ZA200604069B - AKT protein kinase inhibitors - Google Patents

AKT protein kinase inhibitors

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Publication number
ZA200604069B
ZA200604069B ZA200604069A ZA200604069A ZA200604069B ZA 200604069 B ZA200604069 B ZA 200604069B ZA 200604069 A ZA200604069 A ZA 200604069A ZA 200604069 A ZA200604069 A ZA 200604069A ZA 200604069 B ZA200604069 B ZA 200604069B
Authority
ZA
South Africa
Prior art keywords
protein kinase
kinase inhibitors
akt protein
akt
inhibitors
Prior art date
Application number
ZA200604069A
Other languages
English (en)
Inventor
Ian S Mitchell
Stengel Peter
Nicholas C Kallan
Guy P A Vigers
Piscopio Anthony
Miller Scott
Xu Rui
Wang Bin
Keith L Spencer
Han Yongxin
Munson Mark
Blake James
Josey John
Xiao Dengming
Rao Chang
April L Bernacki
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of ZA200604069B publication Critical patent/ZA200604069B/xx

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    • C07ORGANIC CHEMISTRY
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    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B41PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41MPRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B44FSPECIAL DESIGNS OR PICTURES
    • B44F1/00Designs or pictures characterised by special or unusual light effects
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    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
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ZA200604069A 2003-11-21 2006-05-19 AKT protein kinase inhibitors ZA200604069B (en)

Applications Claiming Priority (1)

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US52400303P 2003-11-21 2003-11-21

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ZA200604069B true ZA200604069B (en) 2009-04-29

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US (3) US20050130954A1 (ru)
EP (1) EP1684694A2 (ru)
JP (1) JP2007512364A (ru)
KR (2) KR101223914B1 (ru)
CN (2) CN102786482A (ru)
AU (1) AU2004293026B2 (ru)
BR (1) BRPI0416852A (ru)
CA (1) CA2546754A1 (ru)
IL (2) IL175221A (ru)
NO (1) NO20062884L (ru)
NZ (2) NZ547327A (ru)
RU (1) RU2006121990A (ru)
WO (1) WO2005051304A2 (ru)
ZA (1) ZA200604069B (ru)

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MY179032A (en) * 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
BRPI0518785A2 (pt) * 2004-12-02 2008-12-09 Asubio Pharma Co Ltd composto de anel de 7 membros e mÉtodo de produÇço e aplicaÇço farmacÊutica do mesmo
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GB0516967D0 (en) * 2005-08-18 2005-09-28 Univ Southampton Inhibitors
JP4935675B2 (ja) 2005-08-25 2012-05-23 宇部興産株式会社 光学活性(S又はR)−α−アミノ酸及び光学活性(R又はS)−α−アミノ酸エステルの製造方法
JP2009510073A (ja) * 2005-09-27 2009-03-12 ノバルティス アクチエンゲゼルシャフト カルボキシアミン化合物およびその使用方法
EP1948185A4 (en) * 2005-11-10 2010-04-21 Glaxosmithkline Llc INHIBITORS OF AKT ACTIVITY
JP2009515884A (ja) * 2005-11-10 2009-04-16 スミスクライン・ビーチャム・コーポレイション Akt活性の阻害剤
WO2007076423A2 (en) * 2005-12-22 2007-07-05 Smithkline Beecham Corporation INHIBITORS OF Akt ACTIVITY
WO2007076320A2 (en) * 2005-12-22 2007-07-05 Smithkline Beecham Corporation Compounds
US20090099175A1 (en) * 2006-03-01 2009-04-16 Arrington Mark P Phosphodiesterase 10 inhibitors
US20090124610A1 (en) * 2006-04-25 2009-05-14 Gordon Saxty Pharmaceutical compounds
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