ZA200502305B - Proline derivatives having affinity for the calcium channel alpha-2-delta subunit - Google Patents
Proline derivatives having affinity for the calcium channel alpha-2-delta subunit Download PDFInfo
- Publication number
- ZA200502305B ZA200502305B ZA200502305A ZA200502305A ZA200502305B ZA 200502305 B ZA200502305 B ZA 200502305B ZA 200502305 A ZA200502305 A ZA 200502305A ZA 200502305 A ZA200502305 A ZA 200502305A ZA 200502305 B ZA200502305 B ZA 200502305B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- pyrrolidine
- carboxylic acid
- alkoxy
- formula
- Prior art date
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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Landscapes
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- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Rheumatology (AREA)
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- Urology & Nephrology (AREA)
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- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0225379.7A GB0225379D0 (en) | 2002-10-31 | 2002-10-31 | Therapeutic proline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200502305B true ZA200502305B (en) | 2006-11-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200502305A ZA200502305B (en) | 2002-10-31 | 2005-03-18 | Proline derivatives having affinity for the calcium channel alpha-2-delta subunit |
Country Status (39)
| Country | Link |
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| EP (1) | EP1558246B1 (ru) |
| JP (2) | JP3940416B2 (ru) |
| KR (2) | KR100750782B1 (ru) |
| CN (1) | CN100418525C (ru) |
| AP (1) | AP2005003295A0 (ru) |
| AR (1) | AR041865A1 (ru) |
| AT (1) | ATE468116T1 (ru) |
| AU (1) | AU2003269411B2 (ru) |
| BR (1) | BR0315839A (ru) |
| CA (1) | CA2499698C (ru) |
| CO (1) | CO5550430A2 (ru) |
| CR (1) | CR7802A (ru) |
| DE (1) | DE60332646D1 (ru) |
| DK (1) | DK1558246T3 (ru) |
| EA (1) | EA009767B1 (ru) |
| EC (1) | ECSP055769A (ru) |
| ES (1) | ES2343624T3 (ru) |
| GB (1) | GB0225379D0 (ru) |
| GE (1) | GEP20074127B (ru) |
| GT (1) | GT200300234A (ru) |
| HK (1) | HK1081441A1 (ru) |
| HR (1) | HRP20050351A2 (ru) |
| IL (4) | IL167799A (ru) |
| IS (1) | IS7754A (ru) |
| MA (1) | MA27481A1 (ru) |
| MX (1) | MXPA05004662A (ru) |
| NL (1) | NL1024677C2 (ru) |
| NO (1) | NO330496B1 (ru) |
| OA (1) | OA12954A (ru) |
| PA (1) | PA8587201A1 (ru) |
| PE (1) | PE20040553A1 (ru) |
| PL (1) | PL376703A1 (ru) |
| RS (1) | RS20050333A (ru) |
| TN (1) | TNSN05122A1 (ru) |
| TW (2) | TW200416030A (ru) |
| UA (1) | UA81437C2 (ru) |
| UY (1) | UY28043A1 (ru) |
| WO (1) | WO2004039367A1 (ru) |
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| GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
| US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| WO2005097741A1 (en) * | 2004-04-05 | 2005-10-20 | Pfizer Limited | Process for the recrystallisation of proline derivates |
| WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
| WO2007142028A1 (ja) | 2006-06-06 | 2007-12-13 | Gifu University | 神経因性疼痛を抑制するピロリジン類縁体及びその製造方法 |
| AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
| EP2919788A4 (en) | 2012-11-14 | 2016-05-25 | Univ Johns Hopkins | METHODS AND COMPOSITIONS FOR THE TREATMENT OF SCHIZOPHRENIA |
| JP2016523266A (ja) | 2013-06-26 | 2016-08-08 | 浙江九洲▲藥▼▲業▼股▲ふぇん▼有限公司 | ピロリジン−２−カルボン酸誘導体の調製方法 |
| WO2015003723A1 (en) * | 2013-07-12 | 2015-01-15 | Københavns Universitet | Substituted 4-proline derivatives as iglur antagonists |
| CN104418785A (zh) * | 2013-09-05 | 2015-03-18 | 浙江九洲药业股份有限公司 | 一种药物中间体的制备方法 |
| CN104829513B (zh) * | 2014-02-11 | 2019-02-19 | 浙江九洲药业股份有限公司 | 一种2-羧基-4-甲氧基甲基吡咯烷衍生物的制备方法 |
| CN104844495A (zh) * | 2015-06-05 | 2015-08-19 | 武汉理工大学 | 一种(2s,4s)-4-苯硫基-l-脯氨酸盐酸盐的合成方法 |
| TW202026281A (zh) * | 2018-12-12 | 2020-07-16 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物 |
| WO2020120606A1 (en) * | 2018-12-12 | 2020-06-18 | Esteve Pharmaceuticals, S.A. | New pyrrolidine-2-carboxylic acid derivatives for treating pain and pain related conditions |
| EP3904339A1 (en) * | 2020-04-28 | 2021-11-03 | Esteve Pharmaceuticals, S.A. | Alkylaminoproline derivatives as alfa-2-delta-1 blockers |
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| US4316906A (en) * | 1978-08-11 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of substituted prolines |
| CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
| US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| ZA817601B (en) * | 1980-11-24 | 1982-10-27 | Squibb & Sons Inc | Carboxyalkyl amino acid derivatives of various substituted prolines |
| AU1873992A (en) * | 1991-04-19 | 1992-11-17 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| US5612360A (en) * | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| US6156726A (en) * | 1996-08-02 | 2000-12-05 | Elan Pharmaceuticals, Inc. | Voltage-gated calcium channel antagonist and method |
| JP3196106B2 (ja) * | 1997-03-27 | 2001-08-06 | 参天製薬株式会社 | ロイコトリエンａ４ヒドロラーゼ阻害剤 |
| CA2322558C (en) * | 1998-05-26 | 2006-04-11 | Warner-Lambert Company | Conformationally constrained amino acid compounds having affinity for the alpha2delta subunit of a calcium channel |
| CO5300399A1 (es) * | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
| GB0225379D0 (en) * | 2002-10-31 | 2002-12-11 | Pfizer Ltd | Therapeutic proline derivatives |
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