ZA200606551B - Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists - Google Patents
Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists Download PDFInfo
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- 230000002040 relaxant effect Effects 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 230000003956 synaptic plasticity Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 description 1
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Classifications
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
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Applications Claiming Priority (1)
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| US60896004P | 2004-02-18 | 2004-02-18 |
Publications (1)
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| ZA200606551B true ZA200606551B (en) | 2007-11-28 |
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| AT (1) | ATE483706T1 (de) |
| AU (1) | AU2005270208A1 (de) |
| BR (1) | BRPI0507497A (de) |
| CA (1) | CA2555566A1 (de) |
| CY (1) | CY1110965T1 (de) |
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| DK (1) | DK1723144T3 (de) |
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| HK (1) | HK1099285A1 (de) |
| HR (1) | HRP20100654T1 (de) |
| IL (1) | IL177394A0 (de) |
| NO (1) | NO20063599L (de) |
| NZ (1) | NZ548954A (de) |
| PL (1) | PL1723144T3 (de) |
| PT (1) | PT1723144E (de) |
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| RU (1) | RU2370495C2 (de) |
| SG (1) | SG146657A1 (de) |
| SI (1) | SI1723144T1 (de) |
| UA (1) | UA84318C2 (de) |
| UY (1) | UY28766A1 (de) |
| WO (1) | WO2006014185A1 (de) |
| ZA (1) | ZA200606551B (de) |
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| CN1894241A (zh) * | 2002-08-09 | 2007-01-10 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体－5调节剂的“1,2,4” 噁二唑 |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| CN1942457A (zh) * | 2004-04-20 | 2007-04-04 | 默克公司 | 作为β－促分泌酶抑制剂用于阿尔茨海默氏病的治疗中的1,3,5－取代的苯基衍生化合物 |
| JPWO2006080533A1 (ja) * | 2005-01-31 | 2008-06-19 | 持田製薬株式会社 | ３−アミノ−１，２，４−トリアゾール誘導体 |
| AR058807A1 (es) * | 2005-09-29 | 2008-02-27 | Astrazeneca Ab | 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 |
| TW200811157A (en) | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
| TW200811179A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators VI |
| TW200808800A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
| US7935715B2 (en) * | 2006-07-28 | 2011-05-03 | Boehringer Ingelheim International Gmbh | Compounds which modulate the CB2 receptor |
| TW200821305A (en) * | 2006-10-05 | 2008-05-16 | Astrazeneca Ab | MGluR5 modulators |
| NZ581127A (en) | 2007-05-25 | 2012-06-29 | Abbott Gmbh & Co Kg | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor) |
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| TW200934771A (en) | 2007-10-19 | 2009-08-16 | Astrazeneca Ab | New compounds |
| WO2009054785A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | 1,2,4-triazole ether derivatives as modulators of mglur5 |
| WO2009054786A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5 |
| EP2217565B1 (de) * | 2007-11-07 | 2013-05-22 | Boehringer Ingelheim International GmbH | Cb2 rezeptor-modulierende verbindungen |
| CA2718166A1 (en) * | 2008-03-03 | 2009-09-17 | Stiefel Laboratories, Inc. | Processes for preparing enantiomerically pure diol and dioxolane compounds |
| WO2009151529A1 (en) | 2008-05-14 | 2009-12-17 | The Scripps Research Institute | Novel modulators of sphingosine phosphate receptors |
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| CA2733922A1 (en) * | 2008-08-12 | 2010-02-18 | Astrazeneca Ab | A crystalline form of 4-(5-{(1r)-1-[5-(3-chlorophenyl)isoxazol-3-yl]ethoxy}-4-methyl-4h-1,2,4-triazol-3-yl)pyridine |
| RU2011103225A (ru) * | 2008-08-12 | 2012-09-20 | Астразенека Аб (Se) | Новая кристаллическая форма 4-(5-{(1r)-1-[5-(3-хрорфенил)изоксазол-3-ил]этокси}-4-метил-4h-1,2,4-триазол-3-ил)пиридина |
| EP2342199B1 (de) | 2008-09-25 | 2014-02-26 | Boehringer Ingelheim International GmbH | Sulfonylverbindungen als selektive CB2 Rezeptor Modulatoren |
| EP2379531A1 (de) * | 2008-12-18 | 2011-10-26 | AstraZeneca AB | Verfahren zur herstellung von 3-{4-methyl-5-[(1r)-1-(2-(3-methylphenyl)-2h-tetrazol-5-yl)ethoxy]-4h-[1,2,4]triazol-3-yl}pyridin, 4-methyl-3-methylthio-5-(3-pyridyl)-l,2,4-triazol und (1r)-1-[2-(3-methylphenyl)-2h-tetrazol-5-yl]ethanol |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| JP5705748B2 (ja) | 2009-02-18 | 2015-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する複素環化合物 |
| WO2010114971A1 (en) * | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
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| JP2013505295A (ja) * | 2009-09-22 | 2013-02-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を選択的に調節する化合物 |
| PL3406142T3 (pl) * | 2009-11-13 | 2021-08-30 | Receptos Llc | Selektywne modulatory receptora sfingozyno-1-fosforanu i sposoby syntezy chiralnej |
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