ZA200401042B - Pyrrolo pyrimidines as agents for the inhibition of cystein proteases. - Google Patents
Pyrrolo pyrimidines as agents for the inhibition of cystein proteases. Download PDFInfo
- Publication number
- ZA200401042B ZA200401042B ZA200401042A ZA200401042A ZA200401042B ZA 200401042 B ZA200401042 B ZA 200401042B ZA 200401042 A ZA200401042 A ZA 200401042A ZA 200401042 A ZA200401042 A ZA 200401042A ZA 200401042 B ZA200401042 B ZA 200401042B
- Authority
- ZA
- South Africa
- Prior art keywords
- aryl
- heterocyclyl
- lower alkyl
- halo
- acoet
- Prior art date
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- 230000005764 inhibitory process Effects 0.000 title description 6
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- 108091005804 Peptidases Proteins 0.000 title description 3
- 239000003795 chemical substances by application Substances 0.000 title description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title description 3
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- -1 R4 is H Chemical group 0.000 claims description 226
- 125000000217 alkyl group Chemical group 0.000 claims description 86
- 150000001875 compounds Chemical class 0.000 claims description 77
- 125000005843 halogen group Chemical group 0.000 claims description 38
- 125000003118 aryl group Chemical group 0.000 claims description 37
- 238000000034 method Methods 0.000 claims description 25
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 18
- 201000010099 disease Diseases 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 17
- 150000002148 esters Chemical class 0.000 claims description 15
- 229910020008 S(O) Inorganic materials 0.000 claims description 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 13
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 13
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000004104 aryloxy group Chemical group 0.000 claims description 11
- 229910052760 oxygen Inorganic materials 0.000 claims description 11
- 125000001424 substituent group Chemical group 0.000 claims description 10
- 239000002243 precursor Substances 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 8
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- 125000005842 heteroatom Chemical group 0.000 claims description 8
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims description 7
- 125000003435 aroyl group Chemical group 0.000 claims description 7
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- 125000004043 oxo group Chemical group O=* 0.000 claims description 7
- CYJAWBVQRMVFEO-UHFFFAOYSA-N piperazine-2,6-dione Chemical compound O=C1CNCC(=O)N1 CYJAWBVQRMVFEO-UHFFFAOYSA-N 0.000 claims description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
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- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121033.5A GB0121033D0 (en) | 2001-08-30 | 2001-08-30 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200401042B true ZA200401042B (en) | 2004-10-25 |
Family
ID=9921234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200401042A ZA200401042B (en) | 2001-08-30 | 2004-02-09 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7452886B2 (ru) |
| EP (1) | EP1423391B8 (ru) |
| JP (1) | JP4629334B2 (ru) |
| KR (1) | KR100695845B1 (ru) |
| CN (1) | CN100372849C (ru) |
| AR (1) | AR036374A1 (ru) |
| AT (1) | ATE326469T1 (ru) |
| AU (1) | AU2002333760B2 (ru) |
| BR (1) | BR0212226A (ru) |
| CA (1) | CA2458684C (ru) |
| CY (1) | CY1105573T1 (ru) |
| DE (1) | DE60211530T2 (ru) |
| DK (1) | DK1423391T3 (ru) |
| EC (1) | ECSP044998A (ru) |
| ES (1) | ES2262888T3 (ru) |
| GB (1) | GB0121033D0 (ru) |
| HK (1) | HK1072254A1 (ru) |
| HU (1) | HUP0401301A3 (ru) |
| IL (3) | IL160367A0 (ru) |
| MX (1) | MXPA04001935A (ru) |
| MY (1) | MY157368A (ru) |
| NO (1) | NO328890B1 (ru) |
| NZ (1) | NZ531343A (ru) |
| PE (1) | PE20030418A1 (ru) |
| PL (1) | PL368280A1 (ru) |
| PT (1) | PT1423391E (ru) |
| RU (1) | RU2331644C2 (ru) |
| TW (1) | TWI297690B (ru) |
| WO (1) | WO2003020721A1 (ru) |
| ZA (1) | ZA200401042B (ru) |
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| GB0304640D0 (en) * | 2003-02-28 | 2003-04-02 | Novartis Ag | Organic compounds |
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| EP1797883A3 (en) * | 2003-04-28 | 2007-08-01 | Novartis AG | Pharmaceutical composition comprising a cathepsin S inhibitor and an opioid |
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| ES2722524T3 (es) | 2011-09-02 | 2019-08-13 | Incyte Holdings Corp | Heterociclaminas como inhibidores de pi3k |
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| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
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| KR102054910B1 (ko) * | 2017-12-19 | 2019-12-12 | 한림제약(주) | 피롤로[2,3-d]피리미딘 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
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| WO2022226166A1 (en) * | 2021-04-22 | 2022-10-27 | Protego Biopharma, Inc. | Spirocyclic imidazolidinones and imidazolidinediones for treatment of light chain amyloidosis |
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| NL270922A (ru) | 1960-11-02 | |||
| CH627919A5 (de) | 1977-04-14 | 1982-02-15 | Ciba Geigy Ag | Herbizide mittel. |
| US5958930A (en) * | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
| EP0682027B1 (de) * | 1994-05-03 | 1997-10-15 | Novartis AG | Pyrrolopyrimidinderivate mit antiproliferativer Wirkung |
| US5683999A (en) * | 1995-03-17 | 1997-11-04 | The Dupont Merck Pharmaceutical Company | Cyclic urea HIV protease inhibitors |
| HUP0001507A3 (en) * | 1997-03-19 | 2002-01-28 | Abbott Gmbh & Co Kg | Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
| ATE347362T1 (de) * | 1998-06-30 | 2006-12-15 | Lilly Co Eli | Bicyclische spla 2-inhibitoren |
| PL346700A1 (en) * | 1998-09-18 | 2002-02-25 | Basf Ag | Pyrrolopyrimidines as protein kinase inhibitors |
| PT1235830E (pt) * | 1999-12-10 | 2004-04-30 | Pfizer Prod Inc | Compostos de pirrolo¬2,3-d|pirimidina como inibidores das proteina cinases |
| AU2001247589A1 (en) * | 2000-03-20 | 2001-10-03 | Axys Pharmaceuticals, Inc. | Non-amidine containing protease inhibitors |
| WO2001083460A1 (fr) | 2000-04-28 | 2001-11-08 | Tanabe Seiyaku Co., Ltd. | Composes cycliques |
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2001
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- 2002-08-29 BR BR0212226-0A patent/BR0212226A/pt not_active Application Discontinuation
- 2002-08-29 JP JP2003524991A patent/JP4629334B2/ja not_active Expired - Fee Related
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