ZA200700774B - Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride - Google Patents

Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Info

Publication number
ZA200700774B
ZA200700774B ZA200700774A ZA200700774A ZA200700774B ZA 200700774 B ZA200700774 B ZA 200700774B ZA 200700774 A ZA200700774 A ZA 200700774A ZA 200700774 A ZA200700774 A ZA 200700774A ZA 200700774 B ZA200700774 B ZA 200700774B
Authority
ZA
South Africa
Prior art keywords
methylpropyl
dimethylamino
ethyl
crystalline forms
phenol hydrochloride
Prior art date
Application number
ZA200700774A
Other languages
English (en)
Inventor
Fischer Andreas
Gruss Michael
Buschmann Helmut
Lischke Dagmar
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200700774(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of ZA200700774B publication Critical patent/ZA200700774B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200700774A 2004-06-28 2007-01-26 Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride ZA200700774B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04015091A EP1612203B1 (en) 2004-06-28 2004-06-28 Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Publications (1)

Publication Number Publication Date
ZA200700774B true ZA200700774B (en) 2008-09-25

Family

ID=34925507

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200700774A ZA200700774B (en) 2004-06-28 2007-01-26 Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Country Status (27)

Country Link
US (16) US20070213405A1 (sl)
EP (2) EP1612203B1 (sl)
JP (1) JP4990764B2 (sl)
KR (1) KR101096501B1 (sl)
CN (1) CN1997621B (sl)
AR (2) AR049949A1 (sl)
AT (2) ATE368639T1 (sl)
AU (1) AU2005256512B2 (sl)
BR (2) BR122018014454B8 (sl)
CA (1) CA2572147C (sl)
CY (2) CY1106929T1 (sl)
DE (2) DE602004007905T2 (sl)
DK (2) DK1612203T3 (sl)
EC (1) ECSP17046065A (sl)
ES (2) ES2291780T3 (sl)
HR (1) HRP20110050T8 (sl)
IL (1) IL180373A (sl)
MX (1) MXPA06014741A (sl)
NO (3) NO338605B1 (sl)
NZ (1) NZ551605A (sl)
PE (1) PE20060372A1 (sl)
PL (2) PL1612203T3 (sl)
PT (2) PT1612203E (sl)
RU (1) RU2423345C2 (sl)
SI (2) SI1612203T1 (sl)
WO (1) WO2006000441A2 (sl)
ZA (1) ZA200700774B (sl)

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DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
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DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
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LT3287123T (lt) 2011-03-04 2020-06-10 Grünenthal GmbH Vandeninė farmacinė tapentadolio kompozicija, skirta gerti
KR101970468B1 (ko) * 2011-03-04 2019-04-19 그뤼넨탈 게엠베하 타펜타돌의 비경구 투여
BR112013022556A8 (pt) 2011-03-04 2018-01-16 Gruenenthal Gmbh composição farmacêutica aquosa semissólida contendo tapentadol, seu uso e uso de tapentadol
CN103841964A (zh) 2011-07-29 2014-06-04 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
NO2736497T3 (sl) 2011-07-29 2018-01-20
WO2013111161A2 (en) * 2012-01-10 2013-08-01 Msn Laboratories Limited Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
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CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
CA2868142A1 (en) 2012-04-18 2013-10-24 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CZ304576B6 (cs) * 2012-07-24 2014-07-16 Zentiva, K.S. Oxalát TAPENTADOLU a způsob jeho přípravy
CN102924303B (zh) * 2012-10-31 2013-11-20 合肥市新星医药化工有限公司 盐酸他喷他多晶型c及其制备方法和应用
BR112015026549A2 (pt) 2013-05-29 2017-07-25 Gruenenthal Gmbh forma de dosagem à prova de violação contendo uma ou mais partículas
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BR112016010482B1 (pt) 2013-11-26 2022-11-16 Grünenthal GmbH Preparação de uma composição farmacêutica em pó por meio de criomoagem
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GB2523089A (en) * 2014-02-12 2015-08-19 Azad Pharmaceutical Ingredients Ag Stable polymorph form B of tapentadol hydrochloride
WO2015173195A1 (en) 2014-05-12 2015-11-19 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
AU2015266117A1 (en) 2014-05-26 2016-11-24 Grunenthal Gmbh Multiparticles safeguarded against ethanolic dose-dumping
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Also Published As

Publication number Publication date
PE20060372A1 (es) 2006-05-08
IL180373A (en) 2012-05-31
AR116052A2 (es) 2021-03-25
US20190062263A1 (en) 2019-02-28
WO2006000441A3 (en) 2006-05-04
NZ551605A (en) 2010-01-29
NO341239B1 (no) 2017-09-25
BRPI0512792A (pt) 2008-04-08
PT1612203E (pt) 2007-08-20
ES2359504T3 (es) 2011-05-24
SI1612203T1 (sl) 2007-12-31
ATE496021T1 (de) 2011-02-15
NO343922B1 (no) 2019-07-08
KR101096501B1 (ko) 2011-12-20
BR122018014454B8 (pt) 2021-07-27
BR122018014454B1 (pt) 2019-09-03
EP1799633A2 (en) 2007-06-27
PL1612203T3 (pl) 2007-12-31
EP1612203B1 (en) 2007-08-01
US20230174458A1 (en) 2023-06-08
PL1799633T3 (pl) 2011-06-30
US20180230082A1 (en) 2018-08-16
AU2005256512A1 (en) 2006-01-05
RU2007103297A (ru) 2008-08-10
IL180373A0 (en) 2007-06-03
CA2572147C (en) 2012-10-30
DE602004007905D1 (de) 2007-09-13
DE602005026031D1 (de) 2011-03-03
ATE368639T1 (de) 2007-08-15
AU2005256512B2 (en) 2011-05-19
JP4990764B2 (ja) 2012-08-01
HRP20110050T1 (hr) 2011-02-28
JP2008504326A (ja) 2008-02-14
CN1997621A (zh) 2007-07-11
DK1612203T3 (da) 2007-12-03
US7994364B2 (en) 2011-08-09
US20100160447A1 (en) 2010-06-24
AR049949A1 (es) 2006-09-20
HRP20110050T8 (en) 2011-03-31
US20140296346A1 (en) 2014-10-02
NO20070162L (no) 2007-01-24
EP1612203A1 (en) 2006-01-04
US20160122287A1 (en) 2016-05-05
CA2572147A1 (en) 2006-01-05
CY1106929T1 (el) 2012-09-26
US20210261492A1 (en) 2021-08-26
US20180029976A1 (en) 2018-02-01
SI1799633T1 (sl) 2011-05-31
US20090186947A1 (en) 2009-07-23
ECSP17046065A (es) 2018-11-30
RU2423345C2 (ru) 2011-07-10
US20070213405A1 (en) 2007-09-13
US20200385334A1 (en) 2020-12-10
NO20160914A1 (no) 2007-01-24
ES2291780T3 (es) 2008-03-01
NO20171103A1 (no) 2007-01-24
WO2006000441A2 (en) 2006-01-05
US20140011886A1 (en) 2014-01-09
CN1997621B (zh) 2011-06-15
KR20070039929A (ko) 2007-04-13
PT1799633E (pt) 2011-03-07
US20200102261A1 (en) 2020-04-02
EP1799633B1 (en) 2011-01-19
US20120302643A1 (en) 2012-11-29
DE602004007905T2 (de) 2008-05-08
US20170166515A1 (en) 2017-06-15
US20110294898A1 (en) 2011-12-01
CY1111530T1 (el) 2015-08-05
MXPA06014741A (es) 2007-02-12
NO338605B1 (no) 2016-09-12
DK1799633T3 (da) 2011-03-28

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