 | 2023-12-20 | Apellis Pharmaceuticals, Inc. | Dosierpläne |
US10654932B2 (en) | 2015-10-30 | 2020-05-19 | Genentech, Inc. | Anti-factor D antibody variant conjugates and uses thereof |
JP2018534930A (ja) | 2015-10-30 | 2018-11-29 | ジェネンテック, インコーポレイテッド | 抗d因子抗体及びコンジュゲート |
EP3368682B1 (de) | 2015-10-30 | 2019-12-11 | H. Hoffnabb-La Roche Ag | Verfahren zur messung der faktor-d-aktivität und potenz von faktor-d-inhibitoren |
PT3685847T (pt) | 2015-12-16 | 2023-03-14 | Ra Pharmaceuticals Inc | Moduladores de atividade de complemento |
JP7199966B2 (ja) | 2015-12-23 | 2023-01-06 | ソルボンヌ ウニベルシテ | CD11b/CD18に対するCFHの結合を阻害する薬剤、およびその使用 |
AU2017210042B2 (en) | 2016-01-20 | 2021-01-21 | 396419 B.C. Ltd. | Compositions and methods for inhibiting Factor D |
IL311675A (en) | 2016-04-04 | 2024-05-01 | Bioverativ Usa Inc | Anti-complement factor BB antibodies and their uses |
SI3468990T1 (sl) | 2016-06-14 | 2024-07-31 | Regeneron Pharmaceuticals, Inc. | Protitelesa proti-C in njihove uporabe |
EP3551210A1 (de) | 2016-12-07 | 2019-10-16 | RA Pharmaceuticals, Inc. | Modulatoren der komplementaktivität |
WO2018136827A1 (en) | 2017-01-20 | 2018-07-26 | Vitrisa Therapeutics, Inc. | Stem-loop compositions and methods for inhibiting factor d |
KR20230173731A (ko) | 2017-01-30 | 2023-12-27 | 알렉시온 파마슈티칼스, 인코포레이티드 | 1가 항-프로페르딘 항체 및 항체 단편 |
EP3580241A4 (de) * | 2017-02-10 | 2021-01-06 | The Trustees Of The University Of Pennsylvania | Antifaktor-d-antikörper und verwendungen davon |
CA3059304A1 (en) | 2017-04-07 | 2018-10-11 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
AU2018250695A1 (en) | 2017-04-14 | 2019-11-07 | Kodiak Sciences Inc. | Complement factor D antagonist antibodies and conjugates thereof |
JP2020532285A (ja) | 2017-07-11 | 2020-11-12 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 補体成分c5または血清アルブミンと結合するポリペプチドおよびその融合タンパク質 |
EP3694874A1 (de) * | 2017-10-11 | 2020-08-19 | Bioverativ USA Inc. | Verfahren zur induktion von komplementaktivität |
MX2020005547A (es) | 2017-12-04 | 2020-08-20 | Ra Pharmaceuticals Inc | Moduladores de la actividad del complemento. |
MX2020006113A (es) | 2017-12-13 | 2020-08-24 | Regeneron Pharma | Combinaciones de anticuerpos anti-c5 y usos de las mismas. |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
MX2020010323A (es) | 2018-04-03 | 2021-01-08 | Ngm Biopharmaceuticals Inc | Agentes de union al componente del complemento c3 (c3) y metodos para su uso. |
EP3791180A1 (de) * | 2018-05-10 | 2021-03-17 | The University Of Manchester | Verfahren zur beurteilung von makuladegeneration |
EP3586865A1 (de) * | 2018-06-21 | 2020-01-01 | Charité - Universitätsmedizin Berlin | Ergänzende anaphylatoxinbindemittel und deren verwendung in der behandlung einer person mit okularer wunde und/oder fibrose |
CN113543796A (zh) | 2019-03-08 | 2021-10-22 | Ra制药公司 | 齐鲁考普作为深层组织穿透性c5抑制剂 |
US20230115176A1 (en) | 2019-03-29 | 2023-04-13 | Ra Pharmaceuticals, Inc. | Complement Modulators and Related Methods |
WO2020219822A1 (en) | 2019-04-24 | 2020-10-29 | Ra Pharmaceuticals, Inc. | Compositions and methods for modulating complement activity |
KR20220057530A (ko) | 2019-07-17 | 2022-05-09 | 제미니 테라퓨틱스 서브, 인코포레이티드 | 인자 h 강화 항체 및 이의 용도 |
KR102428619B1 (ko) | 2019-09-25 | 2022-08-04 | 대구가톨릭대학교산학협력단 | 망막병증 치료용 약물 방출 콘택트렌즈 및 이의 제조방법 |
MX2022011156A (es) | 2020-03-13 | 2022-10-13 | Genentech Inc | Anticuerpos anti-interleucina-33 y usos de estos. |
AU2021261257A1 (en) | 2020-04-20 | 2022-12-22 | Genzyme Corporation | Humanized anti-complement factor Bb antibodies and uses thereof |
CN114686481B (zh) * | 2020-12-31 | 2023-08-15 | 北京键凯科技股份有限公司 | 一种抑制cfd表达的干扰rna及其制备方法和应用 |
TW202415387A (zh) * | 2022-06-30 | 2024-04-16 | 美商伊維希比奥公司 | 用於治療眼科疾患之持續釋放二氧化矽水凝膠複合物及其使用方法 |
Family Cites Families (144)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5022A (en) * | 1847-03-20 | Alfred stillman | ||
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
CA1319120C (en) | 1985-04-01 | 1993-06-15 | John Henry Kenten | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5256642A (en) * | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
ATE120454T1 (de) | 1988-06-14 | 1995-04-15 | Cetus Oncology Corp | Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus. |
US4925648A (en) | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
EP0368684B2 (de) | 1988-11-11 | 2004-09-29 | Medical Research Council | Klonierung von Immunglobulin sequenzen aus den variabelen Domänen. |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IE63847B1 (en) | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
ATE144793T1 (de) | 1989-06-29 | 1996-11-15 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
AU654811B2 (en) | 1990-03-20 | 1994-11-24 | Trustees Of Columbia University In The City Of New York, The | Chimeric antibodies with receptor binding ligands in place of their constant region |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
DK0814159T3 (da) | 1990-08-29 | 2005-10-24 | Genpharm Int | Transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
CA2092323A1 (en) | 1990-10-01 | 1992-04-02 | George Y. Wu | Targeting viruses and cells for selective internalization by cells |
ES2129029T5 (es) | 1990-10-05 | 2005-10-16 | Celldex Therapeutics, Inc. | Inmunoestimulacion dirigida con reactivos biespecificos. |
EP0557300B1 (de) | 1990-10-29 | 1997-11-19 | Chiron Corporation | Bispezifische antikörper, verfahren zu ihrer herstellung und deren verwendungen |
CA2095836C (en) | 1990-11-09 | 1999-04-06 | Stephen D. Gillies | Cytokine immunoconjugates |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
AU665758B2 (en) | 1991-04-26 | 1996-01-18 | Surface Active Limited | Novel antibodies, and methods for their use |
ATE199647T1 (de) | 1991-05-14 | 2001-03-15 | Univ Connecticut | Gerichtete abgabe von genen, die immunogene proteine kodieren |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
ATE195656T1 (de) | 1991-06-05 | 2000-09-15 | Univ Connecticut | Zielgerichtete freisetzung von genen, die sekretorische proteine kodieren |
LU91067I2 (fr) * | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
ES2241710T3 (es) | 1991-11-25 | 2005-11-01 | Enzon, Inc. | Procedimiento para producir proteinas multivalentes de union a antigeno. |
ES2313867T3 (es) | 1991-12-02 | 2009-03-16 | Medical Research Council | Produccion de anticuerpos anti-auto de repertorios de segmentos de anticuerpo expresados en la superficie de fagos. |
AU3434393A (en) | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
DE69332948T2 (de) | 1992-03-05 | 2003-11-27 | Board Of Regents, The University Of Texas System | Verwendung von Immunokonjugate zur Diagnose und/oder Therapie der vaskularisierten Tumoren |
WO1993020221A1 (en) | 1992-04-03 | 1993-10-14 | Young Alexander T | Gene therapy using targeted viral vectors |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
HU218069B (hu) | 1992-06-09 | 2000-05-28 | Hoppe Ag. | Kilincses zárrendszer |
US5456909A (en) * | 1992-08-07 | 1995-10-10 | T Cell Sciences, Inc. | Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo |
EP0749475A4 (de) | 1992-08-26 | 1997-05-07 | Harvard College | Verwendung des cytokins ip-10 als anti-tumor agenz |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
ATE200625T1 (de) | 1992-10-09 | 2001-05-15 | Advanced Tissue Sciences Inc | Leberreservezellen |
AU680459B2 (en) | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
US5861156A (en) * | 1993-01-08 | 1999-01-19 | Creative Biomolecules | Methods of delivering agents to target cells |
US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
US5856300A (en) * | 1994-05-12 | 1999-01-05 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
US5679546A (en) * | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
US5627264A (en) * | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
AU2191795A (en) * | 1994-03-23 | 1995-10-09 | Alexion Pharmaceuticals, Inc. | Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation |
US5534615A (en) * | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
US5679564A (en) * | 1994-10-05 | 1997-10-21 | Antex Biologics, Inc. | Methods for producing enhanced antigenic campylobacter bacteria and vaccines |
EP1709970A1 (de) | 1995-04-27 | 2006-10-11 | Abgenix, Inc. | Menschliche Antikörper gegen EGFR, von immunisierten transgenen Mäusen produziert |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
AU715543B2 (en) | 1995-09-08 | 2000-02-03 | Genzyme Corporation | Improved AAV vectors for gene therapy |
AU5711196A (en) | 1996-03-14 | 1997-10-01 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
JP2000508522A (ja) | 1996-03-22 | 2000-07-11 | ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド | アポトーシス誘導分子ii |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
WO2002008284A2 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
CA2273194C (en) | 1996-12-03 | 2011-02-01 | Abgenix, Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
US20050197285A1 (en) * | 1997-03-07 | 2005-09-08 | Rosen Craig A. | Human secreted proteins |
US6472520B2 (en) * | 1997-03-21 | 2002-10-29 | The Trustees Of Columbia University In The City Of New York | Rat PEG-3 promoter |
WO1999027098A2 (en) | 1997-11-21 | 1999-06-03 | Genentech, Inc. | A-33 related antigens and their pharmacological uses |
TR199902553T2 (xx) | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�. |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US6410708B1 (en) * | 1997-11-21 | 2002-06-25 | Genentech, Inc. | Nucleic acids encoding A-33 related antigen polypeptides |
ATE335511T1 (de) * | 1997-08-26 | 2006-09-15 | Amgen Fremont Inc | Ein verfahren zur inhibierung der komplementaktivierung über einen alternativen weg |
US6642051B1 (en) | 1997-10-21 | 2003-11-04 | Targeted Genetics Corporation | Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors |
KR20010031713A (ko) | 1997-11-03 | 2001-04-16 | 벤슨 로버트 에이치. | 맥관형성 및 종양 성장 억제제인 맥관 내피 세포 성장억제제 |
US6595142B2 (en) | 1997-11-13 | 2003-07-22 | M.C.M. Holding A/S | Floor for a transport means and profiles for the construction thereof as well as a vehicle provided with such a floor |
US7282565B2 (en) * | 1998-03-20 | 2007-10-16 | Genentech, Inc. | PRO362 polypeptides |
US7419663B2 (en) * | 1998-03-20 | 2008-09-02 | Genentech, Inc. | Treatment of complement-associated disorders |
US8088386B2 (en) * | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
US8007798B2 (en) * | 1997-11-21 | 2011-08-30 | Genentech, Inc. | Treatment of complement-associated disorders |
US7192589B2 (en) * | 1998-09-16 | 2007-03-20 | Genentech, Inc. | Treatment of inflammatory disorders with STIgMA immunoadhesins |
AU2577799A (en) | 1998-02-09 | 1999-08-23 | Human Genome Sciences, Inc. | 45 human secreted proteins |
ES2488819T3 (es) * | 1998-02-20 | 2014-08-29 | Genentech, Inc. | Inhibidores de la activación del complemento |
US6956107B2 (en) | 1998-02-20 | 2005-10-18 | Tanox, Inc. | Inhibitors of complement activation |
US7112327B2 (en) * | 1998-02-20 | 2006-09-26 | Tanox, Inc. | Inhibition of complement activation |
PT1490386E (pt) | 1998-03-10 | 2008-11-24 | Genentech Inc | Novos polipéptidos e ácidos nucleicos que os codificam |
AU5587799A (en) | 1998-08-27 | 2000-03-21 | Incyte Pharmaceuticals, Inc. | Protein transport-associated molecules |
EP1141285A2 (de) | 1998-12-16 | 2001-10-10 | Genentech, Inc. | Ausgeschiedene und transmembran-polypeptide und dafür kodierende nukleinsäure |
JP3993746B2 (ja) | 1998-12-22 | 2007-10-17 | ジェネンテック・インコーポレーテッド | 腫瘍性細胞成長阻害のための組成物及び方法 |
KR101155191B1 (ko) | 1999-01-15 | 2012-06-13 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
CA2362427A1 (en) | 1999-03-08 | 2000-09-14 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
CZ303128B6 (cs) | 1999-03-11 | 2012-04-18 | Laboratoires Serono Sa | Adhezní molekula 1 regulovaná konfluencí CRAM-1, její kódující nukleová kyselina, protilátky a použití |
US6642353B1 (en) * | 1999-03-17 | 2003-11-04 | Chugai Seiyaku Kabushiki Kaisha | Peptide ligands for the erythropoietin receptor |
AU2883900A (en) | 1999-07-07 | 2001-01-30 | Genentech Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
JP2003514541A (ja) | 1999-11-19 | 2003-04-22 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 18個のヒト分泌タンパク質 |
EP1690872A3 (de) | 1999-12-01 | 2006-08-23 | Genentech, Inc. | Zusammensetzung und Verfahren zur Diagnose eines Tumors |
US6821775B1 (en) * | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
ATE435873T1 (de) | 2000-03-23 | 2009-07-15 | Genentech Inc | Anti-c2/c2a inhibitoren zur komplement aktivierung |
DE60136272D1 (de) * | 2000-04-29 | 2008-12-04 | Univ Iowa Res Found | Diagnostika und therapeutika für makula degeneration erkrankungen |
CA2412211A1 (en) | 2000-06-23 | 2002-01-03 | Genetech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
EP2113516B1 (de) * | 2000-10-10 | 2014-05-21 | Genentech, Inc. | C5 Antikörper, die die Typ II Aktivierung von Endothelialzellen inhibieren |
WO2002030986A2 (en) | 2000-10-13 | 2002-04-18 | Biogen, Inc. | HUMANIZED ANTI-LT-β-R ANTIBODIES |
US20040077575A1 (en) * | 2002-01-11 | 2004-04-22 | Giordano Giovan Giacomo | Inhibition of pathological angiogenesis in vivo |
US6867189B2 (en) | 2001-07-26 | 2005-03-15 | Genset S.A. | Use of adipsin/complement factor D in the treatment of metabolic related disorders |
EP1425042B2 (de) * | 2001-08-17 | 2016-02-10 | Genentech, Inc. | KOMPLEMENT-INHIBITOREN DIE AN C5 UND C5a BINDEN OHNE DIE BILDUNG VON C5b ZU HEMMEN |
TWI323265B (en) | 2002-08-06 | 2010-04-11 | Glaxo Group Ltd | Antibodies |
US20040152105A1 (en) * | 2002-09-06 | 2004-08-05 | Cytos Biotechnology Ag. | Immune modulatory compounds and methods |
WO2005025516A2 (en) * | 2003-09-12 | 2005-03-24 | The Regents Of The University Of California | Monoclonal antibodies specific for conformational epitopes of prefibrillar aggregates |
US7816497B2 (en) * | 2002-10-30 | 2010-10-19 | University Of Kentucky | Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration |
US20060140939A1 (en) * | 2003-02-21 | 2006-06-29 | Fung Sek C M | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
RU2232991C1 (ru) | 2003-04-09 | 2004-07-20 | Государственное учреждение "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" | Способ определения функциональной активности фактора d комплемента человека |
US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
WO2005014849A2 (en) | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
WO2005025509A2 (en) | 2003-09-11 | 2005-03-24 | Board Of Regents, The University Of Texas System | Methods and materials for treating autoimmune diseases and conditions |
US20050169921A1 (en) * | 2004-02-03 | 2005-08-04 | Leonard Bell | Method of treating hemolytic disease |
US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
ES2375490T3 (es) * | 2004-11-18 | 2012-03-01 | Yale University | Métodos y composiciones para diagnosticar degeneración macular relacionada con la edad. |
WO2006071856A2 (en) | 2004-12-23 | 2006-07-06 | Glycofi, Inc. | Immunoglobulins comprising predominantly a man5glcnac2 glycoform |
CN103920142A (zh) * | 2005-02-14 | 2014-07-16 | 爱荷华大学研究基金会 | 治疗和诊断年龄相关性黄斑变性的方法和试剂 |
PL1951279T3 (pl) * | 2005-10-08 | 2017-12-29 | Apellis Pharmaceuticals, Inc. | Kompstatyna i jej analogi w zaburzeniach oczu |
UA99591C2 (ru) | 2005-11-04 | 2012-09-10 | Дженентек, Инк. | Применение ингибиторов пути комплемента для лечения глазных болезней |
US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
PL2097455T3 (pl) * | 2006-11-02 | 2015-04-30 | Genentech Inc | Humanizowane przeciwciała przeciw czynnikowi D |
AR066660A1 (es) | 2007-05-23 | 2009-09-02 | Genentech Inc | Prevencion y tratamiento de condiciones del ojo asociadas con su complemento |
CR20170001A (es) * | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
-
2006
- 2006-11-04 UA UAA200807619A patent/UA99591C2/ru unknown
- 2006-11-04 EP EP15172358.2A patent/EP2998318A1/de not_active Withdrawn
- 2006-11-04 KR KR1020087013385A patent/KR101511787B1/ko active IP Right Grant
- 2006-11-04 MY MYPI20081426 patent/MY151064A/en unknown
- 2006-11-04 MX MX2016001813A patent/MX360959B/es unknown
- 2006-11-04 SG SG10201804008UA patent/SG10201804008UA/en unknown
- 2006-11-04 KR KR1020197006092A patent/KR20190026048A/ko not_active Application Discontinuation
- 2006-11-04 CA CA2624393A patent/CA2624393C/en not_active Expired - Fee Related
- 2006-11-04 JP JP2008539095A patent/JP2009514888A/ja not_active Withdrawn
- 2006-11-04 CN CNA2006800504810A patent/CN101355956A/zh active Pending
- 2006-11-04 SI SI200631974T patent/SI2500030T2/sl unknown
- 2006-11-04 PL PL12172001T patent/PL2500030T5/pl unknown
- 2006-11-04 KR KR1020137030524A patent/KR20130137716A/ko not_active Application Discontinuation
- 2006-11-04 PT PT121720015T patent/PT2500030E/pt unknown
- 2006-11-04 KR KR1020177037729A patent/KR20180002911A/ko not_active Application Discontinuation
- 2006-11-04 RU RU2008122341/15A patent/RU2417099C2/ru not_active IP Right Cessation
- 2006-11-04 WO PCT/US2006/043103 patent/WO2007056227A2/en active Application Filing
- 2006-11-04 CA CA2903896A patent/CA2903896A1/en not_active Abandoned
- 2006-11-04 DK DK12172001.5T patent/DK2500030T4/en active
- 2006-11-04 US US12/092,346 patent/US8753625B2/en not_active Expired - Fee Related
- 2006-11-04 NZ NZ567483A patent/NZ567483A/en not_active IP Right Cessation
- 2006-11-04 NZ NZ594285A patent/NZ594285A/xx not_active IP Right Cessation
- 2006-11-04 EP EP17186993.6A patent/EP3299027A1/de not_active Withdrawn
- 2006-11-04 EP EP12172001.5A patent/EP2500030B2/de active Active
- 2006-11-04 EP EP06836941A patent/EP1942922A4/de not_active Withdrawn
- 2006-11-04 MX MX2011003503A patent/MX337061B/es unknown
- 2006-11-04 CN CN201711120837.XA patent/CN107929731A/zh active Pending
- 2006-11-04 KR KR1020157011618A patent/KR20150055628A/ko not_active Application Discontinuation
- 2006-11-04 AU AU2006311803A patent/AU2006311803C1/en not_active Ceased
- 2006-11-04 HU HUE12172001A patent/HUE026423T2/en unknown
- 2006-11-04 ES ES12172001.5T patent/ES2551202T5/es active Active
- 2006-11-04 KR KR1020167036246A patent/KR20170002684A/ko not_active Application Discontinuation
- 2006-11-04 BR BRPI0619657-8A patent/BRPI0619657A2/pt not_active IP Right Cessation
- 2006-11-04 ZA ZA200803659A patent/ZA200803659B/xx unknown
-
2008
- 2008-04-01 IL IL190547A patent/IL190547A/en not_active IP Right Cessation
- 2008-04-30 MX MX2018014357A patent/MX2018014357A/es unknown
- 2008-05-03 CR CR10041A patent/CR10041A/es unknown
- 2008-05-30 MA MA30972A patent/MA29976B1/fr unknown
- 2008-06-03 NO NO20082483A patent/NO20082483L/no not_active Application Discontinuation
- 2008-06-04 EC EC2008008500A patent/ECSP088500A/es unknown
-
2009
- 2009-09-04 JP JP2009205369A patent/JP2009280626A/ja active Pending
-
2010
- 2010-12-21 RU RU2010152367/15A patent/RU2583927C2/ru not_active IP Right Cessation
-
2012
- 2012-12-10 JP JP2012269482A patent/JP2013049724A/ja not_active Withdrawn
-
2013
- 2013-01-24 ZA ZA2013/00649A patent/ZA201300649B/en unknown
- 2013-03-14 HK HK13103212.1A patent/HK1175718A1/zh not_active IP Right Cessation
- 2013-06-17 PH PH12013501270A patent/PH12013501270A1/en unknown
-
2014
- 2014-05-06 US US14/270,848 patent/US20140335078A1/en not_active Abandoned
-
2015
- 2015-01-29 JP JP2015015014A patent/JP2015083609A/ja not_active Withdrawn
- 2015-06-08 JP JP2015115473A patent/JP2015157862A/ja active Pending
-
2016
- 2016-09-23 HK HK16111213.0A patent/HK1223106A1/zh unknown
-
2017
- 2017-02-20 JP JP2017028964A patent/JP2017095522A/ja not_active Withdrawn
- 2017-02-26 IL IL250772A patent/IL250772A0/en unknown
- 2017-12-15 US US15/844,391 patent/US20180334495A1/en not_active Abandoned
-
2018
- 2018-11-22 IL IL263237A patent/IL263237A/en unknown
- 2018-12-21 JP JP2018238998A patent/JP2019043963A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL263237A (en) | Use of complement pathway inhibitors to treat eye diseases | |
HK1222537A1 (zh) | 用於治療疾病或病症的液體製劑 | |
IL189025A0 (en) | Use of heat shock to treat ocular disease | |
SI2056863T1 (sl) | Zdravljenje očesnih bolezni | |
GB0610867D0 (en) | Treatment of pain | |
HK1201046A1 (en) | Methods of treating ophthalmic diseases | |
EP2187743A4 (de) | Formulierungen zur behandlung von augenerkrankungen oder -leiden | |
IL190779A0 (en) | Compositions for treatment of eye diseases | |
HK1129689A1 (en) | Targeting complement factor for treatment of diseases | |
HK1131047A1 (en) | Treatment of inflammatory diseases | |
EP1919480A4 (de) | Hedgehog-weg-antagonisten zur behandlung von krankheiten | |
EP2083862A4 (de) | Zusammensetzungen und verfahren zur behandlung von augenerkrankungen und -leiden | |
IL193748A0 (en) | Treatment of pain | |
PL2049127T3 (pl) | N-metanokarbapochodne do leczenia chorób serca | |
EP2026822A4 (de) | Topische behandlung für erkrankungen der augenoberfläche | |
ZA200806808B (en) | Treatment of stressed patients | |
EP1988889A4 (de) | Zusammensetzungen und verfahren zur behandlung von ophtamlischen erkrankungen und störungen | |
EP2025342A4 (de) | Therapeutisches mittel oder entwicklungshemmer von polyglutamin-krankheit | |
GB0623740D0 (en) | Treatment of disease | |
GB0616450D0 (en) | Treatment of pain | |
BRPI0716580A2 (pt) | Tratamento de distúrbios fibrosantes | |
ZA200906883B (en) | Methods of treating ophthalmic diseases |