HRP20110050T8 - Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride for use as active ingredient in pharmaceutical compositions - Google Patents

Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride for use as active ingredient in pharmaceutical compositions

Info

Publication number
HRP20110050T8
HRP20110050T8 HR20110050T HRP20110050T HRP20110050T8 HR P20110050 T8 HRP20110050 T8 HR P20110050T8 HR 20110050 T HR20110050 T HR 20110050T HR P20110050 T HRP20110050 T HR P20110050T HR P20110050 T8 HRP20110050 T8 HR P20110050T8
Authority
HR
Croatia
Prior art keywords
methylpropyl
dimethylamino
ethyl
active ingredient
pharmaceutical compositions
Prior art date
Application number
HR20110050T
Other languages
English (en)
Croatian (hr)
Inventor
Fischer Andreas
Buschmann Helmut
Gruss Michael
Lischke Dagmar
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20110050(T8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HRP20110050T1 publication Critical patent/HRP20110050T1/hr
Publication of HRP20110050T8 publication Critical patent/HRP20110050T8/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20110050T 2004-06-28 2011-01-24 Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride for use as active ingredient in pharmaceutical compositions HRP20110050T8 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04015091A EP1612203B1 (en) 2004-06-28 2004-06-28 Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
PCT/EP2005/006884 WO2006000441A2 (en) 2004-06-28 2005-06-27 Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Publications (2)

Publication Number Publication Date
HRP20110050T1 HRP20110050T1 (hr) 2011-02-28
HRP20110050T8 true HRP20110050T8 (en) 2011-03-31

Family

ID=34925507

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110050T HRP20110050T8 (en) 2004-06-28 2011-01-24 Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride for use as active ingredient in pharmaceutical compositions

Country Status (27)

Country Link
US (16) US20070213405A1 (xx)
EP (2) EP1612203B1 (xx)
JP (1) JP4990764B2 (xx)
KR (1) KR101096501B1 (xx)
CN (1) CN1997621B (xx)
AR (2) AR049949A1 (xx)
AT (2) ATE368639T1 (xx)
AU (1) AU2005256512B2 (xx)
BR (2) BR122018014454B8 (xx)
CA (1) CA2572147C (xx)
CY (2) CY1106929T1 (xx)
DE (2) DE602004007905T2 (xx)
DK (2) DK1612203T3 (xx)
EC (1) ECSP17046065A (xx)
ES (2) ES2291780T3 (xx)
HR (1) HRP20110050T8 (xx)
IL (1) IL180373A (xx)
MX (1) MXPA06014741A (xx)
NO (3) NO338605B1 (xx)
NZ (1) NZ551605A (xx)
PE (1) PE20060372A1 (xx)
PL (2) PL1612203T3 (xx)
PT (2) PT1612203E (xx)
RU (1) RU2423345C2 (xx)
SI (2) SI1612203T1 (xx)
WO (1) WO2006000441A2 (xx)
ZA (1) ZA200700774B (xx)

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US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
SI1612203T1 (sl) * 2004-06-28 2007-12-31 Gruenenthal Chemie Kristalne oblike (-)-(1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)-fenol hidroklorida
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
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BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
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US8288592B2 (en) 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts
WO2011138037A2 (de) 2010-05-05 2011-11-10 Ratiopharm Gmbh Festes tapentadol in nicht-kristalliner form
WO2012010316A1 (en) 2010-07-23 2012-01-26 Grünenthal GmbH Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
WO2012028319A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
CA2808541C (en) 2010-09-02 2019-01-08 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
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PT2680834T (pt) 2011-03-04 2018-01-25 Gruenenthal Gmbh Composição farmacêutica aquosa semissólida contendo tapentadol
SI2680832T1 (sl) 2011-03-04 2019-11-29 Gruenenthal Gmbh Vodna farmacevtska formulacija tapentadola za peroralno dovajanje
DK2680833T3 (en) * 2011-03-04 2016-05-23 Gruenenthal Gmbh PARENTERAL SUBMISSION OF TAPENTADOL
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
WO2013111161A2 (en) * 2012-01-10 2013-08-01 Msn Laboratories Limited Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
WO2013120466A1 (en) 2012-02-17 2013-08-22 Zentiva, K.S. A new solid form of tapentadol and a method of its preparation
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CZ304576B6 (cs) * 2012-07-24 2014-07-16 Zentiva, K.S. Oxalát TAPENTADOLU a způsob jeho přípravy
CN102924303B (zh) * 2012-10-31 2013-11-20 合肥市新星医药化工有限公司 盐酸他喷他多晶型c及其制备方法和应用
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
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GB2523089A (en) * 2014-02-12 2015-08-19 Azad Pharmaceutical Ingredients Ag Stable polymorph form B of tapentadol hydrochloride
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WO2015181059A1 (en) 2014-05-26 2015-12-03 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
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SI1612203T1 (sl) * 2004-06-28 2007-12-31 Gruenenthal Chemie Kristalne oblike (-)-(1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)-fenol hidroklorida

Also Published As

Publication number Publication date
DE602005026031D1 (de) 2011-03-03
CY1106929T1 (el) 2012-09-26
US20230174458A1 (en) 2023-06-08
PE20060372A1 (es) 2006-05-08
EP1612203B1 (en) 2007-08-01
BR122018014454B1 (pt) 2019-09-03
US20200385334A1 (en) 2020-12-10
IL180373A (en) 2012-05-31
AU2005256512B2 (en) 2011-05-19
US20180230082A1 (en) 2018-08-16
NZ551605A (en) 2010-01-29
US20180029976A1 (en) 2018-02-01
ES2291780T3 (es) 2008-03-01
DE602004007905T2 (de) 2008-05-08
US20100160447A1 (en) 2010-06-24
KR101096501B1 (ko) 2011-12-20
EP1799633B1 (en) 2011-01-19
US20200102261A1 (en) 2020-04-02
MXPA06014741A (es) 2007-02-12
NO20160914A1 (no) 2007-01-24
US20190062263A1 (en) 2019-02-28
EP1612203A1 (en) 2006-01-04
PL1799633T3 (pl) 2011-06-30
BRPI0512792A (pt) 2008-04-08
RU2007103297A (ru) 2008-08-10
EP1799633A2 (en) 2007-06-27
RU2423345C2 (ru) 2011-07-10
US20160122287A1 (en) 2016-05-05
NO20171103A1 (no) 2007-01-24
ATE496021T1 (de) 2011-02-15
US20170166515A1 (en) 2017-06-15
SI1612203T1 (sl) 2007-12-31
HRP20110050T1 (hr) 2011-02-28
NO341239B1 (no) 2017-09-25
JP2008504326A (ja) 2008-02-14
PL1612203T3 (pl) 2007-12-31
DE602004007905D1 (de) 2007-09-13
WO2006000441A3 (en) 2006-05-04
US7994364B2 (en) 2011-08-09
AR116052A2 (es) 2021-03-25
JP4990764B2 (ja) 2012-08-01
NO343922B1 (no) 2019-07-08
CN1997621A (zh) 2007-07-11
CA2572147A1 (en) 2006-01-05
US20110294898A1 (en) 2011-12-01
US20120302643A1 (en) 2012-11-29
AR049949A1 (es) 2006-09-20
ES2359504T3 (es) 2011-05-24
AU2005256512A1 (en) 2006-01-05
CY1111530T1 (el) 2015-08-05
NO20070162L (no) 2007-01-24
US20210261492A1 (en) 2021-08-26
US20070213405A1 (en) 2007-09-13
WO2006000441A2 (en) 2006-01-05
KR20070039929A (ko) 2007-04-13
SI1799633T1 (sl) 2011-05-31
BR122018014454B8 (pt) 2021-07-27
US20140011886A1 (en) 2014-01-09
PT1612203E (pt) 2007-08-20
DK1612203T3 (da) 2007-12-03
US20140296346A1 (en) 2014-10-02
IL180373A0 (en) 2007-06-03
US20090186947A1 (en) 2009-07-23
NO338605B1 (no) 2016-09-12
ZA200700774B (en) 2008-09-25
ECSP17046065A (es) 2018-11-30
DK1799633T3 (da) 2011-03-28
ATE368639T1 (de) 2007-08-15
CN1997621B (zh) 2011-06-15
PT1799633E (pt) 2011-03-07
CA2572147C (en) 2012-10-30

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