ZA200802723B - Modified 4'-nucleosides as antiviral agents - Google Patents

Modified 4'-nucleosides as antiviral agents

Info

Publication number
ZA200802723B
ZA200802723B ZA200802723A ZA200802723A ZA200802723B ZA 200802723 B ZA200802723 B ZA 200802723B ZA 200802723 A ZA200802723 A ZA 200802723A ZA 200802723 A ZA200802723 A ZA 200802723A ZA 200802723 B ZA200802723 B ZA 200802723B
Authority
ZA
South Africa
Prior art keywords
nucleosides
modified
antiviral agents
antiviral
agents
Prior art date
Application number
ZA200802723A
Other languages
English (en)
Inventor
Du Jinfa
Furman Phillip
Sofia Michael
Original Assignee
Pharmasset Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Inc filed Critical Pharmasset Inc
Publication of ZA200802723B publication Critical patent/ZA200802723B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
ZA200802723A 2005-09-26 2008-03-27 Modified 4'-nucleosides as antiviral agents ZA200802723B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72038805P 2005-09-26 2005-09-26

Publications (1)

Publication Number Publication Date
ZA200802723B true ZA200802723B (en) 2009-03-25

Family

ID=37900393

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200802723A ZA200802723B (en) 2005-09-26 2008-03-27 Modified 4'-nucleosides as antiviral agents

Country Status (17)

Country Link
US (1) US8569478B2 (ja)
EP (2) EP3159351A3 (ja)
JP (1) JP2009510075A (ja)
KR (1) KR20080065272A (ja)
CN (2) CN101310021A (ja)
AR (1) AR056202A1 (ja)
AU (1) AU2006294807B2 (ja)
BR (1) BRPI0616738A2 (ja)
CA (2) CA2904692A1 (ja)
EA (1) EA200800932A1 (ja)
ES (1) ES2617582T3 (ja)
IL (1) IL190390A0 (ja)
NZ (3) NZ609146A (ja)
PT (1) PT1937825T (ja)
UY (1) UY29868A1 (ja)
WO (1) WO2007038507A2 (ja)
ZA (1) ZA200802723B (ja)

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CN113501853B (zh) * 2021-09-13 2021-12-07 南京颐媛生物医学研究院有限公司 4-硫代尿嘧啶脱氧核苷磷酸酯及其抗病毒药物用途
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Also Published As

Publication number Publication date
AU2006294807B2 (en) 2013-01-17
BRPI0616738A2 (pt) 2011-06-28
CA2623522A1 (en) 2007-04-05
NZ567272A (en) 2012-02-24
CN102924549A (zh) 2013-02-13
WO2007038507A2 (en) 2007-04-05
JP2009510075A (ja) 2009-03-12
US8569478B2 (en) 2013-10-29
EP1937825A4 (en) 2010-06-23
EA200800932A1 (ru) 2008-10-30
EP1937825A2 (en) 2008-07-02
CA2623522C (en) 2015-12-08
ES2617582T3 (es) 2017-06-19
US20110021454A1 (en) 2011-01-27
PT1937825T (pt) 2017-03-08
KR20080065272A (ko) 2008-07-11
NZ609146A (en) 2014-08-29
NZ597544A (en) 2013-04-26
EP3159351A3 (en) 2017-05-17
UY29868A1 (es) 2007-04-30
WO2007038507A3 (en) 2007-09-13
CN101310021A (zh) 2008-11-19
AU2006294807A1 (en) 2007-04-05
EP3159351A2 (en) 2017-04-26
AR056202A1 (es) 2007-09-26
EP1937825B1 (en) 2016-12-21
CA2904692A1 (en) 2007-04-05
IL190390A0 (en) 2008-11-03

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