ZA200603106B - Optimized expression of HPV 58 L1 in yeast - Google Patents
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- ZA200603106B ZA200603106B ZA200603106A ZA200603106A ZA200603106B ZA 200603106 B ZA200603106 B ZA 200603106B ZA 200603106 A ZA200603106 A ZA 200603106A ZA 200603106 A ZA200603106 A ZA 200603106A ZA 200603106 B ZA200603106 B ZA 200603106B
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Classifications
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- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
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- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/00011—Details
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- C12N2710/20023—Virus like particles [VLP]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| JP (2) | JP4912885B2 (ko) |
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| CN (1) | CN1942583B (ko) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7858098B2 (en) * | 2002-12-20 | 2010-12-28 | Glaxosmithkline Biologicals, S.A. | Vaccine |
| US8206950B2 (en) | 2003-06-09 | 2012-06-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine and method of making them |
| DK1730175T3 (da) | 2004-03-24 | 2010-08-23 | Merck Sharp & Dohme | Geoptimaliseerde expressie van HPV 52 L1 in gist |
| US20070243587A1 (en) * | 2006-04-14 | 2007-10-18 | Healthbanks Biotech Co., Ltd. | Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus |
| CN101148661B (zh) * | 2006-09-18 | 2013-01-02 | 中国医学科学院基础医学研究所 | 人乳头瘤病毒16型外壳蛋白病毒样颗粒及其制备方法和用途 |
| WO2008112125A1 (en) * | 2007-03-09 | 2008-09-18 | Merck & Co., Inc. | Papillomavirus vaccine compositions |
| DK2147926T3 (en) | 2007-04-29 | 2016-11-28 | Beijing Wantai Biological Pharmacy Entpr Co Ltd | Truncated human papillomavirus type 18 L1 protein |
| BRPI0811016B1 (pt) | 2007-04-29 | 2021-09-21 | Xiamen Innovax Biotech Co., Ltd. | Proteína li truncada do papiloma vírus humano tipo 16 |
| US8748127B2 (en) * | 2007-05-29 | 2014-06-10 | Xiamen University | Truncated L1 protein of human papillomavirus type 6 |
| CN101113417B (zh) * | 2007-06-22 | 2011-04-27 | 山东大学 | Hpv基因酵母体外翻译系统的建立 |
| CN101200696B (zh) * | 2007-11-14 | 2011-07-20 | 山东大学 | 人乳头瘤病毒的酵母增殖模型及建立方法与应用 |
| MX2010005699A (es) * | 2007-11-23 | 2010-09-14 | Shanghai Zerun Biotechnology C | Genes que codifican para la proteina l1 mayor de la capside del virus del papiloma humano y uso de los mismos. |
| KR20090073987A (ko) * | 2007-12-31 | 2009-07-03 | 정운원 | 인간유두종바이러스 유전자형 검사를 위한 프라이머, 프로브 및 이를 포함하는 ｄｎａ칩, 이의 검사 방법 및 검사 키트 |
| EA027784B1 (ru) * | 2008-05-26 | 2017-09-29 | Кадила Хелзкэр Лимитед | Комбинированная вакцина против кори и вируса папилломы человека |
| US9335868B2 (en) * | 2008-07-31 | 2016-05-10 | Apple Inc. | Capacitive sensor behind black mask |
| EP2576840B1 (en) | 2010-05-25 | 2018-10-17 | QIAGEN Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
| CN101857870B (zh) * | 2010-06-12 | 2012-09-05 | 上海泽润生物科技有限公司 | Hpv58 l1基因及载体、菌株和表达方法 |
| CN102336822B (zh) * | 2010-07-16 | 2015-10-14 | 厦门大学 | 截短的人乳头瘤病毒58型l1蛋白 |
| CN102154325B (zh) * | 2011-01-01 | 2013-08-21 | 上海生物制品研究所有限责任公司 | 针对人乳头瘤状病毒的疫苗及其制法和用途 |
| AU2012270418B2 (en) * | 2011-06-15 | 2015-08-13 | Posvax Co., Ltd | Method for enhancing the production yield of human papillomavirus L1 protein |
| CN108624614A (zh) * | 2012-03-28 | 2018-10-09 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv11 l1蛋白的方法 |
| CA2875945A1 (en) * | 2012-06-07 | 2013-12-12 | The Children's Hospital Of Philadelphia | Controlled gene expression methods |
| CN103992395B (zh) * | 2013-02-18 | 2018-07-27 | 北京康乐卫士生物技术股份有限公司 | 重组hpv-58型l1的vlp疫苗及其制备方法 |
| CN110423774A (zh) * | 2013-04-26 | 2019-11-08 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv58 l1蛋白的方法 |
| CN110592133A (zh) * | 2013-05-17 | 2019-12-20 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv31 l1蛋白的方法 |
| CN104164373B (zh) * | 2013-05-17 | 2019-04-02 | 北京安百胜生物科技有限公司 | 用汉逊酵母表达系统产生hpv68l1蛋白的方法 |
| CA2927434C (en) | 2013-10-16 | 2022-07-19 | Merck Sharp & Dohme Corp. | Method of obtaining thermostable dried vaccine formulations |
| WO2016038625A2 (en) * | 2014-09-11 | 2016-03-17 | Cadila Healthcare Limited | Superior human papilloma virus antigens with superior immunological properties and vaccine containing it |
| CN117187263A (zh) * | 2015-03-30 | 2023-12-08 | 上海泽润生物科技有限公司 | 重组人乳头瘤病毒33亚型蛋白表达 |
| CN104878022A (zh) * | 2015-04-27 | 2015-09-02 | 段青姣 | 编码hpv58l1、hpv52l1蛋白的核苷酸序列及其应用 |
| CN106831961B (zh) * | 2015-12-04 | 2019-11-05 | 厦门大学 | 一种人乳头瘤病毒58型l1蛋白的突变体 |
| EP4103227A1 (en) | 2020-02-14 | 2022-12-21 | Merck Sharp & Dohme LLC | Hpv vaccine |
| CN113073105B (zh) * | 2021-03-23 | 2023-06-13 | 重庆博唯佰泰生物制药有限公司 | 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用 |
| CN113549634B (zh) * | 2021-06-07 | 2023-03-31 | 郑州大学 | 编码可溶性hpv58 l1蛋白的基因及其重组质粒的构建与应用 |
| WO2023014853A1 (en) | 2021-08-06 | 2023-02-09 | Merck Sharp & Dohme Llc | Hpv vaccine |
| CN118019547A (zh) | 2021-08-19 | 2024-05-10 | 默沙东有限责任公司 | 热稳定脂质纳米粒子及其使用方法 |
| CN117054647A (zh) * | 2023-07-17 | 2023-11-14 | 广东省一鼎生物技术有限公司 | 一种检测HPV IgG抗体试剂盒及其制备方法 |
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| IL117591A0 (en) | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| US5821087A (en) | 1995-03-30 | 1998-10-13 | Merck & Co., Inc. | Production of recombinant human papillomavirus type II protein utilizing papillomavirus 6/11 hybrid DNA |
| AU743616B2 (en) | 1997-02-07 | 2002-01-31 | Merck & Co., Inc. | Synthetic HIV gag genes |
| EP1002091B1 (en) | 1997-07-09 | 2012-02-29 | Coridon Pty Limited | Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue |
| ATE324436T1 (de) * | 1998-08-14 | 2006-05-15 | Merck & Co Inc | Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln. |
| ATE344052T1 (de) | 1998-08-14 | 2006-11-15 | Merck & Co Inc | Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt. |
| SE514982C2 (sv) * | 1999-09-30 | 2001-05-28 | Active Biotech Ab | Bärare innehållande ett huvudkapsidprotein L1 från humant papillomavirus samt dess användning |
| ATE284898T1 (de) | 1999-08-25 | 2005-01-15 | Merck & Co Inc | Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind |
| US6436402B1 (en) * | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| CZ2003180A3 (cs) | 2000-07-21 | 2003-08-13 | Glaxo Group Limited | Papilomavirové sekvence s optimalizovanými kodony |
| WO2003068804A2 (en) * | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Novel insect cell line |
| CN100506999C (zh) * | 2003-03-24 | 2009-07-01 | 麦克公司 | Hpv31l1在酵母中的优化表达 |
| MY140664A (en) * | 2003-09-29 | 2010-01-15 | Merck Sharp & Dohme | Optimized expression of hpv 45 l1 in yeast |
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