ZA200506881B - Polyethylene glycol linked GLP-1 compounds - Google Patents
Polyethylene glycol linked GLP-1 compounds Download PDFInfo
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- ZA200506881B ZA200506881B ZA200506881A ZA200506881A ZA200506881B ZA 200506881 B ZA200506881 B ZA 200506881B ZA 200506881 A ZA200506881 A ZA 200506881A ZA 200506881 A ZA200506881 A ZA 200506881A ZA 200506881 B ZA200506881 B ZA 200506881B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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EP (1) | EP1605897B1 (zh) |
JP (1) | JP2006520818A (zh) |
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CN (1) | CN1832959A (zh) |
AU (1) | AU2004231461B2 (zh) |
BR (1) | BRPI0407936A (zh) |
CA (1) | CA2518336A1 (zh) |
CO (1) | CO5611157A2 (zh) |
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EC (1) | ECSP056025A (zh) |
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HR (1) | HRP20050683A2 (zh) |
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UA (1) | UA92451C2 (zh) |
WO (1) | WO2004093823A2 (zh) |
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US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
RU2006120079A (ru) * | 2003-12-18 | 2008-01-27 | Ново Нордиск А/С (DK) | Производные глюкагоноподобного пептида-1 (glp-1) |
US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
EP1858543B1 (en) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
KR20070120112A (ko) | 2005-03-18 | 2007-12-21 | 노보 노르디스크 에이/에스 | 연장형 glp-1 화합물 |
TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
JP2008539735A (ja) * | 2005-05-06 | 2008-11-20 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | グルカゴン様ペプチド1(glp−1)受容体アンタゴニストおよびそれらの薬理学的使用方法 |
US8183340B2 (en) * | 2005-05-13 | 2012-05-22 | Eli Lilly And Company | GLP-1 pegylated compounds |
US20080255026A1 (en) | 2005-05-25 | 2008-10-16 | Glycopegylated Factor 1X | Glycopegylated Factor Ix |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
CN101296708B (zh) * | 2005-10-26 | 2011-12-07 | 伊莱利利公司 | 选择性vpac2受体肽激动剂 |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
CN101534846B (zh) | 2005-11-07 | 2014-11-05 | 印第安纳大学研究及科技有限公司 | 显示生理学溶解性和稳定性的胰高血糖素类似物 |
WO2007075534A2 (en) * | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
CA2648936C (en) * | 2006-04-20 | 2013-07-09 | Amgen Inc. | Glp-1 compounds |
CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
CN102827284B (zh) * | 2006-11-14 | 2015-07-29 | 上海仁会生物制药股份有限公司 | 带有聚乙二醇基团的Exendin或其类似物及其制剂和用途 |
WO2008076933A2 (en) * | 2006-12-14 | 2008-06-26 | Bolder Biotechnology, Inc. | Long acting proteins and peptides and methods of making and using the same |
US8669228B2 (en) * | 2007-01-05 | 2014-03-11 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological pH buffers |
JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
AU2008216265B2 (en) | 2007-02-15 | 2014-04-03 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
DK2144923T3 (da) | 2007-04-03 | 2013-05-13 | Biogenerix Ag | Behandlingsfremgangsmåder under anvendelse af glycopegyleret g-csf |
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- 2004-03-19 JP JP2006508916A patent/JP2006520818A/ja active Pending
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- 2004-03-19 CA CA002518336A patent/CA2518336A1/en not_active Abandoned
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AU2004231461B2 (en) | 2009-11-12 |
KR100733940B1 (ko) | 2007-06-29 |
JP2006520818A (ja) | 2006-09-14 |
CA2518336A1 (en) | 2004-11-04 |
CY1114035T1 (el) | 2016-07-27 |
EA200501482A1 (ru) | 2006-06-30 |
US20080113905A1 (en) | 2008-05-15 |
MXPA05009940A (es) | 2005-12-05 |
NZ541534A (en) | 2008-05-30 |
EA009366B1 (ru) | 2007-12-28 |
AU2004231461A1 (en) | 2004-11-04 |
EP1605897A4 (en) | 2010-08-04 |
ES2390270T3 (es) | 2012-11-08 |
WO2004093823A2 (en) | 2004-11-04 |
BRPI0407936A (pt) | 2006-02-21 |
ECSP056025A (es) | 2006-01-27 |
NO20054310D0 (no) | 2005-09-19 |
CR7997A (es) | 2008-11-28 |
NO20054310L (no) | 2005-11-16 |
PL1605897T3 (pl) | 2012-12-31 |
HRP20050683A2 (en) | 2006-07-31 |
SI1605897T1 (sl) | 2012-11-30 |
KR20050111386A (ko) | 2005-11-24 |
PT1605897E (pt) | 2012-09-10 |
EP1605897A2 (en) | 2005-12-21 |
WO2004093823A3 (en) | 2005-12-22 |
UA92451C2 (en) | 2010-11-10 |
DK1605897T3 (da) | 2012-08-20 |
CO5611157A2 (es) | 2006-02-28 |
EP1605897B1 (en) | 2012-07-25 |
CN1832959A (zh) | 2006-09-13 |
US7557183B2 (en) | 2009-07-07 |
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